tag:blogger.com,1999:blog-36840063.post6232667153692687802..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: Did you over eat yourself in to obesity or T2DM?Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger71125tag:blogger.com,1999:blog-36840063.post-49703895708848694002011-11-13T02:31:10.994+00:002011-11-13T02:31:10.994+00:00LIVER:
Someone asked about liver:
All that is ne...LIVER:<br /><br />Someone asked about liver:<br /><br />All that is needed is to fry very LIGHTLY in a pan, of e.g. butter, grass-fed, ideally, optionally mixed with coconut oil.<br /><br />Just enough to change the surface colour all-over from that deep purple colour to light red, all over.<br /><br /><br />Combine with whatever amount you like of whatever muscle meat you like, also gently fried, and, if you are like me, throw one or more free range eggs into the pan and fry them gently.<br /><br /><br />If all that is not enough, then season lightly with good quality pepper and best sea-salt.<br /><br /><br />Enjoy.<br /><br /><br />Kings would have fought battles for this stuff.<br /><br /><br />And rightly so.<br /><br /><br />Kidneys are <b>almost</b> as good.montmorencyhttps://www.blogger.com/profile/12879422255762834319noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-53910146204583296052011-11-12T16:53:26.769+00:002011-11-12T16:53:26.769+00:00"Much of the "pathology" is actuall..."Much of the "pathology" is actually adaptive but being pushed to the point where there are problems in other systems."<br /><br />Yes that's what I'm coming to realise. Systems that are adaptive when used acutely in response to some environmental factor become seriously maladaptive when they are jammed on chronically.<br /><br />Some of them can become unjammed again by changing the environment (mainly diet) but sometimes it's too late. You can avoid the end result without necessarily undoing the damage.<br /><br />I have gnolls on my reading list, when I find time. So far I've been looking at stuff well upstream of the mitochondria, so there's more stuff to look at.<br /><br />Welcome to Narflk by the way. I live just over the border in Suffolk and I guarantee you will never eat so well. Grass-fed beef, lamb, outdoor pigs, fish, local veggies like asparagus and purple sprouting . . . one factor in the local longevity and healthy elderly folks may be sufficient selenium in the soil thanks to the glaciers. OTOH a big negative factor is the James Padgett, aka The Abbatoir. See if you can get referred to the Narflk and Narch, or Ipswich, or consider stocking up on lethal quantities of Propofol, topping yourself will be quicker and less painful than having them do it for you should you have the misfortune to become ill.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-36840063.post-79217597716597043002011-10-18T23:34:20.235+00:002011-10-18T23:34:20.235+00:00"These folks have odd muscle tissue.
a) They..."These folks have odd muscle tissue.<br /><br />a) They don't have many mitochondria, b) many of their mitochondria look crap and c) many of their mitochondria are dying."<br /><br />Is there practical suggestions as to what these folks could do improve the health and/or numbers of their mitochondria?Ianhttps://www.blogger.com/profile/10435549368772424083noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-77518127923127593752011-10-07T05:44:34.518+00:002011-10-07T05:44:34.518+00:00Jane,
I have to say that copper keeps coming up i...Jane,<br /><br />I have to say that copper keeps coming up in CVD, has done for decades. When I get the chance I'll stick up the thoughts on iron overload possibly being a result of met syn and you can have a pick over it for copper status. Not sure when it will happen though, I'll have to go through the cirrhosis series to dig stuff out.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-64527456236888421432011-09-30T14:07:15.763+00:002011-09-30T14:07:15.763+00:00Peter, have a look at this paper on iron in non-al...Peter, have a look at this paper on iron in non-alcoholic fatty liver disease. NAFLD patients apparently have iron overload, which the paper links to copper deficiency.<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/18505688<br /><br />RESULTS: NAFLD patients had lower hepatic copper concentrations than control subjects (21.9 +/- 9.8 vs 29.6 +/- 5.1 microg/g; P = .002). NAFLD patients with low serum and liver copper concentrations presented with higher serum ferritin levels (606.7 +/- 265.8 vs 224.2 +/- 176.0 mg/L; P < .001), increased prevalence of siderosis in liver biopsy specimens (36/46 vs 10/47 patients; P < .001), and with elevated hepatic iron concentrations (1184.4 +/- 842.7 vs 319.9 +/- 451.3 microg/g; P = .020).Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-41631267180462088642011-09-30T05:13:51.571+00:002011-09-30T05:13:51.571+00:00@Jane
