tag:blogger.com,1999:blog-36840063.post3446564676395056337..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: HbA1c: Low glucose and acid (palmitic)Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger27125tag:blogger.com,1999:blog-36840063.post-56644170280020413692014-06-10T21:10:40.969+00:002014-06-10T21:10:40.969+00:00Liphophobia is a faith based proposition. With fa...Liphophobia is a faith based proposition. <a href="http://themedicalbiochemistrypage.org/fatty-acid-oxidation.php#mitochondria" rel="nofollow">With fatty acids being a better source of ATP than glucose</a>, Nature as a liphophiliac should at least be the null hypothesis. This is what natural selection tells us.<br /><br />Not sure how they can <a href="http://tutorial.math.lamar.edu/Classes/DE/SystemsDE.aspx" rel="nofollow">decouple</a> the actions of L-carnitine from palmitate. Be wary of any "scientist" trying to decouple coupled systems.js290https://www.blogger.com/profile/08157385596237909630noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-36876601047826543882014-06-09T12:04:04.472+00:002014-06-09T12:04:04.472+00:00P1 excellent point. Glucose changes the optics in...P1 excellent point. Glucose changes the optics in the brain. You lose the ability of harness polarized light carried on your electrons that get released to your now glycated brain tissue. Non native EMF exposure raises your perceived need for glucose as laid out in my EMF 4 blog post. There grouping in these charts underscores that these people actually represent different populations entirely. One has optimal optic transmission in their brain and the other does not. Here you see the effect of chromophores in the brain. No one seems to see what I see in these charts. This explains how HbA1c ties to Vitamin A and D cycles in the brain. Vitamin A and D cycle link to RXR receptors which directly tie to DHA. It is clear with my view point that they were improperly grouped together in the data and the most important link to longevity was buried.<br />Anonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-25696696277408103182014-06-08T04:14:39.000+00:002014-06-08T04:14:39.000+00:00I was looking at the NHANES III data, which showed...I was looking at the NHANES III data, which showed that A1C < 5 increased mortality. BUT, what was really interesting was that in the groups with AIC in the 4s the standard deviation of the population exploded. In other words, some people who had A1C of 4.5 lived much longer and some people with A1C had much higher mortality.<br /><br />That made me think these were actually different populations entirely, and they were improperly grouped together. Maybe the higher mortality groups were injecting insulin, or had other disease conditions. I've always wanted to understand the reasons for that data.P1https://www.blogger.com/profile/10150386241231733361noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-34522013785393181412014-06-07T09:52:21.211+00:002014-06-07T09:52:21.211+00:00I'm pretty sure Jesus & his Dad were high-...I'm pretty sure Jesus & his Dad were high-fiving each other when they figured out GNG & ketones were advantageous systems to bring together for us meat-machines...especially considering how they loved to see us wonder hungry for days while fighting off other animals!raphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-73085524639731012212014-06-07T09:40:53.714+00:002014-06-07T09:40:53.714+00:00My 2 cents:
My fasting BG level is ~80mg/dL (~ 4....My 2 cents:<br /><br />My fasting BG level is ~80mg/dL (~ 4.5mmol/L) or lower.<br /> <br />Following a 16hr fast (or >), my glycolytically demanding workout (~ 15min) elevates my BG to ~160mg/dL (~9mmol/L).<br /><br />My blood glucose then drops precipitously (below 100mg/dL) and steadily reaches fasting levels thereafter. So GNG does...what it's supposed to do without ‘overstepping’. This walks & talks like metabolic flexibility.<br />In fact, my breath ketone analyzer, Precisions Xtra ketone meter (& the Bayer KetoStix) all tell the same story: my body is still providing detectable & likely impactful levels of beta-oxidation, despite everything else.<br /><br />Whether I then go on to eat a keto or mixed meal post-workout, my post-prandial BG levels tend to drop to to ~60mg/dL (~3.3mmol/L). This is likely due to increased post-exercise musculoskeletal glucose uptake & a capacity to rely on FA substrates. I’m not light-headed, moody or any of that. Actually, I tend to feel particularly energised (whodda thunk it!?).<br /><br />Regardless:<br />- "Effects of a short-term carbohydrate-restricted diet on strength and power performance" http://www.ncbi.nlm.nih.gov/pubmed/23774282<br />- "Ketogenic diet does not affect strength performance in elite artistic gymnasts" http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3411406&tool=pmcentrez&rendertype=abstract<br /><br />“keto is incompatible with glycolytic activity” is a straw-man argument at this point. It’s obviously compatible (to say the least). The question is how does it fare compared to non-keto diets in terms of specific performance, health & longevity measures. What is the interindivdual variability? How can it be tweaked?<br /><br />For heavens sake, “It doesn't matter how beautiful your theory is, it doesn't matter how smart you are. If it doesn't agree with experiment, it's wrong!” - Richard P. Feynmanraphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-86998101668309014682014-06-05T05:38:59.067+00:002014-06-05T05:38:59.067+00:00Lovely find Dustin! Ta.
