tag:blogger.com,1999:blog-36840063.post1190484805506268891..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Gluten: Does coeliac disease require an infection?Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger35125tag:blogger.com,1999:blog-36840063.post-4872159271749528592010-05-13T20:37:02.172+00:002010-05-13T20:37:02.172+00:00Bacteria are not only harmful to humans, too many ...Bacteria are not only harmful to humans, too many industries depend in part or entirely of bacterial action. Lots of important chemicals such as ethyl alcohol, acetic acid, butyl alcohol and acetone are produced by specific bacteria. Bacteria are also used for curing snuff, tanning leather, rubber, cotton, etc.. The bacteria (Lactobacillus often) along with yeast and molds have been used for thousands of years for the preparation of fermented foods such as cheese, butter, pickles, soy sauce, sauerkraut, vinegar, wine and yogurt.....https://www.blogger.com/profile/03718514574350628063noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-85663386463027118222010-05-11T17:53:09.674+00:002010-05-11T17:53:09.674+00:00Oh la laOh la laAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-36840063.post-56038061490158373762010-01-27T14:19:37.782+00:002010-01-27T14:19:37.782+00:00Blogblog, that sounds remarkably sensible.
O P, y...Blogblog, that sounds remarkably sensible.<br /><br />O P, yes, and saturated fat causes heart disease! Dr Heather Mackenzie and Dr Carina Venter seem to have about as much information about the innate immune system as Catherine Collins RD does <a href="http://www.drbriffa.com/blog/2008/06/06/health-professionals-ignore-their-patients-at-their-and-their-patients-peril/" rel="nofollow">on Dr Briffa's site, down in the comments</a>. None.<br /><br />How do these people get in to positions to destroy people's lives?<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-24964353455878406472010-01-25T01:00:50.294+00:002010-01-25T01:00:50.294+00:00Despite of this, they insist wheat is very healthy...Despite of this, they insist wheat is very healthy: "Britons May Be Avoiding Wheat Unnecessarily, UK" - http://www.medicalnewstoday.com/articles/176895.php.https://www.blogger.com/profile/09917531397118353422noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-14664315250979856832010-01-24T00:32:51.514+00:002010-01-24T00:32:51.514+00:00My GP refused to prescribe corticosteroids for my ...My GP refused to prescribe corticosteroids for my IBD. He said that any underlying infection would be masked potentially making the problem much worse.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-35766342836960682512010-01-15T13:11:05.430+00:002010-01-15T13:11:05.430+00:00Peter,
the hemochromatosis/celiac idea is interest...Peter,<br />the hemochromatosis/celiac idea is interesting. I had borderline anemia for years due to Crohn's despite eating a huge amount of red meat. <br /><br />There is also some evidence that regular blood donations are cardioprotective for men.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-58121349538238678412010-01-15T13:00:07.359+00:002010-01-15T13:00:07.359+00:00I am sure that the lack of gut parasites in modern...I am sure that the lack of gut parasites in modern western populations is a major contributor to autoimmune and inflammatory diseases.<br /> <br />I clearly observed the anti-inflammatory role of gut parasites about two years ago. My cat had just used the litter tray and I noticed a wriggling tapeworm segment in his stool. I wormed him later that day. A few days later he developed hay fever for the first time despite being 18 years old. He hadn't suffered any obvious problems at all when he had the tape worm.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-90424234024041663392010-01-14T23:44:00.091+00:002010-01-14T23:44:00.091+00:00Have you ever read "Management of Celiac'...Have you ever read "Management of Celiac's Disease" by Sidney V. Haas (published 1951)? Before it was discovered that Celiacs had a gluten issue he argued that it was a bacteria that was changing what was eaten into something damaging. He was very ahead of his time, he would even be more so today.Mrs. Edhttps://www.blogger.com/profile/02144247274657295271noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-43573663810215573112010-01-14T02:27:11.838+00:002010-01-14T02:27:11.838+00:00Mary said:
"speaking of food phobias: the jap...Mary said:<br />"speaking of food phobias: the japanese consume a great deal of unfermented soy products (like tofu and soymilk). do you consider the japanese a 'disease-prone' society? if so, why do they have the longest average life span?"<br /><br />Nothing could vbe further from the truth. The Japanese consume almost no unfermented soy- tofu and soy sauce are fermented. The total soy consumption in Japan is also quite low.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-47374942518635965212010-01-13T19:18:33.733+00:002010-01-13T19:18:33.733+00:00Now that you're talking life span. I heard som...Now that you're talking life span. I heard some time ago about a theory that age is decided by the length of telomeres. Was that theory valid? If age is about the telomeres, how does insulin influence telomeres?Tim TerlegÄrdhttps://www.blogger.com/profile/04619796336620104732noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-64096588862813966042010-01-13T17:10:02.646+00:002010-01-13T17:10:02.646+00:00My (non-scientific) executive summary: gluten is p...My (non-scientific) executive summary: gluten is plant venom, the adverse effects of which may include (among other things) coeliac. <br /><br />But the coeliac who has gut-problems alleviated (by removal of a bacterial infection, say)ought not to assume he has found the gluten anti-venom.caphuffhttps://www.blogger.com/profile/17630921602227752611noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-30218618737080904072010-01-13T15:28:47.809+00:002010-01-13T15:28:47.809+00:00A new Germ Theory. "Consider a disease with a...<a href="http://www.theatlantic.com/issues/99feb/germs.htm" rel="nofollow">A new Germ Theory</a>. "Consider a disease with a fitness cost of one percent -- that is, a disease that takes a toll on survival or reproduction such that people who have it end up with one percent fewer offspring, on average, than the general population. That small amount adds up. If you have an inherited disease with a one percent fitness cost, in the next generation there will be 99 percent of the original number in the gene pool. Eventually the number of people with the disease will dwindle to close to zero -- or, more precisely, to the rate produced by random genetic mutations: about one in 50,000 to one in 100,000 {..]<br /><br />The most fitness-antagonistic diseases must be infectious, not genetic, Ewald and Cochran reason, because otherwise their frequency would have sunk to the level of random mutations. The exceptions would be either diseases that could be the effect of some new environmental factor (radiation or smoking, for example), or genetic diseases that balance their fitness cost with a benefit. Sickle-cell anemia is one example of the latter."<br /><br />Nigel Kinbrum, take a look at <a href="http://high-fat-nutrition.blogspot.com/2009/12/vitamin-d-and-uv-fluctuations-2.html?showComment=1263395652263#c8155326642473454616" rel="nofollow">this</a> please.Kenhttps://www.blogger.com/profile/01637818790791725275noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-80226455376812099392010-01-13T09:46:57.036+00:002010-01-13T09:46:57.036+00:00All this talk of infection & autoimmune diseas...All this talk of infection & autoimmune disease makes me think....hypovitaminosis D!Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-40798330259798226832010-01-12T23:43:06.809+00:002010-01-12T23:43:06.809+00:00On the topic of induction of autoimmune diseases b...On the topic of induction of autoimmune diseases by viruses and bacteria,<br /><br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/15720242" rel="nofollow">Samarkos (2005), "The role of infections in the pathogenesis of autoimmune diseases."</a>Robert McLeodhttps://www.blogger.com/profile/05270962906437456350noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-88023941309705686782010-01-12T17:11:42.472+00:002010-01-12T17:11:42.472+00:00What you briefly mentioned about pullulanase and I...What you briefly mentioned about pullulanase and IBS made me very interested.<br /><br />Can't find much more detail about it online though, do you have more informationabout that?Mannehttps://www.blogger.com/profile/10303749495583764905noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-38214192562393047052010-01-12T13:59:33.432+00:002010-01-12T13:59:33.432+00:00Please let me add that the above ingestion of phyt...Please let me add that the above ingestion of phytotoxins is considered only in the context of a healthy gut! (I.e. don't be using grains, or any other neolithic gut-shredding items for this. The idea is not to permanently inflame the gut, but to temporarily raise the body's sympathetic nervous system and acute immune response...)gunther gathererhttps://www.blogger.com/profile/15361732213105267048noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-23014531570112673552010-01-12T13:52:30.321+00:002010-01-12T13:52:30.321+00:00Hi Peter,
