tag:blogger.com,1999:blog-36840063.comments2024-03-29T06:45:45.894+00:00HyperlipidPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger21254125tag:blogger.com,1999:blog-36840063.post-7389742751255390722024-03-29T06:45:45.894+00:002024-03-29T06:45:45.894+00:00So there is hope for research aftr all:) Nice to b...So there is hope for research aftr all:) Nice to be back after a while deep diving into deutenomics. In that context I can now read these gold nuggets again in awe. vasenpolvihttps://www.blogger.com/profile/09094718880442747431noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-62339289426847287172024-03-27T22:57:00.742+00:002024-03-27T22:57:00.742+00:00Mct4h "Our living rooms definitely have only ...Mct4h "Our living rooms definitely have only small percentage of it" (ozone"<br /><br />The old brush motor powered blenders and vacuum cleaners helped keep domestic ozone levels up. We had one blender, a 'vitamiser' where you could watch the spark fireworks through cooling vents and smell that acrid tang of O3. Perhaps this is why I was more healthy growing up, the ozone doing more good than the smoothies?<br />;)Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-46900282222693613802024-03-27T21:58:37.892+00:002024-03-27T21:58:37.892+00:00@Karl "Biology is full of tolerance effects ...@Karl "Biology is full of tolerance effects - I think much of this helps us survive single point mutations. The web of nested and redundant feedback loops makes these mutations a detriment - but not fatal."<br /><br />You really should look into some of Michael Levin's work with planarian flatworms and the concept he calls cellular competency or cellular intelligence. In the case of these creatures dna hardly seems to matter at all. He has yet to find a level of mutagen to raise them in which makes any difference to their biology even though it turns their dna to junk. It was pretty junky before he tried. This goes way beyond balancing out snm. It is less like this in humans but not entirely less --- think about the huge range of junk dna found in various cancer cells yet they are still vital, surviving cell types capable of forming colonies. They have high cellular competency. In the case of planarians the whole creature has evolved to have this level of cellular competency.Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-67379986416231277772024-03-27T05:59:03.088+00:002024-03-27T05:59:03.088+00:00@karl
About clean ground ozone, I think the data i...@karl<br />About clean ground ozone, I think the data is missing. I didn't find any study, when would be ozone level of 0.1 mg O3 restored. Our living rooms definitely have only small percentage of it, near zero.We just don't know if this is more or less powerful then D3.<br /> <br />See on-line data from Chopok mountain, really clean environment. Every day min 70 ug, even in winter.<br />https://www.chmi.cz/files/portal/docs/uoco/web_generator/aqindex_slide1/mp_8CHOA_CZ.html<br /> <br />Did you read the inflammation paper. I returned to if after few years and I understand it much more now. It's very interesting.mct4healthhttps://www.blogger.com/profile/05453439249479290441noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-78746013494382722612024-03-27T01:03:00.235+00:002024-03-27T01:03:00.235+00:00I roast my own beans and drink it black. Just that...I roast my own beans and drink it black. Just that coffee plus sugar = cortisol plus ros = time to go hunting and gathering. <br />:)Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-79936224495020150372024-03-26T18:00:39.242+00:002024-03-26T18:00:39.242+00:00@mct4health
First a side point.. O3 is probably...@mct4health <br />First a side point.. O3 is probably only had a minor effect to combat TB - The evidence that it was Vit-D that matters is there. Not to detract from your main points.. <br /><br />What is clear is that MOST of the anti-ox narrative is just wrong. Most of these are polyphenols that don't get absorbed - might help keep metals from getting absorbed but they mostly remain in the digestive tract. True antiox that do get absorbed are associated with bad health effects. <br /><br />A much better way to think about this is that the ROS from MT is a metabolic mode switch. Flipping between the two modes turns on and off a long list of events. Taking something that messes with this system does not seem like a wise idea - just eat human foods instead of packaged foods. <br /><br />One of the missing considerations are possible hormesis effects. I think it is clear by now that low levels of radiation (I think it was a Dr. Cohen in Iowa that first observed this) actually reduce cancer rates. If you consider cancer to be first a MT disease, there are several possible narratives of how this works by effecting ion levels. So it is possible that O3 has a similar effect?