tag:blogger.com,1999:blog-36840063.post5363278732958983442..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: HLA-B27 and EbringerPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger44125tag:blogger.com,1999:blog-36840063.post-79480088103910124682010-08-15T05:21:22.653+00:002010-08-15T05:21:22.653+00:00Hi Susan,
I would certainly agree that increased ...Hi Susan,<br /><br />I would certainly agree that increased gut permeability is core to most auto immune diseases. The diet derived from Prof Ebringer's work is utterly gluten free as part of the low starch approach...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-64078615196131129072010-08-11T17:50:58.081+00:002010-08-11T17:50:58.081+00:00So following another thought, the idea that starch...So following another thought, the idea that starches (un-predigested as in sourdoughs) are touch on the system and that there are other abuses in the gut, create gut permeability. Klebsiella is then 'leaked' and an anti-body is set out against it. This protein mimics collagen I, III, IV and V which then is attacked where it is present throughout the body. AS, RA, Crohn's strictures.<br />Also, D needs K2 (in organ meats, blue cheese and natto) to work properly in it's antimicrobial role with the vagas nerve. Primitive people would have eaten the whole animal.<br />Just some food for thought.Swalkermeerehttps://www.blogger.com/profile/09572895577046305488noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-4115676126916272332008-11-10T19:31:00.000+00:002008-11-10T19:31:00.000+00:00Interesting. I'll keep that in mind. Another pos...Interesting. I'll keep that in mind. <BR/><BR/>Another possibility for the B27 gradient is that it's under selection from something else, maybe a tropical disease. I agree a founder effect seems unlikely if there is a continuous gradient from the equator to the arctic.Stephan Guyenethttps://www.blogger.com/profile/09218114625524777250noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-88946013575091489472008-11-08T21:39:00.000+00:002008-11-08T21:39:00.000+00:00Hi Stephan,I've been thinking about this and I'm s...Hi Stephan,<BR/><BR/>I've been thinking about this and I'm suspicious that having the gene may be quite bad news generally, if you are starch based in your gathering, whatever you do with the starches. The main thing that seems to suggest this is the rarity of the gene, but not it's complete absence, in equatorial areas. This suggests the gene was present in humans before they moved out of Africa. People with the gene did OK the further from the equator they moved. If the gene was neutral under "ideal" conditions (high D, adequate omega 3s etc) there would be no need for it to be rare in starch eating communities and it should be there at a similar frequency as in carnivorous HGs (up to 40% in the Inuit). Hmmm, unless there was some sort of "founder effect"... Less likely as there is a graduation, more frequent B27 as you move north.<BR/><BR/>I think that grains probably make matters a great deal worse, hence the problems in ancient Egyptian skeletons. I guess a high population density, lots of graves and a dry climate make for lots of archaeological finds too.<BR/><BR/>PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-448093835449925132008-11-06T23:58:00.000+00:002008-11-06T23:58:00.000+00:00Hi Peter,I have two questions about all this. Do ...Hi Peter,<BR/><BR/>I have two questions about all this. Do you think these intestinal bacteria would be a problem if intestinal permeability is normal? I think I remember you speculating in a previous post that the problem with the Egyptians was a combination of starch and gluten-induced intestinal damage. I wonder if dairy protein might have the same effect. Then of course there's the aspirin and linoleic acid.