tag:blogger.com,1999:blog-36840063.post4833189153711136574..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: More musing about vaccinesPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger80125tag:blogger.com,1999:blog-36840063.post-42898436008607020992021-06-27T22:17:38.534+00:002021-06-27T22:17:38.534+00:00Very prescient postVery prescient postmipelucohttps://www.blogger.com/profile/03250284885160371362noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-82005013953000679122021-04-27T15:36:04.101+00:002021-04-27T15:36:04.101+00:00Thanks Unknown
cave, yes, I think we are on the s...Thanks Unknown<br /><br />cave, yes, I think we are on the same page re COVID and vaccs.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-53990962015862011912021-04-26T14:14:15.938+00:002021-04-26T14:14:15.938+00:00Michael Eades has been musing about Covid. https:/...Michael Eades has been musing about Covid. https://ckarchive.com/b/75u7h8h7ml8lcavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-68944112343873683092021-04-25T17:58:13.251+00:002021-04-25T17:58:13.251+00:00https://www.reuters.com/world/middle-east/israel-e...https://www.reuters.com/world/middle-east/israel-examining-heart-inflammation-cases-people-who-received-pfizer-covid-shot-2021-04-25/Anonymoushttps://www.blogger.com/profile/03706594519841547103noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-11655720675484522672021-04-20T14:18:00.635+00:002021-04-20T14:18:00.635+00:00I have to say that crossed my mind too but I'm...I have to say that crossed my mind too but I'm not certain. It's quite convincing from the Israeli data that immunosuppression after the first dose of the Pfizer vaccine, as documented in early reports, is real and that goes a long way to explaining the catastrophe in the UK where vaccination coincided with a moderate winter resurgence. Leucopaenia + virus = badness. In Israel infection rates were plummeting at the time of roll out, much as they were in the UK at the time of the now defunct phase 3 trials starting last year.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-43840426389327454642021-04-19T19:11:26.516+00:002021-04-19T19:11:26.516+00:00First evidence of ADE: https://www.medrxiv.org/con...First evidence of ADE: https://www.medrxiv.org/content/10.1101/2021.04.06.21254882v1/Outlawhttps://www.blogger.com/profile/17850651368082684523noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-21234866241011923372021-04-04T04:52:50.688+00:002021-04-04T04:52:50.688+00:00Eric, there was speculation in the comments to a D...Eric, there was speculation in the comments to a Derek Lowe post that inadvertent IV injection of the adenovirus-vectored vaccine might be to blame. Might also explain that more women are suffering than men because of their lower shoulder muscle mass. Aspiration of the syringe is discussed as well. Someone also mentioned these problems are happening in the US with the mRNA vaccines, too.<br /><br />https://blogs.sciencemag.org/pipeline/archives/2021/03/30/blood-clots-and-the-az-vaccine-revisited<br /><br />As always, lotta speculation, not enough time yet to know.LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-64086483317290614802021-04-04T04:33:50.397+00:002021-04-04T04:33:50.397+00:00Captain Sunset,
Talked to my friend a little whil...Captain Sunset,<br /><br />Talked to my friend a little while ago (Saturday night in California), and she said her arm is much better. Says she left work early yesterday as she simply couldn't work. Good to know she's getting better.<br /><br />I am and have been completely aligned with Peter's parting advice in the next post: Unless you feel mortally threatened from COVID, don't jump mindlessly at the jab. <br /><br />Astonishing we've thrown out everything the US FDA was purportedly created for in the rush to stop a disease which is particularly severe for such a relatively small portion of the population.<br /><br />See also: https://twitter.com/puddleg/status/1377825141401391104<br />LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-80272435159339329062021-04-03T14:55:10.667+00:002021-04-03T14:55:10.667+00:00@Bob, As I understand it (from a recent paper - bu...@Bob, As I understand it (from a recent paper - but can't recall which one!) if you have recently had Covid you can get up to a 6-fold reaction to any of the 'new' vaccines. Further, I do know of many doctors (such as Dr Micheal Eades), who do not recommend children or infected folk getting the vaccine. In fact, Dr Eades has stated that he is horrified at the thought of children getting the vaccine. Dutiful colleagues of mine who have had both Covid and the vaccine generally were totally whacked out for a week. Interestingly, as I also understand it there is 100-fold greater amount of ACE2 receptors in the gut as opposed to the lungs. Hence why sewage farms can be good places to pick up Covid levels. I don't think I have had Covid19 but I did have had some odd gut issues in the summer of 2020. Also, I think I believe I have had coronaviruses and other virus infections over the last few years from playing golf in all weathers with all sorts of people, but with no issues. I seem to get quite a few winter sniffles, but they only last a day or so. My take is that these are just simple virus 'update's. They keep me healthy.Captain Sunsethttps://www.blogger.com/profile/02311948187008278883noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-16172838782195912902021-04-03T01:47:09.110+00:002021-04-03T01:47:09.110+00:00"What would happen if you had already recover...