tag:blogger.com,1999:blog-36840063.post8310058763319106064..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Protons (42) Metformin as the next epilepsy drug?Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger17125tag:blogger.com,1999:blog-36840063.post-53145127960520990882015-12-15T22:54:46.931+00:002015-12-15T22:54:46.931+00:00From a google search I see it's already been t...From a google search I see it's already been talked about in some of your other blog posts, I'll go look at them. I should have done that first. I still haven't read the whole site.Betsyhttps://www.blogger.com/profile/03981781557842185747noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-85693830823136213312015-12-15T21:58:17.147+00:002015-12-15T21:58:17.147+00:00Betsy, yes, Ca2+ is clearly very, very important i...Betsy, yes, Ca2+ is clearly very, very important in many functions, not least within mitochondria and related to apoptosis. It's on my to-do list, for the day when I have enough time!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-57874976915120515242015-12-15T20:38:45.806+00:002015-12-15T20:38:45.806+00:00This part of you last comment, Peter, "insuli...This part of you last comment, Peter, "insulin resistance, which looks to be closely tied to bacterial endotoxin absorption" brought to mind that for the bacterial endotoxins to enter a cell, calcium must first enter. It made me wonder if calcium had anything to do with insulin resistance and I found this. <br /><br />Preventing β-cell loss and diabetes with calcium channel blockers.<br /><br />I realize this is a tangent, but I thought someone might be able to expand on it for me. <br /><br />Betsyhttps://www.blogger.com/profile/03981781557842185747noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-87856629511976662152015-12-15T15:22:50.301+00:002015-12-15T15:22:50.301+00:00Wooo, when I get round to it I have this idea that...Wooo, when I get round to it I have this idea that metformin is not an antibiotic, it is a drug which blocks the equivalent of mtG3Pdh in bacteria. It will probably also block the equivalent of insulin signalling in bacteria and put those bacteria in to survival mode to deal with this pseudo starvation. One feature of hungry bacteria is FIAF production and liberation of the percentage of adipose tissue owner by those bacteria. This would make a lot of sense to me. Antibiotics at therapeutic dose rates per se cause weight gain because the few surviving bacteria (hard to eliminate all of them) are living in a sea of plenty and FIAF is not going to be on their agenda. Complete elimination of bacteria will set us up as if we were gnotobiotic organisms with their limited fat reserves because there is no trigger for insulin resistance, which looks to be closely tied to bacterial endotoxin absorption and is another way that bacteria store their energy reserves in our adipocytes.... These are the ways I'm thinking at the moment and there is some support out there.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-85901138331753039542015-12-13T00:45:07.702+00:002015-12-13T00:45:07.702+00:00Metformin use has been a great addition for me. Ve...Metformin use has been a great addition for me. Very interesting blog regarding aed mechanisms of metformin. It enhanced peripheral ketosis without question, I am sure same is true brain. Sleep and mood improved shortly after.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-53744870405174138152015-12-09T23:23:13.926+00:002015-12-09T23:23:13.926+00:00I guess someone needs to convince me that taking a...I guess someone needs to convince me that taking an antibiotic like Metformin is worth it. http://www.cysonline.org/article.asp?issn=2229-5186;year=2011;volume=2;issue=4;spage=219;epage=221;aulast=DashMichaelhttps://www.blogger.com/profile/04352392724157515025noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-82529941227164522282015-12-09T11:06:42.416+00:002015-12-09T11:06:42.416+00:00Peter- agreed, food first. Then meds (or as it is ...Peter- agreed, food first. Then meds (or as it is in this case, Mets). Anonymoushttps://www.blogger.com/profile/15791688232578153396noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-20785331187372975832015-12-08T23:14:30.511+00:002015-12-08T23:14:30.511+00:00This is interesting:
Berberine prevents nigrostri...This is interesting:<br /><br />Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson's disease.Betsyhttps://www.blogger.com/profile/03981781557842185747noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-10026115569217186252015-12-08T22:40:58.698+00:002015-12-08T22:40:58.698+00:00I don't know if this would make you feel more ...I don't know if this would make you feel more comfortable with berberine:<br /><br />The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials.<br />Dong H1, Zhao Y, Zhao L, Lu F.<br />Author information<br />Abstract<br />tThe final analysis showed that administration of berberine produced a significant reduction in total cholesterol (mean difference - 0.61 mmol/L; 95 % confidence interval - 0.83 to - 0.39), triglycerides (mean difference - 0.50 mmol/L; 95 % confidence interval - 0.69 to - 0.31), and low-density lipoprotein cholesterol (mean difference - 0.65 mmol/L; 95 % confidence interval - 0.76 to - 0.54) levels, with a remarkable increase in high-density lipoprotein (mean difference 0.05 mmol/L; 95 % confidence interval 0.02 to 0.09). No serious adverse effects of berberine have been reported. In conclusion, berberine may have beneficial effects in the control of blood lipid levels. However, the efficacy of berberine in treating hyperlipidemia should be further evaluated by more randomized controlled trials in a larger population of patients.<br /><br />Betsyhttps://www.blogger.com/profile/03981781557842185747noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-8089507684821709422015-12-08T22:17:41.358+00:002015-12-08T22:17:41.358+00:00Ken, thanks for the heads up, fixed it.
