tag:blogger.com,1999:blog-36840063.post293996829143751755..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: FIP vaccines etcPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger41125tag:blogger.com,1999:blog-36840063.post-28997995139215862142020-12-19T05:27:08.246+00:002020-12-19T05:27:08.246+00:00Good read Tucker. The drive to convert feline ente...Good read Tucker. The drive to convert feline enteric coronavirus in to feline infectious peritonitis virus is intimately linked to a mutation which allows it to infect macrophages, which drive the formation of lethal solid granulomata or immune mediated vasculitis. This mutation takes time in the FIP model and prompt clearance of the virus (as is usual in field infection) is what seems to be protective against this development. I have to say that this post is completely based on thinking around FIP and reading Lowe has expanded my knowledge base about ADE a great deal. The on going, never ending war between host and pathogen is fascinating. Not just viral either.<br /><br />Ta<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-70141764970328009082020-12-18T19:01:03.168+00:002020-12-18T19:01:03.168+00:00Lowe did an update. tl;dr: no sign of it so far in...Lowe did an update. tl;dr: no sign of it so far in the current vaccine candidates.<br /><br />"Antibody-Dependent Enhancement"<br /><br />https://blogs.sciencemag.org/pipeline/archives/2020/12/18/antibody-dependent-enhancementTucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-84897123055094519132020-12-16T16:35:40.810+00:002020-12-16T16:35:40.810+00:00That's very sad about the horshoe crabs, if tr...That's very sad about the horshoe crabs, if true. You think they'd try to find a better way.<br /><br />I said above that squalene was an adjuvant. Apparently not. It's just one of the lipids they use to encapsulate the payload. <br /><br />I found a range of opinions on whether mRNA vaccines need adjuvants or not. It's generally agreed that they don't need *as much*. Some articles outright say they're self-adjuvanting, others say an adjuvant "may" be helpful.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22246072916287350392020-12-16T10:50:55.146+00:002020-12-16T10:50:55.146+00:00"I did read an article that said no excess sh..."I did read an article that said no excess sharks will be killed in service of making covid-19 vaccine."<br /><br />I did hear that horshoe crabs might be driven to extinction though. Their blood is harvested to make some important, irreplaceable lab reagent.Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-11177580186949372802020-12-15T05:07:38.575+00:002020-12-15T05:07:38.575+00:00cave, intranasal vaccines are usually aimed at res...cave, intranasal vaccines are usually aimed at respiratory pathogens, they're not adjuvated. The only one for cats which showed up briefly in the UK many years ago was aimed at bordatella infection but it never really took off. Of no obvious clinical benefit really. The currently used canine intranasal is aimed at bordatella too but has a marketing lever because many kennels will not accept non vaccinated dogs. There are many other causes of cough in kennelled dogs but bordatella is a significant one.<br /><br />The choice in parenteral vaccines is adjuvated vs live virus. Both have their problems. Live vaccines carry the risk of live viral contaminants, such as SV40 in the human live polio vaccines. ISFM is currently recommending FeLV vaccine as a primary course, booster at a year and then every third year after that. When I was a clinician I would discuss discontinuing FeLV vacc after about 12y of age and advised stopping it after about 15y. Susceptibility drops with age and sarcoma risk increases with number of doses was my logic. For fully indoor cats I would always discuss, and advise, avoiding the vaccine. Unless there were very specific reasons for which the fully indoor cat might still be at risk.<br /><br />The main feline respiratory virus vaccines are all live injected vaccines and I have advised clients for decades that they do not stop infection, merely reduce illness.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-19394784104360601882020-12-14T20:42:33.058+00:002020-12-14T20:42:33.058+00:00Eric, thanks for the Wikipedia link, interesting. ...Eric, thanks for the Wikipedia link, interesting. Learning about aluminum adjuvants in some vaccines finally pushed me over the edge to stop getting the flu shot every year, around 2014. Reinforced by the fact that I just don't get sick anymore, since I stopped eating carbs in 2010. <br /><br />Adjuvants are used in vaccinations because they increase inflammation which increases the immune response, essentially making manufacturing cheaper—excuse me, sorry, I meant more efficient—because you can dilute your vaccine. So it makes sense that adjuvants can be toxic substances like aluminum.