PeterLovely find Dustin! Ta.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-65946697043128455172014-06-05T05:36:19.229+00:002014-06-05T05:36:19.229+00:00Zachary,
High fat and endotoxin is important, it&...Zachary,<br /><br />High fat and endotoxin is important, it's on the "to do" list...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-33554620678591357322014-06-03T18:39:43.693+00:002014-06-03T18:39:43.693+00:00@Dustin, @Peter
This is the first time I have hea...@Dustin, @Peter<br /><br />This is the first time I have heard of no hypoglycemia when in keto. It makes sense to me if the brain is fat adapted. Still why is this not more widely known? I got beat up by some type I's for suggesting very low carb because of their fear of hypoglycemia. Or am I not understanding what http://www.ncbi.nlm.nih.gov/pubmed/5056667/ is implying.OldTechhttps://www.blogger.com/profile/10168775200930828906noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-21761576130638636152014-06-03T17:01:08.799+00:002014-06-03T17:01:08.799+00:00In regard to the Virginia Tech high-fat study.. Af...In regard to the Virginia Tech high-fat study.. After emailing the team inquiring about it they sent me a response:<br /><br />" The high fat diet is 55% fat and is isocaloric for five days. Isocaloric means you will not gain or lose weight, but the total study time is 29 days. This includes baseline testing, a 2 week period of diet standardization (where we tightly control your calories) and the 5 days of high fat diet a post testing. You would need to remain physically inactive for the remainder of the study if you qualify. The diet is a mix between saturated, unsaturated and polyunsaturated, but no trans fat. The diet is foods such as TV dinners, meat and cheese. We provide all food and compensation is $400 for completion of the study. Please fill out this survey to see if you meet the subject criteria."<br /><br />TV Dinners? <br />http://files.gamebanana.com/img/ico/sprays/itsatrap.jpgZacharyhttps://www.blogger.com/profile/15765341233390228928noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-86679552734491229282014-06-03T16:24:17.626+00:002014-06-03T16:24:17.626+00:00I'm not sure why everyone is debating that Pet...I'm not sure why everyone is debating that Peter could have dropped his BG that low and not experienced hypoglycemia. <br /><br />http://www.ncbi.nlm.nih.gov/pubmed/5056667/<br /><br />> After fasting 2 months, administration of weight-adjusted doses of insulin produced identical maximum insulin concentrations and disappearance curves. However, no insulin reactions nor significant rises in catecholamine excretion occurred despite equal extent and rate of glucose fall. Glucose concentrations as low as 0.5 mmoles/liter (9 mg/100 ml) failed to precipitate hypoglycemic reactions.<br /><br />As low as 9 mg/dl, yet no hypoglycemic reactions! In a published study. <br /><br />This isn't debatable, hypoglycemia in the presence of ketones isn't an issue. If people have other studies showing a fat/ketone adapted person or group of people experiencing hypoglycemia through any mechanism, please share. Otherwise, you're making things up.Anonymoushttps://www.blogger.com/profile/07539041641963031749noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-84583636347597296642014-06-02T15:33:00.648+00:002014-06-02T15:33:00.648+00:00Peter!