Hi Jane. If insulin and IGF lead to excessiv...@Jane<br />Hi Jane. If insulin and IGF lead to excessive iron storage as ferritin it is probably likely these also lead to high free iron. <br /><br /><br />There are many, many factors involved in developing glucose intolerance; mineral status is a small one. <br /><br />It would take days to describe every known genetic and environmental and developmental factor that leads to these conditions, and what we know is still really little (which is why there is so much debate, and so much room for people to stay stupid things like "insulin makes you thin" - we are so ignorant, blatantly false statements like this can clear unflagged because we are so uncertain no one is sure enough to say THAT IS FOOLISH AND WRONG). Who is going to argue someone if they themselves barely understand the premise? Who wants to adopt a position which isn't well understood? This is why we tolerate so much conflict in obesity discussions and research - none of us really know, anyway. The evidence isn't strong enough in any direction, it allows for a lot of craziness to break through. <br /><br />Before humans understand things scientifically, it's amazing the level of craziness that can emerge to explain phenomena. Diseases were caused by humors, the treatment was leeching/blood letting. Germs were a hypothetical possibility. Right now, in obesity research, we are in the "germ theory vs blood letting" phase.<br /><br /><br />One major factor that is often ignored: sleep duration. People hardly sleep today, this is the first environment where people routinely, and for long periods of time, starve themselves of sleep, while in the presence of a sugar rich calorie rich diet. The negative effects of sleep deprivation on glucose metabolism and pro-obesigenic/diabetogenic nature of it is some of the most easily replicated research. People have known to become TEMPORARILY diabetic by not sleeping for 24 hrs.<br /> For some reason, people think it is a good idea to sleep 5 hrs a night and wake up early in the morning to go to the gym to lose weight.<br /><br />I think it is just a bit naive to assume that finding the optimal mineral balance will cause or cure us, the big picture suggests a WHOLE lot more than minerals are involved. It would be great if it were that simple, though.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74188523184279402332011-09-30T04:29:12.171+00:002011-09-30T04:29:12.171+00:00Hi All,
The concept of iron overload as a consequ...Hi All,<br /><br />The concept of iron overload as a consequence vs a cause of metabolic syndrome is an important one that has been of interest to me for some time.<br /><br />Back in the PUFA and cirrhosis series I found a table suggesting hepatic iron content was related to degree of fatty liver/NASH on a level playing field iron content of the diet, but the diet information was buried a layer of refs deep and, when I tracked it down, was indeterminate as to exactly how the animals had been fed. Must have been a nutrition paper...<br /><br />I feel it matters as metabolic syndrome appears to be rare in humans on high meat diets until you bring in the Usual Suspects.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-32804763277486452502011-09-30T04:10:00.859+00:002011-09-30T04:10:00.859+00:00No gets an insulin overload (regardless of what th...No gets an insulin overload (regardless of what they eat) if they only eat once or twice a day. <br /><br />The entire three meals a day, plus regular snacks, concept only dates back about 200 years to the start of the industrial revolution. Before then people typically ate one or two large meals a day.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-80219031018127917432011-09-29T16:45:31.083+00:002011-09-29T16:45:31.083+00:00Bolalbi, i do one liter of evil milk per day + lo...Bolalbi, i do one liter of evil milk per day + lots of evil sucrose + evil chocolate, ( plus a shitload of meat and cheese) all this evil insulin @ iron is killing me. you guys are so funny.<br /><br />http://img37.imagevenue.com/galshow.php?gal=gallery_1316767296840_148lo<br /><br />btw i also do, minimal training, sleep a lot and eat tons of yolks. im telling you some day im going to get really fat and sick.D1Shttps://www.blogger.com/profile/08750123947536499341noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-295225628583984232011-09-29T15:32:58.932+00:002011-09-29T15:32:58.932+00:00@blogblog
