tag:blogger.com,1999:blog-36840063.post2109619512166114321..comments2024-03-18T22:09:37.509+00:00Comments on Hyperlipid: Fructose and lactic acid in Naked Mole RatsPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-36840063.post-6986196124212748282017-11-04T08:57:06.421+00:002017-11-04T08:57:06.421+00:00hi Jacob,
Fructose "can't" create m...hi Jacob,<br /><br />Fructose "can't" create more oxygen, but do you mean that to create 1 unit of ATP it uses more oxygen? (compared to glucose, say)raphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-13263030889113045632017-11-04T08:56:10.247+00:002017-11-04T08:56:10.247+00:00hi Wout,
yes, they can shunt fructose down the PP...hi Wout,<br /><br />yes, they can shunt fructose down the PPP to increase biosynthetic intermediates that the cancer will require to sustain high rates of proliferationraphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-20503112639887162972017-08-09T04:02:28.007+00:002017-08-09T04:02:28.007+00:00Maybe less oxygen means less free radicals, and th...Maybe less oxygen means less free radicals, and thus less insulin resistance, and thus fructose is protective in hypoxia because it enters the cell easier than glucose, due to it having a lower F:N ratio than glucose,? I don't think that's correct but maybe.<br /><br />Also, I don't really understand fructose metabolism fully, but perhaps it simply creates more oxygen as a by-product of it's metabolism than glucose?<br /><br />In addition to what you already mentioned.Jacobhttps://www.blogger.com/profile/03767819286295838366noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-34682360086670978902017-07-24T06:32:00.953+00:002017-07-24T06:32:00.953+00:00@raphi am I reading that correctly as "cancer...@raphi am I reading that correctly as "cancer cells could be using fructose to survive?"Wout Mertenshttps://www.blogger.com/profile/05787109608088688477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-30146401985610829232017-06-08T08:48:05.702+00:002017-06-08T08:48:05.702+00:00Hi Peter,
"It doesn't seem to matter how...Hi Peter,<br /><br />"It doesn't seem to matter how you acidify the cytoplasm (fructose is as good a way as any), it's the acidosis which appears to protect against mitochondrial failure" ==> fits pretty well with what I know about cancer cells. The bastards are masters at effluxing protons to maintain a normal (and even slightly higher than normal) pH, and their mitochondria are ALWAYS broken & dysfunctional to some degree.<br /><br />I'd love to see some cancer cell culture experiments repeated with more fructose conditions vs glucose to see how the mitochondrial response differs in a scenario where large ATP demands exist (lots o' replication!)raphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.com