tag:blogger.com,1999:blog-36840063.post1849027739331982896..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Insulin makes you hungry (4) unless you keep it out of your brainPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-36840063.post-83675249727345111642018-08-26T00:37:23.727+00:002018-08-26T00:37:23.727+00:00I didn't scihub this paper, but is there evide...I didn't scihub this paper, but is there evidence they used hyperosmolar duodenal infusion in the 1985 paper? That would be bizarre if so, typically they would use standard iv normal saline.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-2065120970531954782018-08-02T18:36:49.566+00:002018-08-02T18:36:49.566+00:00Insulin, the magic backwards hormone that makes pe...Insulin, the magic backwards hormone that makes people hungry by being absent. The mind boggles.E-Shttps://www.blogger.com/profile/11618396250935467279noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-15638849878376349462018-08-02T14:10:44.508+00:002018-08-02T14:10:44.508+00:00raphi!!!! Go and wash your mouth out with soap and...raphi!!!! Go and wash your mouth out with soap and water! Peter shakes head in astonishment that anyone might do anything so useless. Like fitting indicators to BMWs...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-21136807040845530072018-08-02T11:16:17.267+00:002018-08-02T11:16:17.267+00:00someone should point this out to Guyenet (assuming...someone should point this out to Guyenet (assuming they're idealistic enough to presume it may re-focus his skepticism)raphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-29812206148197807972018-08-02T04:49:02.422+00:002018-08-02T04:49:02.422+00:00raphi, it's not. The question is: How do you s...raphi, it's not. The question is: How do you set the experiment up to get the results you need? Like the anorectic effect of CNS insulin. This happens every time when certain labs perform the injection. But never in Novo Nordisk's lab. Repeatedly. How does this happen? <br /><br />erdoke, yep. Just pubmed hypertonic saline and look what it does intravenously.<br /><br />Colin, the "central insulin drives white adipose tissue expansion" group has a certain amount to say about glycerol plus lots of NADH = gluconeogenesis, ie glucose from fat. They describe elevated FFAs as controlling hepatic GNG. A concept I like. Again, how you set up the experiment might be quite important.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-30146220692430066562018-08-01T19:11:56.145+00:002018-08-01T19:11:56.145+00:00so why is it so hard to figure out what kind of in...so why is it so hard to figure out what kind of insulin makes it into the brain or not?raphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-73177969110415641172018-08-01T19:11:31.558+00:002018-08-01T19:11:31.558+00:00This comment has been removed by the author.raphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-5852359993768955812018-08-01T16:26:12.578+00:002018-08-01T16:26:12.578+00:00FYI, hyperosmolar saline is not inert.
Hyperosmol...FYI, hyperosmolar saline is not inert.<br /><br />Hyperosmolar duodenal saline infusion lowers circulating ghrelin and stimulates intestinal hormone release in young men<br />https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/jc.2018-00699/5056321erdokehttps://www.blogger.com/profile/15499429052272967314noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3950911188259695132018-08-01T12:01:40.899+00:002018-08-01T12:01:40.899+00:00Fascinating, thanks!Fascinating, thanks!Kohquehttps://www.blogger.com/profile/15763681407500312651noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-46105616456346594082018-08-01T09:55:45.003+00:002018-08-01T09:55:45.003+00:00Just finished watching Georgia Ede talking about ...Just finished watching Georgia Ede talking about Mood & Memory (https://www.youtube.com/watch?v=O8eR0R3sMHw) and the brains requirements for Insulin, the hippocampus being the most insulin sensitive area. Physiological insulin resistance will reduce the bodies overall demand for glucose during gluconeogenisis, so does this explain the control of the upper limit of GNG and GNG being demand driven as part of hippocampus insulin/glucose balance. Just trying to understand GNG regulation above normoglycaemia.Chttps://www.blogger.com/profile/10331341413927998704noreply@blogger.com