<BR/><BR/>Also, I was thinking about how so many cultures ferment their starches. I wonder if that leaves less for the intestinal flora. <BR/><BR/>Certainly, if you look at traditional grain foods, they're typically a pile of mush that's been soaked, ground and fermented. Cultures often remove bran if they can. I suppose the goal is to maximize absorption so you don't have to many calories hanging around the gut for bacterial overgrowth.Stephan Guyenethttps://www.blogger.com/profile/09218114625524777250noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-51436473542168713942008-10-19T23:40:00.000+00:002008-10-19T23:40:00.000+00:00By the time humans were hunting big game, weren't ...By the time humans were hunting big game, weren't they often on the savanna/grasslands and out of forest/jungles?Annahttps://www.blogger.com/profile/17033443643442246531noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3797961033831909072008-10-19T21:22:00.000+00:002008-10-19T21:22:00.000+00:00For some perhaps the negative feedback loop would ...For some perhaps the negative feedback loop would present a problem, esp if other hormones were still imbalanced. I can think of a few people 'on the fringe' who would clearly not benefit from vitamin D supplementation -- sarcoidosis (tumor cells over produce 1,25OHD2, cyp 3A4 deviants (hydroxylates D2 and D3), ? others?? probably. There are a few who gain weight (fat, not muscle as expected) who probably have some odd VDR or vitamin D binding protein mutation. Vampires...j/k (I'm reading Twilight -- heavy stuff).<BR/><BR/>Since the canopy was so dense, perhaps that is why aboriginals consume so much grub? I mean literally... larvae, caterpillars, mealworms, bee babies, insect pupae, etc. These rich little buggers are rich in EPA DHA, vitamin A and vitamin D. Sally Fallon/WAP has discussed as well.<BR/><BR/>http://www.food-insects.com/<BR/><A HREF="http://www.food-insects.com/book7_31/Chapter%2010%20Western%20Research.htm" REL="nofollow">Vitamin PUFA content of Grubs</A><BR/><BR/>If it were me *smile* I'd choose a vitamin D/A capsule over a can of worms (as they do in Spain) or turning black/wrinkly as a buffalo's behind. <BR/><BR/>And a bowl of pork butt, Chinese tripe or blood cubes (YYYUUUMM!) wouldn't get turned down by me either! Asthma would stay controlled as would overall hormesis. Hopefully rickets won't hit my BIM again :)<BR/><BR/>-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-24497539676830365072008-10-19T05:23:00.000+00:002008-10-19T05:23:00.000+00:00Hi G,"What if I lived in the tropics?"How do you l...Hi G,<BR/>"What if I lived in the tropics?"<BR/>How do you like the Kitavan diet of yam, cassava and fruits? No hyperlipiding there, that's for certain.<BR/><BR/>Kidding aside, I would seek sun protection as much as possible since that's what the natives do. Those who must work outdoor, the peasants plowing the rice field all day under the sun, you'd see their skin turn as dark as the back of the water buffaloes they walk behind. How much vitamin D do you think they require? <BR/><BR/>In paleolithic time, sunlight is whatever penetrates through the tropical jungle's thick canopy. Oliver Sack in "An Anthropology on Mars" talks about tribes whose members rarely venture to the edge of the forest. (As an aside, their depth perception is so impaired, by spending the whole life in the jungle, that they attempt to reach out and touch the mountain in the horizon.) Needless to say, their vitamin D production is not as prolific as you imagine.<BR/><BR/>If one bypasses the (self-limiting) control-feedback mechanism intended by evolution when taking D3 supplement, perhaps less is more. It's a potent stuff.<BR/><BR/>JohnJohnNhttps://www.blogger.com/profile/07639308289155393659noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-65796849998777327672008-10-18T15:50:00.000+00:002008-10-18T15:50:00.000+00:00John,Neolithic Earth certainly has its challenges....John,<BR/><BR/>Neolithic Earth certainly has its challenges. We have to deconstruct F O O D and environmental triggers (ie sunlight/vitD) to manipulate homeostasis. <BR/><BR/>It appears to me that all traditional cultures consume both vitamins A and D together. For optimum growth, reproduction and prevention of proliferation, A and D appear to work synergistically. Just one example (breast CA) is <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/1654997" REL="nofollow">here</A>. In vivo discussions <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/12757024" REL="nofollow">here</A> and <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/15195890" REL="nofollow">here</A>.