<br /><br />Apparently they're still using aluminum adjuvants in some vaccines, which is mentioned in this CDC article. Another adjuvant that is commonly used these days is squalene, most of which is derived from shark livers. https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/influenza-h5n1-virus-monovalent-vaccine-adjuvanted-manufactured-id-biomedical-corporation-questions<br /><br />I did read an article that said no excess sharks will be killed in service of making covid-19 vaccine. Yeah, right.<br /><br />Peter said "Personally I buy a non-adjuvated vaccine for my cats..." I wonder if such thing is available for us mere civilians here in the US. I do have a question about the feline leukemia vaccine. It's given as an example of another type of vaccine that can cause the sarcomas; do they not give it as a nasal spray anymore? My cat's about five years past due on all her shots. Are nasal spray vaccines also adjuvanted, and have they ever been suspected to cause similar side effects?cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-35368712211993214602020-12-14T15:54:21.925+00:002020-12-14T15:54:21.925+00:00Interesting. Never seen an injection site sarcoma ...Interesting. Never seen an injection site sarcoma in a dog, at least not that I recognised (and they're not hard to spot!).<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-42905820567917679512020-12-14T15:51:28.922+00:002020-12-14T15:51:28.922+00:00I think developing metabolic syndrome is a marker ...I think developing metabolic syndrome is a marker of having qualified as a medic, a sort of badge of honour. I also think three weeks of sleep deprivation under conditions of extreme stress with physical and mental exhaustion will make it a damned sight worse. I think subsisting on Snicker bars from a junk food dispenser because you're too tired to go to the canteen (if you are allowed there from the COVID wards) for a lovely low fat, high carb HeartHealthy pasta dish is only slightly the worse of two evils.<br /><br />Just opinion. I have no evidence.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-77200239697693046172020-12-14T15:38:17.823+00:002020-12-14T15:38:17.823+00:00There is no syndrome like Feline Adjuvant Associat...There is no syndrome like Feline Adjuvant Associated Sarcoma in any other species (that I know of). I only mention it because it does nothing to enhance anyone's confidence in adverse reaction honesty from vaccine manufacturers. Personally I buy a non-adjuvated vaccine for my cats and only give it every three years rather than annually. The sarcoma is actually associated with any chronic trauma location, microchips have also triggered it. But the adjuvant makes a spectacular image in the centre of a highly aggressive sarcoma when viewed by the pathologist. It's the common cause. It's a common tumour. The 1 in 10,000 cited in the literature is bollocks.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-88520214248754648042020-12-14T14:50:58.323+00:002020-12-14T14:50:58.323+00:00https://oem.bmj.com/content/early/2020/12/01/oemed...https://oem.bmj.com/content/early/2020/12/01/oemed-2020-106731<br /><br />7x higher risk of severe covid for medical staff. Doesn't talk about vets, though.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-79041132036713358382020-12-14T13:54:27.279+00:002020-12-14T13:54:27.279+00:00https://en.wikipedia.org/wiki/Vaccine-associated_s...https://en.wikipedia.org/wiki/Vaccine-associated_sarcoma<br /><br />Oh boy! And dogs and ferrets can get it, too. I was never happy about aluminum salts in human vaccines, but this is something else. Is there reason to believe humans are fundamentally different from those carnivores?<br /><br />Re: personal experience, this can be treacherous. I know of plenty of people that have had it but with the exception of one kid in my daughter's class, I haven't met any of these. But a colleage already had four people in his extended family die of the virus. And I know of a colleague (whom I actually knew in person) dying of an embolism in her early forties, but don't know if she had had Covid before. If you go by personal acauaintes only in a reasonably healthy demographic, chances are there isn't anybody with serious damage.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-41628193793001219562020-12-14T09:55:41.037+00:002020-12-14T09:55:41.037+00:00Peter, no I hadn't. Is this associated with an...Peter, no I hadn't. Is this associated with any particular adjuvant? With most conventional human vaccines beng adjuvant enhanced (as is the AstraZeneca?), one would think that if this were an issue with humans, one would have heard about it. mRNA does without, but then it is the new kid on the block, which carries risks of its own.