tag:blogger.com,1999:blog-36840063.post4528022052591445125..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: Coronavirus is possibly everywherePeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger48125tag:blogger.com,1999:blog-36840063.post-73587937106845760472020-04-10T23:39:40.976+00:002020-04-10T23:39:40.976+00:00Hi, Frunobulax,
Thanks for the link. Very helpful...Hi, Frunobulax,<br /><br />Thanks for the link. Very helpful. I think I saw the <i>Small Dead Animals</i> piece the other day for an entirely different reason, and that's why "libertymavenstock" looked familiar. <br /><br />Yes, Gaiziunas's piece is well-written and compelling on the surface. Maybe that's as deep as it goes.<br /><br />You've probably heard of Vladimir Zelenko, the NYC doctor treating patients with low-dose HCL, zinc sulfate, and azithromycin. He reports <a href="https://techstartups.com/2020/04/05/new-updates-dr-vladimir-zelenko-cocktail-hydroxychloroquine-zinc-sulfate-azithromycin-showing-phenomenon-results-900-coronavirus-patients-treated-must-watch-video/" rel="nofollow"> great results</a>. The knock on him appears to be that he has no idea for sure if he is treating COVID patients. If so, he has no idea if he is treating COVID patients who would get better without his treatment. <br /><br />Did you look at the Chinese paper? TruthOrFiction really didn't say anything negative about it, other than that it's a work-in-process, which everything really is now in this crisis atmosphere. <br /><br />One thing I've found compelling is the haemoglobin conjecture combined with Dr Kendrick's clinical experience. It may or may not be right, but it "makes sense".LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-37178727493513294602020-04-10T20:12:19.966+00:002020-04-10T20:12:19.966+00:00@Bob, be also sure to read https://www.truthorfict...@Bob, be also sure to read https://www.truthorfiction.com/covid-19-had-us-all-fooled-but-now-we-might-have-finally-found-its-secret-medium-post/ as followup on this "libertymavenstock" post. <br /><br />Doesn't mean he's wrong, it certainly sounds credible. But there are all kinds of theories thrown around right now that sound equally credible. I'm wary of anything praising hydroxychloroquine, because word here (from virologists like Drosten) is that from the current studies it seems to help somewhat, but it's by no means an effective treatment. Let's hope we get more information from the dozens of studies that are underway. <br />Frunobulaxhttps://www.blogger.com/profile/11809778379384984029noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-7944912927177884502020-04-10T19:57:41.518+00:002020-04-10T19:57:41.518+00:00@Peter, you might be interested having a look at t...@Peter, you might be interested having a look at this: https://youtu.be/JLb5hZLw44s. They touch on the subject of mice used in studies. As you read lots of mice studies, the direct relevance might be that Bret Weinstein stumbled upon the phenomena that mice used in research seem to have longer telomeres than wild mice due to the economics of breeding mice for studies, and that this has some particular consequences for those lucky subjects.<br /><br />On another note, more relevant to the current pandemic, I found this also interesting and would love to hear your thoughts on it: https://ggenereux.blog/2020/04/04/covid-19-vulnerability/MPhttps://www.blogger.com/profile/00728620362004688708noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-19578672225506172052020-04-10T17:59:51.420+00:002020-04-10T17:59:51.420+00:00Hi, cavenewt,
There was an exchange yesterday on ...Hi, cavenewt,<br /><br />There was an exchange yesterday on Malcolm Kendrick's site in the comments on this subject. User barovsky posted this link:<br /><br /> https://web.archive.org/web/20200405061401/https://medium.com/@agaiziunas/covid-19-had-us-all-fooled-but-now-we-might-have-finally-found-its-secret-91182386efcb<br /><br />The article is by a an anonymous character and is unsourced, but I found what appears to be a supporting Chinese paper (now in revision six since March 5)<br /><br />https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173<br /><br />Note Dr Kendrick's response to a comment that COVID-19 was not much more than the flu:<br /><br />"...I have not encountered anything like it before. People are quite well, then they fall of the edge of a cliff. This is, of course, in the elderly population, many co-morbidities. It is, however, weird. Very little distress, then then oxygen level crash, still with little distress. They just go spaced out on you, then they die...."