tag:blogger.com,1999:blog-36840063.post5809949878262040765..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Are you free, T3?Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger40125tag:blogger.com,1999:blog-36840063.post-67923801102893831962014-06-29T03:11:41.478+00:002014-06-29T03:11:41.478+00:00Or you could just check body temperature which dir...Or you could just check body temperature which directly measures the effect of free t3 on the body, because even measuring free t3 ignores the fact that there is an extreme variability in the bodies ability to absorb thyroid hormone(chronic pain or chronic dieting are two examples of thing that can change absorption)-by the way thyroid hormones don't enter cells by diffusion, its an energetic process..so anything that affects cell energy can make you hypothyroid.Anonymoushttps://www.blogger.com/profile/18095861945865244074noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-71123223402349346402012-07-22T02:11:21.259+00:002012-07-22T02:11:21.259+00:00After a week of kelp the kelpie is quite different...After a week of kelp the kelpie is quite different. Wags tail, is affectionate again, looks good (no longer prematurely aged posture and emo behaviour). Despite ongoing rain and darkness.<br />Brilliant.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-35024595711153297532012-07-21T14:39:05.627+00:002012-07-21T14:39:05.627+00:00Has anyone noticed that the groups of people who s...Has anyone noticed that the groups of people who seem to be able to live healthily on a high carb diet (ie Kitavans Tokelauans, Okinawans, to name a few) all live near the ocean? Could the high consumption of fish and increased mineral concentration of the soil be part of the puzzle? Does anyone know of any groups of people who are land locked who enjoy the level of health of the Kitavans on a high carb diet? Also, accroding to Dr Brownstein http://www.vitamincfoundation.org/iodine.htm the great lakes region has some of the lowest soil iodine levels in the world.Olgahttps://www.blogger.com/profile/15346661892269510469noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-55584872081522911622012-07-21T11:07:58.158+00:002012-07-21T11:07:58.158+00:00Link for that post is Ketogenic Diets, Cortisol, a...Link for that post is <a href="http://www.ketotic.org/2012/07/ketogenic-diets-and-stress-part-i.html" rel="nofollow">Ketogenic Diets, Cortisol, and Stress: Part I — Gluconeogenesis </a>Amber O'Hearnhttps://www.blogger.com/profile/10125813379900433577noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-41899613197097920812012-07-21T11:03:27.939+00:002012-07-21T11:03:27.939+00:00Thank you for this.
I completely agree with you...Thank you for this. <br /><br />I completely agree with your comments on the cortisol paper. We just did a post on ketogenic diets and cortisol on ketotic.org. the first part was about the myth that gluconeogenesis requires an excess of it, but the second part is going to address, among other things, why urinary cortisol is not a particularly useful measurement here, and how a ketogenic diet seems to improve what really matters.Amber O'Hearnhttps://www.blogger.com/profile/10125813379900433577noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-18101416128380166812012-07-20T01:49:47.557+00:002012-07-20T01:49:47.557+00:00One more point. Is it possible that there is so m...One more point. Is it possible that there is so much repair going on in the body when switching to low carb that the iodine present in the body is rapidly consumed by various systems resulting in depletion? Where as,the body may be getting a just adequate amount of iodine while it limps along on the SAD from bread containing ca propionate (most breads in North America).Olgahttps://www.blogger.com/profile/15346661892269510469noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-66525290991738904562012-07-20T01:40:22.371+00:002012-07-20T01:40:22.371+00:00Hi Peter:
Thanks for this post about iodine. I am...Hi Peter:<br />Thanks for this post about iodine. I am curious about the link to the paper suggesting that high carb increases T3 production and therefore iodine requirements. It has also been suggested that going low carb may cause iodine deficiency in some people, since bread is a source of iodine due to the use of calcium propionate as a dough conditioner. Here is a post from Richard at Free the Animal about this: http://freetheanimal.com/2010/01/the-hidden-benefit-of-the-sad-iodine.html Any thoughts?Olgahttps://www.blogger.com/profile/15346661892269510469noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-45459830190742993402012-07-19T01:54:21.995+00:002012-07-19T01:54:21.995+00:00Kelp for the Kelpie...Kelp for the Kelpie...Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-60441960601139054172012-07-19T01:44:19.733+00:002012-07-19T01:44:19.733+00:00A few weeks ago our dog (kelpie 2YO) became depres...A few weeks ago our dog (kelpie 2YO) became depressed then spooky, lost hair, and had discouloured patches on skin.<br />She also lost tolerance to fleas and they drove her crazy. We treated her, vet diagnosed flea allergy as cause of hair loss, prescribed antibiotics (she also had mastitis) and steroids.<br />These helped, I also gave her Vit D and fish oil as it's midwinter.<br /><br />Since reading this, thyroid involvement seems likely.<br />I've added kelp to her food and she loves it (which surprised me as she hates greens). I'll keep you updated.<br /><br />Could low vit D and low serotonin in midwinter trigger low thyroid, which would then cause Th2 immune problems, resolved by corticosteroids?<br /><br />This suggests that even the mastistis could be linked to the vthyroid:<br />http://browncnc.wordpress.com/2011/01/26/thyroidendocrine-crosstalk-part-3-a-the-thyroid-gland-has-crosstalk-with-every-tissue-in-your-body/<br />(Admittedly it's from an ayurvedic chiropracter, but it seems credible).<br /><br />There are crucial relationships between the thyroid gland and the reproductive/endocrine systems in males and females.<br /><br />In females, thyroid imbalances lead to pituitary-gonadal dysfunctions which include alterations in FSH and LH hormone coordination and release, ovarian FSH receptor site sensitivity, and peripheral progesterone receptor sensitivity. These imbalances lead to miscarriages, ovarian cysts, infertility, migraines, weight gain, mood disorders, depression, and abnormal menstrual cycles. Sometimes the endocrine symptoms are so pronounced that the thyroid culprit is overlooked. Conversely, the use of synthetic hormones such as birth control pills or hormone replacement therapy (HRT), in addition to insulin surges and stress responses, lead to abnormal spikes of hormones such as estrogen, cortisol, and testosterone, which disrupts healthy thyroid function.<br /><br />Estrogen and thyroid:<br />http://physrev.physiology.org/content/82/4/923.full<br /><br />http://www.wisegeek.com/what-causes-mastitis.htm<br />Diabetes and thyroid problems can also cause mastitis.<br /><br />Yup.<br />This was a very timely post Peter.<br />A little more iodine in the Kelpy's diet from now on.<br />Thanks very much.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-15355195315184341312012-07-16T12:32:42.908+00:002012-07-16T12:32:42.908+00:00smgj said...
"the t3 in dessicated are prote...smgj said...<br /><br />"the t3 in dessicated are protein-bound so it will NOT act identical to syntetic t3 in the body. But how the difference will manifest itself - except for a much longer half-life - I don't know."<br /><br />My endo uses both T3 and compounded desiccated thyroid extract. They both work very well, at the right doses and delivered in time release form. He has had to learn through experience how to set and adjust the doses and forms of administration for each—impossible to derive this info from the chemistry (and he is also a PhD organic chemist). <br /><br />He has found that time release is very beneficial in both cases. An exception is topical administration, as I am doing at the moment, where unlike in the gut it seems that the absorption process itself provides the needed slow release.WilliamShttps://www.blogger.com/profile/09021312909928686165noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-24419630749789575872012-07-16T10:53:20.178+00:002012-07-16T10:53:20.178+00:00@Richard
I am sorry to be the bearer of bad news b...@Richard<br />I am sorry to be the bearer of bad news but body fat is actively regulated by the CNS. This does not mean we can't force weight lower or higher, it only means we will have to FORCE it that way, i.e. under/over eat on purpose many days; and if we fail to do that our weight will naturally edge to the baseline.<br /><br />Progressive weight gain or loss can occur but only in some kind of endocrine pathology; e.g. hyperinsulinemia & hypoglycemia from a tumor or a FUBAR metabo -> fatafataftaf forever.<br /><br /><br />WIth that said, the body fights weight loss. Tricking your fat tissue to deflating -> lower leptin -> suppresion of hypothalamic TRH/TSH, more rT3, less free T3, lower SNS (gimped fat oxidation), diabetilicious liver spewing sugar like crazy, glucose intolerance/IR, and a myriad other ways to make you chub up until the leptin hits the sweet spot (i.e. your fat tissue grows and makes lots of it to soak your brain in it).<br /><br />Really, these findings aren't controversial. They are SUPER common.