tag:blogger.com,1999:blog-36840063.post5969386936771470485..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: Weight loss when it's hard 4. Coming soon; son of diazoxidePeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-36840063.post-87953016797445643712008-05-12T18:27:00.000+00:002008-05-12T18:27:00.000+00:00Bruce,Interesting comment about the funding game d...Bruce,<BR/><BR/>Interesting comment about the funding game distorting how the science is done.<BR/><BR/>The internet provides a new opportunity for online studies where motivated people (like posters here) report their diets and health markers to a freely-available database. Obviously there are many problems when a study ceases to be in a controlled setting. One would instead be trying to work with a mix of data from widely-distributed and self-selecting people. But there must be great possibilities too.<BR/><BR/>(Although even as I write this I began to wonder if it would be workable in a world with radical groups like PETA who might want to push a specific agenda about diet),<BR/><BR/>Paul.paulhttps://www.blogger.com/profile/11319278202196461941noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-181584858783248412008-05-12T00:43:00.000+00:002008-05-12T00:43:00.000+00:00Long-term studies rule. Total M & M (mortality and...Long-term studies rule. Total M & M (mortality and morbidity) are truly the only important measures, IMO. A study looking at markers won't show which group will live longer and be more free of disease. Studies don't look at long-term effects any more. They look at risk factors, markers, surrogate end-points, correlations, associations, etc. This is the only way they can play the funding game. They can't do long-term studies and show that saturated fat is harmful, unless of course they add sunflower oil to a diet containing coconut or beef fat, for example.<BR/>http://cancerres.aacrjournals.org/cgi/reprint/45/5/1997<BR/><BR/>So they do the studies like the old milk-shake-and-carrot-cake made out of coconut or safflower oil. Such a study ignores the most vital issue: which group would live the longest? Which group would get more disease? I say the ones eating safflower oil will die faster, and more painfully than those fed coconut oil.<BR/><BR/>Studies need to start measuring the of total mortality and morbidity. I don't think anyone would appreciate less heart disease, in exchange for more strokes, cancers, suicide, and accidental deaths. But that is what many studies tacitly assume. (Ancel Keys being a good example.)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-36840063.post-31426945140855254962008-05-12T00:41:00.000+00:002008-05-12T00:41:00.000+00:00This comment has been removed by the author.Anonymousnoreply@blogger.com