<br /><br />https://drmalcolmkendrick.org/2020/04/06/covid-with-of-or-because-of/#comment-157928<br /><br />Like you, I'm a layman. I just read these smart guys (Peter and Dr Kendrick) and try to understand. Still, it seems like there's something to this virus-and-hemoglobin thing.LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-6548479183250949582020-04-10T14:36:02.797+00:002020-04-10T14:36:02.797+00:00@Passthecream, I keep running across articles push...@Passthecream, I keep running across articles pushing the Fe hypothesis. The chemistry is way over my head. Is it nonsense, or plausible? A little bit quoted to give a taste.<br /><br />(Sorry it's a pdf) https://osf.io/4wkfy/download/?format=pdf&fbclid=IwAR0llRGqRW8kSAUkCkme_osQZAJ9PJ4UrzCHKhGvmo2CZv_JCxRCAnucRS8<br /><br />"...patients may be experiencing a form of acquired acute porphyria... the role of erythrocytes in the pathophysiology of Covid-19 is under-estimated... human Covid-19 patients have subnormal haemoglobin levels... Hyperbilirubinemia [high bilirubin] is observed... consistent with ineffective erythropoiesis (Sulovska 2016) and rapid haemoglobin turnover. Elevated serum ferritin levels are typical of acute porphyria (Trier 2013) and would be expected upon dissociation of iron from haem [heme]. A mechanism by which SARS-CoV-2 might attack the 1beta chain of haemoglobin has been proposed; the product of open reading frame 8 (ORF8) binds to the porphyrin of haem and displaces iron, according to bioinformatics prediction analyses (Wenzhong 2020). The oxygen-carrying capacity of erythrocytes would therefore be compromised by SARS-CoV-2, thereby exacerbating the difficulties already experienced by the patient, in terms of maintaining partial pressure of oxygen in the alveoli (PaO2)..."cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74171015050920405172020-04-10T08:20:33.385+00:002020-04-10T08:20:33.385+00:00You are probably right Passthecream - I am a reali...You are probably right Passthecream - I am a realistic optimist though, and paradigms don’t break themselves!Dr. Robhttps://www.blogger.com/profile/11677615872346052981noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-82181344711311078582020-04-10T02:01:57.306+00:002020-04-10T02:01:57.306+00:00Dr. Rob, I fear it's more like this
https://e...Dr. Rob, I fear it's more like this<br /><br />https://en.m.wikipedia.org/wiki/Battle_of_Borodino#/media/File:Battery_of_Raevsky.jpgPassthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-23524853164879100882020-04-09T22:29:00.997+00:002020-04-09T22:29:00.997+00:00> Sounds awful I know but sacrifices will have ...> Sounds awful I know but sacrifices will have to be made.<br /><br />You are funny Peter!Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-64113156021662927912020-04-09T14:17:38.251+00:002020-04-09T14:17:38.251+00:00Hi Frunobulax - I guess the point I’m trying to ma...Hi Frunobulax - I guess the point I’m trying to make is that the “root cause” for any disruption in a thermodynamic system must involve energy and entropy. <br /><br />For any aerobic organism the energy is essentially oxygen, the entropy is any stressor on that system.- which in this case is the virus.<br /><br />The virus is affecting the energy/oxygen supply to the cells and generating a load of inflammation/entropy.<br /><br />It’s a simple concept based on a number of heuristics:<br /><br />Life is thermodynamic<br /><br />Energy is needed for life<br /><br />Oxygen is the energy of aerobic life<br /><br />This virus is information looking for energy/oxygen<br /><br />I believe this virus has opened up a window to our evolutionary past and illuminates on how the “game of life” should be played!