tag:blogger.com,1999:blog-36840063.post4141924719524978196..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Neuron fuel and functionPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger40125tag:blogger.com,1999:blog-36840063.post-3272667276130464092014-09-01T00:52:07.851+00:002014-09-01T00:52:07.851+00:00"Long-Term Low Carbohydrate Diet Leads to Del..."Long-Term Low Carbohydrate Diet Leads to Deleterious Metabolic Manifestations in Diabetic Mice"<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/25170869<br /><br />As a reader of this blog and non-medically trained person reading the paper abstract, I think I see: <br /><br />1) "Crap in a bag"<br />2) More protein than fat, making it a bad high protein diet more than a bad low carbohydrate diet: "severely carbohydrate restricted (SR, C∶P∶F = 18∶45∶37)"<br /><br />Awaiting your deconstruction of the study :)Matthewhttps://www.blogger.com/profile/08168033638267621898noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-38225592198548125712014-08-16T22:16:05.748+00:002014-08-16T22:16:05.748+00:00Fascinating! Many interesting implications.
1....Fascinating! Many interesting implications. <br /><br /> 1. Blood glucose below about 60mg/dl must thus be risky only for people on high carb diet, not on ketogenic diet. <br /><br />2. Long term diet high in both fat and carbohydrates damages the brain - which is exactly Dr. Kwasniewski's thesis! His way of putting it was describing a syndrome of some "fat middle aged men with psychopatic brains". <br /><br />3. Fat+glucose=accelerated apoptosis, that must also apply to mitochondria! If accelerated mitochondrial apoptosis is the cause of long term mitochondrial degeneration then diabetic doctors were right all along, telling patients to avoid eating too much fat (on their usual high carbohydrate diet). They were right for the wrong reason! 8-:)<br /><br />4. As both of us have already found out, brain not only can live on ketone bodies but works much better than on glucose! Now I know why!<br /><br />Thanks for posting it, best regards,<br />Stan (Heretic)Stan Bleszynskihttps://www.blogger.com/profile/03922719716458272303noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-20835041581385988592014-08-03T20:56:41.686+00:002014-08-03T20:56:41.686+00:00Prions - mitochondrial protein MAVS activates inte...Prions - mitochondrial protein MAVS activates interferon synthesis by prion generation.<br />In theory CNS viral infections could be a trigger for prion-type diseases if this system becomes disregulated.<br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179916/<br />That could be conceptualised as an innate immunity form of automimmune disease, as opposed to auto-antibodies.<br />Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-47227998297904419252014-07-25T20:53:01.019+00:002014-07-25T20:53:01.019+00:00Jack,
Some things that you write about make sense...Jack,<br /><br />Some things that you write about make sense. Congratulations.<br /><br />When you start gong on about electrons, quantum mechanics, EMF's etc, you just sound like a total nutter. I'm a retired electronic engineer, so I know electronic BS when I see it. And I've seen a lot of it on your blog!<br /><br />Stick to what you know and don't BS people with stuff you've just pulled out of your ass.<br /><br />K?Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-21671482398128308152014-07-25T19:51:35.020+00:002014-07-25T19:51:35.020+00:00(Hope this doesn't double-post...I think I mes...(Hope this doesn't double-post...I think I messed up the captcha the first time.)<br /><br />This is such freaking good stuff, Peter! Really fascinating. I invite anyone who's interested in this kind of thing to read my article on Alzheimer's as type 3 diabetes, and the potential therapeutic role of keto and/or low-carb diets. (Whatever your opinion of the Weston A. Price Foundation, their publication is where my work happens to appear this time.) You can read it on the website, but their online formatting is awfully screwy. Feel free to email me privately and I can send you a pdf that is much more aesthetically pleasing in terms of where the sidebars fit in and how everything flows. (tuitnutrition at gmail dot com)<br /><br />The WAPF version is also a little condensed...the original paper has slightly more scientific detail, especially regarding how the beta-amyloid plaques often seen as a "cause" of AD are actually an *effect,* and, in fact, they're a *protective mechanism* in many ways. The plaques seem to be shutting off glucose metabolism as a failsafe just to keep neurons alive in the face of tremendous glycation and oxidative stress (due to a lifetime of dietary CHO abuse), but because there is no other energy substrate available (i.e. ketones), the neurons essentially starve to death. <br /><br />http://www.westonaprice.org/modern-diseases/type-3-diabetes-metabolic-causes-of-alzheimers-disease/<br /><br />You can find AWESOME coverage of all this in this paper as well:<br />http://people.csail.mit.edu/seneff/EJIM_PUBLISHED.pdf<br /><br />Really can't recommend it highly enough.Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-55101813342727091902014-07-25T19:06:34.751+00:002014-07-25T19:06:34.751+00:00This is such freaking good stuff, Peter! Really fa...This is such freaking good stuff, Peter! Really fascinating. I invite anyone who's interested in this kind of thing to read my article on Alzheimer's as type 3 diabetes, and the potential therapeutic role of keto and/or low-carb diets. (Whatever your opinion of the Weston A. Price Foundation, their publication is where my work happens to appear this time.) You can read it on their website, but their online formatting is awfully screwy. Feel free to email me privately and I can send you a pdf that is much more aesthetically pleasing in terms of where the sidebars fit in and how everything flows. (tuitnutrition at gmail dot com)<br /><br />The WAPF version is also a little condensed...the original paper has slightly more scientific detail, especially regarding how the beta-amyloid plaques often seen as a "cause" of AD are actually an *effect,* and, in fact, they're a *protective mechanism* in many ways. The plaques seem to be shutting off glucose metabolism as a failsafe just to keep neurons alive in the face of tremendous glycation and oxidative stress (due to a lifetime of dietary CHO abuse), but because there is no other energy substrate available (i.e. ketones), the neurons essentially starve to death. <br /><br />http://www.westonaprice.org/modern-diseases/type-3-diabetes-metabolic-causes-of-alzheimers-disease/<br /><br />You can find AWESOME coverage of all this in this paper as well: <br />http://people.csail.mit.edu/seneff/EJIM_PUBLISHED.pdf<br /><br />Really can't recommend it highly enough.Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-90069367866853305862014-07-25T18:01:43.566+00:002014-07-25T18:01:43.566+00:00It seems to me the great confusion with prion dise...It seems to me the great confusion with prion disease is not so much how it begins, but how it continues. Wasn't there some argument a while back that there must be a virus or something that hasn't been identified yet which is keeping the process going? Augusthttps://www.blogger.com/profile/08758314961163692341noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-28741670307849310612014-07-25T14:46:40.652+00:002014-07-25T14:46:40.652+00:00The key is what an electron does to a protein. All...The key is what an electron does to a protein. All foods ae broken down to electrons. DHA captures electrons on cell membranes to assimilate and move them properly. Electrons ionizes protein 3D molecular size and shape to change its function. This is how all prion disease begin. Read about Stanley Prusiner and his Nobel. That is why the movement of electrons can take 20 amino acids and 23,000 genes made from those amino acids and make millions of different proteins. The addition or subtraction of said electrons determines the proteins final chemistry by bending it and shaping it to give it is function. This is the beauty of thermodynamic compliant design. It is the quantum mechanism that all life uses to function. When you realize this you see how physiologic function changes as the environment of electrons around it changes. Nature is the driver of nurture. The building blocks are the template we alter with the information from the environment. This is why circadian biology determines the function of how a mitochondria can and can't work. The size and shape change determine the virulence of the prion disease. Your family members disease was due to this mechanism. You just refuse to scale you knowledge to the quantum scale to understand it. I am under no obligation to make sense to people like Nigel. My obligation is elevate their thinking above where it is now by challenging their current beliefs.Anonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-30711604752643839692014-07-25T14:33:51.786+00:002014-07-25T14:33:51.786+00:00Nigel Kinbrum said...
ItsTheWooo said...