<br /><br />I am reasonably sure we've had it (two teenage kids in school, my wife communting by train daily until March, myself travelling to Newcastle, Amsterdam and all over Germany and mingling with people who had just returned from Silcon Valley and Asia in late February, early March. Still there is no was to be sure now, and longer lasting lost of smell or gratitous vascular disease would be deal breakers for me.<br /><br />Does Boris even know what it says on his tin?<br /><br />As for our state, we have a green (but somewhat conservative leaning MP) and a conservative coalition partner with a conservative education secretary who sometimes reminds me of Miss Umbridge. It is also the homeland of liberalism in Germany (going back to the failed revolutions of 1830 and 1849). Why introduce a curfew that makes little sense when you think about it before seriously enforcing mask rules in public schools or closing retail and schools?Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-60023877029365800712020-12-14T09:01:02.276+00:002020-12-14T09:01:02.276+00:00Re vaccination, hard to say. It's not just me ...Re vaccination, hard to say. It's not just me because people tell me it is a general impression, common in people who don't know me at all.<br /><br />BTW Have you ever heard of "Feline adjuvant associated sarcoma"? It is supposed to be very rare. I have operated on two staff cats for this in the last 5 years and on a number of other cats too. This is brutal, aggressive, radical surgery with a guarded prognosis. Nurses who have lost cats to this and subsequently had to nurse client owned cats through the same op tend to be somewhat cautious about vaccines.<br /><br />More generally people who have tested PCR positive and been ill have, in their demographic, been trivially unwell. One coughed for three days, one lost sense of smell for one day. They kept their kids (no symptoms, not tested) off of school for 10 days.<br /><br />None of the people I work with are overweight, let alone morbidly obese, so this may slew attitudes.<br /><br />I also guess that even people who voted for Bojo did it for reasons other than any sort of trust in him. They wanted Brexit, Bojo is the tool. I doubt anyone is foolish enough to trust him on anything.<br /><br />Obviously all politicians are bent, just some hide it better than others. In some ways you do have to admire Bojo. He makes no effort to hide his character. You get exactly what it says on the can.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-83448960374961936792020-12-14T05:23:27.418+00:002020-12-14T05:23:27.418+00:00And while I am generaly in favor of controlling in...And while I am generaly in favor of controlling infections, I think they have gone overboard in our state. They imposed an 8 pm to 5 am curfew on Saturday but left shops and schools open (until Tuesday when the nationwide shutdown starts). You can still meet with 5 people from two different households but if you don't get home by 8, you have to stay the night. Now if they are concerned about private partying, is it better if folks stay and probably continue partying?Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-89216362270345639872020-12-14T05:17:55.572+00:002020-12-14T05:17:55.572+00:00forgot the link again:
https://www.spiegel.de/wiss...forgot the link again:<br />https://www.spiegel.de/wissenschaft/medizin/coronavirus-infizierte-genesene-tote-alle-live-daten-a-242d71d5-554b-47b6-969a-cd920e8821f1<br /><br />Worldwide numbers (one week average) is the first data insert, excess mortality the third.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-66366438616320207852020-12-14T05:16:21.144+00:002020-12-14T05:16:21.144+00:00Peter,
I typed this up yesterday but somehow it d...Peter,<br /><br />I typed this up yesterday but somehow it didn't get posted. I had not previously seen the low ICU occupancy rate for Covid in the UK:<br />https://www.thesun.co.uk/news/13219465/covid-patients-hospital-still-rising-icu-admissions-falling/<br /><br />So I can see why you say the severity is probably not as bad in the UK as it is elsewhere.<br /><br />So we have < 200 in ICU in England (not UK, so 56 million inhabitants) out of adult ICU capacity of about 4200. Are pretty much all of them being ventilated?