I forgot to mention a key point applyin...@blogblog<br /><br />I forgot to mention a key point applying to everybody, irrespective of hidden hemacromatosis or thalassemias.<br /><br />Your iron absorption mechanism is certainly ok, but was not conceived to cope with milk and milk products chronically boosting insulin levels after age 3. So iron tissue storage slowly becomes upregulated especially in the liver until resistance fatally develops to shield mitochondria from disaster. Then the better the mitochondria the later disaster happens or does not happen at all. Get rid of milk and you'll get rid of iron overload, fatty liver and insulin resistance. Or if you want to eat milk, minimize red meat and stay anemic. After all those who have adapted to milk have better insulin resistance than the others but are not supposed to kill taboo cows. I wouldn't like to call "mitochondrial disfunctionality" the status of those who have not adapted to milk insulin overload in a lifetime. Let's call them paleo energy saving mitochondria. The good old ones needed to hunt without fainting. Now unfairly despised as dysfunctional because of lack of evolutionary gratitude.Alberto Bologninihttps://www.blogger.com/profile/14118673815535322351noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-78907845703753468792011-09-29T15:12:51.950+00:002011-09-29T15:12:51.950+00:00Bolalbi,
"...prevalence of hidden (say heter...Bolalbi,<br /><br />"...prevalence of hidden (say heterozygotic) hemacromatosis..."<br /><br />...me!<br /><br />"...more people than you think have become somehow adapted to cereals and mosquitos, although at a high metabolic cost."<br /><br />Are you implying being a carrier for hemachromatosis is the "cost"? Can you explain that statement further?Johnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22919370494434663592011-09-29T15:02:07.254+00:002011-09-29T15:02:07.254+00:00@blogblog
Thank you very much for your link on gu...@blogblog<br /><br />Thank you very much for your link on gut biota. But the concrete mechanism remains a mystery I understand and a subject of speculation.<br /><br />On iron. You are certainly correct in line of principle but underestimate the prevalence of hidden (say heterozygotic) hemacromatosis in Northern Europe and alpha thalassemias in Southern Europe. Many more people than you think have become somehow adapted to cereals and mosquitos, although at a high metabolic cost. Generally speaking the weak point of the paleo position is that it hugely underestimates how fast evolution can run subject to external environmental pressure. My understanding so far is that that too much insulin causes tissue/liver iron loads by overstimulating ferritin and these cause in turn insulin resistance as a cellular safety net. Most of the benefits of going low carbs / mildly ketogenic is that you reverse the process and deplete your toxic iron stores from tissue and give your mitochondria some relief from peroxidation. Most of the benefits from vinegar, ginseng or curcumin (as far as liver is concerned) is that they help take iron out of tissue back into the blood circle. This obviously means that serum ferritin is a very poor and unreliable indicator of iron status in liver and muscle, especially when you are insulin resistant. To have an understanding of the process look at what happens in toddlers suffering from iron overload because B5 cannot form coenzyme a and wonder why turning them into ketosis is so effective. Insulin is an overall primordial storage signal: fat, iron, we are eating. Ketosis is simply the opposite. Get rid of the existing stocks including iron cellular toxicityAlberto Bologninihttps://www.blogger.com/profile/14118673815535322351noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-46760125206492860772011-09-29T12:31:35.223+00:002011-09-29T12:31:35.223+00:00Hi Wooo, good to see you.
