tag:blogger.com,1999:blog-36840063.post1609261939050508245..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: Zetia, are things getting better?Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-36840063.post-41344418799466206402018-05-06T14:36:01.453+00:002018-05-06T14:36:01.453+00:00Peter Attia sent this link to his email list today...Peter Attia sent this link to his email list today, with a promise to blog about it soon. He describes it as "interesting." I don't know if he means that in a good way or a bad way.<br /><br />"Extremely low LDL-C concentrations cause no clinically relevant side effects."<br /><br /><i>Clinical and pathophysiological evidence supporting the safety of extremely low LDL levels—The zero-LDL hypothesis</i><br /><br />https://www.lipidjournal.com/article/S1933-2874(18)30014-X/fulltext<br /><br />cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-10118189048392134912008-01-25T21:51:00.000+00:002008-01-25T21:51:00.000+00:00Nauseating video!!!!!! Enjoyed the list of world's...Nauseating video!!!!!! Enjoyed the list of world's worst drugs though, some new ones there. A few giggles had in the reading...<BR/><BR/>PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74297571060508169132008-01-25T17:33:00.000+00:002008-01-25T17:33:00.000+00:00You might find this amusing:http://www.marksdailya...You might find this amusing:<BR/><BR/>http://www.marksdailyapple.com/top-ten-stupid-drugs/<BR/><BR/>Mark's comment (in the comment section) is priceless: "So you're saying it doesn't work?"<BR/><BR/>You especially have to watch their marketing video: http://www.zetia.com/ezetimibe/zetia/consumer/about_zetia/index.jsp?vp=sh&src=clip&pg=default<BR/><BR/>"Unlike some statins, ZETIA has not been shown to prevent heart disease or heart attacks."<BR/><BR/>WTF??Psipsinahttps://www.blogger.com/profile/00116559647595861421noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-48087691855359836912008-01-23T09:54:00.000+00:002008-01-23T09:54:00.000+00:00Oops,No overall mortality figures for the calcium ...Oops,<BR/><BR/>No overall mortality figures for the calcium trial, let's just leave it at increase cardiovascular problems as we have no body count. Or, more likely, a non significant increase in all cause mortality but the study wasn't powered to... We'll never know<BR/><BR/>PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-82363521208624882062008-01-23T09:30:00.000+00:002008-01-23T09:30:00.000+00:00Hi Stan,Yes, I fully agree that we should expect a...Hi Stan,<BR/><BR/>Yes, I fully agree that we should expect a very low LDL-C to be associated with vascular catastrophes. From my basic viewpoint, arterial damage is repaired using LDL-C using the apoB 100 receptor. Low LDL-C is produced by the statins because each liver cell is so desperate for cholesterol it puts out every LDL-C receptor on its surface it can manage. I guess initially the endothelial cells do the same, so modest LDL-C reductions are tolerated relatively well and the pleiotrophic effects predominate. If there are any pleiotrophic effects from your drug that is. As LDL-C gets below some magic number the endotheial cells can put out as many receptors as they like, they can't have what isn't there. My guess is that the LDL-C level at which problems become apparent is determined by the anti inflammatory and antioxidant effects of the hypocholesterolaemic agent. For torcetrapib and clofibrate these were woefully inadequate. Now ezetimbe too. The statins hang on in there as no one reads the J-litt paper. And now ANOTHER gem from Dr Davis, calcium supplements raise HDL-C, drop LDC and kill people. I have never, ever, ever, ever found a better source of information disproving the lipid hypothesis than Dr D!!!!! Yet still he believes.....<BR/><BR/>PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-80186007292263947342008-01-22T18:12:00.000+00:002008-01-22T18:12:00.000+00:00Perhaps a cholesterol-heart disease connection or ...Perhaps a cholesterol-heart disease connection or correlation is real after all? <BR/><BR/>Strong negative correlation in the low total cholesterol or low LDL range is also a correlation!<BR/><BR/>What makes me think so is that the latest Merck study seems to be consistent with the J-LIT study!<BR/><BR/>Both used simvastatin and both studies have shown worsening of cardiovascular risk, by a large factor (2 and 6 respectively) for those patients who have lowered their cholesterol the most! <BR/><BR/>Perhaps it's not just that unlike the statin, Ms "Easy Timbie" may have blocked some essential fat absorption but perhaps the lack of serum cholesterol itself, below certain threshold, might have contributed to the disease, for example through the shutdown of self regeneration and healing?<BR/><BR/>Regards<BR/>Stan (Heretic)Stan Bleszynskihttps://www.blogger.com/profile/03922719716458272303noreply@blogger.com