<i>"What would happen if you had already recovered from the field virus and so were very primed to effectively attack anything looking remotely like a SARS-CoV-2 virus surface protein?"</i><br /><br />I might have a hint of a preliminary answer to that. I know someone who works on a food processing assembly line. Despite double-masking, face shields, gowns, boots, and gloves, she was diagnosed with symptomatic COVID last December. PCR-positive. I was almost certainly exposed as I took her to urgent when she was first ill (and swabbed) and present to help her get her results over the phone. I never had any symptoms. <br /><br />On Thursday she got her first Moderna shot, courtesy of her employer. I would have suggested she not bother, but this would not have worked as a subject for discussion. On Friday she complained of headache, trembling, and a very sore and swollen left arm. I suddenly imagined legions of IgG antibodies (and probably cytotoxic T-cells) attacking her "infected" muscle cells.<br /><br />We'll see how long she takes to recover. But I'm of the opinion now that getting the mRNA vaccine after a field infection is not only unnecessary but probably a bad idea. Hopefully not a <i>very</i> bad idea.LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-74507002578196434342021-04-02T15:51:00.730+00:002021-04-02T15:51:00.730+00:00@Peter / @Numbbum, I am 70 in July. Until about a ...@Peter / @Numbbum, I am 70 in July. Until about a year ago the game of golf was on a bit of a decline, but since the lockdowns, it has now (seemingly) exploded in popularity, which I find interesting as I come at golf from a rugby heritage. Anyway, back in the summer (2020) I tried to get a board member of England Golf to team up with the Ramblers to do a quick survey on active members to see who had suffered with covid. My thinking was that the older demographic might throw up some surprises in respect of vitamin d3 levels (...I am a vit D believer from way back!), but alas it repeatedly fell on deaf ears. Anyway, along similar lines, I have discussed LDL & Cholesterol and Statins & the pros of LCHF with many fellow golfers, and it is virtually impossible to have anything of a sensible 'grown-up' conversation with those who take the statin view. Dogma rules. Discussions often descend into food spluttering 'madness'. This has never happened before - with the exception of discussions on religion! My mind was turned on statins about 10 years back over the effects they had on some elderly family members, and the efforts of DR MK. As Peter stated such matters do become something of a long-haul! Highly defensive sunk cost errors run very deep.Captain Sunsethttps://www.blogger.com/profile/02311948187008278883noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-66977752845247922302021-04-02T11:58:14.378+00:002021-04-02T11:58:14.378+00:00"Captain, I still think late 2023 we might ha..."Captain, I still think late 2023 we might have some idea re vaccine safety and efficacy. Until then it’s a matter of managing the degree of coercion. At the moment it feels like there is some kickback starting, but LC vs LF felt that way for 15 years before we now finally have some progress."<br /><br />Stents are still being fitted and statins are still being handed out like Smarties to ever younger people. Don't hold your breath.Numbbumhttps://www.blogger.com/profile/12492641412567235281noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-43386532166027717722021-04-02T08:39:44.962+00:002021-04-02T08:39:44.962+00:00This was in this morning's newsfeed at Zeit.de...This was in this morning's newsfeed at Zeit.de. I can't permalink because it keeps changing:<br /><br />30 blood clot cases after AstraZeneca vaccination in the UK<br /><br />Nowhere have so many people been vaccinated with the AstraZeneca drug as in the United Kingdom, but it is only now that a cluster of blood clots is coming to light: According to authorities, 30 cases have been recorded there in which a rare blood clot occurred after vaccination with the drug. The number of cases has risen sharply in the past two weeks - from an initial five to 30.<br /><br />According to our medical editor Tom Kattwinkel, that's probably because in the U.K., only people over 80 initially received the AstraZeneca vaccine, and it's only now being used for younger people, who are at higher risk for these thromboses.<br /><br />The UK Medicines and Healthcare products Regulatory Agency says no thromboses have been recorded following use of the BioNTech/Pfizer vaccine.<br /><br />Translated with www.DeepL.com/Translator (free version)Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-32161150362590189672021-04-02T04:47:44.366+00:002021-04-02T04:47:44.366+00:00Hey Peter,
Have you ever had a look into the epid...Hey Peter,<br /><br />Have you ever had a look into the epidemic of hair loss among young men? I haven‘t looked yet but the simple „too much T/DHT“ which some people give as an answer doesn‘t strike me as convincing or even as being an answer. <br /><br />Thanks,<br />MariusMariushttps://www.blogger.com/profile/07929229222478455844noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-53915874378673046272021-04-01T12:02:15.081+00:002021-04-01T12:02:15.081+00:00Greifswald study published as a preprint:
https://...Greifswald study published as a preprint:<br />https://www.researchsquare.com/article/rs-362354/v1<br /><br /><br />https://www.zeit.de/wissen/gesundheit/2021-03/astrazeneca-corona-impfstoff-regelung-alter-nebenwirkungen-zweite-impfung-faq<br />Now 31 cases in Germany in 2.7 million vaccinated, all under 60, most significantly younger and 29 female. In the UK, 5 cases among ??, but UK seems to have vaccinated mainly 80+ with this vaccine.<br /><br />As of 29 March, the Paul Ehrlich Institute (PEI) has been notified of 31 cases of specific cerebral venous thrombosis that occurred following vaccination with Vaxzevria from AstraZeneca. 19 of the affected people suffered from a deficiency of blood platelets at the same time, nine people died. 29 of those affected were women aged between 20 and 63. The men were aged 36 and 57.<br />In the meantime, 2.7 million people across Germany have received the vaccine from AstraZeneca. So there is one case for every 87,000 people vaccinated. This means that although the complication is very rare, it mainly affects those who do not have an increased risk of contracting Covid-19 - namely younger people. "Thus, this particular complication seems to occur much more frequently among younger people after vaccination with AstraZeneca than previously known," said infectiologist and vaccine researcher Leif Erik Sander to ZEIT ONLINE. <br /><br />To put this into perspective: when about 1.6 million doses had been vaccinated on 16 March, only one case of a complication such as cerebral venous thrombosis could have been expected by chance, according to the Paul Ehrlich Institute. However, with more than 2.7 million vaccinations in the meantime, the few cases that have occurred are now an accumulation that must be investigated.<br /><br />Recently, the UK announced that 30 million people in the UK have now received their first dose of an approved vaccine. However, it is not entirely clear how many of these have received AstraZeneca's Vaxzevria vaccine and, more importantly, how old they were. As of 14 March, five cerebral vein thromboses occurred after vaccination with Vaxzevria - more recent figures have not yet been published. This means that this complication seems to be much rarer. The reason for this is currently being investigated. An obvious hypothesis: the average age of those who received the drug from AstraZeneca is probably much higher than in Germany, for example. An analysis of more than one million vaccinated people in Scotland shows that Vaxzevria was mainly given to people over 80, while those under 65 were mainly given the vaccine from BioNTech (KHub: Bernal et al. 2021). And an accumulation of cerebral venous thrombosis and platelet deficiency after vaccination with Vaxzevira was only found in Germany in people under 60 years of age.<br /><br />Translated with www.DeepL.com/Translator (free version)<br /><br />Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-42573531774790841502021-03-31T19:57:39.484+00:002021-03-31T19:57:39.484+00:00Oh, BTW E-S, I also worry about cross contaminatio...Oh, BTW E-S, I also worry about cross contamination at the sampling sites. Can't help but recall the Dilbert cartoon about the hazmat suit. https://dilbert.com/strip/2020-10-20<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-19371287253957323112021-03-30T18:54:01.433+00:002021-03-30T18:54:01.433+00:00Bob, I’ve spent the last 20 years watching apparen...Bob, I’ve spent the last 20 years watching apparently sensible people being incredibly stupid. At times I despair of humans…<br /><br />Captain, I still think late 2023 we might have some idea re vaccine safety and efficacy. Until then it’s a matter of managing the degree of coercion. At the moment it feels like there is some kickback starting, but LC vs LF felt that way for 15 years before we now finally have some progress.<br /><br />E-S, no I didn’t but the twitter-sphere gives the impression it’s much as you might expect running 1,000,000 PCR tests a day with inexperienced staff. The sceptics have been saying this all year. They are fully vindicated, not that they need vindication.<br /><br />Eric, I looked briefly at the abstract of the study a little while ago. Do you follow Miki Bendor? He has a paper out with Raphi looking at the selective pressure to develop brain size in this way. Brains are expensive in the extreme. Having a gene which gives you a big brain is a metabolic massive cost. It would only persist if it provided a survival advantage, which it clearly did. I have a lot of time for Miki’s ideas as to what that survival advantage might have been.<br /><br />salix, no, not something I’ve thought much about but the article gives some clues. Athletes have major blood glucose excursions both up and down. What crap do athletes eat? And I would assume that these people have constructed their inner mitochondrial membranes and cardiolipins out of linoleic acid or its derivatives. Throw a few ROS at these and the mitochondria are f*cked… Would we expect to see the same change in an athlete who never, ever was hyperglycaemic and who never, ever consumed heartheathypolyunsaturates? Interesting questions.