tag:blogger.com,1999:blog-36840063.post3134654557442278369..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: IgG IgA and sniffing a virusPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger79125tag:blogger.com,1999:blog-36840063.post-26699340668244793992020-12-25T09:51:20.094+00:002020-12-25T09:51:20.094+00:00Finally, something that really will make a differe...Finally, something that really will make a difference:<br /><br />https://youtu.be/WvLjYyZ6wtUPassthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-5148098731665852722020-12-24T07:29:57.276+00:002020-12-24T07:29:57.276+00:00"(R(0)=5 means something)"
It means tha..."(R(0)=5 means something)"<br /><br />It means that any single thing or combination of things that each weaken transmission by 10% makes an important contribution. I had read 2 though rather than 5. About the same as flu and colds.<br /><br /><br /> If by your reasoning masks make no vast improvement then they also do no vast harm so there's no harm in using them in tight situations if you use the right type and handle them properly. Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-49136668601636294632020-12-23T17:42:30.845+00:002020-12-23T17:42:30.845+00:00Aerosols have a huge surface area to volume - such...Aerosols have a huge surface area to volume - such droplets can evaporate in seconds - the particle size does matter. <br /><br />Yes, virion are delicate - but they don't survive long - but do survive long enough - when an infectious person sheds a few million with a cough or sneeze(some goes out the side anyway).. even if 90% of the virus is destroyed - it just doesn't matter.<br /><br />It is obvious that the masking doesn't cause significant inflections of the death rate - seasonality does - take a look at Sweden's death graph here:<br />https://www.worldometers.info/coronavirus/country/sweden/<br /><br />What is key to note is the seasonality - large inflection in the fall as innate immune systems decline. Also - the second hump falls off more rapidly - this is a typical viral graph - things we have known for decades. <br /><br />If masking was at all effective, we would expect to see such inflections from the policy implementations - but don't. The original bit from the CDC saying public masking is not effective was true then - and still is true. <br /><br />Masking, light sterilizers are not going to keep you from getting exposed - (R(0)=5 means something) you CAN do things to change what happens WHEN you get exposed - keeping blood sugar normal (postprandial below 110) and vitamin D above 50 can change a nasty flu like experience into something non symptomatic - perhaps just feeling a bit tired for a day. Your innate immune system matters. <br /><br />The idea that we can stop a virus is hubris - on par with trying to stop it from raining. Pretending that this virus is not like others is not helping the public. The idea that there has been huge breakthroughs in virology in the last year just isn't true - What the CDC knew hasn't changed - only the politicizing of policy is new. <br /><br />Viruses have evolved to spread - we have evolved to resist them - and we do a pretty good job at it if we don't eat a sickly diet and get enough sun.karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22447758774480495312020-12-23T00:50:27.921+00:002020-12-23T00:50:27.921+00:00I bought some luxeonstar 280nm leds earlier in th...I bought some luxeonstar 280nm leds earlier in the year to build a mini low voltage portable sterilizer. They're not very powerful but there must be ~310nm leds more easily available in higher power levels. Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-51924241846543621052020-12-22T13:58:06.047+00:002020-12-22T13:58:06.047+00:00Eric, that was a side comment. Just mentioning th...Eric, that was a side comment. Just mentioning that we are going to make an materials aging cabinet and have been already looking into UV lamps. That made me think of obtaining specific wavelength lamps for stimulating D production after the Vitamin D thing came up. We have already sourced some lamps in the correct wavelength for the project.Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-2860819086168832352020-12-22T10:53:33.759+00:002020-12-22T10:53:33.759+00:00@ Justin: just reread your earlier post. What is i...@ Justin: just reread your earlier post. What is it you want to age? Narrow band UV-B is not the best for aging. Actually, if you want to age human skin, good old UV-A, aka sunbed, would be my pick.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-91138443361754122832020-12-22T03:18:10.495+00:002020-12-22T03:18:10.495+00:00Dr. Bob --- hard to know who to believe ---
&quo...Dr. Bob --- hard to know who to believe ---<br /><br /><br />"Scientists, meanwhile, are hard at work trying to figure out whether B.1.1.7 is really more adept at human-to-human transmission—not everyone is convinced yet—and if so, why. They’re also wondering how it evolved so fast. B.1.1.7 has acquired 17 mutations all at once, a feat never seen before." <br /><br />https://www.sciencemag.org/news/2020/12/mutant-coronavirus-united-kingdom-sets-alarms-its-importance-remains-unclearPassthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-73395417035861449142020-12-22T03:03:46.533+00:002020-12-22T03:03:46.533+00:00Justin, fyi, a newspaper article about testing hos...Justin, fyi, a newspaper article about testing hospital airflows with smoke:<br /><br />https://www.smh.com.au/national/victoria/ventilation-blamed-for-covid-spread-as-design-problems-are-detected-20201219-p56ox4.html<br />Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-4580017471501771672020-12-21T21:33:08.257+00:002020-12-21T21:33:08.257+00:00Eric, thanks a million for all of that. Can't...Eric, thanks a million for all of that. Can't wait to dive into that literature. Was telling my boss about it today.Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3012690463329560212020-12-21T12:55:03.138+00:002020-12-21T12:55:03.138+00:00@ Justin:
Philips seem to be pretty much the only...@ Justin:<br /><br />Philips seem to be pretty much the only vendor of ultra narrowband UV-B (TL-01 series). Fortunately, they have a pretty good library of pertinent studies.<br /><br />When I looked into this, there were also Ushio and a vendor from Eastern Europe but AFAIR, their spectrum was not as clean.<br /><br />This is what goes into handheld lamps:<br />https://www.lighting.philips.ch/prof/konventionelle-lampen-und-leuchtstofflampen/speziallampen/phototherapy/uv-b/uv-b-narrowband-pl-l-pl-s<br /><br />a broader product overview:<br />https://www.lighting.philips.com/main/prof/conventional-lamps-and-tubes/special-lamps/phototherapy/uv-b/uv-b-narrowband-tl<br /><br />This is their literature download. Googling will also find several independent papers:<br />https://www.lighting.philips.com/main/products/special-lighting/phototherapy#downloads<br /><br />Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-35836842043384850452020-12-21T11:32:21.878+00:002020-12-21T11:32:21.878+00:00Pass, good info on the cigarette vapors. I might ...Pass, good info on the cigarette vapors. I might do some experiments at work with our in house masks and a N95. Wonder how vaping vapors compare?Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-65838369561839791552020-12-21T11:28:16.921+00:002020-12-21T11:28:16.921+00:00Eric, that's cool on the lamps. We are actual...Eric, that's cool on the lamps. We are actually looking at making our own aging cabinet for a contract at work and have been looking at lamps. Do you have a link to the brand you used? It would be nice to figure out what the safe equivalent dose would be. Abviously time/distance are your knobs if wattage is fixed.Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-7990012866028328402020-12-21T11:24:10.435+00:002020-12-21T11:24:10.435+00:00Pass, Thanks for the link! I'm familiar with ...Pass, Thanks for the link! I'm familiar with electrostatics and tribocharging. We used to use HV power supplies and coronas to charge the webs so they would pin/align better. Pretty cool stuff. Looks like they are probably using a gradient filter with all the layers, so as not to blind the smaller pores. Still noodling the idea of either plasma treatment or adding a wetting agent to the polymer and allowing it to bloom to the surface. Not sure if it would be better to have some hydrophilicity in there like you would probably want with a water filter or an incontinence pad. I guess if they stay with the hydrophobic quality of polyester/pp it would just act as more of a shield. I guess the electrostatic charge might potentially overcome the hydrophobic nature of the polymer assuming a liquid encapsulated virus is still attracted. Otoh, I have tribo charged polymers and they still seem to repel water. <br /><br />We actually made our own masks back in April from merv 15 bag house filter material and some other layers. Treated it with an antimicrobial/antiviron based on the literature. We got favorable results for bacteria, but my boss didn't want to pay for the viral data. Ours are microwavable too. Lol!Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-79593296568774095922020-12-21T08:19:21.402+00:002020-12-21T08:19:21.402+00:00https://pubmed.ncbi.nlm.nih.gov/15987844/
https:/...https://pubmed.ncbi.nlm.nih.gov/15987844/<br /><br />https://pubmed.ncbi.nlm.nih.gov/10573558/Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-89949332078111652092020-12-21T08:19:03.585+00:002020-12-21T08:19:03.585+00:00Here are a couple of links but not the one I was t...Here are a couple of links but not the one I was thinking of. The retinyl acetate form there is a bit nasty compared to the usual palmitate or stearate esters. <br /><br />Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-82719767994617259792020-12-21T07:22:36.235+00:002020-12-21T07:22:36.235+00:00Eric, I will search. I recall that vitE and vitA a...Eric, I will search. I recall that vitE and vitA are also oppositional. The oil solubles are strange but vitA is strangest of all. Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74594550943610327082020-12-21T05:47:21.769+00:002020-12-21T05:47:21.769+00:00@ Dr. Rob, Justin: The masks outside thing only ma...@ Dr. Rob, Justin: The masks outside thing only makes sense in crowded surroundings. Not sure what the rules were in Italy this summer. In Germany masks outside became mandatory only end of November and only at farmer's markets and in pedestrian zones and outside of train stations etc. In summer, the only instance I came across was a local regulation at the Münster farmer's market which tends to be very crowded.