<BR/><BR/>Most cultures prepare brides, mothers-to-be and nursing moms with special diets of rich soup (marrow-derived A and D), cream/milk, and rich meats. (btw my 'anecdotal success' is that this is the formula for GINORMOUS mammaries without requiring surgery). On the walkabout, tribal males/warriors consumed milk and blood; vitamin A is enriched (RBP) in blood.<BR/><BR/>Makes a whole lotta sense to me too...dunno about the ebb and flow of hormones. I guess there is a purpose? What if I lived in the tropics?<BR/><BR/>-GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-68021455411822138402008-10-18T00:45:00.000+00:002008-10-18T00:45:00.000+00:00Peter,"I like to think that decent nutrition decre...Peter,<BR/>"I like to think that decent nutrition decreases the susceptibilty to infection."<BR/><BR/>Don't you think decent nutrition (and frequency of its occurrence - fasting) is how we control the bugs?<BR/><BR/>On prions: the grouping of CJD, DM and AD makes sense (more so than Erbinger's MS and CJD/BSE) since mis-folded proteins seem to be behind the problems.JohnNhttps://www.blogger.com/profile/07639308289155393659noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-51158102308622685122008-10-18T00:29:00.000+00:002008-10-18T00:29:00.000+00:00Dear bg,"Are we just killing ourselves slowly...Dear bg,<BR/>"Are we just killing ourselves slowly? With or without bugs?" <BR/>Rhetorically or not, it would happen faster (in my view) without the bugs. The environment that we exist in includes the microbiota within and the chemical soup we're swimming in. The former you can do something about but it's clearly not a paleolithic Earth we're living in.<BR/><BR/>Re. vitamin D: I'm sure we all have anecdotal successes with manipulating its level upward but several issues remain:<BR/><BR/>Shouldn't the level of circulating 1,25(OH)2D experience the same ebb and flow of the seasons - evolutionaryly speaking?<BR/>What is the longterm effect of amping up 1,25(OH)2D year round?<BR/>And lastly, shouldn't A & D be considered together the way they exist in food?<BR/>Regards,<BR/>JohnJohnNhttps://www.blogger.com/profile/07639308289155393659noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-60804699513403608562008-10-17T20:44:00.000+00:002008-10-17T20:44:00.000+00:00Hi Gyan,Have a read here:http://www.ncbi.nlm.nih.g...Hi Gyan,<BR/><BR/>Have a read here:<BR/><BR/>http://www.ncbi.nlm.nih.gov/pubmed/10205084<BR/><BR/>The role of both viruses and bacteria in the triggering of auto immune diseases does seem to vary from simple links such as rheumatic fever/streptococcus through to much more complex, with Freed suggesting that the viral neuraminidase exposes sugar moieties which are normally hidden. Quite how this ties in to traditional management of viral problems is wide open... Freed's comments are near the end.<BR/><BR/>I think mammalian cells use sugar-lectin systems as communication mechanisms. The difference is that these systems are biodegradable by mammalian systems too. Not so wheat germ agglutinin... <BR/><BR/>PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-64331021794346546692008-10-17T20:22:00.000+00:002008-10-17T20:22:00.000+00:00Stan,Well it's hard to decide. I found his OP work...Stan,<BR/><BR/>Well it's hard to decide. I found his OP work early on very interesting, and felt you could possibly tie increased blood brain barrier permeability in to immune mediated neurological damage as per Ebringer. I did a fair bit of searching and there were hints that OPs do increase BBB permeability. Your systemic antibodies need to get in to the CNS to cause disease there.<BR/><BR/>The Mn3+ and infrasound I found harder to follow the logic to, especially why infrasound effects should largely (but not completely) spare organic farms. Then I noticed that a commercial test system to detect prions uses sub sonic waves to amplify prions to detectable levels, so that took me back slightly. Lost the link to this firm. Found it through Red Flags initially.<BR/><BR/>I was also interested in the possibility of an excitotoxin based disease, again with OPs improving BBB penetration.<BR/><BR/>Ultimately I just don't know.