tag:blogger.com,1999:blog-36840063.post1234040820099091190..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: High fat fed mice on stearic acidPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger68125tag:blogger.com,1999:blog-36840063.post-11619130882836384752016-03-28T07:11:21.217+00:002016-03-28T07:11:21.217+00:00R Cobb,
Not been there. There is a limit to what ...R Cobb,<br /><br />Not been there. There is a limit to what subjects drive my thought train...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-82917680942825511202016-03-21T01:37:19.095+00:002016-03-21T01:37:19.095+00:00Miss the posts Peter. off topic perhaps but what a...Miss the posts Peter. off topic perhaps but what about K2 (MK4 and MK7 respectively) and D3 assisting calcium absorption?R Cobbhttps://www.blogger.com/profile/12611174654877389979noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-78214880314065480182016-03-20T01:31:42.511+00:002016-03-20T01:31:42.511+00:00I see that sales of meldonium have shot through th...I see that sales of meldonium have shot through the roof since it was banned!Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-40796124873370089012016-03-15T18:11:54.430+00:002016-03-15T18:11:54.430+00:00I just thought you guys may find the article inter...I just thought you guys may find the article interesting. There are some interesting meds in Eastern Europe, not available in US for legal reasons. It looks like most Eastern European sportsmen were on it. I personally found it interesting that the drug researchers thought than the inhibition of L-carnitine biosynthesis and transportation was cardioprotective. Here in US it is a beloved bodybuilders supplement. <br />Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-11980027477614758112016-03-15T17:35:49.310+00:002016-03-15T17:35:49.310+00:00@Galina -
You are talking about Meldonium - https...@Galina - <br />You are talking about Meldonium - https://en.wikipedia.org/wiki/Meldonium<br /><br /> a fatty acid oxidation inhibitor ...<br /><br />Interesting Rat paper<br />http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00319.x/full<br /><br />Why isn't this drug on the USA market?<br /><br />http://www.karger.com/Article/Abstract/210015<br /><br />https://jakegshelley.wordpress.com/2016/03/03/what-is-melodoniummildronate/<br /><br />Here is the mind numbing bit - as Melduonium got banned - why not metformin as well?<br /><br />My hunch is it does its good bit by reducing oxLDL - <br />http://europepmc.org/abstract/med/25177814<br /><br /><br />There are safety issues and a lot of research that needs to be done to bring this to market in the western world - might not happen due to politics. <br /><br />There are other ways to reduce oxLDL - I don't eat much LA and use a few other dietary bits that have gotten my level down to about 5-percentile of the general public.karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-91088020644813059662016-03-15T03:20:20.776+00:002016-03-15T03:20:20.776+00:00I hope it is not complitely off topic guys, but I ...I hope it is not complitely off topic guys, but I just wanted to share some article from Russion language news outlet translated into English https://translate.google.com/translate?hl=en&sl=ru&u=http://www.svoboda.org/&prev=search about the the substance just added to the WADA list of banned substances. The unusual thing - it was initially created with the purpose to utilize a rocket fuel.<br />" Meldonium - an international name of the drug, which is produced in Latvia. Its trade name "Mildronat". It was created by the Institute of Organic Synthesis in conjunction with the Second Moscow Medical Institute to help patients with heart disease to survive the hard times when, for whatever reason, they have deteriorating blood supply to the heart muscle. Synthetic substance - a copy of the natural substance with a very small change, one carbon atom is replaced by a nitrogen atom. A natural substance called gammabutirobetain it in our body is a precursor of carnitine, and that, in turn, - fatty acids through the mitochondrial membrane transporter, there is the formation of the cell, to the place of their oxidation, that is, to generate energy. We assumed that this mechanism only works if there is enough oxygen when the heart can oxidize all fatty acids, which it supplied with blood. Once the oxygen starts to miss, these oxidized fats simply accumulate inside the cell. Fatty acids, activated using carnitine like detergent, i.e. soap. Since all the cell membranes are composed of lipids, i.e. fat base, they are dissolved, and a cell is destroyed. The idea was that if we slow down biosynthesis of carnitine, and will contribute to its removal from the body, then the lack of oxygen, or ischemia, the heart muscle does not die. It worked. there are now two opposing camps in the world: some argue that it is necessary to use carnitine, it promotes energy production, while others say that it is good when a