tag:blogger.com,1999:blog-36840063.post5672837331163131436..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Insulin detemir (1)Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger23125tag:blogger.com,1999:blog-36840063.post-42725201953598598332015-05-07T23:33:38.766+00:002015-05-07T23:33:38.766+00:00I was doing some research into pancreatic amylin a...I was doing some research into pancreatic amylin as a causal factor in alzheimer's.<br />Long story but amylin can increase or decrease amyloid plaques; it seems to be the simultaneous presence of insulin in the brain that makes amylin beneficial, if insulin is deficient and there's lots of amylin that's bad news.<br />Now this is relevant because - brain insulin is deficient in hyperinsulinaemia, which causes insulin resistance of brain.<br />So brain diabetes, type 3, is a disease of not enough insulin, too much amylin, and, of course, too much glucose.<br />As for the effect of insulin on appetite - why assume that it has any important or non-contingent effect?<br />The example of amylin is salutary - the direction of its effect depends on the level of another hormone, insulin (and God knows what else).Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-51702440241294676842015-05-07T12:47:18.216+00:002015-05-07T12:47:18.216+00:00Hi Peter. Have you come across this study? I tho...Hi Peter. Have you come across this study? I thought it was interesting, that timing of carb consumption made such a difference. http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.48/pdfOlgahttps://www.blogger.com/profile/15346661892269510469noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-20988896113029706862015-03-21T01:49:18.259+00:002015-03-21T01:49:18.259+00:00Nice post, very interesting :-)
BTW, just for &q...Nice post, very interesting :-)<br /><br /><br />BTW, just for "curiosity", is possible that you wanted to write "mucho problema" instead "mucho problemo"?Nic Flamelhttps://www.blogger.com/profile/14509560920020645866noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-47005272748702187012015-03-09T19:11:38.456+00:002015-03-09T19:11:38.456+00:00Neato! excellent post.
IanNeato! excellent post.<br /><br />IanAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-36840063.post-20954078992014683002015-03-07T23:22:05.197+00:002015-03-07T23:22:05.197+00:00" Melanotan-II was also injected intracerebro..." Melanotan-II was also injected intracerebroventricularly as a positive control, and significantly reduced food intake and body weight, "<br /><br />my beloved MT2, this stuff is so amazing. kills appetite and makes you slim without even trying. Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-13931767803420847692015-03-04T01:14:40.880+00:002015-03-04T01:14:40.880+00:00wellnesswish,
My dyslexic fingers made a typo, it...wellnesswish,<br /><br />My dyslexic fingers made a typo, it should be "penicillin" not "insulin" of course. The whole sentence should read:<br /><br /><i>"High animal fat diet used to be a normally recommended diet for patients with TB, up until the discovery of penicillin."</i><br /><br />Diets very high in chicken stew, geese fat etc were used in those days, 19-th century until 1940-ties, in Europe.<br /><br /> I think they did the right thing for the wrong reason - to fatten the patients since TB sufferers tended to under-eat and be underweight. In many cases it worked. It was regarded a disease of poverty, associated with thin body type.<br /><br /><br />Stan Bleszynskihttps://www.blogger.com/profile/03922719716458272303noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-55763867866141864382015-03-04T00:52:07.907+00:002015-03-04T00:52:07.907+00:00TB diet was sunlight, fresh air, and rich food - e...TB diet was sunlight, fresh air, and rich food - eggs, salmon - generally vit D. And niacin is very important, nicotinamide is TB antibiotic.<br />Those who died were usually poor and anorexic, hence rich food needed to counter poor appetite.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-25595449558059899972015-03-03T21:37:20.466+00:002015-03-03T21:37:20.466+00:00BTW, I had to edit the BMI group which lost weight...BTW, I had to edit the BMI group which lost weight on detemir, it was those >35kg/m2, not 40 as I originally wrote (from memory). Mea culpa.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-76470815187534335672015-03-03T21:34:12.343+00:002015-03-03T21:34:12.343+00:00JED, good, you're welcome. I generally write a...JED, good, you're welcome. I generally write about how the world looks to me...