<BR/><BR/>History is littered with non contagious diseases being attributed to a virus, now there is a hyperinfective misfolded protein. Hmmmm.....<BR/><BR/>PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-66727889415735273382008-10-17T19:59:00.000+00:002008-10-17T19:59:00.000+00:00IFWC,Can't really comment on these as they're not ...IFWC,<BR/><BR/>Can't really comment on these as they're not anything I've tried, others may know more. Hope it works for you.<BR/><BR/>PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-9376250745572281672008-10-16T22:27:00.000+00:002008-10-16T22:27:00.000+00:00Thanks for comments. I've been eating somewhat "n...Thanks for comments. I've been eating somewhat "normal" the past day or two, part fat part protein part carbs.<BR/><BR/>Can any of you share comments on the Anabolic Diet? (Type into Google for overviews) It's 60% fat and 40% protein 5 days a week, then carb up on the weekend. Perhaps this would better suit me, so I'd like some of your opinions since, I think for now, I need to avoid high fat 24/7.IFWChttps://www.blogger.com/profile/06931295252886678059noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22134489907468173712008-10-16T20:05:00.000+00:002008-10-16T20:05:00.000+00:00What do you think about the Purdy's hypothesis of ...What do you think about the Purdy's hypothesis of BSE/CJD (manganese poisoning)?Stan Bleszynskihttps://www.blogger.com/profile/03922719716458272303noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-6033898333212989792008-10-16T16:57:00.000+00:002008-10-16T16:57:00.000+00:00Hmm, perhaps some digestive enzyme supplements mig...Hmm, perhaps some digestive enzyme supplements might work to assist your digestion until your own enzyme production can keep up with your new diet?<BR/><BR/>I rarely get indigestion anymore now that I hardly ever eat really sugary or starchy foods (I swilled antacids for about ten years when I ate a lot of pasta and tomato sauce, though) and eat a lot more saturated fats, but last week I made something with a *lot* of coconut oil and cocoa & a bit of honey and ate too much of it, resulting in an uncomfortable evening. I took some Swedish Bitters in water (very refreshing)before bedtime and that seemed to really calm the heavy GI feeling.<BR/><BR/>There is a lag time for enzyme production to ramp up in response to a new diet. I know that if I eat wheat flour or potatoes now, even a moderate amount, I get a lot of gas or sleep fitfully because I probably make too little amylase to break it down effectively. I think digestive enzymes for fat and meat are the same. But they come back with regular ingestion of the foods that need them.Annahttps://www.blogger.com/profile/17033443643442246531noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-51405974476895303352008-10-16T04:41:00.000+00:002008-10-16T04:41:00.000+00:00Sorry, that should have been low fat diets OR shor...Sorry, that should have been low fat diets OR short term low fat physician supervised low calorie diets. <BR/><BR/> I need to remember to review and edit before hitting Publish :-)Annahttps://www.blogger.com/profile/17033443643442246531noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-75942486401901782922008-10-16T04:38:00.000+00:002008-10-16T04:38:00.000+00:00ifwc,Hope you are feeling better now. Were gall s...ifwc,<BR/><BR/>Hope you are feeling better now. <BR/><BR/>Were gall stones ruled out? I know a number of people who, after years of general low fat diets or shorter term, but more intense low fat physician-supervised calorie restricted liquid diets, ended up at the emergency room convinced they were having heart attacks. <BR/><BR/>But what they all had were blocked gall bladders because they weren't regularly squirting bile salts in response to fat consumption (lack of bile salt need in a low fat diet), causing bile sludge to accumulate and eventually, form gall stones. Then, when fat is consumed again, the bile is blocked when it tries to quirt out, causing lots of pain and discomfort, often feeling like a heart attack. <BR/><BR/>BTW, people who have their gall bladders removed often can consume fat normally. Ironicallygall bladder suffers are often advised to stay on a low fat diet, or they do so on their own because eating fat creates discomfort. The abnormality of such a low fat diet is never addressed. And gall bladder surgery is one of the most common surgeries performed, so the medical establishment isn't really interested in promoting diets that keep gall bladder function intact.