tag:blogger.com,1999:blog-36840063.post8403990358345128133..comments2024-03-18T22:09:37.509+00:00Comments on Hyperlipid: Protons (29) Uncoupling with fatty acidsPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-36840063.post-14941488128137129602013-11-14T22:33:23.042+00:002013-11-14T22:33:23.042+00:00Several bits that start with treatment of epilepsi...Several bits that start with treatment of epilepsia have been published - and the suggestion has been made that manic-depression is closely related - the question I don't see a good answer to is this positive effect due to ketogenic diets reduction of inflammation ( think TNF CRP - inflammatory interleukins ) or by some quite different mechanism. <br /><br />Tying this back to Peters post - CQ10 supplements send a portion of the population into sever brain fog. (I think I just lost my coffee mug again ... ) karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-75831405299190467092013-11-14T21:50:58.749+00:002013-11-14T21:50:58.749+00:00I can't remember if I've posted this elsew...I can't remember if I've posted this elsewhere, but it's a very informative resource when it comes to the issue of glucose levels in cell culture<br />http://www.sigmaaldrich.com/life-science/cell-culture/learning-center/media-expert/glucose.html<br /><br />And, golly gosh, try launching the (culture) Media Expert by clicking on the upper right icon, some real goodies in that.<br />I finally learned the basis of pyridoxine toxicity there. Non-enzymatic Schiff base reactions denaturing proteins, of course.<br />So obvious once one knows...Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-21526125427739342332013-11-14T21:39:58.211+00:002013-11-14T21:39:58.211+00:00Hi Woo, I think you are correct. I suspect very hi...Hi Woo, I think you are correct. I suspect very high calories ketogenic eating can raise fasting insulin, although 24/7 insulin exposure will be reduced compared to eating CIAB style. It strikes me as possible that low carb, rather than zero carb, might result in lowest insulin exposure. But ketosis for mood control is another ball game and probably comes with its own trade offs. Sanity is a marked up-side.<br /><br />My fasting ketones are one plus and spike after my main meal. Simply a ton of fat per unit carbs, nothing to do with weight loss immediately post prandially...<br /><br />Tee hee Leon!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-61892128289533949482013-11-14T12:27:47.939+00:002013-11-14T12:27:47.939+00:00The title produced this thought:
"Uncoupling...The title produced this thought:<br /><br />"Uncoupling with Fatty Acids" usually leads to Coupling with Former Fatty.<br /><br />Win win.<br />LeonRoverhttps://www.blogger.com/profile/07219165631035107225noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-27531573209308928052013-11-14T00:41:34.349+00:002013-11-14T00:41:34.349+00:00I have definitely noticed animal fat/ SFA seem to ...I have definitely noticed animal fat/ SFA seem to promote stronger fasting ketosis and greater energy. I suspect if I alter diet so that most fats are coming from this source (and not dairy) I would find it much easier to maintain ketosis as well as weight.<br /><br />However reducing fat content of diet and simply using my fat tissue for energy necessitating drop in insulin level seems to be best way to initiate a stronger fasting ketosis for me at this point.<br /><br />When I was actually overweight with highly IR fat tissue / hypertrophic adipocyte, this would all be non issue; fasting ketosis was easy and quite strong just via carb restriction. I think leptin figures in a lot too (leptin facilitates body fat oxidation in numerous ways, and at lower weight with lower leptin is harder to maintain fasting ketosis).<br /><br /><br />I've decided fasting ketosis is most specific for insulin levels and weight loss, all other ketosis is not that important at all.<br /><br /><br />This is kind of off topic I know, sorry!ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-35380145393562792232013-11-14T00:35:41.270+00:002013-11-14T00:35:41.270+00:00Peter as you may or may not know I've discover...Peter as you may or may not know I've discovered my fasting ketosis is highly variable and seems most reactive to dietary fat content. Likely this would not be an issue if I was on a more strict protocol with less protein and less carb, but for health/wellness reasons I prefer to keep protein higher around 70-80 most days and my carbs are moderately restricted at 30 net.<br /><br />Now I am *always* in ketosis following this diet, however, my fasting ketosis is only trace when I consume enough dietary fats (usually in form of dairy or nuts). If I eat the same amount of protein and carb but restrict fats to a slight deficit, my fasting ketosis is moderate (dark) and I lose body fat quite obviously. <br /><br />I am quite certain I am in ketosis throughout (my urine is also quite dilute, nice TMI there, so even trace ketosis likely represents significant ketogenesis, whereas the darker levels represent an even more enhanced ketosis).<br /><br /><br />After tinkering I've come to conclusion that dietary fat places burden of insulin resistance so that fasting insulin is actually higher , thus weak fasting ketosis and symptomatic manifestation of body fat gain or maintenance. <br /><br />My posptrandial ketosis is stronger on high cal diet, so it's not an issue of being "in ketosis", it seems more to be a combination of the fact I very very very easily gain body fat (duh, quite weight reduced/hypotrophic adipose) and the high fat/cal ketogenic diet -> higher fasting insulin -> body fat retention/gain.<br /><br /><br />Emotionally I feel better losing wt as well with stronger emotional ketosis symptoms (I follow ketogenic diet for mood benefits primarily) so there is no downside for me to losing wt. I think this is backbone of why I always crave to diet - a higher calorie keto diet does not make me feel as good as a slight neg energy one (at least, until the effects of stress response destabilize my mood and health e.g. progressive insomnia and activation).<br />ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.com