"Nig...Nigel Kinbrum said...<br />ItsTheWooo said...<br />"Nigel - my understanding is LBD is not like alzheimers or cardiovascular dementia which is by FAR the most common types, LBD is more like an autoimmune disease and is progressive and often rapid onset in nature, which is why a keto diet would not help in this instance. LBD is more like prion disease like Jack Kruse stated. It's a death sentence and often is rapid."<br />Hi. I'm glad we're on speaking terms again. I don't visit your blog any more, which is why I don't annoy you any more! :-D<br /><br />My response to Jack Kruse was to refute his suggestion that DHA would have made all the difference. He assumed (as per usual) that I'm some kind of idiot who doesn't know what I'm doing. Can you sense the sarcasm oozing from my words?<br /><br />LBD is in-between Alzheimer's & new variant Creutzfeldt–Jakob disease in terms of life expectancy, with a MTTD of 6 years.<br /><br />You must upgrade your game Nigel. Not all versions of ketosis are thermodynamically the same. Those with DHA alter CNS pathologies. I dont think you're a moron. I think you suffer from poor thoughts on some things. Humans are social creatures. We are born physically, neurologically, and epistemologically dependent on others, for evolutionary reasons. Therefore, we do not build our worldview directly from nature as all other animals do. We learn primarily from elaborate symbolic communication with other humans.Many ideas are put in our heads by others with out you thinking much about it.It is a great shortcut that allows advanced knowledge to be additive across many lives and lifetimes. A uniquely human neurological adaptation. But our greatest asset is also our greatest blind spot. Since much of our knowledge is predominantly “absorbed” in this way, through language and concepts, rather than fully experienced and verified firsthand, it leaves us extremely vulnerable to potential manipulation by other humans, whether intentionally or unintentionally. The most useful piece of learning for the uses of life is to unlearn what is untrue.<br />Truth happens to individuals not to crowds.....http://www.sciencedaily.com/releases/2014/07/140722091603.htm<br /><br />CITES:<br />http://www.lipidworld.com/content/pdf/1476-511X-12-16.pdf<br />http://www.nature.com/.../v35/n11/full/npp201098a.html<br />http://www.ncbi.nlm.nih.gov/pubmed/22057807<br />http://www.ncbi.nlm.nih.gov/pubmed/22316559<br />Guess how this mechanism works? DHA. DHA breaks down into protectins resolvins and maresin's. The more DHA you have in cell membranes the better you respond. http://onlinelibrary.wiley.com/.../j.1471-4159.2007.../fullAnonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-42404767807303402652014-07-25T14:24:44.097+00:002014-07-25T14:24:44.097+00:00This came from my forum regarding ketosis: Momma28...This came from my forum regarding ketosis: Momma28 says, "Truly the brain does HEAL in Ketosis! Testimony of a Two Year old!<br />The story begins in January of this year when I am given custody of a 16 month old nephew lost to the system by a drug abusing, alcoholic mother. I'd only seen him once before this. He made no eye contact or any attempts at physical connection. He had jerky, palsy-like movements and seizures intermittently throughout the day. He weighed 18 pounds and was 28 inches tall; just 46th percentile on the growth charts. He would only eat bananas, white bread toast and commercial milk that was being microwaved and put in a bottle, oh, and of course, soda. He had by this time been given 22 vaccines.<br /><br />His first week here I let him choose what he would eat to ease him in with the other 6 kids and let him acclimate. The second week it was on....nothing was offered but what I wanted him to eat. Three days later and lots of tantrums and shed tears and he was eating meats for the first time in his life. He was given watered down Welch's with D3, Iodine, a multivit liquid and probiotics in it throughout the day. He was also given a B12 transdermal patch. His diet was fresh veggies all loaded with organic butter or bacon fat. Meats were offered with each meal and he soon grew to love them. All seizures halted within the first week most likely due to lack of dietary fats. His palsy-like movements have gradually ceased as well and have become much more normal. In fact, his balance has more than improved, its incredible. <br /><br />It took him 6 weeks to learn his name. Since then, he has learned so much more...body parts, animals, fruits and veggie names and songs. His cognitive function, that was about an 8 month old, is now just slightly behind his 2 years that he turned last week. He has been on a ketogenic diet for 8 full months now and today is 30 (77th%) pounds and 34 (87th%)inches tall. He has grown 6 inches and gained 12 pounds in 8 months! Unheard of! He makes eye contact, responds to facial...Anonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74199512047425791702014-07-24T06:53:28.949+00:002014-07-24T06:53:28.949+00:00I like this blog it gives me more information
Lec...I like this blog it gives me more information <br /><a href="http://www.goverhorticulture.com/Lechuza.html" rel="nofollow">Lechuza Planters</a>Anonymoushttps://www.blogger.com/profile/06739595680597927909noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-90355984214463247242014-07-23T07:26:11.356+00:002014-07-23T07:26:11.356+00:00ItsTheWooo said...
