tag:blogger.com,1999:blog-36840063.post2662120306707188689..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Endocannabinoids in brain and adipocytesPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger13125tag:blogger.com,1999:blog-36840063.post-23582596096878529922023-04-01T09:50:53.139+00:002023-04-01T09:50:53.139+00:00Not in Africa, they aren't, I assume.Not in Africa, they aren't, I assume. <br />Gyanhttps://www.blogger.com/profile/09941686166886986037noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-52505712711954158462023-03-31T01:39:32.071+00:002023-03-31T01:39:32.071+00:00water, pot has the interesting reputation of being...water, pot has the interesting reputation of being an appetite stimulant, but it is also possible to smoke so much of it that you lose weight, like to the point of being malnourished, because you lose the ability to be hungry normally-- you can only even contemplate food if you're completely baked, and it's hard to afford that for enough meals to stay reasonably healthy. <br /><br />Knew a guy, rail-thin, quit smoking to join the military. Gained over 20 pounds in basic training, because it was the first time in years that he'd been hungry, and also suddenly had access to all the food he wanted to eat. Cannabis is weird. Not sure it'd work for making cattle fat. Plus we already use antibiotics for that, and they're cheap. JustPeachyhttps://www.blogger.com/profile/06128069966879300756noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-14883495286691695112023-03-29T17:33:08.979+00:002023-03-29T17:33:08.979+00:00karl, I had an injury at work which required a wee...karl, I had an injury at work which required a week on flucloxacillin. I gained a kilo. It melted away at the end of the course. I wonder about FIAF. This is produced by gut bacteria to ensure storage of "their" excess available calories in the adipocytes of their host mammal. If we wipe out n% of gut bacteria, do we leave a glut of food for the remaining bacteria/yeasts which have the correct plasmid or intrinsic immunity to the ab? Giving the gut microbiota ++++calories -> store fat ++++. Just an idea, no data.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-63505778041720775422023-03-29T16:03:41.645+00:002023-03-29T16:03:41.645+00:00karl—my potential comment was headed off at the pa...karl—my potential comment was headed off at the pass when you said:<br /><br />"So I'm left with the possibility that we have up to 3 concurrent pandemics - T2D, endocrine disruptors, LARGE scale [iatrogenic] harm. Much of this can be grouped into effects of what Bret Weinstein calls hyper novelty. Throwing wrenches into complex systems.."<br /><br />That's exactly my feeling. All of these pandemics are a result of our evolutionarily-inappropriate lifestyles, and when looked at that broadly, are all symptoms on the same spectrum. And because of financial incentives there is absolutely no interest in prevention, just potential drug targets. <br /><br />Our habit of reductionism blinds us to the big picture. Reductionism can be useful, for example in recognizing the dangers of linoleic acid and its prevalence in modern food, even meat, thereby giving us strategies for avoiding it. So even while appreciating individual trees, I think it's really important to keep our eye on the forest at the same time.<br /><br />I'm not going to hold my breath hoping the global bureaucracy will change its focus anytime soon. (Everything is global these days, so I don't think it's very useful focusing only on one's own country). In that vein, here's a fascinating article about "Spontaneous Order in Complex Systems" https://www.eugyppius.com/p/spontaneous-order-in-complex-systems. <br /><br />The illustration is of an ant mill, a.k.a. ant wheel. Which is a fascinating concept in itself https://en.wikipedia.org/wiki/Ant_mill<br /><br />cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-62776025096374983952023-03-29T01:06:06.752+00:002023-03-29T01:06:06.752+00:00Time - half-life of LA is likely to interfere with...Time - half-life of LA is likely to interfere with seeing the LA connection in human diets. Standard behavioral psychology has shown that the time to reward matters greatly in changing behaviors. A diet that takes 2 years to start to kick in is not likely to be followed - similar to long term effects of lead(Pb) exposure - cause and effect can be greatly separated in time - and thus ignored by humans. <br /><br />(Speaking of LA - I was sad to learn that Ray Peat passed away last thanksgiving)<br /><br />,.,.<br />There is a cross over between estrogen and weight balance and T2D. Many confounding bits of narratives. <br /><br />I first noticed that many young women at the gym I run at when it is cold out, have exaggerated estrogen characteristics, producing a rather unattractive caricature of the female form. I'm old now - afraid that my memory might not be perfect - so I spent a night looking at old high school pictures to confirm this. I am pretty sure that this is real. <br /><br />I was talking to a relative that drives bus the other day. He was telling me about young girls in 2nd-3rd grade that he drives that have to wear brassieres! I mentioned this to my wife and she is telling me about young boys in the Philippines that are now growing breasts. Couple that with the reports of falling testosterone and sperm counts and I think there is something of a endocrine poisoning pandemic going on. These endocrines don't just change bodies - but effect the brain as well and may well explain some of the current bizarre social changes?