<br /><br />In Germany (pop 83 million) we have 4000 in ICU, half of them ventilated, out of a total capacity of currently due to staff shortages 27,000. It may simply be that doctors, justly or not, are taking the decision to transfer to ICU more lightly. <br /><br />When we look at infection rates, the UK and Germany have been at give or take 20,000 per day for the last four weeks, and deaths by Covid are eerily similar at 430 resp. 440. France, through a long lockdown, has infections down to 10,000 and deaths are lagging but now at 370 (used to be in 500-600 territory). Spain, which was in a bad place in September, is now down to 6,600 infections and 200 deaths.<br /><br />Sweden is now at 5,900 infections / day and 64 deaths. At the same time, the Stockholm region has 100% ICU occupancy now and they are having to transfer patients to Finland and Norway. The reason they are seeing few deaths (even compared to Spain which has the same average infection rate for the past week) is that they have been trending up whereas everyone else had plataued (UK, Germany) or was receding (France, Spain).<br /><br />Italy is at 17,000 infections and 650 deaths. They had their peak infections about two weeks ago so hopefully deaths are going to be much lower in two weeks time.<br /><br /><br />The picture that I see here is that infection rates seem to matter, pandemic history and ICU capacity not so much.<br /><br />Now, excess mortality (available for most countries out to mid November) is a different story:<br />Significant second peaks in Spain, France, Italy, Switzerland, Austria, the Netherlands, Portugal and a triple peak in Belgium. Very little in the UK, nothing in Germany, Sweden. Italy is only reporting into August. This, again, supports your take that the UK is doing okish.<br /><br />It will be interesting to look at December numbers when they are out.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-77352725208287264092020-12-14T04:46:37.459+00:002020-12-14T04:46:37.459+00:00Peter,
are your work colleagues reserved about g...Peter, <br /><br />are your work colleagues reserved about getting vaccinated because they think they don't need it or because they are sceptical about side effects or long term damage? Apparently, a survey by the German vaccination council (I suppose our equivalent to SAGE when it comes to vaccines) found out that medical personal are more reserved than the average population about getting vaccinated. No explanation was given, but Karl Lauterbach (a very vocal MP and former epidemiologist) tweeted immedeately that this was driven by a false sense of security (PPE, and doctors appear to feel invincible in general) and that they should reconsider both their personal risk, the risk of becoming spreaders, of not being able to care for their patients, and about setting an example. Full guilt assault!<br /><br />But I am curious if reservations about efficacy and safety do exist. What do your colleages say?Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-4149773667128231122020-12-13T05:45:14.437+00:002020-12-13T05:45:14.437+00:00Bob, I can imagine the thing about criminals being...Bob, I can imagine the thing about criminals being more careful during police strikes to be true in the US, and even barely so. Many people keep guns at home and may used them against an intruder with few restrictions. They do use them even when the police are not on strike because "it's their right" and they will be quicker than any patrol. Still, burglary rates are high on an international scale.<br /><br />In countries with fewer guns at home and more restrictions on their use in self-defense, even that explanation falls apart.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-9257166144578075862020-12-12T19:46:46.420+00:002020-12-12T19:46:46.420+00:00"...the criteria for admission are lower now ...<i>"...the criteria for admission are lower now than they were in the spring because there is no overwhelming problem at the moment."</i><br /><br />I wonder if this is true in California as well. We're "locked down" again more severely than ever (apparently LA Mayor Garcetti decreed "no non-essential walking" -- oh, brother!) mostly over declining ICU capacity. <br /><br />It's easy to think of some variables as fixed in nature, like hospital admissions. But, if Heneghan is right, some variables are, um, variable (I guess like PCR test thermal cycles). Makes it impossible to do apples-to-apple comparisons.LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-56971175604251095112020-12-12T09:27:02.671+00:002020-12-12T09:27:02.671+00:00Eric, the same has been said for current hospitali...Eric, the same has been said for current hospitalisations for COVID in the UK, the criteria for admission are lower now than they were in the spring because there is no overwhelming problem at the moment. At least that's Carl Heneghan's view. Given the choice between trusting someone specialised in evidence based medicine vs Matt Hancock I feel a tendency towards someone who is not a pathological liar... Easy choice really!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-62953243639725497662020-12-12T06:25:07.003+00:002020-12-12T06:25:07.003+00:00sorry, here's the link:
https://www.swr.de/swr...sorry, here's the link:<br />https://www.swr.de/swraktuell/so-wirkt-der-teil-lockdown-100.htmlErichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-42008756606435847432020-12-12T06:24:46.367+00:002020-12-12T06:24:46.367+00:00Peter, it is always interesting what I can learn h...Peter, it is always interesting what I can learn here. It would be interesting to see if the gap is fully made up of deadly outcomes of elective procedures. Maybe it is just people staying away from GPs and not getting prescribed what I call elective or ill-advised medicines.<br /><br />Just looking at Covid deaths, the UK, France, and Germany are not too different, it is just that they are coming from different places. It with widespread immunity that should be there in the UK and France, I find it surprising that deaths are still that high.<br /><br />The UK might be looking somewhat better right now because of increasing immunity (my guess was that this should have been achieved by summer, but somehow it wasn't) or because it entered a serious second lockdown much earlier. Germany is getting serious just now, and they are still talking about keeping schools and shops open until right before Xmas.<br /><br />Re ICU-occupancy, I doubt you can compare countries. The UK always had a low ICU capacity (which may be a good thing for various reasons), so a given severity of Covid might land you in ICU in Germany, but not the UK.<br /><br />This graph (at the very bottom of the article) has ICU occupancy over time in Germany. Orange is Covid without ventilation, brown is Covid with ventilation. Their total is around 4000 now. Overall capacity has been going down since November for various reasons:<br />- staff being sick<br />- more staff needed to care vor Covid than for other patients<br />- elective procedures limited, hence less need for reserve capacity<br />- hospitals trying to pressure politcs into more actionErichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-68960690403647062872020-12-11T21:33:40.519+00:002020-12-11T21:33:40.519+00:00Thanks Bob, hadn't read about police strikes, ...Thanks Bob, hadn't read about police strikes, interesting. The Dr strikes phenomenon I read about back in the late 70s. It was well established then. Yea gods, did I read all sorts of stuff before 'tinternet.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-21667211516577822252020-12-11T21:25:57.380+00:002020-12-11T21:25:57.380+00:00Eric,
It is simple fact. Elective procedures bene...Eric,<br /><br />It is simple fact. Elective procedures benefit well being but are never risk free. They stop during Drs strikes.<br /><br />https://www.sciencedirect.com/science/article/abs/pii/S0277953608005066<br /><br />COVID restrictions are very different to a Drs strike.<br /><br />ICU occupancy for November is out now, ICNARC have accurate, up to date data until Dec 2nd. We are about 600 case occupancy in ICU above average for Nov (which is around 2,800 most years) but admission rate is currently dropping rapidly, certainly faster than it rose. Obviously not everyone leaves the ICU alive but falling admission rates are clearly excellent... The incomplete data for the following few days suggests an on going fall in admissions through early December. From<br /><br />https://www.icnarc.org/Our-Audit/Audits/Cmp/Reports <br /><br />using the link in the first section to "COVID-19 report".<br /><br />My feeling is the UK was unlucky in Spring and is doing ok-ish now. Germany looks to be the converse... As Tegnell has said, we will have to wait a year or two to see how things really work out.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-81576479315557211432020-12-11T21:21:04.087+00:002020-12-11T21:21:04.087+00:00Hi, Eric,
I've read this is also true of poli...Hi, Eric,<br /><br />I've read this is also true of police strikes and crime, at least in the USA. The reason given is that police are under certain constraints when dealing with suspects (yes, I realize it's controversial how constrained police sometimes are), but private citizens are not so constrained, and crooks know it. So they're less likely to break into someone's abode and deal with a furious and frightened resident who can't call the on-strike cops. <br /><br />Just another reminder things don't always work the way they're "supposed" to.LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.com