tag:blogger.com,1999:blog-36840063.post3590741750801180689..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: So you want some DHA?Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger15125tag:blogger.com,1999:blog-36840063.post-67982381494914760562021-03-28T17:39:01.690+00:002021-03-28T17:39:01.690+00:00Hi Elmumo,
The paper didn't use any sort of t...Hi Elmumo,<br /><br />The paper didn't use any sort of tracer system, which is what you would need. The whole drive of modern research is to supply more DHA. Trying to find details of it's catabolism, let alone putative efflux from the brain, is hard.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-26466067424601660482021-03-26T21:17:26.972+00:002021-03-26T21:17:26.972+00:00Thanks Peter. Quite interesting. I havent read the...Thanks Peter. Quite interesting. I havent read the paper (I probably should before asking), but how do they know the increase in circulating DHA in plasma is a result of conversion (i.e. synthesys from ALA), and not simply as a result of the body mobilising stored DHA from cells (e.g. brain cells)? If it is the latter, this graph then would not reflect an increase in total DHA.Elmumohttps://www.blogger.com/profile/03217616274798047419noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-75855971139953363962020-09-01T02:31:36.789+00:002020-09-01T02:31:36.789+00:00https://sci-hub.tw/https://doi.org/10.1016/j.plefa...https://sci-hub.tw/https://doi.org/10.1016/j.plefa.2012.04.003Robinhttps://www.blogger.com/profile/05253746091041864293noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-14654804222170369972020-08-28T07:19:30.493+00:002020-08-28T07:19:30.493+00:00Purp, I have to say I have long wondered about Deb...Purp, I have to say I have long wondered about Deborah Clegg, able to reduce rodent food intake using intracerebral insulin at Cincinnati (as a first author) but unable to replicate this in Novo Nordisk's lab with Jessen and Bouman.<br /><br />Does she not know about the tweak or does she know but not dare use, or even suggest its use, outside of the lab where it is probably routine and unquestioned? Wouldn't you like to know?<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-37468965458011456102020-08-28T05:24:56.331+00:002020-08-28T05:24:56.331+00:00Interesting about the tweaks - it's the same e...Interesting about the tweaks - it's the same everywhere it seems. Every lab I had the pleasure to work in had certain tweaks - way more benign than in nutrition research, but then again they are as far removed from that discipline as possible - but the old guard knows that certain procedures don't work as written and have work arounds and tweaks. And if too much of the old guard leaves at once, even old seemingly tried and true methods simply don't work anymore.Purposelessnesshttps://www.blogger.com/profile/05310957056111105419noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-87120974699473237992020-08-27T06:34:11.192+00:002020-08-27T06:34:11.192+00:00Hi Abu,
Taking a fish oil capsule on a diet with ...Hi Abu,<br /><br />Taking a fish oil capsule on a diet with 10% of calories as linoleic acid looks about as sensible as taking a vitamin D capsule and expecting the benefits of being a heliophile in summer!<br /><br />Not worthless but far from ideal...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-18654818572630181212020-08-26T18:59:09.057+00:002020-08-26T18:59:09.057+00:00@Tim Thorpe, I'm trying to puzzle out how the ...@Tim Thorpe, I'm trying to puzzle out how the parsley figures in. cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-83726778963363797022020-08-26T16:55:40.155+00:002020-08-26T16:55:40.155+00:00Assuming n-3 is valuable, it also makes one wonder...Assuming n-3 is valuable, it also makes one wonder how much is really necessary to get a benefit, if n-6 is low.ctviggenhttps://www.blogger.com/profile/06768434099612988952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-52715248954879037372020-08-26T12:40:37.316+00:002020-08-26T12:40:37.316+00:00This is very interesting, as it provides an explan...This is very interesting, as it provides an explanation of why EPA/DHA supplementation is the wrong way to approach a low n-3 index.Abu Dhabihttps://www.blogger.com/profile/01799929892999002230noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-14982274511423179242020-08-26T12:12:43.863+00:002020-08-26T12:12:43.863+00:00> The main food related debris in those was sna...> The main food related debris in those was snail shells<br /><br />Would second that, there is a parasite (Rat Lungworm) where the adult/egg/larval<br />cycle is between rats, rat faeces, snails, and whoever fancies Escargot with<br />parsley (sometimes your dog, as Peter will know). That could only evolve if<br />the snail part of their diet was significant and stable.<br /><br />Our lawn-rat is sometimes seen trotting around randomly, then suddenly getting<br />a scent and digging, quickly. It leaves craters of about 1cm. I think this is<br />grubs, maybe the ones which make "daddy-long-legs". I assume that's another <br />high-fat delicacy.Tim Thorpehttps://www.blogger.com/profile/15008761926330005017noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-58368436405070514992020-08-26T04:23:06.531+00:002020-08-26T04:23:06.531+00:00Oh, and DHA to around 2% of plasma lipids using fl...Oh, and DHA to around 2% of plasma lipids using flax oil on a background of LA at around 6% of dietary calories. But I suspect a lot of people will actually have LA up at 18% of dietary calories. Heart healthy!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-14666932687177994262020-08-26T04:15:53.879+00:002020-08-26T04:15:53.879+00:00That's cool Tucker, puts humans exactly on to ...That's cool Tucker, puts humans exactly on to the surface plot from Gibson's rat paper, where an increase in ALA from 0.5 to 1.5 markedly increases plasma DHA. It fascinates me that further increases in dietary ALA, ie drinking varnish aka linseed/flax oil to 12% of calories will lower DHA to only 1% of plasma fatty acids. assuming the data continue to hold. On a 2000kcal diet you would need less that 30g of flax oil a day to become profoundly DHA deficient, assuming no dietary DHA...<br /><br />I love rat papers and, obviously, Ramsden is a hero!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-59291260855544451592020-08-25T17:56:46.150+00:002020-08-25T17:56:46.150+00:00Ramsden: "Dietary omega-6 fatty acid lowering...Ramsden: "Dietary omega-6 fatty acid lowering increases bioavailability of omega-3 polyunsaturated fatty acids in human plasma lipid pools"<br /><br />https://twitter.com/TuckerGoodrich/status/864449739441524736?s=19Tucker Goodrichhttps://www.blogger.com/profile/09455436946187786398noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-47734428651741029102020-08-25T15:40:59.846+00:002020-08-25T15:40:59.846+00:00Pass, My personal experience with domestic rats is...Pass, My personal experience with domestic rats is that they thrive on a diet of plasterboard and electrical insulation. I have noted that they've sometimes dug up the remains of a chicken carcass from where I bury the ones which die of old age...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74446392375366519842020-08-25T15:08:11.798+00:002020-08-25T15:08:11.798+00:00Peter - tweaks = duplicity with certitude!
Fwiw w...Peter - tweaks = duplicity with certitude!<br /><br />Fwiw when I was growing up we didn't leave a lot of mammoth bits lying around (has anyone contemplated mastodons?) but living next to a watercourse we often came across rats' nesting areas in our garden, sheds etc. The main food related debris in those was snail shells and almond shells plus hollowed out stones of fruit such as peaches and plums, and various seed bearing grasses, a mix of significantly fatty food sources. They also loved chewing up the old tallow candles my father kept in his shed and any bits of soap lying around, ditto. <br /><br />Snails seem to average around 20% sfa plus mufa as a proportion of total fa. Good source of cholesterol like other molluscs and crustaceans. <br /> <br />https://pubmed.ncbi.nlm.nih.gov/7854013/<br />Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.com