<br /><br />The golden rule: The better , more effective, more powerful the diet... the more severe the lack of leptin, thyroid, and counter regulation to the fat growth suppression.<br /><br />Therefore, VLC = me suppression of leptin & thyroid, cuz VLC = inhibited fat growth.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-89430876058742694152012-07-16T07:04:18.992+00:002012-07-16T07:04:18.992+00:00GeorgeH - That are very interesting thoughts about...GeorgeH - That are very interesting thoughts about omega3s and thyroid. I'll certainly look for more onformation on the subject.<br /><br />When it coms to hot/cold one also have to realise that iron stores, copper and zinc have an impact on basal temperature.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-36840063.post-43050747785930935632012-07-15T23:12:51.701+00:002012-07-15T23:12:51.701+00:00In terms of hot and cold as symptoms of t3 levels,...In terms of hot and cold as symptoms of t3 levels, what about serotonin?<br />Will supplementing 5-HTP when "euthyroid sick" alter symptoms?<br />t3 enhances serotonin; what if low serotonin is sometimes mistaken for, or the only troublesome symptom of, euthyroid low T3?<br />This experiment, if successful, might suggest simpler adjustments than gaining weight or taking T4/T3.<br />Intakes of EPA, DHA and AA might also need to be higher than in some strict low-PUFA diet plans, due to LDL-R/thyroid crosstalk phenomenon.<br />As indeed they are in Inuit diet.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-29375373201441578212012-07-15T17:30:07.144+00:002012-07-15T17:30:07.144+00:00@Karl - High iodine may actually rise TSH - in ord...@Karl - High iodine may actually rise TSH - in order to get the iodine into the thyriod. Dr. Brownstein talks about this. <br /><br />And it's nearly useless to discuss the effect of iodine on thyriod without adding selenium into the equation. Iodine without enough selenium may severly harm. <br /><br />As for the fact that LCHF seems to lower thyroid pathways, it may well be that fat-adapted humans need less thyriod hormons. But I don't think blood tests ever will tell us the truth about that. <br /><br />@WilliamS - the t3 in dessicated are protein-bound so it will NOT act identical to syntetic t3 in the body. But how the difference will manifest itself - except for a much longer half-life - I don't know.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-36840063.post-85409707863357771632012-07-14T14:51:42.840+00:002012-07-14T14:51:42.840+00:00This paper http://www.ncbi.nlm.nih.gov/pubmed/7326...This paper http://www.ncbi.nlm.nih.gov/pubmed/7326852 looked at long-term Thyroid hormone status in obese patients on a (very) hyporcaloric diet some of whom recieved supplemental T3 and others a placebo.<br /><br />The extract tells us nothing about the diet - one assumes it's low fat at the level of calories unless protein and/or carbs are very low.<br /><br />I assume they were looking at weight loss as a proxy for metabolic rate correlated to hormone status.<br /><br />No difference in weight loss between groups, no sig change for placebo group in T4/rT3 or free T3.<br /><br />Mind you this was severe long term calorie restriction.SS Bikerhttps://www.blogger.com/profile/00678581205592336725noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-6772986182089552942012-07-14T12:42:11.100+00:002012-07-14T12:42:11.100+00:00Javeux said...
"Is the 'alternative'...Javeux said...<br /><br />"Is the 'alternative' part of Blanchard's approach referring to CAM junk? From what I've read, there seems to be a lot of sense in the idea of T4+T3, but having proponents associate themselves with CTM and other unscientific treatments seems like a great way to lose credibility."<br /><br />I haven't read the new manuscript, but I imagine "alternative" here refers to his use of T3 and pig thyroid extract—which, outside of psychiatry at least, is well outside the mainstream standard of care and is the province of "alternative" practitioners. <br /><br />The "traditional" part I imagine refers to his use of T4, which mainstream docs use exclusively for hypothyroidism but many "alternative" practitioners shun. (They seem to think it's unnatural, but really it is a kind of bioidentical hormone replacement. So is T3.)<br /><br />I see plenty of "junk" and "unscientific treatments" in both conventional and alternative medicine. Lots of glass houses in both worlds I'm afraid.WilliamShttps://www.blogger.com/profile/09021312909928686165noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-60483371804383364652012-07-14T12:24:12.330+00:002012-07-14T12:24:12.330+00:00ItsTheWooo said...