'High insulin lea...Hi Wooo, good to see you. <br /><br />'High insulin leads to excessive storage of iron.' Not sure what you mean by this. Insulin is a member of the growth factor family, and all members of this family increase intracellular iron because it's needed for growth. <br /><br />The iron we are talking about is free or loosely bound iron. Iron stored in ferritin isn't really a problem. But, it can be released from ferritin by reactive oxygen species. Oxidative stress means free iron, and damage.<br /><br />'..The abnormal mineral status did not cause the hyperinsulinemia..' <br /><br />So what did cause it? In glucose intolerance, the first phase of insulin secretion is lost and the second phase enhanced, meaning delayed hyperinsulinemia. See 'Metabolic abnormalities in impaired glucose tolerance'.<br /><br />Obviously, beta cells are not doing their job. They are not sensitive enough to glucose, and they're making too much insulin when they shouldn't and too little when they should. They are damaged, and eventually their owners will be diagnosed with diabetes.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-66373801281267455412011-09-29T08:54:57.115+00:002011-09-29T08:54:57.115+00:00@blogblog,
'The fact is that the scientific c...@blogblog,<br /><br />'The fact is that the scientific community currently have no detailed understanding of iron regulation in mammals. It will be decades before this changes.'<br /><br />It's true that iron regulation is very complex, so much so that it's probably correct to say the scientific community as a whole has no detailed understanding of it. But it's quite different among scientists who work on it. There is in the literature, if you read it diligently for a long time as I have done, a very good understanding.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-49099582722508716032011-09-29T04:08:22.511+00:002011-09-29T04:08:22.511+00:00@Jane
High insulin leads to excessive storage of i...@Jane<br />High insulin leads to excessive storage of iron; high levels of iron go on to contribute to disease and further worsen insulin sensitivity, but ultimately high iron levels are not causative of the problem, they are merely symptomatic yet another symptom of having too much insulin too much of the time.<br /><br /><br /><br />http://www.nejm.org/doi/full/10.1056/NEJM200009213431215<br /><br />"High body iron stores are associated with abnormally altered glucose homeostasis in patients with type 2 diabetes,3 and serum ferritin concentrations are higher in patients with diabetes than in the general population.4 The development of hemochromatosis in some patients with type 2 diabetes may be the consequence of an anomalous trend toward iron accumulation mediated by mechanisms other than mutations in the HFE gene."<br /><br /><br />http://www.medical-hypotheses.com/article/S0306-9877%2803%2900231-7/abstract<br /><br />"There is growing evidence that increases in both hematocrit and body iron stores are components of the insulin resistance syndrome. The ability of insulin and of IGF-I – whose effective activity is increased in the context of insulin resistance – to boost activity of the transcription factor hypoxia-inducible factor-1α (HIF-1α), may be at least partially responsible for this association. HIF-1α, which functions physiologically as a detector of both hypoxia and iron-deficiency, promotes synthesis of erythropoietin, and may also mediate the up-regulatory impact of hypoxia on intestinal iron absorption. Insulin/IGF-I may also influence erythropoiesis more directly, as they are growth factors for developing reticulocytes. "<br /><br /><br /><br />I think it is very naive to assume all metabolic diseases are nothing more than attributed to mineral status. It is clear at this point in time that mineral status does affect metabolic status (e.g. magnesium is very important for normal glucose tolerance), however the abnormal mineral status of glucose intolerant people is mostly attributed to <b>abnormal levels of insulin</b>. Just as glucose intolerant hyperinsulinemic people clearly are storing food energy as body fat, it is also true they are storing - ushering in cells - excessive sodium, magnesium, iron, just to name a few.<br />The abnormal mineral status did not cause the hyperinsulinemia, it is symptomatic of it, however once in place it does worsen the trend.