tag:blogger.com,1999:blog-36840063.post441899503652961771..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Life (11) FerredoxinPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-36840063.post-10826336619972921072016-02-11T07:54:12.259+00:002016-02-11T07:54:12.259+00:00"Nothing in Biology Makes Sense Except in the..."Nothing in Biology Makes Sense Except in the Light of Evolution" - Theodosius Dobzhansky<br /><br />Peter have you tried playing around with the Ferredoxin sequence in Dotlet? http://myhits.isb-sib.ch/cgi-bin/dotlet<br />Who knows, an interesting comparisons could pop up.<br /><br />I'm repeating myself, but, I love the Life Series!<br /><br />[Shameless plug have nothing to do with the origin of life: new post up on cancer ==> exploring the link between metabolism & genetics https://raphaels7.wordpress.com/2016/02/10/cancer-linking-metabolism-to-genetics/]raphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-28262488953853618282016-02-11T07:30:18.468+00:002016-02-11T07:30:18.468+00:00"As far as I can tell it has no bearing on an..."As far as I can tell it has no bearing on anything we might do today but I still like it."<br /><br />Not so sure it has 'no bearing'.. <br /><br />It is one bit, of one of the threads, of the "what bit gets broken(tm)" enigma that I keep obsessing about.<br /><br />There is this nice <a href="https://upload.wikimedia.org/wikipedia/commons/d/d5/MTHFR_metabolism.svg" rel="nofollow"> diagram </a> on wikipedia. <br /><br />There is a correlation with hyperhomocysteinemia with T2D and PN (as well as CAD). There is some evidence (not good enough) that bringing down homocysteine with B12, betaine(TMG)etc might slow/stop the progression (not reverse) of PN.<br /><br />Yet the question remains is it the smoke or the fire. Reducing homocysteine has not turned out to look effective in treating CAD - yet that does not rule out causation. <br /><br />Understanding this twisted web of control loops is VERY HARD - and adding a bit of evolutionary history might help free up some clues - clues we really need. <br /><br />I keep thinking of the sulfur in some vents - sulfur holding metal co-factors in enzymes - removal of heavy-metals ? <br /><br />,.,.<br />Control loops - it occurred to me that something that holds our weight-set-point is likely to be something that integrates -- (see <a href="https://en.wikipedia.org/wiki/PID_controller" rel="nofollow"> PID loops </a> ). The leptin feedback seems a bit like that. I wonder what a shortage of leptin feels like compared to a carb crash? I don't think appetite is a single subjective sensation.karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.com