tag:blogger.com,1999:blog-36840063.post2458826379184060267..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: Lactate as bulk energy transportPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger17125tag:blogger.com,1999:blog-36840063.post-16010789215645404382019-05-08T14:23:27.313+00:002019-05-08T14:23:27.313+00:00Dr. Kwasniewski says something that perhaps you ca...Dr. Kwasniewski says something that perhaps you can clarify. It is at the end of his letter/answer to someone. This is using Google Translator. (I don't read Polish).<br /><br /><br />https://translate.google.com/translate?sl=auto&tl=en&u=http%3A%2F%2Fwww.dr-kwasniewski.pl<br /><br />"Bronchial asthma.<br />14-11-2006"<br /><br />The heart is the biggest when it has to burn glucose in the process of glycolysis, smaller when it has to process glucose in the so-called pentose pathway, smaller when it needs to burn ketones and free fatty acids, and the smallest when it does not burn anything and all the energy needed to he obtains his work from active phosphate compounds, mainly from ATP. It is "electric" energy coming from batteries. After the energy from ATP is taken up by the brain and heart, the compound is sent back to the liver, exercised muscles and other tissues, recharged and the cycle repeats hundreds of thousands of times a day. ATP itself manages daily body 50-100 kg, depending on the weight of the body and the intensity of the effort, especially mental, but also physical. And other active phosphorus compounds (accumulators) are produced in the human body a dozen or so. <br /><br />And they are also used as sources of clean energy. With intense mental work, ATP levels in brain tissue are rapidly declining, and biochemists, physiologists and physicians continue to claim that glucose is the only source of energy for the brain, and in the absence of glucose, ketone bodies can cover up to 75%. brain demand for energy.<br /><br /> <br />Glucose is not burnt in the brain at all. It is transformed into NADPH a key compound needed for almost all syntheses and for pentoses, i.e. compounds (sugars) necessary for the construction of many structures in the body. They are a component of nucleic acids (DNA, RNA), structures responsible for inheritance and for all electromagnetic communication between cells, organs and environment, they are needed to build many enzymes and numerous glycoproteins, ie protein-sugar compounds - pentoses such as ribose, ribulose, arabinose, xylose, lysosose, xylulose. Without these sugars, pentoses (five-carbon sugars), there would be no life on Earth. <br /><br />When the body needs more pentoses or NADPH, more carbohydrates are directed to processing in the pentose pathway, which is not beneficial for the body. With the best model of nutrition, the body performs the least "stupid" work and is the slowest to remodel. Once it adapts to Optimal Nutrition, it does not have to adapt to other products, it does not have to lose energy, NADPH and - pentoz. <br /><br />Therefore, in people using Optimal Nutrition, so-called basic metabolism is the smallest compared to all other nutrition models, and it should be that way, and it's good. <br /><br />"Dorodna" - means the so-called grown-up youth is a very bad result of nutrition, which forces the synthesis of larger amounts of NADPH or pentozes, a lot of unnecessary work, acceleration of maturation and menopause and leads to a significant reduction in the duration of human life.<br />....G. L.https://www.blogger.com/profile/04636356389732983665noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-41638937684578738032019-02-10T14:39:03.834+00:002019-02-10T14:39:03.834+00:00atavist, I think that protein intake might just ha...atavist, I think that protein intake might just have some influence on glutamate supply. Not all of us favour 1.6g/kg/d!<br /><br />Eric, I’ve had that paper for some time, it might get a post. The cat is amazing, hope it makes it. We had a near drowning in iced water to resuscitate years ago, it had some neuro probs afterwards, can’t recall the long term outcome.<br /><br />karl, the paper on statins is interesting in how it is constructed. I think the the whole “opposite effect in skeletal muscle vs cardiac muscle” is incorrect. Looks more like depleting CoQ generates RET. Just a little will multiply mitochondria (which will also be CoQ depleted by the statin). A lot will produce myopathy. They compared “normal” cardiac muscle with/without statin against “myopathic” skeletal muscle vs non myopathic muscles, presumably all on a statin. The table S2 is a dud link. No huge surprise they are opposite. As you say, it’s a statin paper, it will be bent.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-32484241001214146912019-02-08T23:04:41.559+00:002019-02-08T23:04:41.559+00:00RE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3...RE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871217/ <br /> <i>Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways </i><br /><br />But - what if most cancers are really about dysfunctional MT? (They don't respond well to the extrinsic pathway for apoptosis from the immune system). If they are using the cell-wall to produce energy - blood sugar matters - out growing the immune system? If lactate is a trans cell energy carrier - this gets more complicated.<br /><br />Of course both narratives might be true - or not.<br /><br />RE - the OT <i>Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1</i><br /><br />First - I am reluctant to trust any paper on Statins - politically toxic - distorted by grant money - but - if I take this paper on face - if the upside is better heart muscle at the expense of skeletal muscle - what happens to BG? Cancer rates? Then there is the bit "quercetin prevented this deleterious atorvastatin effect" -- trouble is in the weight lifting community, people have figured out that antioxs can block muscle gain.. and 25 mg/kg/day is a lot! I see they posted no conflicts, yet the atorvastatin was supplied free by Pfizer. It is interesting that people are starting to see ROS as a signal -- <br /><br />Further OT: Kendick was shooting fairly close at the CTT (from Oxford) - if what he insinuates is true - and the CTT has a monopoly on holding the data - it could explain why the down side is hard to get a handle on. I don't like monopolies - they hurt the public. Statins do fit the junk science pattern where the effect keeps diminishing over time (and disappears in research not run by Pharma)karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-61765672057762504542019-02-08T10:18:22.420+00:002019-02-08T10:18:22.420+00:00This comment has been removed by the author.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-44642102767040064842019-02-08T10:17:13.796+00:002019-02-08T10:17:13.796+00:00Even more unrelated:
https://www.ndtv.com/world-ne...Even more unrelated:<br />https://www.ndtv.com/world-news/in-montana-frozen-cat-fluffy-covered-in-ice-survives-after-vets-rally-to-thaw-her-1990204Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-59907867406515354962019-02-07T16:13:38.867+00:002019-02-07T16:13:38.867+00:00Unrelated, just wanted to let you have this little...Unrelated, just wanted to let you have this little gem:<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365271/Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-6913538970509537572019-02-06T03:43:39.695+00:002019-02-06T03:43:39.695+00:00I think because they exhibit stronger hypoxia than...I think because they exhibit stronger hypoxia than the others?<br /><br />"Strikingly, under conditions of hypoxia or defective mitochondrial function, glutamine can become the major source of lipogenic acetyl-CoA through reductive carboxylation"<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392845/<br /><br />Does keto have an impact on glutamine? If not, are the neoplastic cells really stressed out by Seyfried/Warburg?altavistahttps://www.blogger.com/profile/10443439015369042857noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-8924953325445998482019-02-05T15:08:51.867+00:002019-02-05T15:08:51.867+00:00altavista, interestingly pancreas and pancreatic c...altavista, interestingly pancreas and pancreatic cancer were the most glutamine fluxing of all of the tissues/tumours looked at in the paper. I doubt anything is simple!!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-16961514778286623162019-02-05T13:32:54.284+00:002019-02-05T13:32:54.284+00:00It's a lot more complex than this unfortunatel...It's a lot more complex than this unfortunately.<br /><br />"in the presence of physiological albumin, we found that cultured <br />murine PDAC cells grow indefinitely in media lacking single essential amino acids"<br /><br />The methods seem legit, but then I don't know my aminoacids well.<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316379/altavistahttps://www.blogger.com/profile/10443439015369042857noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-38663665545881030752019-02-05T07:05:59.943+00:002019-02-05T07:05:59.943+00:00George, yes, my feeling is that this sort of inter...George, yes, my feeling is that this sort of interplay will be going on all over the body, except, apparently, within the brain.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-17005737830920794972019-02-05T00:23:09.213+00:002019-02-05T00:23:09.213+00:00This ties in with something I read in a textbook (...This ties in with something I read in a textbook (on google books) about glycogenolysis and liver zoning;<br />Glycogen is stored in parenchymal cells in deep liver zones supplied with blood lower in 02.<br />The first step of glycogenolysis is anaerobic - conversion to lactate.<br />The lactate is then taken up by hepatocytes in more oxygenated liver zones and converted to glucose.<br />Presumably anaerobic glycogenolysis in the low 02 zones supplies the ATP needed to make fresh glycogen when glucose reappears there in quantity.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-6037852625863400142019-02-04T16:06:28.112+00:002019-02-04T16:06:28.112+00:00It is the one I was looking for BTW.It is the one I was looking for BTW.Peterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-88545748787922839802019-02-04T12:04:03.601+00:002019-02-04T12:04:03.601+00:00raphi, try this one. You might like it. https://ww...raphi, try this one. You might like it. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871217/<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-62112142154580334142019-02-04T11:01:16.844+00:002019-02-04T11:01:16.844+00:00oops, sorry raphi, wrong paper. Can't find the...oops, sorry raphi, wrong paper. Can't find the one I want at the moment. Will try later<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-73494781766076435872019-02-04T10:46:45.703+00:002019-02-04T10:46:45.703+00:00raphi http://cancerres.aacrjournals.org/content/65...raphi http://cancerres.aacrjournals.org/content/65/22/10164.longPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-33127289337731049522019-02-04T09:29:52.079+00:002019-02-04T09:29:52.079+00:00raphi, I have a paper somewhere which suggested th...raphi, I have a paper somewhere which suggested that phospho-enol pyruvate was the transformation factor between rapid cancer growth and reversion to a more benign phenotype. But they had to use an "in their lab only" three dimensional cell culture technique, so this needs a major replication effort, which seems unlikely to be easily done...<br /><br />I can't really see this as a black and white scenario, a thyroid adenoma is very different from a thyroid carcinoma. I followed some of the cell lines used in this paper https://www.ncbi.nlm.nih.gov/pubmed/24670634 back to see how aggressive the original in-vivo tumour was in the patient who started a given cell line. I was "fascinated", if that is the word, by the poor prognosis for people with anaplastic** thyroid cancer, which has a completely non functional complex I in the cell line. The term* "bloody 'opeless" springs to mind!<br /><br />Peter<br /><br />*The late LC Vaughan who tried to teach myself and the rest of my year some surgery in the 70s. "In these days of guarded prognosis, the prognosis is not just guarded, it's bloody 'opeless". Broad welsh accent required. Stuck with me!<br /><br />** Anaplastic is a word you never want to see on a path report.Peterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-18433335835487944572019-02-04T08:16:39.318+00:002019-02-04T08:16:39.318+00:00"The rapid exchange of both tissue lactate an..."The rapid exchange of both tissue lactate and pyruvate with the circulation may help to equate cytosolic NAD+/NADH ratios across tissues, allowing the whole body to buffer NAD(H) disturbances in any given location. Nearly complete lactate sharing between tissues effectively decouples glycolysis and the TCA cycle in individual tissues, allowing independent tissue-specific regulation of both processes"<br /><br />Isn't that just the so-called Reverse Warburg-Effect?<br /><br />"Ox-phos = housekeeping<br />Glycolysis = anabolism"<br /><br />Looks like that to me. More ammo for Seyfriedraphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.com