<br /><br />When we observe that people with high insulin have high levels of intracellular magnesium/low mag levels, do we assume lack of magnesium caused their high insulin, or is it more likely that a multifactored environmental/genetic reaction resulted in hyperinsulinemia, which then skewed their magnesium status?<br />If the magnesium was primary, why are we not curing diabetes and obesity with magnesium yet?<br /><br /><br />To assume a simple mineral supplement or eating bone broths or whatever can resolve or cause these issues, most of the time, reduces the complexity of glucose intolerance and subsequent diseases to uselessness.<br /><br /><br />I more than anyone wished it was true, but I have seen only slight benefits from addressing my mineral status - slight benefits are still significant to well being, but in no way is it true that my severe endocrine and weight problems are as simple as high or low mag and iron. <br /><br /><br />**Note, when I was obese, my H&H levels were abnormally elevated, which I attribute, in hindisight, to hyperinsulinemia + uncontrolled PCOS (as elevated testosterone further increases H&H, in addition to insulin + IGF). <br /><br />After weight loss and control of PCOS my H&H levels are low normal, and when I was very food restricted/thin/not on leptin I was mildly anemic.<br /><br />The reason people become anemic after weight loss, even if they take minerals and eat red meat, is because you can NOT store iron and make hgb without insulin and IGF.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-39415530379811797312011-09-28T23:00:21.671+00:002011-09-28T23:00:21.671+00:00@nancan,
cereal based diets cause absolute havoc w...@nancan,<br />cereal based diets cause absolute havoc with the health of cats and dogs. It totally disrupts their gut flora causing a multitude of health problems. <br /><br />A acquaintance of mine cured her labrador retriever of severe atopic eczema in a month simply by switching from dried food to canned food.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-6224144258990451412011-09-28T22:54:16.561+00:002011-09-28T22:54:16.561+00:00@Jane,
The fact is that the scientific community...@Jane,<br /> <br />The fact is that the scientific community currently have no detailed understanding of iron regulation in mammals. It will be decades before this changes.<br /> <br />The 120 million year evolutionary history of humans as primates suggests that we are extremely well adapted to the amounts of iron encountered in a meat based diet. <br /><br />The presence of iron deposits in diseased tissue doesn't prove that iron causes the disease. It simply shows that iron accumulates in certain disease states.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-19259178680281083002011-09-28T18:17:21.295+00:002011-09-28T18:17:21.295+00:00@John
"Calorie restriction induces mitochondr...@John<br />"Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency"<br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/<br /><br />Another interesting datum "Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia" - autophagy would otherwise recycle those elderly mitochondria and make way for new ones. http://www.jbc.org/content/284/45/31484.full<br /><br />Maybe hyperinsulinemia is the kiss of death hereJontyhttps://www.blogger.com/profile/17359486435643820872noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-88788163781413271262011-09-28T17:03:02.742+00:002011-09-28T17:03:02.742+00:00Olga & blogblog: Motley, my two-yo neutered ma...Olga & blogblog: Motley, my two-yo neutered male cat, is apparently as carb sensitive as I am. On any cat food with grains in it he develops a nasty oily coat and heavy dandruff. I changed his diet to mainly fish and chicken, a bit of cod liver oil, with a small amount of gluten free, high protein kibble, and he's sleek and handsome. We both are eating essentially the same vlc diet--and we are glad we do!nancanhttps://www.blogger.com/profile/08256619100764408537noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-92095667899989032222011-09-28T14:04:23.967+00:002011-09-28T14:04:23.967+00:00Jonty,
What is the name of the paper [López-Lluch...Jonty,<br /><br />What is the name of the paper [López-Lluch G, 2006] you cited? I tried to look at all 2006 papers and didn't see the claim about insulin.Johnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-42505978900931508642011-09-28T13:31:12.386+00:002011-09-28T13:31:12.386+00:00@blogblog,