<br /><br /><br />Dr. Robhttps://www.blogger.com/profile/11677615872346052981noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22044621068919270422020-04-09T03:28:34.184+00:002020-04-09T03:28:34.184+00:00to Dr.Rob - may be it is the link you wanted to se...to Dr.Rob - may be it is the link you wanted to see https://www.npr.org/sections/health-shots/2020/04/07/828091467/why-some-covid-19-patients-crash-the-bodys-immune-system-might-be-to-blame<br />Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-39066416809632781842020-04-08T23:01:02.958+00:002020-04-08T23:01:02.958+00:00Peter this is real off topic, but is your go to fe...Peter this is real off topic, but is your go to feed protocol for dogs with diarrhea? I was thinking scrambled eggs in a little bit of beef tallow would be a good start since egg should be easily assimilated. Made some white rice for him cooked in beef broth earlier today. Any advice would be greatly appreciated!Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-48227769260048494022020-04-08T17:30:03.622+00:002020-04-08T17:30:03.622+00:00@Passthecream, this suggests how the virus gets in...@Passthecream, this suggests how the virus gets into RBCs. https://www.evolutamente.it/covid-19-ards-cytokine-storms-the-recycling-of-ascorbic-acid-by-macrophages-neutrophils-and-lymphocytes/.<br />ClareAnonymoushttps://www.blogger.com/profile/10182500559751473274noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-1366068930140074272020-04-08T15:22:00.191+00:002020-04-08T15:22:00.191+00:00Well, not 'through' those cells obviously....Well, not 'through' those cells obviously. RBCs being presented homehow, ready to get their haemoglobin oxidised again.<br /><br />BTW quinine sulphate is the basis of one treatment for porphyria. Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-19721942109106446662020-04-08T15:15:55.523+00:002020-04-08T15:15:55.523+00:00Peter, the haemoglobin hypothesis mentioned above ...Peter, the haemoglobin hypothesis mentioned above is interesting for a couple of reasons one of which would be the release of reactive Fe and consequent damage from that which could include lipoperoxidation, in turn relating to the observations of increased 4HNE and the drop in circulating pufa levels in ARDS per your recent posts on that topic. <br /><br />But how do the virus proteins get into blood, specifically RBCs to be able to do that? <br /><br />So, a question arising is whether ARDS always involves the destruction of haemoglobin and release of reactive iron species from that, triggering something like the lipoperoxidation cascade as described by Spitteler? I imagine there is a lot of damage in severe respiratory infections, cells bursting/necrosis I presume and virus bits everywhere and blood circulating through many of these lung cells which have functions centered on haemoglobin and gas exchange. Big mess.<br /><br />Choloroquine and relatives sound like Swiss army knife chemicals, they get everywhere and do lots of different things and hang around for some time. Your lysosome idea is interesting. One other proposal is that they change the pH of endosomes and might interfere with endocytosis of viruses --- they are better known for doing the same thing to the digestive vacuoles of malaria bugs infesting RBCs.Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-15960372984638342562020-04-08T13:42:45.125+00:002020-04-08T13:42:45.125+00:00Man, I wish Dr. Art Ayers still maintained his blo...Man, I wish Dr. Art Ayers still maintained his blog. He always posted good stuff.Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-32248178019899847932020-04-08T09:04:08.974+00:002020-04-08T09:04:08.974+00:00@Rob I used auto immunity as an abbrevation for &q...@Rob I used auto immunity as an abbrevation for "immune system activation for an unknown reason, other than external stimulation" (virus, bacteria etc.). Having said this, it should be clear that there is no such thing as an "auto immune reaction". There is always a causal chain for the activation, as the immune system doesn't just activate itself. But with our medicine rarely looking for root causes, a lot of the time we don't understand the reason for the activation. <br /><br />Can't really comment on your hypoxia theory. You may be onto something here. But I'm not familiar enough with this area, so it takes more time to digest a theory like this (time which I didn't have in the last days). But I'll have a go at it for sure soon.Frunobulaxhttps://www.blogger.com/profile/11809778379384984029noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-88297407262708455372020-04-08T05:01:16.326+00:002020-04-08T05:01:16.326+00:00Hi - it’s not auto immunity it’s the innate immune...Hi - it’s not auto immunity it’s the innate immune system overreacting to the problem.