tag:blogger.com,1999:blog-36840063.post5549160369660152488..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: Hepatic insulin resistance in KD fed micePeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger44125tag:blogger.com,1999:blog-36840063.post-30463974820143898012011-05-16T05:54:22.951+00:002011-05-16T05:54:22.951+00:00@Cavenewt,
I don't have any unique informatio...@Cavenewt,<br /><br />I don't have any unique information of vit D.<br /><br />SSRI antidepressants help nerve regeneration.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-50852411702609945262011-05-11T18:38:44.495+00:002011-05-11T18:38:44.495+00:00@blogblog
Vit D is one of the supplements I take....@blogblog<br /><br />Vit D is one of the supplements I take. Is there more info about Vit D and neuroregeneration you want to point me to, in addition to what I can google?cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3449856322839163302011-05-10T16:34:47.597+00:002011-05-10T16:34:47.597+00:00Hey Lucas,
It was very interesting also to me tha...Hey Lucas,<br /><br />It was very interesting also to me that 'protective' lipid patterns are the same produced by OD, ketosis, IF, low carb and most 'paleo' folks. These are also found in Ashkenazi Jewish long-living centenarians and their children (though the TGs are higher probably from the grains).<br /><br />Smoking -- I was being facetious but glad you have made some thoughts about it. My consults with authors/bloggers who understand the stats better than I do have agreed like you smoking is not detrimental based on the context of metabolic derangements. Take the French, no associated CAD or cancers with smoking and their diet is more ideal than the US -- high fat, low transfat, low n-6, low carb/gluten/starch/fructose and perhaps I believe stress is reduced (by smoking *haa*).<br /><br />Lab testing may or may not be useless -- it can illuminate in darkness and sometimes confuse without context. CONTEXT!! as Peter describes... For instance take potassium -- depends on context -- contrast normoglycemic K versus ketoacidotic K? Then add an insulin drip and check the K!! It doesn't work in isolation as does anything...<br /><br />Thanks for your insights,<br />GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-60505121782385373232011-05-10T10:22:16.902+00:002011-05-10T10:22:16.902+00:00@Cavenewt,
have you tried vitamin D?@Cavenewt,<br /><br />have you tried vitamin D?blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-32666806646739415542011-05-10T05:32:35.733+00:002011-05-10T05:32:35.733+00:00@blogblog
Good to hear that the allergies (and ho...@blogblog<br /><br />Good to hear that the allergies (and hopefully, by extension, strengthened autoimmune response) tapers off. Corticosteroids are contraindicated in multifocal motor neuropathy, my personal lottery prize. Instead, I'm on immunoglobulin. Next thing to try is rituximab. The idea is to keep the immune system at bay while waiting for axon regeneration, for which, my Mayo neuro says, medical science has nothing to offer (hence the idea that ketone bodies might help, for which there are some rat studies that offer hope.)cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-26929748324507608282011-05-10T03:50:24.038+00:002011-05-10T03:50:24.038+00:00@Canvenewt,
the allergies taper off quickly and of...@Canvenewt,<br />the allergies taper off quickly and often disappear completely after a couple of months.<br /><br />Dr Lutz advised a preemptive course of low dose corticosteroids for anyone with an autoimmune disease or severe allergies who went on a VLC diet.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-25358704723229004122011-05-09T19:23:25.919+00:002011-05-09T19:23:25.919+00:00"Allergies, such as hay fever, often become m..."Allergies, such as hay fever, often become much worse in the early stages of VLC as the immune system becomes much more aggressive. This was noted many years ago by Dr Wolfgang Lutz. It is certainly my own experience."<br /><br />I also saw that in "Life without Bread" but it seemed almost a throwaway comment without any elaboration. You say in the "early stages". Does immune aggressivity continue, or does it slacken off? What if one has an autoimmune disease? I do, and ketones might help in peripheral nerve regeneration, but am concerned about increasing the damage from the immune system. I can't find much info about KD and autoimmune.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-24209464363450077182011-05-09T06:20:03.957+00:002011-05-09T06:20:03.957+00:00The Japanese are only thin because the BMI says th...The Japanese are only thin because the BMI says they are. The BMI doesn't measure body composition and always gives a lower result for shorter people. East Asians, such as the Japanese, actually have considerably higher average body fat percentages than causcasians. In fact quite slender Japanese women may have well over 30% body fat.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-31612999669745066102011-05-08T11:39:44.003+00:002011-05-08T11:39:44.003+00:00@gunther,