"Nigel - my understanding ...ItsTheWooo said...<br />"Nigel - my understanding is LBD is not like alzheimers or cardiovascular dementia which is by FAR the most common types, LBD is more like an autoimmune disease and is progressive and often rapid onset in nature, which is why a keto diet would not help in this instance. LBD is more like prion disease like Jack Kruse stated. It's a death sentence and often is rapid."<br />Hi. I'm glad we're on speaking terms again. I don't visit your blog any more, which is why I don't annoy you any more! :-D<br /><br />My response to Jack Kruse was to refute his suggestion that DHA would have made all the difference. He assumed (as per usual) that I'm some kind of idiot who doesn't know what I'm doing. Can you sense the sarcasm oozing from my words?<br /><br />LBD is in-between Alzheimer's & new variant Creutzfeldt–Jakob disease in terms of life expectancy, with a MTTD of 6 years.<br /><br />Cheers, NigeNigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-32174174014339631662014-07-19T09:03:12.875+00:002014-07-19T09:03:12.875+00:00This comment has been removed by the author.Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-91524879622035085462014-07-19T09:02:56.359+00:002014-07-19T09:02:56.359+00:00I really wish keto diets would be used more for me...I really wish keto diets would be used more for mental conditions, but at the moment the step #1 should be the hard look at statines as a significant contributer to mental impairments especially for old people. Recently another person thanked me for bringing his attention a year ago to sertain side effects of Lipitor which was prescribed to his dad for preventive purposes. The old guy started to age faster, developed memory and speech problems. After the discontinuation of Lipitor, he feels much better - his speech is back to normal, muscles weisting got reversed, memory improved.Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-89835137465793912452014-07-19T01:35:27.085+00:002014-07-19T01:35:27.085+00:00http://en.wikipedia.org/wiki/Dementia_with_Lewy_bo...http://en.wikipedia.org/wiki/Dementia_with_Lewy_bodies Not offically autoimmune but this clearly different from common alzheimers/vascular dementia. <br /><br />IT appears to specifically attack cholinergic system (dementia) and substantia nigra (parkinsons) and seems more of an autoimmune like process in comparison to the other dementias that clearly destroy the brain as an entity.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-10266156633163423062014-07-19T01:28:35.028+00:002014-07-19T01:28:35.028+00:00Nigel - my understanding is LBD is not like alzhei...Nigel - my understanding is LBD is not like alzheimers or cardiovascular dementia which is by FAR the most common types, LBD is more like an autoimmune disease and is progressive and often rapid onset in nature, which is why a keto diet would not help in this instance. LBD is more like prion disease like Jack Kruse stated. It's a death sentence and often is rapid.<br /><br />OTOH the vaaast majority of elderly dementia patients have common alzheimers (which is related to insulin deficiency in the brain and neurodengeration that is slow steady and progressive) or they have cardiovascular dementia, which involved plateus and rapid sudden declines in cognition which is secondary to vascular insults/mini strokes in the brain that occur randomly. IN these cases, ketogenic diet has way more potential to help as it will help the brain heal from insults and provide alternative/superior fuel sources in insulin deficiency (alzheimers) or from vascular trauma (vascular dementia).ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-73402111396026792972014-07-18T14:43:58.626+00:002014-07-18T14:43:58.626+00:00Peter, I'm not sure what you say about neurons...Peter, I'm not sure what you say about neurons and glucose is quite right. Here's what Wikipedia says about it.<br /><br />"The central role of [glucose transporter] GLUT3 in cerebral metabolism has been challenged by the astrocyte-neuron lactate shuttle (ANLS) hypothesis,[6] which proposes that astrocytes play the key role in the coupling of neuronal activity and cerebral glucose utilization. In this hypothesis, the astrocyte, which relies on GLUT1 for glucose transport, is the primary consumer of glucose in the brain, providing lactate as the primary energetic fuel for neurons. However, by modeling the kinetic characteristics and glucose concentrations in neurons and glia, it was concluded that the glucose capacity of neurons via GLUT3 far exceeds that of astrocytes via GLUT1.[7] Additionally, demonstrations of increase in GLUT3 expression associated with increased cerebral glucose utilization provides further confirmation of the central role of GLUT3.[5]"<br />http://en.wikipedia.org/wiki/GLUT3<br /><br />My understanding is that neurons only use lactate because they need most of their glucose for the pentose phosphate pathway to produce NADPH and keep their glutathione reduced.Janehttps://www.blogger.com/profile/18175128589806816624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-12613979868138310682014-07-16T20:40:00.955+00:002014-07-16T20:40:00.955+00:00Eddie/lowcarb team member--
While Rome burns... ...Eddie/lowcarb team member--<br /><br />While Rome burns... vs. Why Rome burns....<br /><br />$20 says Peter appreciates the Who's Whose catch.Anonymoushttps://www.blogger.com/profile/04055373832780595376noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-61131174749969536952014-07-16T07:37:37.911+00:002014-07-16T07:37:37.911+00:00I nearly forgot...