"Your situation reminds m...ItsTheWooo said...<br /><br />"Your situation reminds me of my own. You know T3 will helps hypothyroid patients, just like I know leptin will help weight reduced obese patients.<br /><br />Ultimately there is no money to be made in any of these treatments, because you can't patent hormones"<br /><br />Yes, and in addition the unbelievable resistance to change in the medical establishment is another big problem. After all, T4 is unpatentable, too, like insulin. <br /><br />Some of it I think is justifiable fear of reprisals for venturing outside the standard of care. The system is highly authoritarian, despite all the propaganda about "evidence based medicine." Some is just a failure to think, plus careerist resistance to admitting error, institutionalized rigidities, etc. <br /><br />It is so easy to dismiss highly promising, virtually risk-free ideas such as trials of low-dose T3 or leptin supplementation for suffering patients—no supporting randomized controlled studies! Of course the emperors saying this know perfectly well how much of what doctors do routinely lacks RCT support as well. <br /><br />There are other kinds of evidence. Like watching patients get better before your eyes. That does require being willing to open them. This will take a long time.WilliamShttps://www.blogger.com/profile/09021312909928686165noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-11130061682372538902012-07-14T10:10:41.617+00:002012-07-14T10:10:41.617+00:00WilliamS,
Is the "alternative" part of ...WilliamS,<br /><br />Is the "alternative" part of Blanchard's approach referring to CAM junk? From what I've read, there seems to be a lot of sense in the idea of T4+T3, but having proponents associate themselves with CTM and other unscientific treatments seems like a great way to lose credibility. <br /><br />By the way, there's an ongoing petition for T4+T3 research for anyone in the UK http://epetitions.direct.gov.uk/petitions/19000Javeuxhttps://www.blogger.com/profile/07981313840146597986noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-56358656490190226102012-07-14T05:52:30.556+00:002012-07-14T05:52:30.556+00:00@mfairchild
Evolutionarily, the original thyroid ...@mfairchild<br /><br />Evolutionarily, the original thyroid hormone was probably iodine. What is added to the iodine makes it more potent. <br /><br />Way high iodine can cause a form of hypothyroidism, but what I think you are talking about is that one needs less thyroid hormone if there is more iodine available - thus I would expect that iodine would push TSH down as the iodine acts like very weak T3. (At one time they treated hypothyroidism with iodine - that was all they had. ) <br /><br />Two more links<br />http://iodineonmymind.com/facts<br /><br /><br /> http://www.anaesthetist.com/icu/organs/endocr/thyroid/thyfx.htmkarlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-36098619321559919132012-07-14T04:30:48.504+00:002012-07-14T04:30:48.504+00:00Woo
I don't think it's quite that bad, bu...Woo<br /><br />I don't think it's quite that bad, but then I've never been obese or even close. I had 10 extra lbs for a long time, and didn't worry much about that.<br /><br />I agree that the idea of food reward causing obesity is quite unsupportable, and the reward idea is, as you say, an effect, not a cause. <br /><br />The problem here is that we may be talking about several different situations: Normal people who have some extra weight, thin people who want to stay that way, fat people who can be helped and easily recover, and fat people who can lose weight and still have serious problems with their metabolism. <br /><br />The way I see it the answer for all of this is low carb, possibly with varying degrees of very low carb to start with. Regardless of the patient or complaint. <br /><br />What has to be considered is that the results may be slightly different and the people may have various reactions over-all. But if someone complains enough about the results of low carb, they can try the alternate approach. Which would be what??? <br /><br />Second, as discussed elsewhere, "normal" thyroid means very little. Years ago (about 25), when i weighed 145 as opposed to 155 now, after being at 165 for many years, I was told by my doctor that based on my thyroid levels I should be fat and sleepy. But clearly i wasn't. So there was no need to do anything.<br /><br />The question is whether you want to treat the patient or the numbers. <br /><br />Going into a lengthy analysis of how the system works chemically and biologically is necessary at some level, but there is always a good chance you have it wrong. Not because you haven't thought about it carefully, but because just like any other scientific proposition, it is just the best information we currently have. <br /><br />What does matter is how people feel on low carb and if their health generally or frequently or sometimes improves. <br /><br />I am uncertain from your post, as with most of your posts, exactly what your bottom line is in terms of low carb. It seems like you are saying your thyroid is dropping, in an effort to preserve the fat and save energy, Perhaps. Or it could be you simply do not need all that thyroid hormone if you are not metabolizing that much carbohydrate. <br /><br />How do you feel?<br /><br />My view remains that as an omnivore a few carbs is okay and may even be good. But carbs in excess makes the body believe that an adequate supply of real food (protein and fat) is not available. So the body starts to store the excess carbs as fat for use later. The body is waiting and hoping for better times and proper food. Sad to say, in the current Age of Carbs, that day may never come. <br /><br />After some period of time of excessive carb consumption the metabolism is hopelessly damaged. Or is it? At that point low carb may help, but the question is whether the damaged metabolic parts can recover, and if so, how long will it take? Weeks or months, or years? <br /><br />The idea that the fat is trying to save itself which results in lower thyroid is related to the idea of the set point. We might as well talk about food reward.Richardhttps://www.blogger.com/profile/13579689230767618822noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-53681905814715531152012-07-14T02:30:45.180+00:002012-07-14T02:30:45.180+00:00@WilliamS
