tag:blogger.com,1999:blog-36840063.post1977848417441641602..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: LIRKO mice (3) The MCQPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger65125tag:blogger.com,1999:blog-36840063.post-2336309225415910272011-12-08T06:42:14.819+00:002011-12-08T06:42:14.819+00:00Peter,
Off topic but....
You have mentioned a st...Peter,<br /><br />Off topic but....<br /><br />You have mentioned a starch free diet for defense against some gut pathogens... Would one be able to consume brown rice syrup on this diet along with fruits, squash and veggies to meet glucose needs?<br /><br />Thanks!Billhttps://www.blogger.com/profile/18337151567894804577noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-1603907968559640962011-11-22T11:19:24.253+00:002011-11-22T11:19:24.253+00:00BTW, about cytoplasmic ROS generation. It looks a...BTW, about cytoplasmic ROS generation. It looks as if things might work like this: mitochondrial superoxide gets converted into hydrogen peroxide by manganese-SOD, and goes to the cytoplasm where it activates the pentose phosphate pathway, producing NADPH which can be used to make more ROS. So mitochondrial ROS oscillations would be linked to cytoplasmic ROS oscillations, which can cause calcium oscillations because oxidation activates Ca channels and inhibits Ca pumps on the endoplasmic reticulum.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-17055290402399574852011-11-22T10:56:02.788+00:002011-11-22T10:56:02.788+00:00Peter, Stephan's second post in the series is ...Peter, Stephan's second post in the series is about inflammation, and says 'blocking an inflammatory signal prevents the insulin resistance caused by obesity'. There is an important recent paper on why this might be. Very small amounts of inflammatory cytokines can disrupt or even abolish pancreatic beta cell calcium oscillations. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948622/<br /> <br />Beta cell calcium oscillations are the basis for oscillatory insulin secretion, which prevents insulin resistance. This means that the chronic low-grade inflammation seen in obesity could cause insulin resistance by acting on beta cells.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-59149753579976122342011-11-21T06:46:27.779+00:002011-11-21T06:46:27.779+00:00Hi Jane, just getting time to catch up. I would ag...Hi Jane, just getting time to catch up. I would agree that insulin controls many many more things than lipolysis and glucose uptake. Mg undoubtedly and I am quite willing to believe Mn too. And probably Zn and chromium. I have long wondered about exactly WHY insulin controls K+ uptake. Much of this probably comes back to insulin and cells becoming metabolically active. I have no doubt what so ever that free radicals are crucial signalling molecules. I think there is a world of difference between free radicals produced by fructose metabolism in the cytoplasm and those produced at complex 1 during beta oxidation. They probably send differing messages and have differing outcomes. One of the most interesting things about the twins papers was that the obese twin(s) not only had markedly reduced mitochondrial DNA in their adipocytes but also that the control NFs for mitochondrial biogenesis were also downregulated. If we had cells crying out for mitochondria I would expect peroxisome proliferator–activated receptor γ coactivator 1 to be upregulated, not downregulated. This has me thinking about signalling and free radicals. I'll be looking at the paper and a number of others on cytoplasmic ROS generation as I get the chance. It also needs looking at in the context of more electron transfer chains vs increased uncoupling as methods of decreaseing free radical signalling. Nick Lane has vitamin and (probably more relevant) mineral deficiencies as potentially significant but concentrates more on signaling when deficiency is not present...<br /><br />Pablo and blogblog, the idea reminded me of the Naked Mole Rat so I didn't poo poo it immediately. It doesn't help me decide what to put on my plate tonight!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22588954074943560592011-11-20T21:21:23.449+00:002011-11-20T21:21:23.449+00:00@Pablo,
the article is complete nonsense.
Curren...@Pablo,<br />the article is complete nonsense. <br /><br /><b>Current Gerontology and Geriatrics Research<br />Volume 2010 (2010), Article ID 423087, 12 pages<br />doi:10.1155/2010/423087<br /> <br />Typologies of Extreme Longevity Myths</b><br /><br />http://www.hindawi.com/journals/cggr/2010/423087/blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-59623220835694463812011-11-20T20:15:39.490+00:002011-11-20T20:15:39.490+00:00Peter, what do you think about this?
