tag:blogger.com,1999:blog-36840063.post5252640208201543277..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: Insulin in the brain: off topic gigglePeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger12125tag:blogger.com,1999:blog-36840063.post-31993444150420287612012-08-07T17:07:19.174+00:002012-08-07T17:07:19.174+00:00O Numnos., Oh sh*t. Too tired!O Numnos., Oh sh*t. Too tired!Peterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-64245463716715724242012-08-07T07:48:23.245+00:002012-08-07T07:48:23.245+00:00@Peter
Er, I was being sarcastic....as it was a s...@Peter<br /><br />Er, I was being sarcastic....as it was a shits 'n' giggles pieceSS Bikerhttps://www.blogger.com/profile/00678581205592336725noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-1766424703719594322012-08-07T01:54:09.835+00:002012-08-07T01:54:09.835+00:00@Unknown
Caffeine, nicotine, and alcohol are my f...@Unknown<br /><br />Caffeine, nicotine, and alcohol are my favorites, but I'm limited to those drugs that won't show up in a urinalysis.Sam Knoxhttps://www.blogger.com/profile/15632591648777098250noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-14579248835803839632012-08-06T21:44:55.416+00:002012-08-06T21:44:55.416+00:00I try to avoid it only to cave and read a few days...I try to avoid it only to cave and read a few days after he posts an entry like some kind of weak willed junk sick addict. The crazy cancels out the response to nausea, sort of how haloperidol or metoclopramide does.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-16032179954055221722012-08-06T20:38:38.477+00:002012-08-06T20:38:38.477+00:00O Numnos, no no no. You are not following the proc...O Numnos, no no no. You are not following the process through. Central insulin promotes DNL in adipocytes using the sympathetic nervous system. DNL generates palmitoleate which increases whole body insulin sensitivity, normally in association with increased adipocyte storage of the de novo lipids, ie it makes you fat, as per the micrographs (did you look at them?). This is obvious, you would expect that high insulin indicates an need for running metabolism on glucose and a need to divert fat to storage. Blocking this action by knocking down selected hypothalmic insulin receptors should leads to whole body insulin resistance (reduced palmitoleate from adipocytes) and a need to increase insulin to maintain normoglycaemia if you are on a high carbohydrate diet, with a subsequent storage of fat in adipocytes secondary to this hyperinsulinaemia, obviously once the hyperinsulinaemia is sufficient to overcome the lack of palmitoleate generation in adipocytes.<br /><br />You're sounding like an obesity researcher, sorry for the gross insult.<br /><br />These might help you:<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/21284985<br />http://www.ncbi.nlm.nih.gov/pubmed/18805087<br /><br />@Unknown, see a pharmacist!<br /><br />@Its, we all know you're crazy as well as very perceptive, but how the hell do you STILL mamange to read WHS? That is pathological! Are you stealing ondansetron from work????<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-18647418471367459542012-08-06T20:19:11.528+00:002012-08-06T20:19:11.528+00:00karl,
The writing style itself is so different. ...karl,<br /><br />The writing style itself is so different. Whereas the tone used to seem inquisitive, papers are now written as close-minded persuasions. <br /><br />As Woo sort of implies, Whole Health Source made a similar transition, but it took only a couple years.Johnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-60095221461278819092012-08-06T20:03:19.969+00:002012-08-06T20:03:19.969+00:00Yaya sleep stupid peter.
I remember once I invest...Yaya sleep stupid peter.<br /><br />I remember once I investigated S. Guyenet's references and discovered he completely misrepresented them. Like, entirely and utterly , overt fraud. It was apparent when he copy + pasta'd he didn't G.A.F. what the link contained, just as long as he could put a number next to his writing and make it look all serious.<br /><br />Scary to think they are all this bad. Or worse.<br /><br />PS <a href="http://wholehealthsource.blogspot.com/2012/07/how-should-science-be-done.html" rel="nofollow">this was funny</a>. Here he's pretending to be an objective impartial servant of science, blindly going where the evidence leads him. HAHA! This from the same man who just a few weeks ago was behaving like a SNL superfan regarding his hypothesis. According to Stephan Guyenet, if the food reward hypothesis were matched against god + insulin hypothesis in football the score would be 338439 to 1.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-69602428376219555812012-08-06T18:32:51.208+00:002012-08-06T18:32:51.208+00:00It used to be that there were a few bad papers pub...It used to be that there were a few bad papers published - it is getting to the point where there are more bad papers (where the experiment is flawed, the conclusions defy logic, application of matlab without understanding the underlying statistics or just plain fraud) than good. Instead of advancing science they are muddying the water. <br /><br />I do remember that insulin has been used to stimulate appetite in treating anorexia. Has this been forgotten?<br /><br />I think there are a number of papers that are intended to simply keep the grant money flowing - carefully designed as to not challenge the accepted theory. The effort should be to establish the arrow of causation of correlations - apply the null hypothesis - yet there are so many experiments that no matter what the results were - at the end we have learned nothing.karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-26954491496100719832012-08-06T17:17:32.971+00:002012-08-06T17:17:32.971+00:00It's offtopic, I seem to have taeniasis possib...It's offtopic, I seem to have taeniasis possibly acquired after a few days in Thailand.<br />What drugs would you recommend?Unknownhttps://www.blogger.com/profile/15980830760192539367noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-62185516282959570782012-08-06T16:25:36.041+00:002012-08-06T16:25:36.041+00:00I think the bottom line is that insulin's anab...I think the bottom line is that insulin's anabolic affect is substantially greater than its affect to promote satiety. <br /><br />Besides the complication of needing to consider what receptor insulin binds to ( which is really what matters ), if insulin was any good suppressing appetite then injecting insulin should reduce food intake and reverse obesity.<br /><br />But we all know what injecting insulin really does..............Kindkehttps://www.blogger.com/profile/15841418412425329998noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-69570640257983882782012-08-06T14:29:57.777+00:002012-08-06T14:29:57.777+00:00@O Numnos: "where it (insulin)modulates a var...@O Numnos: <i>"where it (insulin)modulates a variety of functions, including the regulation of food intake..."</i><br /><br />So are we to assume that "regulation" of food intake has only one action... that of <i>inhibiting</i> it?FrankGhttps://www.blogger.com/profile/01980497914756341565noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-90135526872071911332012-08-05T20:25:12.301+00:002012-08-05T20:25:12.301+00:00And yet in the discussion the authors state "...And yet in the discussion the authors state "where it (insulin)modulates a variety of functions, including the regulation of food intake..."<br /><br />And ref #28 http://www.ncbi.nlm.nih.gov/pubmed/12021765?dopt=Abstract<br /><br />Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats.<br /><br />There you go, satiety hormone ;-)SS Bikerhttps://www.blogger.com/profile/00678581205592336725noreply@blogger.com