tag:blogger.com,1999:blog-36840063.post4671776525936027639..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Obesity and diabetes (1)Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-36840063.post-75471774319459802712021-07-16T12:13:07.518+00:002021-07-16T12:13:07.518+00:00Conversely, should diabetic numbers worsen while t...Conversely, should diabetic numbers worsen while the adipocytes are shrinking under low carb esting, either basally lipolysing(?) at first, and then responding to energy demands via neuro/endocrine signals as insulin lowers...<br /><br />... and then improve as lipolysis and weight loss stall, when insulin settles at nice new lower levels, letting energy demands be met by dietary fat?Itu Chaudhurihttps://www.blogger.com/profile/04984960595507153422noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-1975822001961561722021-07-16T12:02:53.926+00:002021-07-16T12:02:53.926+00:00terrific summary
With increased basal lipolysis f...terrific summary<br /><br />With increased basal lipolysis fat oxidation, whole body, increases and induces the normal physiological insulin resistance which occurs via ROS/Protons mechanism.<br /><br />Is it right to say that basal lipolysis causes more fat ox in the liver, thus ROS/protons resists insulin action, which allows glycogenolysus even with post prandial glucose around in the blood, so T2DM.Itu Chaudhurihttps://www.blogger.com/profile/04984960595507153422noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-20501357499491195052021-06-29T11:39:10.322+00:002021-06-29T11:39:10.322+00:00Hi Martin, yes, true. Also rumoured is that adipoc...Hi Martin, yes, true. Also rumoured is that adipocyte hypertrophy is easily corrected but adipose hyperplasia is un-correctable w/o adipocyte apoptosis. The glitazones activate PPAR gamma and signal the generation of more small adipocytes, linoleic acid will go on to fill these new small cells, combining adipose hypertrophy with hyperplasia. This strikes me as a Bad Thing, unless you like weighing 400kg. You can do the same with 4HNE, as they did here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594100/ excepting that 4HNE also blunts insulin signalling (so doesn't transiently improve your lab numbers), something the glitazones don't, so your diabetic labs look better for a while as you gain some extra weight....<br /><br />Linoleic acid as the core problem, its derivative 4HNE as a signal molecule a layer up, glitazones as a pharma disaster.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-34192044007514707302021-06-29T08:47:32.748+00:002021-06-29T08:47:32.748+00:00The stored lipid droplet is almost as complicated ...The stored lipid droplet is almost as complicated as a cellular organelle, has a phospholipid membrane etc.<br /><br />https://images.app.goo.gl/b4GgEBbf6uBzma9BAPassthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-40559465815453417202021-06-29T04:37:17.943+00:002021-06-29T04:37:17.943+00:00Sorry Cave, I've been immersed in basal lipoly...Sorry Cave, I've been immersed in basal lipolysis for months now. I forget what a complete closed book it was to me in the early phase, how much reading it took to realise we don't know a great deal about how it is controlled (partly signalling from the proteins which coat the lipid droplet, as they stretch, they signal). It looks a lot like the system used by the sympathetic nervous system to facilitate lipolysis when we need it. It's controlled by the cyclic AMP signalling process. It's augmented by caffeine and some related drugs.<br /><br />As research about weight control seems under the ascendancy of brain researchers obviously adipocyte physiology understanding is not much of a priority...<br /><br />I actually started here https://pubmed.ncbi.nlm.nih.gov/26723122/ where the research is based on cattle, so side steps any b*llocks about hedonism re food, food addiction and other such junk science. Cattle research is also utterly financially driven (ketosis in dairy cows might wipe out a large chunk of the profit from a lactation) so unlikely to be influenced by religious dietary ideas. Then I found a huge human literature, which is reinvented every decade or so.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22804558383416300332021-06-28T21:48:22.410+00:002021-06-28T21:48:22.410+00:00Hi, cavenewt.
I had a similar question 1). I'...Hi, cavenewt.<br /><br />I had a similar question 1). I'd never heard of "basal lipolysis" until this post. When I googled it, the very first hit was the same as the first link in the post, which didn't help me much for a definition.<br /><br />But when I googled "basal lipolysis definition" it led me to https://www.cambridge.org/core/journals/nutrition-research-reviews/article/regulation-of-adipocyte-lipolysis/08D91A549DE1C469D6265EDB5985B95A. <br /><br />From the introduction:<br /><br />"Under normal conditions, the adipose tissue is able to fine-tune a series of neuroendocrine signals to precisely adapt the balance between TAG synthesis (lipogenesis) and breakdown (lipolysis) to meet physiological needs."<br /><br />I haven't finished the paper, which is long and technical (for me, anyway), but the process says, "homeostasis" to me. Maybe someone can provide a better explanation.LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-9427704245933236242021-06-28T19:09:38.464+00:002021-06-28T19:09:38.464+00:00Nice, thanks. Healthy adipocytes probably shouldn&...Nice, thanks. Healthy adipocytes probably shouldn't distend above certain limit but proliferate instead. Something is making them sick.<br /><br />In this paper they used troglitazone (due to liver failures withdrawn diabetic drug) to make insulin resistant rats insulin sensitive. Seems related to the topic.<br /><br />"Troglitazone Increases the Number of Small Adipocytes without the Change of <br />White Adipose Tissue Mass in Obese Zucker Rats"<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC508690Martin Siphttps://www.blogger.com/profile/07728943723802772732noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-18150275155684435592021-06-28T19:05:28.869+00:002021-06-28T19:05:28.869+00:00This comment has been removed by the author.Martin Siphttps://www.blogger.com/profile/07728943723802772732noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-7384613085681193772021-06-28T19:05:16.297+00:002021-06-28T19:05:16.297+00:00This is fascinating, even though I'm strugglin...This is fascinating, even though I'm struggling to keep my head above water. Can I get someone's help with some basic questions:<br /><br />1. Is "basal lipolysis" different from "lipolysis"?<br /><br />2. Is spilling FFAs different from lipolysis (bypassing lipolysis is how I've been thinking of it)? Is spilling FFAs what leads to elevated triglycerides in the bloodstream? <br /><br />3. I've been reading hyperlipid for many years. Until recently I assumed all cells in the body were at the same level in terms of insulin resistance. I'm finally realizing that adipose cells can act differently from other cells. Can someone point me to basic information on why there's a difference and how it occurs?<br /><br />Thanks!cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.com