im looking at...Peter, what do you think about this?<br />im looking at the data and it seems solid (lol)<br /><br />http://www.jgrinstein.com/html/section_1_1.htmlD1Shttps://www.blogger.com/profile/08750123947536499341noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-14222438932922296672011-11-20T20:10:41.102+00:002011-11-20T20:10:41.102+00:00This comment has been removed by the author.D1Shttps://www.blogger.com/profile/08750123947536499341noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-21841194265999550742011-11-20T19:12:10.757+00:002011-11-20T19:12:10.757+00:00@Jane, it's probably not, but I couldn't ...@Jane, it's probably not, but I couldn't resist using "inconvenient truth" when referring to poo. Like I said, I really have nothing useful to say ATM. :)Arbyhttps://www.blogger.com/profile/14410677491085665147noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-90826601753763990722011-11-20T18:43:07.576+00:002011-11-20T18:43:07.576+00:00David,
I'm curious... Why would you guess tha...David,<br /><br />I'm curious... Why would you guess that a lot of obese people are quite constipated?<br /><br />My own experience is that when I was obese, I was usually (always) the opposite. <br /><br />-AlCoachhttps://www.blogger.com/profile/07108014237791854719noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-47104486407161017662011-11-20T15:58:38.026+00:002011-11-20T15:58:38.026+00:00Arbitrage54, why was what David said an inconvenie...Arbitrage54, why was what David said an inconvenient truth for me? I though it was rather funny.<br /><br />blogblog, agreed.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-79911734944128119222011-11-20T11:56:30.386+00:002011-11-20T11:56:30.386+00:00I'd be inclined to say that most westerners ha...I'd be inclined to say that most westerners have way to much calcium and far too little magnesium in their diets.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-77546925421733871952011-11-20T11:35:44.955+00:002011-11-20T11:35:44.955+00:00This comment has been removed by the author.blogbloghttps://www.blogger.com/profile/18029519906193388609noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-39306726747072569232011-11-20T05:18:01.997+00:002011-11-20T05:18:01.997+00:00@Peter, I finally got an account so I could post c...@Peter, I finally got an account so I could post comments, though I have nothing useful to say ATM. Love your blog.<br />@David, an inconvenient truth for Jane, but it needed to be said.Arbyhttps://www.blogger.com/profile/14410677491085665147noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-7744397158085312892011-11-19T02:23:54.318+00:002011-11-19T02:23:54.318+00:00@Jane re Stephan: "Obese people have been fou...@Jane re Stephan: "Obese people have been found to have a low magnesium intake."<br /><br />I'm all in favor of magnesium, and even supplement with it on occasion. And who can object to an epsom salts bath? But it has a tendency to, umm, really "move the mail."<br /><br />I'm guessing that a lot of obese people are actually quite constipated. And, seriously, the intestinal trasit time has a good deal to to with how many calories are absorbed...<br /><br />I'd bet that if you took a group of obese people and made them down 3,000 mg of magnesium each day, they'd become thinner. Rapidly.David Isaakhttps://www.blogger.com/profile/04928598446742324391noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-42966842061938603162011-11-18T13:51:07.957+00:002011-11-18T13:51:07.957+00:00Peter, that email I sent you on Stephan's insu...Peter, that email I sent you on Stephan's insulin resistance post has now been forwarded to Stephan himself. Here is the email in case your readers are interested. <br /><br />Stephan says:<br /> <br />'I read an interesting paper in 2009 titled "Insulin Resistance is an Antioxidant Defense Mechanism" (1). The authors presented compelling evidence that exposure to excess nutrients causes cells to produce excess reactive oxygen species, which in turn shuts down insulin signaling. This was presumably due to the fact that the mitochondria, the cells' tiny furnaces, were overloaded with energy.'<br /> <br />In fact the message of this paper is that insulin resistance is caused at least partly by manganese deficiency. Calling it energy overload misses the point. The cells are not deliberately producing ROS to protect themselves against energy overload. They produce ROS in an oscillatory fashion for signalling purposes, and their mitochondria oscillate too. The cells oscillate between insulin sensitivity and insulin resistance, and insulin resistance is what you get if you abolish oscillatory insulin secretion. <br /> <br />Stephan again: <br /> <br />'Then there is the idea that mitochondrial dysfunction causes obesity. Now, we have entered into the realm of pure speculation.'<br /> <br />Obese people have calcium overload in their adipocytes. This is not speculation. Calcium overload means malfunctioning mitochondria. Mitochondrial calcium normally oscillates, and so does lipolysis, which is inhibited by calcium. <br /> <br />Magnesium-ATP pumps the calcium out of the cell or into the endoplasmic reticulum where it can't harm the mitochondria or inhibit lipolysis. Obese people have been found to have a low magnesium intake.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-68096721193281050092011-11-18T04:50:37.390+00:002011-11-18T04:50:37.390+00:00Now, now, Al, if you keep on baiting poor cwaiand ...Now, now, Al, if you keep on baiting poor cwaiand (or whatever), I shall stop reading your comments in retrospect.<br /><br />I suppose it's a bit like travelling back in time and killing your own grandfather.Petehttps://www.blogger.com/profile/10708630752848505853noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-950000421174700772011-11-17T18:28:26.881+00:002011-11-17T18:28:26.881+00:00cwaiand,
Peter didn't go and "not" ...cwaiand,<br /><br />Peter didn't go and "not" read Stephan's blog to comment there how he will not be reading any longer - he said this on his own blog in response to another commenter.<br /><br />You came to Peter's blog to "not" read so you could comment directly to Peter how you won't read any longer.<br /><br />I'll chalk this up to: "common sense is not common to all".<br /><br />Like I said, write it down on a piece of paper and throw it away.<br /><br />-AlCoachhttps://www.blogger.com/profile/07108014237791854719noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-47512927644081354202011-11-17T04:20:37.023+00:002011-11-17T04:20:37.023+00:00berto;
so peter can say it but i can,t?