<br /><br />Part of what I think you are reacting to is from the false narrative that "ROS is always bad" - "The less the better". Interfere with this ancient signal at your own peril. Same narrative with inflammation - appropriate inflammation is a really good thing - it is healing. Turn off inflammation and your next cut could kill you. <br /><br />This tendency to put something into terms of bad-vs-good does not help us. <br /><br />So I don't find it surprising that O3 helps with wound healing<br /><br />Some of this reminds me of the dive I did trying to understand the politicized ozone layer jazz - ignoring earlier data when the 'ozone hole' was actually larger. Turns out that if there is less ozone - more UV gets through and produces - wait for it - more ozone. I never could reconcile all the contrary bits in this story - could be it was mostly about expiring patents. <br /><br />@Oassthecream<br />Biology is full of tolerance effects - I think much of this helps us survive single point mutations. The web of nested and redundant feedback loops makes these mutations a detriment - but not fatal. I suspect that we also develop tolerance to chronically elevated cortisol.<br /><br />What is not in the paper is the association between elevated BP and CVD - which is confounded with sodium retention due to chronically elevated insulin in most of today's population. It could be the blocking of autophagy by insulin is the bigger problem for CVD.<br /><br />Every other paper on coffee seems to contradict the last one - my take is if coffee was seriously harmful, we would know about it by now. Most likely coffee produces some harms and some benefits. Anyway, I have mine dark roasted with heavy cream - delicious. (so I'm probably biased).karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-67378212856490519772024-03-25T07:46:40.339+00:002024-03-25T07:46:40.339+00:00Strong coffee please, white with four sugars but d...Strong coffee please, white with four sugars but don't stir it, I don't like it sweet. 1pm to 7pm after the second cup is just when you are itching to practise BMM ( bank manager mutilation), or make some trades on a bear market.<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257922/#:~:text=Caffeine%20increases%20cortisol%20secretion%20in,of%20caffeine%20in%20the%20diet.Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-51579898827665337382024-03-24T19:43:38.829+00:002024-03-24T19:43:38.829+00:00Nice post. Nice post. Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-29063561213890841122024-03-24T13:43:15.639+00:002024-03-24T13:43:15.639+00:00Thank you, Peter, nicely said. I would only add m...Thank you, Peter, nicely said. I would only add my favorite HIF1A to switch on by excessive ROS, if fats cannot be created as rescue metabolism. Which by the way still switch to make fat. Fat synthesis is seemingly the most effectively rescue pathway to consume mitochondrial NADH and cytosolic NADPH instead of using oxygen.<br /><br />The chronic inflammation I see as inability to switch from anaerobic fermentation to OXPHOS.<br />"Redox regulation in metabolic programming and inflammation"<br />http://dx.doi.org/10.1016/j.redox.2017.01.023<br /> <br />There are also interesting environmental aspects, like missing clean ground ozone, which nobody see. <br /> <br />https://mct4health.blogspot.com/2022/11/ozone-o3-has-antioxidant-effects-are-we.html<br /> <br />https://mct4health.blogspot.com/2023/09/ozone-and-nitric-oxide-how-do-they.html<br /> Jaromir mct4healthhttps://www.blogger.com/profile/05453439249479290441noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22435118202858623902024-03-23T11:11:54.938+00:002024-03-23T11:11:54.938+00:00@karl said: (Higher levels of ROS found in cancers...@karl said: <i>(Higher levels of ROS found in cancers appear to damage mDNA - which begs the arrow of causation question - is caner caused by mutations or does do the mutations cause cancer?)</i> <br /><br />I think you said the same thing twice (mutations → cancer ?) — but I think I know what you're saying.<br /><br />In my (biased) opinion the vast multitude of somatic mutations and genomic instability observed in tumor cells arise as downstream effects of mitochondrial issues and the disease (tumor progression) itself. One can certainly inherit or acquire genetic mutations that make them more susceptible to the disease (i.e., risk factors), but they are neither necessary nor sufficent to cause cancers.Bob Kaplanhttps://www.blogger.com/profile/01935827386824072891noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-7596292302853911712024-03-23T10:16:54.989+00:002024-03-23T10:16:54.989+00:00@cavenewt