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-72915306236407240522015-03-03T20:47:49.896+00:002015-03-03T20:47:49.896+00:00A literary reference to the treatment of TB may be...A literary reference to the treatment of TB may be found in the book _A Nun's Story_ by Kathryn Hulme. (There is also a wonderful movie starring Audrey Hepburn which is very faithful to the book). The main character, Sister Luke, contracted TB while nursing in the Congo. She was successfully treated with bed rest and a very rich diet. I don't remember the details of the diet except that it included a lot of eggs, and she even had to be woken during the night to eat. That, apparently, was standard treatment in the time period between the (not so) great world wars.JanKnitzhttps://www.blogger.com/profile/06178703790352191912noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-40790845785383904362015-03-03T16:49:20.282+00:002015-03-03T16:49:20.282+00:00Interesting. I remember, as a resident in a drug-r...Interesting. I remember, as a resident in a drug-rep lunch, being told about statins...I remember asking why we would want to block a pathway to making a hormone that our bodies require to live. I remember being ignored by the rep. I never wrote a script for the drugs after I started working on my own.<br />I'm not surprised about the research.Larcanahttps://www.blogger.com/profile/10109743909244156390noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-2208453844014276932015-03-03T15:43:26.803+00:002015-03-03T15:43:26.803+00:00As a scientist working for Big Pharma, I am both a...As a scientist working for Big Pharma, I am both amazed by and grateful for this blog post. A very big thank you for characterising the corporate R&D attitude so accurately and objectively. (Any positive outcome of a Pharma vs Academia comparison is a pleasant surprise.)<br /><br />Drawing our attention to a good and honest piece of science is appreciated too, of course.<br /><br />Thank you, thank you. This made my day.JEDhttps://www.blogger.com/profile/08007534397092792045noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22584235508839519702015-03-03T14:10:31.254+00:002015-03-03T14:10:31.254+00:00@wellnesswish,
In my family we have a war time an...@wellnesswish,<br /><br />In my family we have a war time anecdote of a relative who cured himself from a TB with eggs, butter, salted pork fat from a black market. In order to do it he sold absolutely everything valuable he had. It took him approximately a year.Antibiotics were not available at that time and place. May guess the success rate of such intervention is far from 100%, and a young man could have better chances with a such diet intervention than a child . I also want to remind about another remedy from the pre-antibiotics times - blood transfusions. While being a child, I used to have an endless succession of boils in different places which required a surgical intervention until I got a blood transfusion from my father.It worked as a switch.<br /><br />I can't resist to add another anecdotal information. In the book by Weston Price "Nutrition and Physical Degeneration" http://gutenberg.net.au/ebooks02/0200251h.html he witnessed a huge TB problem on the Gaelics islands where grocery stores selling jams and cookies operated successfully, while the populations on isolated and less modern Gaelics islands were healthy.<br /><br />From my amateur perspective the combination of a good diet (a grassfed butter, eggs, caviar, liver once a week, liberal amount of the meat from ruminant animals, strict limitation of sweets in all forms including juices and honey, may be even limitation of very sweet fruits like oranges, grapes and watermelons) and a healthy life-style (enough sleep and rest, a sunshine,a fresh air) are the elements which may help and will not hurt.<br />When we can't relay on antibiotics 100% any longer, the only options left are the remedies from pre-antibiotics times.<br /> Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-91920195206490409302015-03-03T14:07:57.723+00:002015-03-03T14:07:57.723+00:00"My concern is that TB bacteria would also th..."My concern is that TB bacteria would also thrive on this diet?"<br /><br />TB is pretty clearly associated with malnutrition. Weston Price found this, and it's common knowledge for the folks trying to suppress TB today. So to Peter's point about paleo in Yosemite, a nutrient-dense diet would be the way to go.<br /><br />"The relationship between malnutrition and tuberculosis"<br /><br />http://tangledbramble.com/files/The-relationship-between-malnutrition-and-tuberculosis.pdf<br /><br />That said, I wouldn't forgo other treatment options, but fixing diet would be the first thing to do.Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-92082833828853033012015-03-03T12:52:25.049+00:002015-03-03T12:52:25.049+00:00This blog entry is amazing on many levels.