<BR/><BR/>Use it or lose it.<BR/><BR/>If it isn't gall bladder troubles, I hope you find some answers and solutions that feel comfortable and promote your health.Annahttps://www.blogger.com/profile/17033443643442246531noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-17650771425328150852008-10-15T09:04:00.000+00:002008-10-15T09:04:00.000+00:00I have been facing viral fever in my family and I ...I have been facing viral fever in my family and I wonder what is the recommendation regarding eating in viral fever.<BR/><BR/>Also regarding the lectin angle and post-fever development of autoimmune diseases, it has been suggested to Starve the Fever by a 3-day water fast or at best some cooked vegetable broth.<BR/>But are eggs/meat problematic lectin-wise or otherwise?<BR/>Milk is also supposed to be out.Gyanhttps://www.blogger.com/profile/09941686166886986037noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-848539384079550952008-10-15T08:33:00.000+00:002008-10-15T08:33:00.000+00:00G,You're loosing me in some (lots!) of the abbrevi...G,<BR/><BR/>You're loosing me in some (lots!) of the abbreviations!<BR/><BR/>I keep trying to fit things like the bug for cancer and the absence of cancer from non modernised natives together. Are the bugs new, have we "improved" them, does sugar depress the immune system (yes) and the bugs are there but harmless (like H pylori) before accultration...?<BR/><BR/>There has to be some coherence there!<BR/><BR/>Got to go cut, stitch and chemo.<BR/><BR/>PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-7037030777303145432008-10-15T08:26:00.000+00:002008-10-15T08:26:00.000+00:00Well, there's a pair of interesting comments back ...Well, there's a pair of interesting comments back to back...<BR/><BR/>IFWC, any numbers re glucose/ketones?<BR/><BR/>Would you care to put up a couple of day's menus. It's interesting to consider there may be people who cannot eat this way. I've always thought metabolic typing might become less and less important the closwer to the OD you get. Maybe not....<BR/><BR/>PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-72939851651841387602008-10-15T03:29:00.000+00:002008-10-15T03:29:00.000+00:00Folks,Ended up in the Emergency Room due to chest ...Folks,<BR/><BR/>Ended up in the Emergency Room due to chest pains, discomfort, and almost passing out due to lightheadedness.<BR/><BR/>Any advice or support is appreciated. My second meal of the day, 4 hours after the first, starts the episodes the past day or two and today it was just too much. Considering dropping the diet...IFWChttps://www.blogger.com/profile/06931295252886678059noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-17849191497255578462008-10-14T21:28:00.000+00:002008-10-14T21:28:00.000+00:00Peter:I don't need any mumbo-jumbo research papers...Peter:<BR/>I don't need any mumbo-jumbo research papers to tell me that I feel 50 years younger and spryer since I ditched those noxious substances called sugars/grains. Not only no pain but my depression has flown the coop now that I feel like a spring chicken.<BR/><BR/>Keep up the good work young man, I love your turn of phrase.Waterlilyhttps://www.blogger.com/profile/06531444639484426157noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-9512858204355170862008-10-14T14:55:00.000+00:002008-10-14T14:55:00.000+00:00John -- btw those 'proponents' arguing against sec...John -- btw those 'proponents' arguing against secosteroids have an excellent point. Not vit D -- but is our innate immunity on hyperdrive? What do you think about lectins in the innate immunity? Lectins/MBLs 'glom' on to anything to try and neutralize: bacteria or fungus or prokaryotes -- uterus, ovaries, insulin, insulin receptors. Why not mitochondria or cytochrome P450s? <BR/><BR/>Peter -- ideas? Or your beautiful immunologist wife??? (I think NKFb is involved, right?) (Like my biochem, my immunology s*cks.)Dr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.com