sufficient amount of oxygen, and then brings harm.The medicine we first booked in the Soviet Union in 1984. The drug is one of the most popular cardiovascular agents in the former Soviet Union, and there are two reasons. Firstly, this product has virtually no side effects, it can be used for years, and the sick and healthy, everyone is state of crisis, stress overload. Secondly, we have created the world's first and so far only with the action of the drug mechanism that helps millions of people to survive in an environment where their heart should have been killed. And not only the heart. The peculiarity of its action is that energy production in muscle cells from the combustion is switched from burning fat to burning sugars. And when we burn sugar, we save oxygen, but spend carbon."Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-4996997704343829132016-03-08T23:30:58.922+00:002016-03-08T23:30:58.922+00:00'....current President of the Australian Diabe...'....current President of the Australian Diabetes Society."<br /><br />AKA SNAFU.Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-1400617437247492902016-03-08T18:50:30.691+00:002016-03-08T18:50:30.691+00:00@Leo: "Does physiological insulin resistance ...@Leo: "Does physiological insulin resistance cause increased insulin levels ?"<br /><br />No. T2DM insulin resistance does, insulin goes down on LC, which causes physiological IR.Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-41232928623184224952016-03-08T14:12:44.568+00:002016-03-08T14:12:44.568+00:00Hi, I have a question that might seem stupid becau...Hi, I have a question that might seem stupid because Peter might have already answered it. I can't seem to find it even though I am avid reader of his blog. Does physiological insulin resistance cause increased insulin levels ?<br />Thank youLeohttps://www.blogger.com/profile/02706753561708576904noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-9403535216849753682016-03-07T18:23:46.772+00:002016-03-07T18:23:46.772+00:00"The real question is why was it published? W..."The real question is why was it published? What possible motivation do they have to simply muddy the water? Who is getting money? Where is it coming from?"<br /><br />See his full bio at the link below, but here are some relevant bits:<br /><br />"This research has led to the hypothesis that increased insulin secretory demand may be a mechanism that contributes to diabetes and that strategies that promote metabolic deceleration may be beneficial."<br /><br />Well, just lowering insulin demand through a simple dietary manipulation would pretty much kill that line of research...<br /><br />"A/Professor Andrikopoulos is the current President of the Australian Diabetes Society."<br /><br />http://www.findanexpert.unimelb.edu.au/display/person14408<br />Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-26894330483995767982016-03-07T17:04:01.686+00:002016-03-07T17:04:01.686+00:00@Topaz Windswift
Don't confuse that paper wit...@Topaz Windswift<br /><br />Don't confuse that paper with <i>real science</i> - the important information is hidden away in the supplementary information.<br /><br />If you look at the dietary contents - the format shows that these are not even from the same company - using differing feed lots prevents one from having a single variable(one of the things you see in <i>real science</i>). <br /><br />There is no analysis of the amount of LA in the diets. It is well known that LA + sugar makes mice fat. This paper should not have been published - should be retracted. <br /><br />(There are two basic forms of science papers - and they really don't mix - one is stamp-collecting - the collection of data from which one might infer a hypothesis - the other is experimental science - where one tries to test a hypothesis - and that requires single variable experiments - which this failed to even come close to. ).<br /><br />The real question is why was it published? What possible motivation do they have to simply muddy the water? Who is getting money? Where is it coming from? Are PETA people involved?karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-18860146348109391912016-03-07T14:33:33.797+00:002016-03-07T14:33:33.797+00:00"I'd love to have your views on this"...<br /><br />"I'd love to have your views on this"<br /><br />LOL. Everything is wrong w/ that study. 6% sucrose isn't "paleo", for starters. Those mice also get fat regardless of what you feed them.<br /><br />See here:<br /><br />"Paleo diet fattening?"<br />http://www.marksdailyapple.com/dear-mark-paleo-diet-fattening/#axzz410qBU2RW<br /><br />and here:<br /><br />"Of mice and men, again"<br />http://www.fathead-movie.com/index.php/2016/02/22/of-mice-and-men-again/<br /><br />There's this. <br /><br />"Campaign to Have “Paleo” Mouse Study Retracted"<br />http://www.dietdoctor.com/campaign-to-have-paleo-mouse-study-retracted<br /><br />Feinman's a biochemist, who's published a bit on these topics:<br />https://www.facebook.com/richard.feinman.7/posts/959579280793676<br /><br />That should cover it. :)Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-24933381558537338832016-03-07T13:37:53.526+00:002016-03-07T13:37:53.526+00:00There was some derisory comment above. George deal...There was some derisory comment above. George dealt with it very neatly at his 'hopefulgeranium' blogspot.Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-78483540576287256522016-03-07T10:25:38.982+00:002016-03-07T10:25:38.982+00:00I'd love to have your views on this
