tag:blogger.com,1999:blog-36840063.post7452310745179817572..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: BAM15 and semaglutide are not insulin sensitising Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-36840063.post-7641716066305124312023-01-09T12:17:43.738+00:002023-01-09T12:17:43.738+00:00Damn it raphi, I have a sh1tload of stuff to do to...Damn it raphi, I have a sh1tload of stuff to do today and you drop that one in to comments!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-9844793835673691702023-01-09T08:30:52.094+00:002023-01-09T08:30:52.094+00:00diabetics become less pathologically insulin resis...diabetics become less pathologically insulin resistant after cold exposure https://www.nature.com/articles/nm.3891 is it NOT because of uncoupling?<br /><br />"Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake"<br /><br />"We therefore examined biopsies taken before the hyperinsulinemic-euglycemic clamp to determine whether insulin signaling in skeletal muscle was affected by cold acclimation. Notably, phosphorylation of the serine-threonine kinase AKT at both Thr308 (data not shown) and Ser473 (Fig. 2e), as well as total AKT (data not shown), were unaffected by cold acclimation"raphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.com