Allergies, such as hay fever, often bec...@gunther,<br /><br />Allergies, such as hay fever, often become much worse in the early stages of VLC as the immune system becomes much more aggressive. This was noted many years ago by Dr Wolfgang Lutz. It is certainly my own experience.<br /><br />Will some future anthropologist find a Barbie Doll and conclude that all 20th century women were two metres tall with incredibly long legs, weighed only 50kg, had gigantic breasts and tiny waists?blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-67919090598732198912011-05-08T09:23:59.200+00:002011-05-08T09:23:59.200+00:00Honey, with its high fructose content, and nuts, h...Honey, with its high fructose content, and nuts, high in carbs and PUFAs, can cause metabolic derangement to the point where you look like a Venus figurine. Both of these are and have been present in Europe for thousands of years and were certainly present when the figurines are supposedly dated. In addition, many cultures have been known to revere a sacred woman whom they overfeed and who doesn't have to engage in labour activities and so can lay around all day eating. <br /><br />In short, if this woman even existed at all, she was not an average hunter gatherer. Making sweeping statements about the dangers of LCHF based on extrapolations from what the figurine looks like is pretty ridiculous. I don't know where his evidence comes from that she was eating pure protein and fat.<br /><br />He also goes on to trash VLC because he tried it and his allergies came back. There are thousands of Neolithic things in the air now, including new agricultural creations, that never existed in the paleolithic and if they did certainly not in their present numbers. But he chooses to blame it on not eating carbs. Do people on the SAD not have allergies then?gunther gathererhttps://www.blogger.com/profile/15361732213105267048noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-54550040498717535102011-05-08T09:19:47.568+00:002011-05-08T09:19:47.568+00:00@John
I'm 85kg/182cm and often considered thi...@John<br /><br />I'm 85kg/182cm and often considered thin because most of my weight is in my core not my arms and chest. I would probaly need to be 100kg+ to look "big". <br /><br />The great irony is that most females don't like huge muscles and most men aren't attracted to skinny or muscular women. Yet heterosexuals inadvertently spend huge amounts of effort to make themselves less physically attractive.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-76533578456688991952011-05-08T06:03:06.994+00:002011-05-08T06:03:06.994+00:00I can't say I'm impressed with the Venus p...I can't say I'm impressed with the Venus posts. Particularly the second one.<br /><br />Two groups are overfed the same number of calories of either fat or CHO, the researchers notice for apparently the first time that it costs energy to convert CHO into fat since it's not fat to begin with, declare that overeating fat will therefore make you fat faster than overeating CHO, and somehow the blogger thinks this means Greeks are fatter than Japanese because the Greeks get more of their calories from fat. "Maybe."<br /><br />Because everyone knows we naturally overeat by an amount determined by geeks in lab coats with bomb calorimeters.Chrishttps://www.blogger.com/profile/15974892385564973512noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-10573910747902117822011-05-08T05:52:57.427+00:002011-05-08T05:52:57.427+00:00donny,
I would agree this is an interesting line ...donny,<br /><br />I would agree this is an interesting line of thought without simple answers. I notice that Jenny Ruhl cited this rather interesting study<br /> <br />http://ajpheart.physiology.org/content/299/6/H1917<br /><br />and I've been thinking about this paper for some time<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/17088453<br /><br />but I've not had the time to see if the changes apply body wide or just to cardiac muscle.<br /><br />Acipimox is the darling of FFAphobes. Not so popular with us lipophiles.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-17425170206155830092011-05-08T03:25:25.204+00:002011-05-08T03:25:25.204+00:00blogblog,
Yes, I personally think muscular hips a...blogblog,<br /><br />Yes, I personally think muscular hips and "waist" looks better as well, probably because I associate it with athleticism. Early 20th century strongmen had that physique. Heavy single-limb lifts or using lots of deadlift variations definitely achieves that. Nowadays, bodybuilders are considered lucky if their waists stay small during mass gains. Louie Simmons (of Westside Barbell) says almost all the best athletes he knows have thick muscular waists. I'm muscular but not hugely (175 @ 5'9), and you can't see my spine even at full flexion. My friends who seem to work hard only at bench and "arms" have very underdeveloped erector spinae (among much else). Funny how having good hip and back musclulature causes others to underestimate your weight. <br /><br />donny,<br /><br />Are you rewriting your comment? It was interesting.Johnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-48596642857749372352011-05-08T02:59:02.316+00:002011-05-08T02:59:02.316+00:00@John,