'It likely that iron accumulation ...@blogblog,<br /><br />'It likely that iron accumulation is a symptom of underlying disease (eg diabetes) rather than a cause.'<br /><br />Can you give me arguments and/or evidence for this? If the iron is not causing the damage, what is? <br /><br />It's true that iron absorption is regulated. A high-iron diet will result in down-regulation of iron transporters. The problem is that these are also manganese transporters.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-57180434264439489422011-09-28T11:51:33.182+00:002011-09-28T11:51:33.182+00:00@Jane,
the problem is determining cause and effect...@Jane,<br />the problem is determining cause and effect. It likely that iron accumulation is a symptom of underlying disease (eg diabetes) rather than a cause. A healthy human is able to control absorption of iron from the gut. <br /><br />All mammals have evolved from insectivores/carnivores so we have had about 120 million years to adapt to eating meat. <br /><br />Everything I have read suggests that plant foods were minor component of both Inuit and Masai diets. In the case of the Masai plants seemed to be used mainly for medicinal use rather than as foods.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-41672004633802984262011-09-28T10:10:48.435+00:002011-09-28T10:10:48.435+00:00Hi blogblog, this is an interesting question. Eat...Hi blogblog, this is an interesting question. Eating the whole animal would obviously help, but I'm not sure it would solve the problem. Even the Inuit and Maasai ate quite a lot of plant food (see Chris Masterjohn on this) which would have provided both manganese/copper and compounds that prevent iron absorption such as tannins and phytate.<br /><br />But nowadays you can't just eat a whole cow. Is it enough to eat liver now and then? Well, liver does have a lot of copper, but it has a terrible iron-manganese ratio. Not as bad as muscle meat - even grass-fed beef has an iron-manganese ratio of about 100, see this paper -<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/20374819<br /><br />- but beef liver has a ratio of 20 when ideally it would be closer to 1. Manganese is very easy to excrete, unlike iron, so it's difficult to get too much unless you work in a manganese smelter.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-21939942508599155222011-09-28T08:12:47.488+00:002011-09-28T08:12:47.488+00:00Without knowledge in biochemistry may I be so bold...Without knowledge in biochemistry may I be so bold as to speculate that it is the insulin resistance/diminished insulin action, i.e. intracellular insulin deficiency that causes mitochondrial dysfunction/damage and altered metabolism? <br /><br />"Insulin signaling meets mitochondria in metabolism"<br />http://www.ncbi.nlm.nih.gov/pubmed/20638297 (abstract only)<br />"Insulin Signaling Regulates Mitochondrial Function in Pancreatic β-Cells"<br />http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0007983<br />"Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart"<br />http://circ.ahajournals.org/content/119/9/1272.long<br />"Effect of Insulin Deprivation on Muscle Mitochondrial<br />ATP Production and Gene Transcript Levels in Type 1<br />Diabetic Subjects"<br />http://diabetes.diabetesjournals.org/content/56/11/2683.full.pdf<br />"Intracellular site of insulin action: Mitochondrial Krebs cycle"<br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC323891/pdf/pnas00318-0102.pdf<br /><br />I didn't read these, just browsed at the concluding parts but they seem interesting. <br /><br />Defective mitochondria are not unique to insulin resistant muscle, they are also present in cancer cells (Warburg effect). There is a theory that upregulation of glycolysis leads to genomic instability which may lead to cancer. The link between cancer and metabolic syndrome may be mitochondrial dysfunction?? <br />"Cancer as a metabolic disease" <br />http://www.nutritionandmetabolism.com/content/7/1/7<br /><br />Just some thoughts...a khttps://www.blogger.com/profile/10796036786797487858noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-78648662553937440722011-09-28T03:46:15.781+00:002011-09-28T03:46:15.781+00:00@Jane,
the problem is actually due to a not eating...@Jane,<br />the problem is actually due to a not eating any organ meats rather than eating too much red meat. <br /><br />A (human) carnivore needs to eat the whole animal not just the muscle tissue.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.com