See http://paleozonenutrition....I nearly forgot...<br /><br />See <a href="http://paleozonenutrition.com/2011/10/12/my-current-view-of-the-zone-diet/#comment-31414" rel="nofollow"><b>http://paleozonenutrition.com/2011/10/12/my-current-view-of-the-zone-diet/#comment-31414</b></a><br />"But, your blog post explains to me why this happened and I very much appreciate that. You get fed so much “carbs are evil” from the paleo world to the point that you feel like a failure when you don’t lose weight/sleep perfect/turn into a fitness model just “doing paleo.” I don’t ever lose weight eating paleo, feel like I’m starving even after eating a ton of protein or fat, and then I crash and burn every couple of months into a huge sugar binge that goes on for weeks or months."<br /><br />The correct answer to the question posed at the top of your blog is:-<br />Both. As to the amounts of each, it all depends.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-83463755769739720332014-07-16T07:23:23.364+00:002014-07-16T07:23:23.364+00:00Jack Kruse said...
"Parkinson's is a prio...Jack Kruse said...<br />"Parkinson's is a prion like disease Nigel and that is why she did not get full benefits. DHA is the key to the brain's keto template."<br />She was being given 10ml/day of Seven Seas high-strength Fish oil with EPA & DHA. See <a href="http://nigeepoo.blogspot.co.uk/2009/03/look-after-your-brain.html" rel="nofollow"><b>http://nigeepoo.blogspot.co.uk/2009/03/look-after-your-brain.html</b></a> and <a href="http://nigeepoo.blogspot.co.uk/2011/02/mums-proposed-ketogenic-diet-for.html" rel="nofollow"><b>http://nigeepoo.blogspot.co.uk/2011/02/mums-proposed-ketogenic-diet-for.html</b></a><br /><br />Some broken things can't be fixed.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-50630299382594108992014-07-15T17:26:50.021+00:002014-07-15T17:26:50.021+00:00Parkinson's is a prion like disease Nigel and ...Parkinson's is a prion like disease Nigel and that is why she did not get full benefits. DHA is the key to the brain's keto template. Peter is knocking a real big door here. I hope it wakes up some people. Not all ketotic templates are thermodynamically the same. People seem not to understand this. This is why mitochondria in brain and heart resist apoptosis and live for autophagy. Anonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-77743103275094314702014-07-14T10:41:10.883+00:002014-07-14T10:41:10.883+00:00I can only comment on Lewy Body Dementia (an α-syn...I can only comment on Lewy Body Dementia (an α-synuclein protein disease) & the related Parkinson's Disease Dementia, but putting my mum on a ketogenic diet (which had a lot of initial problems, due to some care staff not understanding terms like "No sugars & starches". "This rice pudding's O.K, isn't it?" SMH.) gave her a dual-fuel brain.<br /><br />Although a ketogenic diet improved her mental faculties, <b>it didn't halt the progression of her disease</b>. It only "turned back the clock" for a while.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-36233157204474827452014-07-14T06:51:57.464+00:002014-07-14T06:51:57.464+00:00We need a Facebook group for medical professionals...We need a Facebook group for medical professionals disgusted by lack of keto diet application watching ppl disabled by strokes and diabetes of the brain into invalid statusItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-86030268486455469872014-07-14T06:50:14.578+00:002014-07-14T06:50:14.578+00:00It kills me knowing that a keto diet would likely ...It kills me knowing that a keto diet would likely arrest and even reverse some dementia...but instead they are given statins, aricept/namenda, insulin and lots of refined glucose.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-16155466325036134482014-07-13T11:40:39.442+00:002014-07-13T11:40:39.442+00:00Thanks for the great post! As an anecdote, I'...Thanks for the great post! As an anecdote, I've noticed on my nursing home rounds, that many a demented patient is placed on Namenda but continues to eat a very high carbohydrate based diet.<br />Namenda was marketed to doctors under the indication of moderate to severe dementia. But even mild memory impairment can get them placed on it.<br /> At that point it's like a bandage over a surgical dehiscence, eh? Patients and their families are not aware of the benefit of ketones and would likely chose diet change over yet another drug.Larcanahttps://www.blogger.com/profile/10109743909244156390noreply@blogger.com