in our university exercise prescription cl...@John,<br /><br />in our university exercise prescription classes we were taught to emphasise functional multi-joint exercises such as squats (even using body weight alone) as much as possible. Training isolated muscles using single joint movements such as biceps curls was discouraged (except for rehabilitation) and any movements involving repeated bending of the spine such as crunches, side bends and dorsal raises were not allowed. Perfect technique was considered far more important than the weights used (eg 5kg bench presses for the elderly).<br /><br />If you look at photos and drawings of HGs and pre-industrial males you will see relatively thin arms and legs, thick muscular waists and large buttocks. This is about as far from modern aesthetic weight training as possible. <br /><br />Heterosexual women typically show a strong preference for the classical male physique and a strong dislike of the bulky modern body building physique.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-52527094226935343572011-05-08T01:54:53.127+00:002011-05-08T01:54:53.127+00:00This comment has been removed by the author.donnyhttps://www.blogger.com/profile/02107555662488785352noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74712182425211277762011-05-07T18:49:23.311+00:002011-05-07T18:49:23.311+00:00I don't see that the question of de novo lipog...I don't see that the question of de novo lipogenesis matters, at least so far as whether fructose causes fatty liver or not. Fill the liver up with glycogen, and the brain will have a steady supply of glucose, as will the liver itself, so not much need to oxidize fats there, so maybe they accumulate. Some of the "inflammatory" hormones, like tumour necrosis factor increase free fatty acid/triglyceride cycling, so pairing inflammation with increased liver glycogen might not be the best situation.<br /><br />If you look at big fluffy ldl, it's a more efficient way to deliver free fatty acids to the cells that need them. I think triglycerides become high usually because the body is trying to make up for a functional shortage of triglycerides. Type II diabetic's endothelial cells overexpress lipoprotein lipase--this seems an obvious sign of a local need for free fatty acids that isn't being properly met. <br /><br />Does palmitic acid normally induce physiological insulin resistance in endothelial cells?donnyhttps://www.blogger.com/profile/02107555662488785352noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-57653821960354769422011-05-07T18:19:46.174+00:002011-05-07T18:19:46.174+00:00After reading Don's article, I realized how im...After reading Don's article, I realized how important the mind-set of the person ,who is trying to find the healthy way of eating ,is. I think,his female clients who reported weight gain , breast abnormalities and other interesting things on the LCHF, became his clients on the first place in order to find a life-style nanny for themselves, so it made it not theirs, but his responsibility to make proper decisions about details of their diets. Listening to your own body is a very important part of finding what is working for you. Looks like those ladies concentrated on finding as much as possible pleasures in food while on the diet( because they payed another person to make diet decisions ) and manage to find a way to make even the LC diet fattening. How it was achieved - I don't know. My guess is - munching ,a lot of nuts, sugar substitutes.Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-67395538776007497662011-05-07T16:19:58.234+00:002011-05-07T16:19:58.234+00:00The only problem I have with Don's article is ...The only problem I have with Don's article is the tone (and the less than 30% fat, "mostly unsaturated"). What happens in 3 months if he ends up losing muscle and gaining fat? He then loses a lot of credibility. Instead of being so sure of himself (was he not sure 1 year ago?), he can openly treat it as an experiment. <br /><br />blogblog,<br /><br />I'm skeptical that the chest is important* for any athletic endeavor (besides powerlifting). I cannot think of one thing where its strength/power is the limiting factor. Lats play a significant role in many movements though. I like to emphasize glutes [spinal erectors (maybe hamstrings too) come for the ride] as I think they get the most work (and hence contribute the most) during the the best exercises (squats, deads, sprints, etc).<br /><br />*In the sense that it probably doesn't need direct training. I have a well-developed chest (not compared to my back and legs though) doing mostly deadlifts, squats, olympic lifts, chins, sprints, and various hamstring exercises. My arms are quite small though in comparison.Johnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-41859210540629289862011-05-07T14:44:33.996+00:002011-05-07T14:44:33.996+00:00I read Don's article and have to totally disag...I read Don's article and have to totally disagree. The main job of an HG male is kill your enemies with a spear or club and steal their women and food supply. A few extra kilos of fat will help soften the blows and protect the organs.