you are s...berto;<br /><br />so peter can say it but i can,t?<br />you are skewed.cwaiandhttps://www.blogger.com/profile/04837925374165088179noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22490069428524652002011-11-17T01:50:54.565+00:002011-11-17T01:50:54.565+00:00cwaiand,
Next time you'd like to get somethin...cwaiand,<br /><br />Next time you'd like to get something off your chest that was inspired by "not" reading something you obviously read, simply write it down on a sheet of paper and toss it away. This way, you'll say what you need to, and the rest of us won't see you as a hypocrite.<br /><br />-AlCoachhttps://www.blogger.com/profile/07108014237791854719noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-83200247592304182802011-11-16T23:45:30.143+00:002011-11-16T23:45:30.143+00:00peter
i used to read you.nowaday,s i don,t see ...peter<br /><br /> i used to read you.nowaday,s i don,t see the point.your arguments are skewed.<br /><br />cjcwaiandhttps://www.blogger.com/profile/04837925374165088179noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-81132322124014074212011-11-16T20:31:18.256+00:002011-11-16T20:31:18.256+00:00pyker, do you mean palatability or reward? LMAO. A...pyker, do you mean palatability or reward? LMAO. As john says "Damn, that's an all time great!"<br /><br />Stan, well I knew I was doing something wrong! But there are plus sides to Stephanwatching. When you see the typical end-product, <a href="http://high-fat-nutrition.blogspot.com/2007/12/who-pays-piper.html" rel="nofollow">Hunter's</a> group in <a href="http://high-fat-nutrition.blogspot.com/2010/01/who-pays-piper-ignorant-or-bent.html" rel="nofollow">Belfast</a> comes to mind or Susan Jebb in the UK, you always wonder whether they were always how they are today or whether there had been a time when they were more sentient. Watching the changes in Stephan I feel privileged. It feels comparable to being "on shift" when the first pulsar, LGM-1, was discovered by Bell and Hewish... Of course you still are left wondering at the reasons for the shift from sentience to current state.<br /><br />Adam, you may have noticed that I never really get chance to take part in the discussions in comments, it's probably a toddler associated syndrome! I don't really have a need to convince people, I'm interested in how physiology works and I see no real use in Stephan's ideas. Equally I have zero interest in convincing him, or any who agrees with him, that he is incorrect. That's their problem. I only engaged in the Taubes bashing debacle because a) I largely agree with Taubes b) Stephan's critique was so awful I had to point out the awful economies with the physiology cited. He does seem like a proto-Hunter. Whether his ideas, ignoring 3rd rate bashing of Taubes, hold water does not really interest me. I have to say it must be very difficult to be wrong about everything and so it is even conceivable that he is correct in some aspects, who knows... Like John I used to read Stephan. Nowadays I don't see the point.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-14217848530701526762011-11-16T07:56:19.149+00:002011-11-16T07:56:19.149+00:00Adam Smith, people who understand science aren'...Adam Smith, people who understand science aren't trying to rediscover the conservation of energy.js290https://www.blogger.com/profile/08157385596237909630noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-2648385964716488592011-11-15T03:23:47.681+00:002011-11-15T03:23:47.681+00:00First point: I like and read this blog. I also li...First point: I like and read this blog. I also like and read Stephan's blog. I'm still agnostic about many nutritional points and I enjoy both blogs, like many paleo lurkers.<br /><br />Second point: I really enjoy the claims that Stephan's blog is filled with "sycophants" when his blog comments have a lot more dissenting arguments than this one.<br /><br />Many commenters here raise good points, as do many on Stephan's blog, but it's more fun when the actual arguments take center stage instead of the people putting them forward. This is supposed to be science, not pro wrestling.Adam Smithhttps://www.blogger.com/profile/00603954690517159560noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-25347060097483262832011-11-14T16:16:28.119+00:002011-11-14T16:16:28.119+00:00Chris, tough man, i would love to hear your say th...Chris, tough man, i would love to hear your say that to me in person.<br />I can picture your greasy face under my feet and it makes me smile. Anyway, lets not derail this further.D1Shttps://www.blogger.com/profile/08750123947536499341noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-84786721160412335612011-11-13T23:41:52.905+00:002011-11-13T23:41:52.905+00:00Woo, we know why pablo posts so often on here: he&...Woo, we know why pablo posts so often on here: he's mentally ill and is looking for validation.Chrishttps://www.blogger.com/profile/15974892385564973512noreply@blogger.com