<br /><br />As for a light source to make Vit. D in summer, I would use narrow band UV-B (311 nm), probably the best compromise between Vit. D potential and low skin cancer impact. I have used a handheld lamp for a few years but never had the courage to use it for more than a few minutes. I have bought two 100 W tubes, though, which are sitting unused.<br /><br />@ Pass: I would love to read your references about Vit A and D antagonism. Biologically, it does not make sense to me right now.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-42043778932175044372020-12-21T04:30:49.580+00:002020-12-21T04:30:49.580+00:00"I haven't made the experiment of wearing..."I haven't made the experiment of wearing a mask in the vicinity of a smoker but I do recall just how pervasive that smoke is, you can smell it a few feet away in the open air if unlucky."<br /><br />A few feet away? I can smell it across the street. If you're a nonsmoker, cigarette smoke is godawful. Maybe if we could get the virus exhalations to smell as bad, it would be easier to avoid.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-23961037758863119222020-12-21T04:14:56.693+00:002020-12-21T04:14:56.693+00:00I'd be interested to know how a 'variant&#...I'd be interested to know how a 'variant' is not a mutation. Is it wearing different coloured socks?<br /><br />We are all mutants. Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-78979699567807981482020-12-21T04:12:33.044+00:002020-12-21T04:12:33.044+00:00Cigarette smoke aerosols are within the size range...Cigarette smoke aerosols are within the size range of interest:<br />https://www.sciencedirect.com/science/article/abs/pii/0095852260900374<br /><br />I haven't made the experiment of wearing a mask in the vicinity of a smoker but I do recall just how pervasive that smoke is, you can smell it a few feet away in the open air if unlucky. It's a good model of what we're up against. <br />Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-17870172242039070002020-12-21T03:59:34.107+00:002020-12-21T03:59:34.107+00:00Justin, the P95 polyester fabric is specially wove...Justin, the P95 polyester fabric is specially woven and treated electrostatically, that's what I meant by 'electret' up above. (Just like in an electret microphone, ie a more or less permanent stored charge separation in a dielectric.)<br /><br />Details: https://groups.oist.jp/nnp/diy-face-maskPassthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-7440283724433449772020-12-21T03:56:05.978+00:002020-12-21T03:56:05.978+00:00I suspect that vitD is like vitA, only gets moved ...I suspect that vitD is like vitA, only gets moved out to the periphery when the liver stores are full, nicely packaged etc. But A and vitD are mutually antagonistic btw. I have several refs somewhere ( where?) but these are easy to search and find anyway. Just get more sunlight on bare skin and stop eating so many leafy greens and sweet potatoes. Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-58596206246109584802020-12-20T22:33:17.787+00:002020-12-20T22:33:17.787+00:00Eric and pass, thanks, it has been my understandin...Eric and pass, thanks, it has been my understanding also that a virus particle doesn't just float around by itself – it hitches a ride on a larger aerosol or droplet.<br /><br />Very interesting about vitamin D being stored in the fat cells. Of course other things are liberated during fat mobilization, like toxins and PUFAs. Nice to think of some good ingredients in there too.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-83454442900598495512020-12-20T17:58:43.223+00:002020-12-20T17:58:43.223+00:00Dr. Rob, My thoughts exactly on the masks/summer t...Dr. Rob, My thoughts exactly on the masks/summer thing. That was our low hanging fruit opportunity to also build up immunity when when people are less suseptable due to vitamin D or whatever imparts better immune response.<br /><br />Interesting idea on liberating D during the low UV B/food availability months. I have been practicing 18 hour internment fasting for well over 10 years now. At the very least, Monday through Friday. I think tissue turnover on a regular basis is important. House cleaning through regular autophagy. Being in the feed state all the time just doesn't make sense to me from an evolutionary standpoint.Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-54803878752327559472020-12-20T16:57:19.729+00:002020-12-20T16:57:19.729+00:00It always struck me as madness that some European ...It always struck me as madness that some European countries mandated masks in the middle of summer - for what is quite clearly a seasonal virus- for many people the face is the only part of their anatomy that ever gets exposed to the sun and even then it’s smothered in factor 50 - no wonder vitamin d deficiency is now the most common vitamin deficiency in the world!<br /><br />My hypothesis is that vitamin d is stored in the fat cells as an evolutionary adaptation to survive the long cold winters. Fat loss during the winter months due to diminishing food supply would have released vitamin D to support the immune system. Modern lifestyles and in particular over indulgence during the Xmas period will prevent this release of vitamin D and we can therefore expect an increase in infections in January. The environment really is the key to health.Dr. Robhttps://www.blogger.com/profile/11677615872346052981noreply@blogger.com