rq and Be...Ken, thanks for the heads up, fixed it.<br /><br />rq and Betsy, metformin is interesting because it tells us very critical things about the interaction of the redox state of the cytoplasm and the state of the electron transport chain. It’s effect on diabetes is pathetic compared to a genuine LC diet and I would expect a similarly limited effect on seizures. Berberine would need to be telling us interesting things about the front end of the electron transport chain and how this modifies insulin signalling before I would get too excited about it. Berberine for diabetes looks like a very low efficacy tool compared to ketogenic eating, just looking at the improvements cited in Betsy’s paper. Plus it lowers cholesterol. Falling cholesterol as a very gloomy prognostic marker to me…<br /><br />Jasmin and Elsa, I can see a role for metformin for people who are struggling with LC. But food first… Also, as Betsy pointed out, met is far from problem free, though not awful as drugs go.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-68227746688306204812015-12-08T22:04:07.027+00:002015-12-08T22:04:07.027+00:00I am not seeing that a low carb diet blocks glucon...I am not seeing that a low carb diet blocks gluconeogenesis. This is different from a low carb diet in any number of ways, you can see that by the possible side effects. <br /><br />Cheap substitute for sure. Cheap not meaning inexpensive.Betsyhttps://www.blogger.com/profile/03981781557842185747noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-14154857893729860062015-12-08T21:29:57.458+00:002015-12-08T21:29:57.458+00:00They should market it as such ("low-carb in a...They should market it as such ("low-carb in a pill: does everything the diet does for you, without all the effort of cooking" ).Anonymoushttps://www.blogger.com/profile/15791688232578153396noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-85166781288227924882015-12-08T20:33:01.928+00:002015-12-08T20:33:01.928+00:00Personally I prefer Met with it's long history...Personally I prefer Met with it's long history, safety profile and many studies behind it as a quick search on Pubmed shows. Not to mention it's dirt cheap.Jasmin Johendhttps://www.blogger.com/profile/10174428786206885943noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-72856519279193308952015-12-08T15:45:10.704+00:002015-12-08T15:45:10.704+00:00One link seems to be wrong
Inhibition of Lactate...One link seems to be wrong <br /><br />Inhibition of Lactate Dehydrogenase to Treat Epilepsy should link to<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/26154793<br />(or direct to NEJM)<br /><br />Ken<br /><br />ps. thanks for this continuing series of fascinating and quite vital ideas.Ken Strainhttps://www.blogger.com/profile/17858942560493966406noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-5045313098499941412015-12-08T13:25:01.377+00:002015-12-08T13:25:01.377+00:00Thank you for the link to berberine, rq, I then fo...Thank you for the link to berberine, rq, I then found this: http://www.sciencedirect.com/science/article/pii/S0026049508000462<br /><br />Exactly the information I need for some friends that won't stop taking statins.Betsyhttps://www.blogger.com/profile/03981781557842185747noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-10132159687104187122015-12-08T06:12:19.540+00:002015-12-08T06:12:19.540+00:00Looks that way to me. I think it's also LC in ...Looks that way to me. I think it's also LC in a pill as far as our gut microbiota is concerned...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3190364326687695932015-12-07T23:57:01.593+00:002015-12-07T23:57:01.593+00:00Low-carb in a pill, as you said. Low-carb in a pill, as you said. Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.com