"a long life span and good health ...Hi Peter,<br /><br />"a long life span and good health is a trait of the Hiroshima survivors which has been attributed to the per-acute selection pressure at the time of the blast and merely acutely during the firestorm which followed, then during the weeks before any medical aid arrived"<br /><br />Could it also be due to hormesis from the radiation exposure itself? I'm not suggesting this is good for you, but it may be an aspect along with what you pose above.<br /><br />This brings me to an outlying factor in health that's caught my attention recently: that of lack of hormesis, ie. no challenge to cells in one's lifestyle. I've been experimenting with eating certain "inflammatory" foods such as nightshades, with interesting results. <br /><br />I was wondering how you felt about hormesis in general, since you don't discuss it much on the blog,. I agree with you that vegetables aren't optimal human food, but they may serve a purpose when intermittently SEPARATELY eaten from real food and ONLY for hormetic purposes. The idea is to invoke the same cell-protection effects as fasting or exercise. <br /><br />Here are some fascinating studies:<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/17913594?dopt=Abstract<br /><br />http://www.nature.com/ejcn/journal/v61/n2/abs/1602507a.html<br /><br />http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6X1H-4PJM9F8-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4a6944b9a488089a3e5e00c9b919eef9<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/18648607?dopt=Abstract<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/18543123?dopt=Abstract<br /><br />Cheers, Ggunther gathererhttps://www.blogger.com/profile/15361732213105267048noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-6600300089269573852010-01-12T12:47:49.029+00:002010-01-12T12:47:49.029+00:00Heike, the most important thing I can see about lo...Heike, the most important thing I can see about longevity seems to be insulin sensitivity. If you can eat a diet of potatoes and maintain reasonable levels of glycaemia with reasonable levels of insulin you are probably on to a (genetic) winner. Others might get there accidentally by having a second rate tolerance of carbohydrate (probably fructose) and yet get to old age by accidentally avoiding carbohydrate. At the moment I just see most degenerative diseases improving with carb restriction. I'd rather hope that this might extend life, or healthy life anyway. Of course a very carb based diet might well be low in protein and so in cystein too, the other longevity hypothesis.<br /><br />Donny, I never got to extend this post the Gottschall's diet, the possible roll of probiotics in IBD, how they might be correcting a bacterial problem... This then eventually allows you to eat gluten and all the fun that that brings. If the SCD worked for me, I'd be loathe to go back to traditional eating, but many people seem able, and relieved, to do this.<br /><br />Rob, Over the years I treated a number of dogs with very severe skin disease usinga meat and bone meal diet. When it worked it worked really well and I always assumed it was eliminating gluten and gut damage. But I ALWAYS would give a secondarily infected skin at least two weeks of broad spectrum antibiotics, as well as the diet change. You have to ask if you were treating the skin or the gut with the abs. But still the diet change was needed as antibiotics alone had always been tried before, so perhaps the diet was a trigger too. The problem clinically is that you deal with such small numbers of patients and so few have co operative owners... <br /><br />Plenty of plant proteins are sticky/lectin/lectin-like. Believable. <br /><br />Caphuff, I guess this depends on what you are going to do with the horse.....!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-1200837656781037702010-01-12T12:47:22.489+00:002010-01-12T12:47:22.489+00:00Poonja, Not that I can see. How are you getting on...Poonja, Not that I can see. How are you getting on with Rath/Pauling? I have some time for this hypothesis (as pharmacology goes) but Dr Davis suggests it doesn't work for elevated Lp(a) per se, but I don't think he has mentioned it's effect on CAC score progression/regression. Have you had any numbers/scores to assess effectiveness?