<br /><br />Hypoxia is a “big” problem to an aerobic organism - so all hell let’s loose.<br /><br />Hypoxia ➖ ⬆ HIF-1 ➖ ⬆ LPS ➖ ⬆ TLR (4) ➖ ⬆ Innate immunity ➖ Cytokine storm<br /><br />Hypoxic conditions favour anaerobes - imbalance in Microbiome- SIBO type symptoms <br /><br />However, as we know, there are good anaerobes and bad anaerobes - if we can get good anaerobic bacteria to reduce the bad ones then potientially we can reduce the inflammation.<br /><br />https://pubmed.ncbi.nlm.nih.gov/23568206/ <br /><br />Dr. Robhttps://www.blogger.com/profile/11677615872346052981noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-82904830265525909672020-04-08T04:42:12.128+00:002020-04-08T04:42:12.128+00:00@Bob Being from Germany I listen to the daily podc...@Bob Being from Germany I listen to the daily podcast from Christian Drosten (available on Youtube and Spotify), the leading Corona researcher maybe in all of Europe because he's been researching other Corona viruses for 20+ years. It's a great source because he talks more than 30 minutes a day, anwering a lot of questions and discussing newest research. He talked about this autoimmune reaction a lot in the context of antiviral agents, which he considers to be effective only if administered in the first week after infection. The podcast in German of course, so this may not help you much :) <br /><br />But I guess you'll find a lot of references to that. A quick google (try corona cytokine storm) finds https://www.nytimes.com/2020/04/01/health/coronavirus-cytokine-storm-immune-system.html and more.Frunobulaxhttps://www.blogger.com/profile/11809778379384984029noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74390785792274851282020-04-08T02:44:48.220+00:002020-04-08T02:44:48.220+00:00Hi, Frunobulax.
"With COVID-19, the thing th...Hi, Frunobulax.<br /><br /><i>"With COVID-19, the thing that kills us is the autoimmune reaction that starts in the second week, a malfunctioning immune system."</i><br /><br />I'd love to see a reference for this. I hadn't heard of anything like this before. Thanks!LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-12019651791903812722020-04-07T19:38:36.660+00:002020-04-07T19:38:36.660+00:00Fruno, I regard diseases of civilisation as evolut...Fruno, I regard diseases of civilisation as evolution in action. On a population basis evolution works by the non-reproduction of individuals poorly suited to the new circumstances. Miki Ben-Dor had a great post on this years ago. Met Syndrome is now applying real selection pressure by affecting children and reproductive age adults giving DM T2 rather than just affecting the elderly. Medicine is the blunting of this evolutionary progress. Turning back the clock, environmentally, should stop the process and relegate medicine to the side lines with respect to chronic diseases.<br /><br />Hi Dr Rob, there’s a lot to get my head round there, it will take time.<br /><br />Ông Mỹ, our best hope for a short pandemic is to find that it’s nearly over by the time we get serology testing available!<br /><br />Hi annlee, I find that one a bit difficult to get too enthusiastic about. Most of the pathophysiology sounds quite normal for the progression from serious infection through SIRS to ARDS from what I’ve read.<br /><br />Tucker and cave, yes, they never tested for coronavirus unless the patient was influenza negative. In the middle of a pandemic in China due to arrive in the USA. Amazing. So 8% is the absolute lowest number. What was the value for the healthy population (rhetorical question).<br /><br />Justin, with the number of antiviral drugs coming out of the woodwork it’s a wonder there are any viruses left. Oddly enough I have plenty of ivermectin lying about for worming the goats. I’m not thinking of splashing it on myself.<br /><br />Shaza, this time. Maybe not always.