<br /><br />Of course this might be an example of my own confirmation bias (once I learned about confirmation bias I started seeing it everywhere ). Could it be possible that the T2D is the cause of endocrine problems? <br /><br />There is a rather long list of possible substances that might be causing endocrine problems.. (perfluorocarbons, polychlorinated biphenyls, phthalates, bisphenol-A etc etc (but what is not on the list yet?) - I don't think we know at this point what it is. I've heard some points that suggest that there is a correlation with packaged foods - not sure. I think it would be a bad idea to trust any official narrative coming from captured institutions. <br /><br />The other possibility is the endocrine effects might be connected to the T2D pandemic? <br /><br />One other thing happening is large changes in the excess death rates - Dowd thinks it is related to an experimental medical treatment - but in the back of my head I've been thinking that the public has been getting sicker and sicker for a long time.<br />https://phinancetechnologies.com/HumanityProjects/Projects.htm#Nav_ExcessDeaths<br /><br />So I'm left with the possibility that we have up to 3 concurrent pandemics - T2D, endocrine disruptors, LARGE scale latrogenic harm. Much of this can be grouped into effects of what Bret Weinstein calls hyper novelty. Throwing wrenches into complex systems.. <br /><br />It bothers me that the research is all about potential drug targets instead of helping identify and limiting exposures. <br /><br />I'm finding about zero information of the mechanism of action or how antibiotics induce weight gain in livestock - I'm assuming it is not yet known. ( and we might want to reframe preservatives and call them food-storage-antibiotics for a bit of fun). <br /><br /><br /><br />https://www.nejm.org/doi/full/10.1056/nejmoa064725karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-90741337501419039002023-03-28T12:22:55.316+00:002023-03-28T12:22:55.316+00:00That makes total sense.
LA and carbohydrate: Nuts ...That makes total sense.<br />LA and carbohydrate: Nuts are autumn food. <br />Positive hunger loop fills up the adipocytes.<br />When winter is coming there is need for heat and eating if food is available.Anonymoushttps://www.blogger.com/profile/11937150116794428412noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-70089155186532199062023-03-28T08:44:11.782+00:002023-03-28T08:44:11.782+00:00Hi Peter,
I would stick with the idea that it depe...Hi Peter,<br />I would stick with the idea that it depends on the ratio between beta-oxidation of fats in mitochondria and peroxisomes. Fats and substances that interact with CB1 receptors seem to only affect PPAR receptors and thereby activate peroxisomes at lower insulin levels than usual with meals and thus affect the switch between fat burning and fat production/storage. PUFAs activate peroxisomes more and possibly through CB1, deactivation of CB1 receptors therefore deactivates peroxisomal beta oxidation, this leads to activation of mitochondria and UCP. What do you think?<br />Jaromir<br /><br />The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001692/<br />mct4healthhttps://www.blogger.com/profile/05453439249479290441noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-66479497243119920262023-03-27T16:01:45.044+00:002023-03-27T16:01:45.044+00:00When GT wrote that getting fat makes you hungry I ...When GT wrote that getting fat makes you hungry I was initially non-comprehending/puzzled and then impressed/convinced. But I still can't accept carbs vs fats w/o the LA effect...<br /><br />PPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-35480864019679886892023-03-27T15:08:34.177+00:002023-03-27T15:08:34.177+00:00I'm glad you continued rambling — that helped ...I'm glad you continued rambling — that helped me quite a bit.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-68641405267291523852023-03-27T06:16:25.798+00:002023-03-27T06:16:25.798+00:00TCH and CDB are agonist-antagonists, and pot use (...TCH and CDB are agonist-antagonists, and pot use (including moderate and intermittent and "former" smoker status) seems to reduce risk of T2D or obesity to a measurable extent, but only in those countries where LA intakes are highest. There's a meta or review of this somewhere, also good diabetes prevention in French patients with chronic Hep C.<br /><br />https://hal.science/hal-03109215/file/JVH-00069-2020_HAL.pdfPuddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-9938471467573323942023-03-26T21:01:47.101+00:002023-03-26T21:01:47.101+00:00Or THC rather than CBD!
POr THC rather than CBD!<br /><br />PPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-47190707655413093982023-03-26T21:01:02.820+00:002023-03-26T21:01:02.820+00:00Haha. Why use CBD when you have LA? Dirt cheap and...Haha. Why use CBD when you have LA? Dirt cheap and of zero recreational potential. And LA works!<br /><br />Ah, ChatGPT... As we know garbage in = garbage out. I think AI would be firmly on the side of seed oils and cholesterophobia. It's only a "reading and guess the end of the sentence" app, as far as I understand (which isn't much!) it has no analysis built in.<br /><br />Reminds me of SETI where perhaps STI (search for terrestrial intelligence) might be a good/better start. With apologies to Avi Loeb.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-79190993968790704122023-03-26T20:14:27.894+00:002023-03-26T20:14:27.894+00:00So when they start using cbd to fatten livestock, ...So when they start using cbd to fatten livestock, we'll know for sure? I've been meaning to try ChatGPT on Hyperlipid, with the prompt, "explain it to me like I'm 11" It may be my best chance to better understand....waterhttps://www.blogger.com/profile/14164346917947511229noreply@blogger.com