Induction of omega-oxidation of monocarb...@cavenewt<br />Induction of omega-oxidation of monocarboxylic acids in rats by acetylsalicylic acid<br />https://pubmed.ncbi.nlm.nih.gov/1752948/<br />mct4healthhttps://www.blogger.com/profile/05453439249479290441noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-79840654350523430192024-03-23T10:06:37.150+00:002024-03-23T10:06:37.150+00:00Malcolm Kendrick has a nice post — and quip — on i...Malcolm Kendrick has a <a href="https://drmalcolmkendrick.org/2016/05/07/what-causes-heart-disease-part-xiii/" rel="nofollow">nice post — and quip — on inflammation</a>: <br /><br />"Whenever I see anyone stating that inflammation is a cause of anything I simply change the word inflammation to the word ‘healing,’ to see how sensible it then sounds."Bob Kaplanhttps://www.blogger.com/profile/01935827386824072891noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-36872847945198822922024-03-23T09:04:39.763+00:002024-03-23T09:04:39.763+00:00@karl
I don't suspect AzA not be beneficial, ...@karl<br />I don't suspect AzA not be beneficial, it is used I think often in dermatology.<br /> <br />It fits to my picture of how dicarboxylic acids control fasting metabolism. Omega oxidation and peroxisomal metabolism, not insulin, likely controls level of FFA in fasting state. And here omega-3/omega-6 C18 fats take place, PPARa/PPARg. Surprisingly AzA could be protective the same way as ALA, by elevating formation of acetate. <br />It's interesting, that DNL and GNG elevates and suppresses together. Acetate can suppress both. It reminds me computer restart. Understanding fasting I see as the key, I'm trying to delve into.<br />Jaromir mct4healthhttps://www.blogger.com/profile/05453439249479290441noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-29388730790810735752024-03-23T03:44:18.941+00:002024-03-23T03:44:18.941+00:00@altavista... It's even less serious than that...@altavista... It's even less serious than that. There's a pretty good discussion by Bret Weinstein and Heather Heying at https://rumble.com/v4kf5t9-the-217th-evolutionary-lens-with-bret-weinstein-and-heather-heying.html, (01:44:40) Intermittent fasting and early death. Better, also listen to the prior segment about another talk at the same AHA conference, (01:33:20) Sunbathing and heart disease.<br /><br />The best word for both of these "scientific talks" would be "silly".cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-67991588927947704202024-03-23T03:19:39.056+00:002024-03-23T03:19:39.056+00:00The flaneur has spoken.
https://twitter.com/nntal...The flaneur has spoken.<br /><br />https://twitter.com/nntaleb/status/1770463325878440264<br /><br />Sample too small, confounders too big.altavistahttps://www.blogger.com/profile/10443439015369042857noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-58982783148006460772024-03-22T15:57:20.915+00:002024-03-22T15:57:20.915+00:00sorry for OT, but very interesting: https://www.ny...sorry for OT, but very interesting: https://www.nytimes.com/2024/03/21/obituaries/yvonne-barr-overlooked.htmlErichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-29370516912816211502024-03-22T13:18:12.951+00:002024-03-22T13:18:12.951+00:00Karl Pufa start to oxidise as soon as you heat ...Karl Pufa start to oxidise as soon as you heat them up in metal cookware and the lipoperoxides produced generate a catastrophic cascade of lipoperoxidation when consumed. Perhaps this is another dusastrous aspect of modern foods and food preparation. In terms of ancestral foodstuffs, bulk quantities of oil cooking in a pot over the hearth probably wasn't on anyone's menu.<br /><br />Now it may be that uncooked seeds and raw mongongo nuts are not quite as harmful as the contemporary hard baked equivalents? Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-80760136635032836852024-03-22T08:53:33.418+00:002024-03-22T08:53:33.418+00:00In our supermarket meat sections they simply light...In our supermarket meat sections they simply light everything with horrible pink-purple tinted led lighting. It makes all the meat glow beautifully. To see what you're getting you need to take the alleged meat away from the cabinets to more ordinary lighting to persuse and generally it turns grey or green. But one thing which stands out in my mind from when I was visiting the UK, the lamb chops were all very pale and anaemic looking which was horrifying to me since I am used to Australian chops which are a healthy dark red colour. I don't know if the paleness, paler than even a pork chop, was due to breeding, feeding or post treatments, but Yuk!Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-24427574931047399792024-03-22T02:12:46.752+00:002024-03-22T02:12:46.752+00:00@mct4health
Looked at your links - this one:
htt...@mct4health <br /><br />Looked at your links - this one:<br />https://pubmed.ncbi.nlm.nih.gov/23361364/ => better link =><br />https://sci-hub.se/10.1007/s11010-013-1566-1<br /><br />I was not able to find the actual diet data-sheets - realize that listing things like carbohydrate can be misleading (is it sucrose or cornstarch? Same in both diets? (they often pump sucrose in the HFD ) and fat (which is often NOT animal fat, but plant oils - often hydrogenated). <br /><br />The question is if consuming these plant-oils would do more harm via modulation of clotting factors (UP) - vs the claimed secondary metabolite.<br /><br />After years of reading papers on the health claims of supplements etc - I think the state of the art is dismal - most of them are poorly controlled studies - often funded by the people selling the supplement. <br /><br />My alternative is to trust of evolution, which means we are likely well evolved to eat fish/meat as hunter gathers - exposed to times of fasting and not very far along with evolving to eat farmed products. I don't think these ancestors had access to bottles of various oils.<br /><br />I tried lots of life-style-hacks along the way. (artificial sugars for for example that I now believe are harmful (spikes insulin)). Many life-style-hacks interventions will turn out to have unintended consequences - similar to other novel foods. The heuristic(rule of thumb) I use now is to no buy any foods that have an ingredient list (likely to have additives - no all additives get listed - some additives are unprescribed antibiotics paraded as preservatives) and to eat only foods my great grandmother would know - back when T2D was exceedingly rare. <br /><br />@altavvista<br />I generally suspect anything from the AHA is likely garbage. Chinese paper - not published. Recall study - lots of contrary papers.<br />https://www.abstractsonline.com/pp8/#!/20343/presentation/379<br /><br />Also, when people go on crash diets - which might be confused with intermittent fasting - they CAN damage their hearts. No one is going to do a good study as there is no patentable pill to sell. <br /><br />@cavenewt<br />Papers that change the names of terms are suspect - NAFLD becomes MASLD (tiresome).. <br />Anyway - here is a better link:<br />https://www.medpagetoday.com/gastroenterology/generalhepatology/109281<br /><br />Interesting - my father was a subject of the original 'doctors study' for low dose aspirin. (It was not a good study - the experimental group not only got ASA - but also magnesium.)<br /><br />Of course NAFLD is not the only out come of having T2D(AKA insulin tolerance). Much better to quit eating the wrong foods. Foods with ingredient labels are not really human foods - tend to be addictive.karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74171733856626435062024-03-20T15:23:55.441+00:002024-03-20T15:23:55.441+00:00Fatty liver? No worries! Just take beby aspirin!
...Fatty liver? No worries! Just take beby aspirin! <br /><br />"In small study, baby aspirin cuts fat buildup in liver disease patients." https://www.statnews.com/2024/03/19/baby-aspirin-liver-disease-masld/<br /><br />It's paywalled, and I didn't bother to search for the study paper.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-90732256523675553002024-03-19T21:39:25.546+00:002024-03-19T21:39:25.546+00:00https://www.statnews.com/2024/03/19/intermittent-f...https://www.statnews.com/2024/03/19/intermittent-fasting-study-heart-risk/altavistahttps://www.blogger.com/profile/10443439015369042857noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-11106802222820902612024-03-19T19:25:18.967+00:002024-03-19T19:25:18.967+00:00@karl
They surely oxidize, but our intestines are ...@karl<br />They surely oxidize, but our intestines are different from rodents. And if they are oxidized even more, they can be beneficial, like AzA.<br /> <br />A lipid peroxidation product 9-oxononanoic acid induces phospholipase A2 activity and thromboxane A2 production in human blood<br />https://doi.org/10.3164%2Fjcbn.12-110<br /> <br /> <br />The Induction of Lipid Peroxidation in Rat Liver by Oral Intake of 9-Oxononanoic Acid Contained in Autoxidized Linoleic Acid<br />https://doi.org/10.1080/00021369.1985.10867151<br /> <br /> <br />Intestinal and Hepatic Uptake of Dietary Peroxidized Lipids and Their Decomposition Products, and Their Subsequent Effects on Apolipoprotein A1 and Paraoxonase1<br /> https://pubmed.ncbi.nlm.nih.gov/34439506/<br /> <br /> <br />Protective effects of azelaic acid against high-fat diet-induced oxidative stress in liver, kidney and heart of C57BL/6J mice<br />https://pubmed.ncbi.nlm.nih.gov/23361364/<br /><br />Some papers from my blog....