<br /><br />Chris, yes, perhaps, but I doubt many people who are made gluten tolerant would really stick to the coeliac diet. It's the pain which saves you. <br /><br />PJ, this is exactly how I see the world. I do wonder how well any normal people find it to comply with a gluten free diet. My problems are so minor that I consider Pubmed to be a major protective influence, comparable in effectiveness to surrogates for information, like gut pain. The really unfortunate people are on omeprazole for life and their Dr pooh poohs coleiac. A half hearted elimination will do nothing other than convince you that gluten is not the problem and you were born with an omeprazole deficiency. <br /><br />Mary, I wasn't aware that the Japanese ate much soy, I'd not call 8g/d a lot really...<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/9446845<br />http://jn.nutrition.org/cgi/content/full/128/2/209/T1<br /><br />gn, yes, I've heard similar discussions. Actually a long life span and good health is a trait of the Hiroshima survivors which has been attributed to the per-acute selection pressure at the time of the blast and merely acutely during the firestorm which followed, then during the weeks before any medical aid arrived. Only the fittest and luckiest survived. So much has changed in Japan, but currently some things still seem better than in the West (from the view of someone who has never been there!). I remember a documentary about Japan which claimed they had more MRI scanners per head than anywhere else at the time. If the scan said you had a terminal illness they tended not to operate/chemo for the sake of it. Probably this decreases medically induced deaths! And that reminds me of doctors' strikes, there have been several, death rates drop!<br /><br />Elizabeth, I used to ferment my cream but 6 months in very cramped and then cold conditions stopped me. Now that we have a superb kitchen and effective heating I might re start but when I look back critically I can't see a huge change in anything from stopping. I used to do this:<br /><br />http://high-fat-nutrition.blogspot.com/2008/01/easiyo.html<br /><br />Casein can undoubtedly open tight junctions in the gut. Once it has done that a host of triggers is available for stiff joints. I guess if you really want to know if it is casein you could work down from ghee through butter to double cream. Yogurt would have to be another experiment.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-73399173003770767882010-01-12T12:47:02.034+00:002010-01-12T12:47:02.034+00:00Hi Pyker, Hee hee, it will be menthol. Interesting...Hi Pyker, Hee hee, it will be menthol. Interestingly I've seen some amazing case reports in the mainstream using menthol application for treating suicidal grade neuropathic pain (from chemotherapy) with marked effect. Apart from free radical effects there are also menthol receptors in the nervous system! Plants would hardly develop pharmaceuticals without reason. <br /><br />Matt, some interesting papers discussed there. I guess you are well aware of Dr Ravnskov's infection hypothesis of atherosclerosis?<br /><br />Roj, yes, as a mild intolerant that's the way I would see it.<br /><br />Stan, coeliac disease is associated with a number of specific HLA subtypes, used for many things as part of the immune system. It would be very interesting to find the bug, characterise its surface proteins and look whether specific HLA subtypes of the host are particularly ineffective at getting rid of the bug. I suspect the bug is ubiquitous (so if you "cured" coeliac it would only last until the next encounter) and there might be something special about the immune system of genetic coeliacs. The adaption may be favoured in mild form as a protection against iron overload. <br /><br />http://www.ncbi.nlm.nih.gov/pubmed/15929194<br /><br />Treating the chronic anaemia of coeliac allows haemochromatosis to be unmasked when the gut is healed. You than start to ask whether haemochromatosis was selected against in HGs and is allowed to persist by mild coelaic when the extreme form makes you a non survivor as per sickle cell anaemia. But of course high iron intake was probably common in pre agriculture times but might not give liver problems in the absence of agricultural omega 6 PUFA. So coeliac might protect against the effects of PUFA on a "normal" human iron intake. Getting a bit convoluted here! But yes, ultimately there could be a recent onset advantage to tolerating mild coeliac.