I know you're a busy guy but i'd be...Peter!<br />I know you're a busy guy but i'd be curious to know your thoughts about this study being done at my local university:<br />http://www.vtnews.vt.edu/articles/2013/03/032013-fralin-diabetesgrant.html<br /><br />I find it outrageous they're putting average joes on a high-fat diet for 5 days and testing for endotoxin, intestinal permeability, and skeletal muscle metabolism. I sent them an email to volunteer, mostly as a joke. :)Zacharyhttps://www.blogger.com/profile/15765341233390228928noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-67626945900457938022014-06-02T05:39:17.689+00:002014-06-02T05:39:17.689+00:00I have a raleigh 20 torpedo duomatic. It goes up a...I have a raleigh 20 torpedo duomatic. It goes up any hill. It runs on elevated ketones only. No probs.Michael Frederikhttps://www.blogger.com/profile/01329099816577248881noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-65676478799723407822014-06-02T05:16:30.602+00:002014-06-02T05:16:30.602+00:00karl,
http://www.ncbi.nlm.nih.gov/pubmed/20852246...karl,<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/20852246<br /><br />Mel published this at this while she was at the AHT, we've more data since. The meters are not perfect but the Freestyle Lite was never 20% out compared to the commercial lab at the Trust or to our bench top machine in Berkshire.<br /><br />No one expects 2.7mmol/l to be accurate any more than the 1.9mmol/l was accurate when Mel checked her BG on some random glucometer at the Trust at the end of a 13hour shift w/o eating in deep ketosis. The figures may not be accurate but they don't represent 4.0mmol/l either. There is a rumour the meters are designed to under read at low readings but there are zero data published data to back this up, we really looked. We also generated low glucose samples by letting blood stand before paired readings and they seemed fairly good. We we using discard feline samples, not human. Hence the study to see if they were OK.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-70100685763984112122014-06-02T04:57:54.022+00:002014-06-02T04:57:54.022+00:00Nigel, I have an elderly Raleigh Clubman 12 speed ...Nigel, I have an elderly Raleigh Clubman 12 speed racing bike, circa 1980. One day I pedalled it up <a href="https://picasaweb.google.com/lh/photo/uzlshYMhDkvw2M56PtSOxM2E1u5iyrd9IOLe2kxeZt8?feat=directlink" rel="nofollow"><b>Applepie Hill</b></a> hill out of Compton. I used first gear. A few days later I did it in second gear. Next in third gear. After a couple of weeks I could get up in 12th gear. The steepest bend is close to 1 in 5. I did it one more time in 12th gear then lost interest. As you note, I’m not much in to exercise.<br /><br /><a href="https://picasaweb.google.com/lh/photo/a8bMbBig-sW3xDgoJ2Ots82E1u5iyrd9IOLe2kxeZt8?feat=directlink" rel="nofollow"><b>Streatley Hill</b></a> climbs out of the Thames Valley at Goring Gap. I can only manage this hill in 1st gear but it is steep enough and sustained enough that it feels very much like I work at VO2 max throughout the climb.<br /><br />None of the climbs elicited anything suggesting a hypo. What was very noticeable was that, on cresting either hill, there was no lactic acidosis, no payback time for oxygen debt, respiratory minute volume just dropped to normal cycling demands and there was no need to pause at the top of the rise. Deep ketosis, no idea what carb level I was on, but rather low.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-88348852036331177242014-06-01T23:44:07.845+00:002014-06-01T23:44:07.845+00:00First - 2.7mmol/l is about 46mg/dl - I don't...First - 2.7mmol/l is about 46mg/dl - I don't believe your meter. The truth about those meters is they are only slightly accurate +/-15% or +/-20% over a small range. Finding the complete specifications for a particular meter is often impossible (they simply claim they are FDA approved). <br /><br />Next - keto adaption takes time that seems to vary between people and simply eating excess protein will push you out of it. Testing with keto sticks or looking at post-prandial BG will let you know where you are. I wonder if we lose the adaption faster than we gain it?<br /><br />I have a question - not sure if there is a clear answer. I know low-carb people that have excellent fasting BG but their HbA1c didn't look so good. This could be because of Different reasons<br />1 -, they are getting high post-parndial BG from protein and don't know it <br /><br />2 - the HbA1c test is not as accurate for people eating low carb.<br /><br />3 - The accuracy of HbA1c has been over-sold.<br /><br />See - <br /><br /> http://chriskresser.com/why-hemoglobin-a1c-is-not-a-reliable-marker <br /><br /><br />I am quite disappointed that most MDs don't look at postprandial BG - A lot of the time fasting BG looks good until after a lot of damage is done. Early detection could greatly improve the lives of people willing to avoid carbs.<br /><br />There is also the question of peak BG - would the average claimed by HbA1c show the actual damage done or just the area under the curve? I doubt that the damaging effects of BG are linear.karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-88793565670439623042014-06-01T14:30:53.104+00:002014-06-01T14:30:53.104+00:00Nigel, that my blood sugar is higher on a VLC diet...Nigel, that my blood sugar is higher on a VLC diet as a response to an intense physical activity (over-wise it is very slowly dropping during the day if I fast and perform only regular day-time activities) makes me think than it is the adaptation of my body to the low level of glycogen.Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-29782102984661506212014-06-01T12:27:15.886+00:002014-06-01T12:27:15.886+00:00john said...