<br />Jaromirmct4healthhttps://www.blogger.com/profile/05453439249479290441noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-88410159286546929232024-03-19T17:23:04.396+00:002024-03-19T17:23:04.396+00:00Inflammation is very poorly and variously defined ...Inflammation is very poorly and variously defined (hand waving?) - the shift in the CVD mantra is now slowly away from frantic hand-waving about LDL to hand-waving about inflammation - which they pretend to measure in no end of ways. <br /><br />My take is inflammation is actually a range of responses to injury or infection. Mostly a really good thing that stops infections and starts tissue repair processes. These processes are utterly complex and not reducible to some blood test. Also, some people equate inflammation to ROS levels - (ROS actually appear to be a genetically ancient signal that helps control a cell - true systemic anti-oxides appear to do harm by screwing up this homeostasis signal. )<br /><br />(Higher levels of ROS found in cancers appear to damage mDNA - which begs the arrow of causation question - is caner caused by mutations or does do the mutations cause cancer? )<br /><br />The term 'inflammation' seems to be used as a tool to push the supplement of the week or to support weak disease narratives.<br /><br />,.,.<br /><br />Another inconvenient fact that those parroting the ungrounded CVD narratives have to deal with is something I found in a deep deep dive into oxLDL (sometimes oxoxLDL - and oxLp(a) etc). There is an intervention that lowers oxLDL - but no one gets to sell a new pill - simply reduce dietary PUFA. Statins may actually increase oxLDL. <br /><br />Another way to think about oxLDL is it that the oxidation has damaged the fatty acid that LDL transports - or it can be seen as damaged LDL. <br /><br />My take is that CVD is primarily a thrombotic disease - plaque appears to be blood clots that are paved over with new intima. What is key is it is not about lipids - rather that oxLDL and friends increase clotting - Remember that LP(a) where the (a) is a genetic relative of firbrogen. "The LPA gene that codes for apo(a) evolved from plasminogen in Old World monkeys: high homology between apo(a) and plasminogen" So these clots are full of fibrin and amyloid proteins - mis-folded. <br />CVD is a thrombotic disease probably only related to lipoprotiens via the clotting factors they transport. <br /><br />https://www.sciencedirect.com/science/article/abs/pii/S0049384814003685<br />https://www.sciencedirect.com/science/article/abs/pii/S0939475320300971<br /><br />Anyway - I was able to lower my oxLDL levels to the bottom 5-percentile of the population by avoiding PUFAs in the diet. <br /> <br /><br />@ mct4health<br /><br />PUFAs want to oxidize - the double carbon bonds are not as stable as what we see in SFAs. The question is how long before they do oxidize?karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-82187517845050584042024-03-19T16:10:53.406+00:002024-03-19T16:10:53.406+00:00Hm, LA is tricky, very confusing. When not oxidize...Hm, LA is tricky, very confusing. When not oxidized, almost nothing happens. When burned, excessive insulin sensitivity appears (I think by supplying NAD+ via DECR), this elevates fat storage and after a while it elevates H2O2 and LA is auto-oxidized. This triggers protective measures like peroxisomes or pseudohypoxia on. And here researcher's missing the point. The final product of peroxisomal beta oxidation is protective systemic acetate. Nobody measures flow of acetate. We are totally blind. If in the fat mixture is some other trigger of peroxisomal protection, then acetate is produced from the start. This way omega-3 alpha linolenic acid works but not other longer omega-3. <br />Rodents are sensitive to level of oxidation of LA. Their gut don't suppress products like 9-ONA, that's why they react on LA immediately. Humans have gut protection, products like 9-ONA are not absorbed. LA have to be oxidized in the tissue. That I see as the main difference between rodent vs human papers.<br />And the missing elefant in the room is flow of acetate, it can involve intestinal and hepatic sources. Main function is suppresion of de-novo lipogenesys and supply of cytosolic acetyl-CoA, de-facto restart of the cell metabolism. That's my explanation of variabilities in LA research. Unless researcher's start measure peroxisomal activity, dicarboxylate and acetate flow, we stay blind.<br />Jaromir<br />mct4healthhttps://www.blogger.com/profile/05453439249479290441noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-44682863583808118652024-03-18T22:09:37.509+00:002024-03-18T22:09:37.509+00:00@karl
I don't know if CO affects things nutri...@karl<br /><br />I don't know if CO affects things nutritionally, but it certainly doesn't improve the taste. Lived overseas for a year, was surprised at first that beef was a totally different color... finally realized that's what color it was *supposed* to be. JustPeachyhttps://www.blogger.com/profile/06128069966879300756noreply@blogger.com