<br /><br />The modern male gym physique is almost totally non-functional. A lot of emphasis is put on muscle groups that are relatively unimportant such as the lats and biceps. These are barely used in ground dwelling apes like us. The thighs and upper arms are far too big. The buttocks and chest are relatively underdeveloped, the deep core stabilising abdominal and lower back muscles are usually weak and trying to create a sixpack is an effective way to permanently damage your lower back. <br /><br />A functional male body has a well developed chest, buttocks and shoulders, a reasonably thick muscular abdomen (without a sixpack) and relatively slender arms and legs.<br /><br />Body fat is pretty much irrelevant as long as it is not much higher than 15% for males.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3986211603984358722011-05-07T14:04:10.490+00:002011-05-07T14:04:10.490+00:00@Dr. BG,
They are only statistics so we cant draw...@Dr. BG,<br /><br />They are only statistics so we cant draw any conclusions based on it. As most people here I think blood tests, generally, are useless. The key point should be why do these people had high HDL/low TG? We will never know. But, the thing that is interesting to me was that the "protective" blood lipid panel was exactly the same produced by a KD, OD, or similar.<br /><br />Now, for the most part blood lipids are just a reflection of your diet. I dont think that you are healthy if you have high HDL/low TG but eat a SAD. Indeed, most of my patients have "healthy" blood tests, except for not so high HDL. But they feel awful and have a wide range of metabolic damage. <br /><br />Re: smoking. I havent found convincing evidence for smoking being the only cause for diseases associated, specially with CVD. IMO, smoking aggraviates a damaged metabolism, but is not the cause. You see, people who smoke tend to eat a bad diet, high in sugar, PUFAs and overall carbohydrates. The metabolic effects of smoking resemble that of fasting and or a HFLC: increase in plasma FFA and energy expenditure, adrenergic and somatotropic stimulation, muscle insulin resistance, increase in O2 uptake, inhibition of glycolysis, etc. High PUFA means more risk of oxidation by oxidants in cigarette. High BG induces glucotoxcity and AGE formation, and metabolic dysregulation by the Randle Cycle, considering that thanks to smoking you have more plasma FFA. Seems that the metabolic effects induced by smoking are not compatible with a diet high in carbs, PUFA, fructose....<br /><br />Is the damage the same when someone eats an almost no glucose/fructose, starch, low PUFA, high saturated fat diet? What if he fasts regularly? Exercises? This is a very interesting question.Lucas Tafurhttps://www.blogger.com/profile/15688922609280098571noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-77449358311778295702011-05-07T12:03:52.698+00:002011-05-07T12:03:52.698+00:00@Pieter,
I had a cholesterol test done two years ...@Pieter,<br /><br />I had a cholesterol test done two years ago as a bit of a prank. <br /><br />TC: 7.7 (298 in US terms). <br />HDL: 5.5. <br />LDL: 2.2. <br />Triglycerides: 0.2 (18 in US terms)<br /><br />The poor doctor was very concerned and stated that I had one of the highest cholesterol levels he had ever seen. <br /><br />To achieve this magical result I only eat meat, cheese, cream, butter, dark chocolate and a few berries.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-59498679186228530012011-05-07T06:22:06.879+00:002011-05-07T06:22:06.879+00:00Hi Makro,
I read Don's posts and I note that ...Hi Makro,<br /><br />I read Don's posts and I note that he was not getting the results he wanted with ultra low carb in either himself or his clients. Chris M has commented on the body composition of the ultra LC mice in this post's paper too. I would concur that ultra LC (and <5% protein!) will not make you look like Anthony Colpo.<br /><br />My only problem with Don's posts is the concept that art imitates reality. Last time I was forced in to watching a few minutes of Friends or Sex in the City I had an epiphany. <br /><br />Americans are all slim attractive people! No one is obese. I've seen the art!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-43161421934134932932011-05-06T07:32:59.021+00:002011-05-06T07:32:59.021+00:00OT:
Don Matesz has been blogging up a storm about...OT:<br /><br />Don Matesz has been blogging up a storm about the metabolic perils of animal fats over at Primal Wisdom. <br /><br />Would be interesting to hear your take, if you are in need of topics. <br /><br />http://donmatesz.blogspot.com/2011/05/venus-revisited-2.html<br /><br />http://donmatesz.blogspot.com/2011/05/venus-revisited.htmlMakrohttps://www.blogger.com/profile/02491044243856840846noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-37200880045387507152011-05-05T23:48:35.632+00:002011-05-05T23:48:35.632+00:00Lucas,
So provocative with that link... smoking i...Lucas,<br /><br />So provocative with that link... smoking is as safe as eating cr*p and having a high 'bad' LDL (granted one has a high fat, low carb ratio of High HDL/Low TGs... like me 105/36)?? *haa*<br /><br />GDr. B Ghttps://www.blogger.com/profile/15451872961651116061noreply@blogger.com