A low-carb...I'd love to have your views on this<br />A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice<br /><br /><br />B J Lamont, M F Waters and S Andrikopoulos<br /><br />http://www.nature.com/nutd/journal/v6/n2/full/nutd20162a.html#bib15Anonymoushttps://www.blogger.com/profile/16144381919965733013noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3696062527891019582016-03-06T23:13:08.281+00:002016-03-06T23:13:08.281+00:00Thanks tucker!Thanks tucker!Anonymoushttps://www.blogger.com/profile/12211318454232938351noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-34099805039166479462016-03-06T14:15:19.617+00:002016-03-06T14:15:19.617+00:00@Passthecream: "Is the LA level high in T2d f...@Passthecream: "Is the LA level high in T2d for the reasons you're discussing here ie dietary plus storage, or ??? "<br /><br />As I'm sitting here drinking my coffee w/ whipping cream (one of the best things ever)...<br /><br />I did this post a while back, one of the things they discuss is the correlation between the LA metabolites they're looking into and T2DM. So yes. 4-HNE is produced by the either carb-induced or self-oxidation of LA in the mitochondria. 4-HNE is toxic, full stop. It's not the only toxic LA metabolite, there's also acrolein, which is apparently much more toxic, but most of what I could find was about 4-HNE.<br /><br />http://yelling-stop.blogspot.com/2016/02/the-cause-of-metabolic-syndrome-excess.html<br /><br />So, for T2DM:<br /><br />"The Lipid Peroxidation By-Product 4-Hydroxy-2-Nonenal (4-HNE) Induces Insulin Resistance in Skeletal Muscle through Both Carbonyl and Oxidative Stress"<br />http://press.endocrine.org/doi/abs/10.1210/en.2011-1957#sthash.ZiwZ2AyH.dpufTucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-83848824963257045552016-03-06T10:41:54.218+00:002016-03-06T10:41:54.218+00:00Another LA vs general nastiness paper, sorry if th...Another LA vs general nastiness paper, sorry if this has come up before but it looked too good to ignore.<br /><br />http://m.diabetes.diabetesjournals.org/content/54/5/1506.long?view=long&pmid=15855339<br /><br /><br />Is the LA level high in T2d for the reasons you're discussing here ie dietary plus storage, or ??? <br /><br />Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-45196186880608736722016-03-04T02:39:29.767+00:002016-03-04T02:39:29.767+00:00Plasma Lipid Fatty Acids During Fasting
Am J Clin ...Plasma Lipid Fatty Acids During Fasting<br />Am J Clin Nutr 1963<br /><br />https://www.dropbox.com/s/a5lapueikmav9ui/Plasma%20Lipid%20Fatty%20Acids%20During%20Fasting.pdf?dl=0 <br />Motorwayhttps://www.blogger.com/profile/07977251345330224001noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-2563521108475369312016-03-04T01:38:23.528+00:002016-03-04T01:38:23.528+00:00Karl 'Someone eats a meal particularly high in...Karl 'Someone eats a meal particularly high in LA - some of the LA enters our adipocyte - this adipocyte needs ATP - burns some of the available FA - high in LA '<br /><br /><br />I wonder if the location of the fat cell matters? They tend to be thought of as outermost but not all are. Core fats in land animals where the local temps are higher are more saturated whereas peripheral fats are less so eg the canonical boot polish, neatsfoot oil which used to be rendered from cowlegs, has a much lower sat fat content. (but which ufa?) Likewise the fats of sea mammals being less saturated etc.<br /><br /><br />CPassthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-31244218100655419222016-03-03T19:17:20.703+00:002016-03-03T19:17:20.703+00:00"...we probably want levels that we were like..."...we probably want levels that we were likely to evolved to use."<br /><br />Not "probably":<br /><br />"Higher intake of specific types of fat--including vegetable, monounsaturated, and polyunsaturated fats and linoleic acid--rather than total fat intake may be associated with a greater risk for advanced AMD. Diets high in omega-3 fatty acids and fish were inversely associated with risk for AMD when intake of linoleic acid was low."<br /><br />"..."Age-related macular degeneration (AMD) is the most common cause of legal blindness of elderly people in the world...."<br /><br />http://yelling-stop.blogspot.com/2011/02/linoleic-acid-and-blindness.html<br /><br />Therefore, you can re-write that to read "excess LA consumption is the most common cause of legal blindness"...Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-15953059127465535162016-03-03T18:50:17.088+00:002016-03-03T18:50:17.088+00:00What if we look at why LA is preferentially stored...What if we look at why LA is preferentially stored in adipose tissue first?<br /><br />Let us do sort of a <i>thought simulation</i>(thought experiments are an oxymoron) - lets go back to Petro's protons.<br /><br />Someone eats a meal particularly high in LA - some of the LA enters our adipocyte - this adipocyte needs ATP - burns some of the available FA - high in LA and thus induces inappropriate insulin sensitivity - increasing the amount of FA uptake exactly when the ratio of LA is particularly high. So what gets stored over various meals has a high ratio of LA.<br /><br />Now - during a fast - the body needs energy - LPL starts it thing - the adipocytes that contain the most LA are going to again become the most inappropriately insulin sensitive - slowing the release of FA - particularly from the cells with high LA content. Might really have to do a long fast to flush out the LA. (So could fasting increase LA => AA?) <br /><br />,.,.,<br />Now if we are burning LA we produce fewer mitochondria - less turnover. Not sure how this effects incorporation of LA into mitochondria, but it is one place to look. The lipids in cell membranes tend to have PUFAs as part of the Phospholipid bilayer. These PUFAs can increase permeability of the membrane - see:<br /><br />https://en.wikipedia.org/wiki/Lipid_bilayer#Phases_and_phase_transitions<br /><br />Mitochondria may need this permeability thus select for PUFA's & MUFA's<br /><br />Membrane biology is tied to immune function and effected by PUFA's... see<br /><br />http://ajcn.nutrition.org/content/84/6/1277.long<br /><br />Changing the ratio of O-3(long chain?) and o-6 may have consequences - even with major histocompatibility complex (MHC) my take is balancing the ratio is only a band-aid - we probably want levels that we were likely to evolved to use.karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-79984271475954466372016-03-03T13:12:29.961+00:002016-03-03T13:12:29.961+00:00"'the fact that LA is preferentially inco..."'the fact that LA is preferentially incorporated into the mitochondria, '<br /><br />"But why?"<br /><br />The only explanation I've been able to find is, "we don't know". There's still a lot going on in the mitochondria that's not understood. We do know that the membrane containing LA in the mitochondria, cardiolipin, is created using whatever random fatty acid is nearby, and can work just fine w/ other fatty acids (without producing the oxidation), yet rapidly replaces those other fatty acids with LA when given the chance. (Except in the brain: LA is largely excluded from the brain.)<br /><br />"Im certain this involves another one of those J curves ie not to little, not too much,just right."<br /><br />Agreed. "just right" is likely in the neighborhood of 1-2% E, not 7-15% E, as in the Modern American Diet.<br />Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-28541008458814899562016-03-02T23:31:09.752+00:002016-03-02T23:31:09.752+00:00Sorry that's item 10, problem 8.Sorry that's item 10, problem 8.Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-46789050235993010442016-03-02T23:28:49.850+00:002016-03-02T23:28:49.850+00:00'the fact that LA is preferentially incorporat...'the fact that LA is preferentially incorporated into the mitochondria, '<br /><br />But why? Im certain this involves another one of those J curves ie not to little, not too much,just right. <br /><br />Problem 10 in Cunnane2003 - some la is synthesized from 16 chain fa's. So that is not de novo synthesis but synthesis nonetheless. Again why?Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-17695227816715816032016-03-01T20:35:24.787+00:002016-03-01T20:35:24.787+00:00"...the rapid burning, converting or storing ..."...the rapid burning, converting or storing of LA remimiscent of the way fructose is handled...."<br /><br />In some respects, in others not so much.<br /><br />We read a lot about "oxidative damage" and the importance of anti-oxidants to help the body deal with oxidative damage. It's involved in every aspect of the metabolic syndrome (which includes some types of cancer, Alzheimer's, ad nauseum).<br /><br />The oxidative damage referred to is the result of the fact that LA is preferentially incorporated into the mitochondria, where it alters the fundamental way they work, generating that oxidative damage. The primary marker for oxidative damage is a chemical, 4-HNE, which is only generated from LA or AA. So 4-HNE is a marker for excess, toxic, LA consumption.<br /><br />So the next time you see "oxidative damage", replace it with "LA poisoning", and see where that takes you.<br /><br />It's far more sinister than fructose, which, in the absence of oxidative damage, doesn't seem to be harmful at all.Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.com