"Nigel,
I've been somewhat l...john said...<br />"Nigel,<br />I've been somewhat low carb for 4-5 years now and have never really noticed anything that would seem like glycogen shortage. However, only in this past year did I stop "carb refeeds," which I did just out of taste. I haven't had an appetite for sweet potatoes, etc in a long time for some reason. I probably eat <100 carbs per day and do weightlifting, climbing, and ballet. I did notice that when eating high carb my muscles got "pumped" more easily."<br />Cheers, John. As I think that muscle glycogen stores are "trickle-charged" by blood glucose while relatively sedentary, whether or not someone on a VLC diet runs out of muscle glycogen depends on the frequency and duration of high-intensity exercise.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-23160544883889958662014-06-01T11:58:12.420+00:002014-06-01T11:58:12.420+00:00Galina L. said...
"Hi, Nige!
It was a while w...Galina L. said...<br />"Hi, Nige!<br />It was a while when I measured everything. When I did it for couple weeks I cycled between 30 to 65 grams of carbohydrates a day. It took me almost a year to be adapted to fasted exercises, and I had an unpleasant experience doing so."<br />Thanks! How often do you do 1.5 hour cardio with intervals >85max?<br /><br />It's interesting that your blood glucose level is on the high side on a VLC diet. This supports my idea that hepatic glucose production is not tightly-controlled.<br />Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-13896679244159291942014-06-01T03:53:32.533+00:002014-06-01T03:53:32.533+00:00Very interesting and wondering if most are not rea...Very interesting and wondering if most are not really low protein say <20% and extremely high fat? <br />I'm more in the <100g carbs and higher >30% protein but <40% and never seen my BG go below 3.8 and H1AC around 4.5 and never measured ketogenic but close and my gave up as no meter ketone meter worked for after using 7 of them, with support line so maybe I was just borderline and never fat adapted?Stuarthttps://www.blogger.com/profile/07905609129969558707noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-17467075229160970862014-05-31T22:32:49.129+00:002014-05-31T22:32:49.129+00:00To be in the palmitate without carnitine state, yo...To be in the palmitate without carnitine state, you'd need to have scurvy.<br />While we're talking about ascorbate,<br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615720/<br /><br />Mitochondria, Energy and Cancer: The Relationship with Ascorbic AcidPuddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-72492120822676286442014-05-31T19:58:15.113+00:002014-05-31T19:58:15.113+00:00Nigel,
I've been somewhat low carb for 4-5 ye...Nigel,<br /><br />I've been somewhat low carb for 4-5 years now and have never really noticed anything that would seem like glycogen shortage. However, only in this past year did I stop "carb refeeds," which I did just out of taste. I haven't had an appetite for sweet potatoes, etc in a long time for some reason. I probably eat <100 carbs per day and do weightlifting, climbing, and ballet. I did notice that when eating high carb my muscles got "pumped" more easily. <br /><br />Maybe my protein intake helps, or maybe I get by with just enough glycogen. I do eat high kcal (4-5000). <br /><br />There was a study in gymnasts, who seemed to do okay on ketogenic diets, though they were very high in protein (40-50% cal I think). <br /><br />I've never measured my blood glucose personally though in fasting lab measurements it's been low 80s. Johnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-24292795225554161762014-05-31T18:36:46.604+00:002014-05-31T18:36:46.604+00:00Very interesting post.
I have been wondering for ...Very interesting post.<br /><br />I have been wondering for some time what normal glucose would be for keto-adapted. This, of course, was not the focus of this post or the paper, but still this post and paper seems to suggest that LG may not be [as] damaging when keto-adapted despite the fact that the paper did not consider ketones.OldTechhttps://www.blogger.com/profile/10168775200930828906noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-12479735455415099672014-05-31T18:12:38.859+00:002014-05-31T18:12:38.859+00:00Hi, Nige!
It was a while when I measured everythin...Hi, Nige!<br />It was a while when I measured everything. When I did it for couple weeks I cycled between 30 to 65 grams of carbohydrates a day. It took me almost a year to be adapted to fasted exercises, and I had an unpleasant experience doing so.Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-75811011523792443992014-05-31T16:27:29.155+00:002014-05-31T16:27:29.155+00:00Galina L. said...
"I doubt I have much of gly...Galina L. said...<br />"I doubt I have much of glycogen due to my LC diet which I follow for last 6 years."<br />Hi Galina. How many grams of carbs/day do you eat? I consider LC to mean ~100g/day and VLC to mean <50g/day.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-27966085720897636672014-05-31T15:22:00.550+00:002014-05-31T15:22:00.550+00:00I do agree keto dieting and high intensity exercis...I do agree keto dieting and high intensity exercise dont mix well. <br /><br />A few max intensity interval sprints on the elliptical machine at the gym and I feel very light-headed and have to lay down. a few times ive come close to passing out. <br /><br />Same as when I go for high reps on squats. <br /><br />Maybe you can argue im not "fat adapted" whatever that means, but my exercise performance is much better when im carb'ed up.Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.com