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-63116374022931843032010-01-11T20:54:29.557+00:002010-01-11T20:54:29.557+00:00"all of the gifts of direct gluten consumptio..."all of the gifts of direct gluten consumption and toxicity (which probably don't need enzymic digestion to be received)"<br /><br />So I guess this would be an exception to the rule against looking gift horses in the teeth, eh? :)caphuffhttps://www.blogger.com/profile/17630921602227752611noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-62852240963605473952010-01-11T17:09:25.864+00:002010-01-11T17:09:25.864+00:00Sorry- pestering again on topic of autoimmune. Are...Sorry- pestering again on topic of autoimmune. Are casein problems leaky gut then? Is that what is really going on- had 200ml 45% fat cream this morning in the coffee. To see what the reaction would be - and nothing else all day and will wait to see tomorrow what the level of pain is. Had a streaming nose immediately and after the sore dry eyes. Now for the joint pain. Perhaps the really high fat cream will prove to be more tolerable for occasional forays into the unknown of dairy consumption. <br /><br />I do find it addicitve and it doesn't make me feel great afterwards but hey.. I still adore whipped cream, how sad is that - what we do to have our favourite things. Intersestingly it did not effect my blood glucose readings much - stayed from 4, down to 3.7 back to 4.5 now which is 9 hours later. <br /><br />Thanks,Elizabethhttps://www.blogger.com/profile/10507234874030906337noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-46663508603436417282010-01-11T16:04:30.074+00:002010-01-11T16:04:30.074+00:00Peter,
There are four hypotheses for how autoimmu...Peter,<br /><br />There are four hypotheses for how autoimmune diseases manifest (molecular mimicry, cryptic antigens, superantigens, and bystander activation). All, more or less, do require infections to actually induct an autoimmune condition. <br /><br />However, I have been wondering if food allergens may be able to act as superantigens. Consider the MHC molecule. Let's say something binds on the outside, reconfigurating the protein and now suddenly a MHC that previously would not bind to 'self' proteins now does bind to one.Robert McLeodhttps://www.blogger.com/profile/05270962906437456350noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-70387783482513802532010-01-11T14:19:07.523+00:002010-01-11T14:19:07.523+00:00Wouldn't it make sense for the lion's shar...Wouldn't it make sense for the lion's share of adaptation to symbiosis to be made by the shorter-lived bacteria? Species that killed the host wouldn't make it. We haven't had much time to adapt to sugar and corn oil and soy, but to our gut bacteria, it's been ages, and we're caught in the cross-fire. The speed with which the host could adapt wouldn't have to enter the picture. I guess studies where obese rodents are seeded with gut bacteria from lean rodents fit into this idea.<br /> Maybe the right probiotics could help minimize the effects of accidental trace gluten ingestion?donnyhttps://www.blogger.com/profile/02107555662488785352noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-15612123229655489822010-01-11T13:10:13.668+00:002010-01-11T13:10:13.668+00:00An interesting post, thanks Peter! I avoid grains ...An interesting post, thanks Peter! I avoid grains myself (in particular in the mornings), and it does me good. <br /><br />It still brings me back to my comment of a few days ago. Around 95% or more of Europeans consume what you and I would consider VAST amounts of grain, without being stunted in their growth or suffering from MS en masse. Life expetancy keeps rising, too. <br /><br />Also, the two or so comments on the Japanese diet. My gran also lived to nearly 90 and looked fit & healthy. Only for her, lots of potatoes & flour based foods, not a veg in sight. <br /><br />Eating grains is doubtless prevalent. I think it is possible that different people(s) process gluten in different ways. <br /><br />It seems to be true though that virtually everybody wants to have a lie-down after eating pasta for lunch! <br /><br />Thanks for the good work!Heikehttps://www.blogger.com/profile/12232073112144038810noreply@blogger.com