tag:blogger.com,1999:blog-36840063.post1352303630148377719..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Insulin makes you hungry (11) But not in Denmark?Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-36840063.post-77343758023788923172019-11-20T04:57:49.505+00:002019-11-20T04:57:49.505+00:00Hi Brad, yes, you could make that case...
PeterHi Brad, yes, you could make that case...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-12342144835254740062019-11-19T15:59:49.532+00:002019-11-19T15:59:49.532+00:00Could another explanation be that the people whose...Could another explanation be that the people whose adipocytes are the most insulin resistant produced the most insulin to store away all of the glucose? Those same people would then have the highest FFAs, presumably, and would consume less at a the ad lib meal.<br /><br />Brad Marshallhttps://www.blogger.com/profile/04068446509764297652noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-28111357078843459092019-11-10T18:21:22.588+00:002019-11-10T18:21:22.588+00:00I believe stacking the deck is quite normal in thi...I believe stacking the deck is quite normal in this field...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-77176258752190159522019-11-10T13:20:20.173+00:002019-11-10T13:20:20.173+00:00Hello Peter,
what bothers me about the Danish stu...Hello Peter,<br /><br />what bothers me about the Danish study is the clear line they drew between lean and obese. (I do not think these men were lean but rather very well-nourished. That body fat?) Anyway, look at their BG and Insulin at baseline. <br /> <br />Not every lean person has such good BG. And being obese does not mean metabolically deranged. It seems to me they selected their participants to fit the stereotypical "lean" and "obese". The obese did a reduction diet. My guess is they did that because their insulin/BG were not right to begin with. <br /><br />The results have nothing to do with leanness or obesity or weight reduction but with insulin response. The title is misleading. I think.Alexhttps://www.blogger.com/profile/15567909385379524496noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-78406906602111124852019-11-10T08:49:58.068+00:002019-11-10T08:49:58.068+00:00Hi Gretchen,
I've had a look and I think prob...Hi Gretchen,<br /><br />I've had a look and I think probably not. It is a little confusing because she labels both 150mg/dl and 300mg/dl as "hyperglycaemia". I see triangles as low (ie normal) insulin high glucose (300mg/dl), solid circles as high insulin high glucose (150-ishmg/dl) and open circles as high insulin low (70-ish mg/dl) glucose. Control group not shown. That makes sense but I agree, you have to look at the lines very carefully!<br /><br />Boundless, yes, although I would phrase it differently. More like wheat flour contains an insulin mimetic which drives calories in to storage, resulting in secondary hunger. Same statement but looking at it at a more basic biochemical level. Stops you having to worry about mechanism.<br /><br />Anand, interesting. Do you see Rodin's results as invalid?<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-81624699497424284112019-11-09T23:18:17.404+00:002019-11-09T23:18:17.404+00:00Fig 1 in Rodin seems to have labels switched. A is...Fig 1 in Rodin seems to have labels switched. A is glucose and B is insulin.<br />Gretchenhttps://www.blogger.com/profile/17019921800841883073noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-36158198357387266362019-11-09T15:33:14.955+00:002019-11-09T15:33:14.955+00:00re: …standardised, solid test-meal, consisting of ...re: <i>…standardised, solid test-meal, consisting of a sandwich of 135 g wheat bread with…</i><br /><br />When appetite stimulation is the topic, wheat needs to be off the table, because it's not just 60% rapidly-metabolized branched-chain glucose. The proteins are also known to independently provoke appetite.<br /><br />The other insights into what might have been learned here aside, it would have been a less confounded trial if they'd used an iso-glycemic gluten-free bread, or just sugar.Boundlesshttps://www.blogger.com/profile/08563387214789901056noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-15502953657005965192019-11-09T11:53:34.397+00:002019-11-09T11:53:34.397+00:00I would think from this paper that for people if t...I would think from this paper that for people if their metabolism is not broken, insulin tends to increase satiety. These people remain lean, because for them the hormonal system is working properly. But for those people whose metabolism is broken (almost everybody these days), this does not work. And so they tend to eat more because their hunger signals are all out of whack. So it is probably better to eat something that gives better satiety. For many people it would be a low carb diet. But for people like Jimmy Moore, the low carb diet is not providing satiety, so they tend to get fat. I do think a high protein diet will essentially force satiety, because protein in excess is difficult for the body to use or store. This will work regardless of the person. But for all other diets individual response matters.Anand Srivastavahttps://www.blogger.com/profile/15616369007370348265noreply@blogger.com