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-45000016495350277322021-03-30T17:11:16.889+00:002021-03-30T17:11:16.889+00:00Hi Peter, would love to hear your thoughts on impa...Hi Peter, would love to hear your thoughts on impaired mitochondrial function in people who get too much exercise:<br /><br />https://www.nature.com/articles/d41586-021-00703-x<br /><br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-36840063.post-29345742247090274622021-03-30T12:22:53.654+00:002021-03-30T12:22:53.654+00:00@Peter did you see the BBc’s fresh evidence of fau...@Peter did you see the BBc’s fresh evidence of faulty practices in NHs testing for Covid ? https://www.bbc.com/news/uk-56556806<br /><br />This is so disgraceful I have no words.<br /><br />@Eric - what about the smooth transition of brain size along hominins & hominids ? Also a larger brain has big thermodynamic implications, hence why homo sapiens has innovations for keeping the braincase from overheating, like plenty of vascularized foramina. Doesn’t look like a singular switch at all...E-Shttps://www.blogger.com/profile/11618396250935467279noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-66320992847446878372021-03-30T10:15:10.873+00:002021-03-30T10:15:10.873+00:00Hi Peter,The GP/NHS txt’s keep coming, but it’s no...Hi Peter,The GP/NHS txt’s keep coming, but it’s not the hypodermic, but the hyperbole that bothers me. I’ve been jabbed up more than most folk in the UK, but what actually does bother me is the sheer amount of rank, and comprehensive technocratic stealth being pushed. I’ve experienced this global-like fervour before when called up for National Service/The Vietnam War in Australia (in ‘72), and later (in ‘78) when I was country manager for a small UK engineering group in Iran. Having arrived in Tehran for a 3-year stint in March it soon became evident to me that matters were not good in the country. As such, I kept sending back reports to London, and so in November the Chairman, and the MD of a subsidiary rerouted a visit to Australia to come and check matters out. In a few days, we managed to meet a lot of people including the local MI6 man, Bankers, and the British Ambassador (Anthony Parsons - the ambassador of the UK’s second-largest Embassy, after Washington). Well, all kinda poo-pooed my fears, and not least the BBC, and the US and UK MSM, as well as the (large) US Military contingent. So, they soon left for Australia after some heated words with me. When they arrived in Sydney on the 5th November they bought the first Newspaper they could in the transit lounge, and the front page of most of the Sydney Morning Herald was a picture of an armed mob who had taken over the whole of the British Embassy and ransacked its main building. I finally left Tehran on the 24th of December on one of the last scheduled flights out - Singapore Airlines to Copenhagen. Anyway, sorry for the digression!<br />Captain Sunsethttps://www.blogger.com/profile/02311948187008278883noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-41995469512672242662021-03-29T21:33:57.221+00:002021-03-29T21:33:57.221+00:00Peter, I'd like to find someone giving IgA tes...Peter, I'd like to find someone giving IgA tests. A company in my state (Salimetrics in Calfornia) has a saliva test, but it's for folks doing "studies". They don't offer it to individuals (I asked), and they don't know of any labs using it.<br /><br />Everything else I've seen is serology.<br /><br />A few weeks ago I ago I spoke with a retired molecular biologist. I wanted his take on IgA, ADE, and so on. He said, "Those are good questions, but they are not the important questions. The important thing is to get this plague behind us". <br /><br />What a fustercluck.<br />LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-13585480586492522092021-03-29T21:24:40.423+00:002021-03-29T21:24:40.423+00:00Justin,
I think you answered your own question in...Justin,<br /><br />I think you answered your own question in the link provided. It says "vaccine candidate". <br /><br />AstraZeneca begins clinical trials on the nasal vaccine.<br /><br />https://www.ft.com/content/48fe2e97-f9e5-4291-b965-0728bfc42213<br /><br />I think we're some way from "availability". Remember, the messaging for the intravenous vaccine is badly mangled. It's "We don't know if it prevents infection" vs "Take the shot to protect others." LA_Bobhttps://www.blogger.com/profile/09775262019154051166noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-8698759638606563832021-03-29T19:54:04.216+00:002021-03-29T19:54:04.216+00:00OT - lead exposure - OA - CAD - T2D..
https://www...OT - lead exposure - OA - CAD - T2D..<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132016/<br />https://pubmed.ncbi.nlm.nih.gov/16670857/<br />https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(18)30025-2/fulltext<br />https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(18)30128-2/fulltextkarlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-61098072555924475662021-03-29T08:44:52.023+00:002021-03-29T08:44:52.023+00:00Hi Justin,
Sorry I missed that. I've no idea ...Hi Justin,<br /><br />Sorry I missed that. I've no idea if anyone is marketing an intranasal vaccine. If so I suspect it would produce better immunity, espec IgA, but I've no idea if it's available...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-63350937140498649902021-03-28T20:47:44.104+00:002021-03-28T20:47:44.104+00:00Captain Sunset, I guess that kind of answers my qu...Captain Sunset, I guess that kind of answers my question. I like the narrow band analogy! Lol!Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.com