One I ...This blog entry is amazing on many levels.<br /><br />One I didn't know some pt populations lose weight on levemir. Small minority but still interesting.<br /><br />Two, I never really considered the research was so bad that insulin had no anoretic effect at ALL. we have type 1dm hyperphagia, for example, which responds to insulin...but it is possible I suspect the insulin may be correlated with leptin, as insulin makes leptin and t1dm is therefore hypoleptinemic.<br /><br />Just a great entry as usual.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74791424905216950182015-03-03T07:04:14.836+00:002015-03-03T07:04:14.836+00:00@peter @stan thank you for feedback. In world whe...@peter @stan thank you for feedback. In world where so much info now found on internet, not so much for TB!wellnesswishhttps://www.blogger.com/profile/03355607197838600260noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-83509117962357735672015-03-03T06:33:04.402+00:002015-03-03T06:33:04.402+00:00Thanks TuckerThanks TuckerPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-82817535410683959572015-03-03T05:58:16.405+00:002015-03-03T05:58:16.405+00:00Stan, researchers can still do the "insulin s...Stan, researchers can still do the "insulin suppresses appetite" in their own labs. If you read around some of the papers to work out where (geographically) these groups are and what their concept base is you end up with words like "hedonism" and "dopamine" in their work. There is a group which has found the molecular link between eating fat and making dopamine. So when I eat my six egg yolks in butter in half an hour I'm going to feel like I smoked a pipe of crack and will ballon in to morbid obesity as soon as I can repeat the experience until I run out of money and start stealing to feed my habit. They are largely based in psychiatry departments, not a place where I would look for anything resembling science. But they still get their results on home territory in 2015... Those poor rats.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-38576767593848110842015-03-03T05:48:17.123+00:002015-03-03T05:48:17.123+00:00Hi wellnesswish, sorry, I've never worked thro...Hi wellnesswish, sorry, I've never worked through this. A couple of points which I've speculated on are that dairy cows get TB because they are fed a high carbohydrate diet, to the point of lactic acidosis as the carbs ferment in their rumen. Cattle should eat a cellulose based diet with chronic low blood glucose and elevated short chain free fatty acids.<br /><br />Hyperglycaemia (BG over 10 mmol/l) is profoundly depressing on immune function. Diabetics develop multiple infection related complications which are trivial to a non diabetic. You need an immune system to deal with TB.<br /><br />TB used to be as frightening as cancer in the past. Back in my early days of reading about food I picked up anecdote about a person self curing TB by what would, nowadays, be called a paleo approach based on literally hunting and gathering, in Yosemite if I recall correctly. My own feelings would lean in this direction.<br /><br />I would also tend to look at the differences in metabolism between a well oxygenated pertidish and the anoxic centre of a caseous TB nodule. Metabolising LCFAs with ample oxygen is one thing. Doing the same without oxygen is more of a challenge.<br /><br />Just some random thoughts...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-6910311064863654632015-03-03T02:17:41.440+00:002015-03-03T02:17:41.440+00:00Peter,
Very interesting! Did you look at why did...Peter,<br /><br />Very interesting! Did you look at why did the original research found an anorectic effect in the first place? Was it a pure fraud or some kind of mistake/incompetence like Ancel Keys' case gone too far, which the involved people were then too afraid to retract? Unfortunately, if the "scientists" own funding is at stake, miracles do happen! The "Climate Change" "research" springs to my mind... <br /><br />wellnesswish,<br /><br />High animal fat diet used to be a normally recommended diet for patients with TB, up until the discovery of insulin.<br /><br />Stan (Heretic)<br />Stan Bleszynskihttps://www.blogger.com/profile/03922719716458272303noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-30003195864439058622015-03-02T22:58:53.016+00:002015-03-02T22:58:53.016+00:00Sorry to pose a question so off topic (but I did e...Sorry to pose a question so off topic (but I did enjoy the post AND could follow it, sometimes peter's science is way over my head). <br /><br />Vet might have some insight on TB? Imagine if adult child diagnosed active (pleural and not infective) TB in this day and age! Google tells me TB bacteria do well on FFA yet all my instincts tell me that low carb moderate protein and high fat is good food for recovery and health maintenance. My concern is that TB bacteria would also thrive on this diet? <br /><br />I would welcome any thoughts on this hypothetical situation?wellnesswishhttps://www.blogger.com/profile/03355607197838600260noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-1719215761822682222015-03-02T20:44:54.707+00:002015-03-02T20:44:54.707+00:00And yes, you're to be commended for your restr...And yes, you're to be commended for your restraint, Peter. :)Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-54480026008459312602015-03-02T20:44:09.999+00:002015-03-02T20:44:09.999+00:00Yet another idea that fails to be replicated by th...Yet another idea that fails to be replicated by the people who are trying to monetize it.<br /><br />Academic science is pretty badly broken...Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.com