<br /><br />Scotpole, anaesthetists always self question. What is the best protocol has to worked out, it won’t come from experts on high. We can probably always improve. Backing off on the frusemide might be a good start. There are similar discussions in the UK.<br /><br />ctviggen, the worry for the USA is that the percentage of people who are metabolically healthy is quite small. Considering that most diabetics are only diagnosed based on elevated fasting blood glucose the guesstimate is that they have probably had “diabetes in-situ” for a decade before they get given the label. That puts even “healthy” people at risk<br /><br />There is a responsibility for the development of diabetes and associated problems. That does NOT lie with the patient or “pre-patient”. As you know I consider that these people are in trouble because they have been told for decades to avoid fat, especially to avoid saturated fat and that sugar and starch are healthy. Vegetable oils, sugar and starch simply make people hungry and this cannot be argued with in the long term. Two or three steps down the line gives the “label” of diabetes.<br /><br />Each death is a serious loss. At some stage the dietary advisory bodies need to take responsibility for this outcome. This particular pandemic does appear to target those with metabolic syndrome and this does not develop without reason.<br /><br />Kajus, sadly I’ll never be able to nose breathe. An at least one time broken nose as a kid. Seriously stenosed, both nostrils.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-7825227164157420352020-04-07T16:55:54.535+00:002020-04-07T16:55:54.535+00:00https://www.youtube.com/watch?v=AiwrtgWQeDc&t=...https://www.youtube.com/watch?v=AiwrtgWQeDc&t=33s<br /><br /><br />It seems logical procedure to breathe with nose Buteyko style for co2 to carry oxygen to the lungs, someone who has experience with this. Helped me to get better lung capacity.<br />Kajushttps://www.blogger.com/profile/06750298925760439779noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-31421203268106159202020-04-07T14:14:57.243+00:002020-04-07T14:14:57.243+00:00@Gyan Just statistics. Before modern medicine, chi...@Gyan Just statistics. Before modern medicine, children usually had a high mortality rate in any pandemic.<br /><br />@ctviggen I didn't want to be disrespectful in any way. (I'm in a high risk group myself, with an autoimmune disease and recovering from metS. There is a decent chance that I'll kick the bucket if I get Corona.) <br />I apologize if I have offended you. Hope those people recover quickly. Frunobulaxhttps://www.blogger.com/profile/11809778379384984029noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-27552101745928275742020-04-07T12:38:23.337+00:002020-04-07T12:38:23.337+00:00Ctviggen
If people with metabolic syndrome are dis...Ctviggen<br />If people with metabolic syndrome are disproportionately affected by this virus then it is certainly justified to say that adoption of a diet that rectifies metabolic syndrome would reduce severity of the viral disease Gyanhttps://www.blogger.com/profile/09941686166886986037noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-38235617281951986442020-04-07T12:32:57.934+00:002020-04-07T12:32:57.934+00:00@frunobulax
How justified it is say that children ...@frunobulax<br />How justified it is say that children immune systems are Weak? Gyanhttps://www.blogger.com/profile/09941686166886986037noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-85725548317959048302020-04-07T00:40:12.766+00:002020-04-07T00:40:12.766+00:00@Dr Rob,
loved your pdf and interpretation of the...@Dr Rob,<br /><br />loved your pdf and interpretation of the smoking effect. If nicotine is effective by downregulating ACE2 then andrographis extract is the logical drug-of-choice for COVID-19, even more so because it also has innate immunity effects similar to probiotics, elderberry and echinacea and significantly increases seroprotection rates after vaccination.<br />https://hopefulgeranium.blogspot.com/2020/03/you-cant-boost-your-immunity-or.html<br /><br />This latter is why they're trialing BCG vaccine, but there's most evidence for probiotics.<br />https://hopefulgeranium.blogspot.com/2020/04/probiotics-for-prevention-of-upper.htmlPuddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.com