tag:blogger.com,1999:blog-36840063.post7006818416427211344..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: Metformin (09) IsletsPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger14125tag:blogger.com,1999:blog-36840063.post-20329432088645491922018-10-28T05:24:37.564+00:002018-10-28T05:24:37.564+00:00Bob, yes, but if you view endometriosis as metabol...Bob, yes, but if you view endometriosis as metabolic syndrome as expressed by the uterus it should come as no surprise that blocking mtG3Pdh should ameliorate it by attenuating insulin signalling....<br /><br />Galina, glad they found something that helped a little<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-54022032097950298202018-10-27T23:03:33.608+00:002018-10-27T23:03:33.608+00:00cavenewt -they managed to obtain a ready-to use ke...cavenewt -they managed to obtain a ready-to use keto-mix and and thanks god it worked. Poor kid somehow vomits that mix less that a breast milk. We all keep fingers crossed for that family. Sorry to take attention to an unrelated problem.Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-77111768541586618072018-10-27T19:10:45.853+00:002018-10-27T19:10:45.853+00:00Metformin seems to be one busy drug! Among its oth...Metformin seems to be one busy drug! Among its other effects, it may even work against endometriosis.<br /><br />https://www.sciencedirect.com/science/article/pii/S1110569012000957LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-10182446520183958842018-10-24T19:35:50.904+00:002018-10-24T19:35:50.904+00:00@Galina...wet nurse or donated pumped breast milk ...@Galina...wet nurse or donated pumped breast milk an option?cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-25997232415909723552018-10-24T19:09:48.371+00:002018-10-24T19:09:48.371+00:00I hope they can help...
PeterI hope they can help...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-76497234166396418762018-10-24T12:21:42.149+00:002018-10-24T12:21:42.149+00:00Тhank you, Peter. I passed the information to the ...Тhank you, Peter. I passed the information to the parent. It is amazing, but one of Pateomedicina doctors happens to speak Russian language because he is a former student of the Military Medical Academy in Moscow. Sure, child is nutritional guidance, however, it is the usual kind. Sory to jerk you into an odd problem.<br />Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-35700814094145997022018-10-24T05:45:30.199+00:002018-10-24T05:45:30.199+00:00Hi Galina,
That’s way outside any area I have any...Hi Galina,<br /><br />That’s way outside any area I have any experience with and I’d expect one so young to be under medical supervision for the cancer management, which should include nutritional support. Once one is under medical support the options to go to something akin to the paleo ketogenic diet seem very limited. But I’d start by contacting the paleo group in Hungary, their technical papers are here and look reasonable to me<br /><br />https://www.paleomedicina.com/en?page=tartalom&tipus=cikk<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-66141007411275141772018-10-23T14:21:08.437+00:002018-10-23T14:21:08.437+00:00I am sorry that I am writing out of the post subje...I am sorry that I am writing out of the post subject, however, in order to help to a friend, I decided to ask you, if you may give some suggestions how to make a supplemental liquid food for a baby who is 13 months old. He is undergoing a chemo now due to a bladder cancer, his mom doesn't have enough milk, and he is loosing weight fast. Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-37443066262505253102018-10-23T04:05:14.501+00:002018-10-23T04:05:14.501+00:00Unkown and cave,
That needs a bit of thinking abo...Unkown and cave,<br /><br />That needs a bit of thinking about. It seems pretty clear that a ketogenic diet might be an adjunct to cancer management in a significant number of cancers. Going to extremes might increase the proportion but I tend to look at ketone bodies from the ETC point of view and they look a bit like acetyl-CoA with a little NADH thrown in. Their only drive to generate ROS are from Complex II, whereas FFA metabolism has mtETFdh to fall back on for RET generation which might trigger apoptosis in a glucose adapted cancer cell. Hence the teasing data on stearic acid...<br /><br />https://www.ncbi.nlm.nih.gov/pubmed/19267249<br />https://www.ncbi.nlm.nih.gov/pubmed/19838949<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-46940370026751358702018-10-22T17:15:34.577+00:002018-10-22T17:15:34.577+00:00Sorry, I didn't finish my comment. To go back ...Sorry, I didn't finish my comment. To go back to your original question to Peter, I'm curious if eating a standard carb-rich diet, but bringing your glucose down to near zero with drugs while consuming exogenous ketones, would kill you or not.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-60971245053704995102018-10-22T17:11:59.969+00:002018-10-22T17:11:59.969+00:00I guess so... Coincidentally, I just ran across th...I guess so... Coincidentally, I just ran across this today:<br /><br />"1. Blood glucose below about 60mg/dl must thus be risky only for people on high carb diet, not on ketogenic diet." by Stan Heretic). A hyperlipid post well worth revisiting.<br /><br />http://high-fat-nutrition.blogspot.com/2014/07/in-comments-following-previous-post.html?showComment=1408227365748#c3822559219854812571cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-41093559319938362032018-10-21T20:57:28.086+00:002018-10-21T20:57:28.086+00:00I saw that Dom D'agastino went to zero for 30 ...I saw that Dom D'agastino went to zero for 30 minutes while under ketosis and consuming exogenous ketones and felt no negative effects?<br />Anonymoushttps://www.blogger.com/profile/13380276885728096697noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-17821219219429095052018-10-21T17:35:38.677+00:002018-10-21T17:35:38.677+00:00@Unknown, I think that would be a death sentence f...@Unknown, I think that would be a death sentence for the host (and, thereby, the cancer).cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-78754856765278729162018-10-21T14:22:36.799+00:002018-10-21T14:22:36.799+00:00Peter, is it plausible that if you could bring glu...Peter, is it plausible that if you could bring glucose down to near zero for 1-2 days with drugs,(while consuming exogenous ketones) you could kill most if not all cancer in the host, animal or human?<br /><br />Best RegardsAnonymoushttps://www.blogger.com/profile/13380276885728096697noreply@blogger.com