Your situation reminds me of my own. You...@WilliamS<br />Your situation reminds me of my own. You know T3 will helps hypothyroid patients, just like I know leptin will help weight reduced obese patients.<br /><br />Ultimately there is no money to be made in any of these treatments, because you can't patent hormones... at least not for long. I'm not surprised no one cares about hte overwhelming research showing leptin replacement + diet will control obesity, and I"m also not surprised a tiny dusting of T3 makes life a ton better for hypothyroid patients. <br /><br />Also, re diabetes: the morons in charge already warn diabetics not to control their blood sugar TOO well and to keep their a1c in the range of vessel and nerve damage. This is based from studies with aggressive use of OHAs and insulin leading to excessive deaths in general.<br /><br />The people Stephan Guyenet works for are waiting for the magic obesity drug that works by some novel mechanism to cauterize the reward pathways in the brain and produce anorexia. So far they've not had luck with this, it tends to make people want to kill themselves even when they succeed. Who would have thought: suppressing reward pathways leads to misery. Duh. Drug induced depression.<br /><br />It's also quite unfortunate that a chronically activated reward value of food is a symptom of obesity and not a cause, and eating less of glucose food w/o fixing anything else is a grossly sub optimal way of attempting to control it.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-51006866913254883812012-07-14T00:48:59.226+00:002012-07-14T00:48:59.226+00:00karl said:
"There is no agreement on just ho...karl said:<br /><br />"There is no agreement on just how to treat hypothyroidism - the research to figure out if T4+T3 treatment is worth it has not been done - yet the body produces 20% as T3 and there are tissues that can not on their own convert T4=>T3 so my take is combined T4+T3 is the conservative treatment - most likely to mimic nature. (The problem with using T3 is is has a shorter half life.)"<br /><br />You are right. <br /><br />For years my endo has been asking the big shots at Harvard to do these studies—or at least send over a resident or two to observe the results in his practice. They won't.<br /><br />The T3 studies that have been done, and are held up as refutation of combined T4/T3 therapy, used grossly too much T3. In this scenario, patients who've been on T4 only therapy initially feel like a million bucks since they're starved of T3, but eventually feel like crap due to T3 overdose and the resulting depletion of long term T4 reserves.<br /><br />We hypothyroids do need T3 in addition to T4, but we don't need a massive overdose. Try giving 10x too much insulin to a diabetic in a study and see how "evidence based medicine" evaluates insulin therapy. The dead bodies will be a bit of a problem.<br /><br />I can tell you that after years of experimentation, my endo has found that almost every hypothyroid person needs both T3 and T4 supplementation, but with T3 does only 1.2% or so of T4 does. In contrast, Armour and other pig thyroid extracts contain roughly 20% T3. Great in the short run for patients starved of T3 by conventional docs, but terrible in the long run.<br /><br />The conventional docs are wrong to say we poor suffering hypothyroids need only T4. The holistic docs are wrong to say we need only "natural" (pig) thyroid extract, which has *too much* T3. We are not pigs (most of us, anyway). And unlike the pigs, we get the pig hormones like Armour via our digestive systems and livers, which radically change the ratios of the constituent hormones. Grinding up pig thyroids and putting them in your mouth is "natural" in only a bizarro kind of way. The pigs don't actually do that. <br /><br />You are also correct that T3, the active hormone, has a short half life, unlike T4, the long term storage form of thyroid hormone. Early on, my endo realized that T3 (or thyroid extract, which he also uses to supply T3, along with T2, etc.), should be delivered in a time-release form. He once met a pharmacist at a party who explained how easy it would be to prepare time-release T3 or pig thyroid extract, providing exactly the desired (low) dose of T3 over many hours. The rest is history: thousands of happy patients, many refugees from the Harvard big shots, but apparently none migrating in the opposite direction. I know I won't. It works. Their way does keep you alive, but for much of the time you're not sure what the point is. I know. I did it for years.<br /><br />The studies to validate this could be done, should be done. But as you say, T3 is un-patentable, like low carb diets. We need a NuSci for hypothyroidism. It's almost as big an epidemic as obesity.<br /><br />For anyone interested, the latest on all this will be here:<br /><br />http://www.amazon.com/Functional-Approach-Hypothyroidism-Traditional-Alternative/dp/1578263875/ref=sr_1_3?ie=UTF8&qid=1342225763&sr=8-3&keywords=kenneth+blanchard+hypothyroidism<br /><br />If you can't wait, his earlier book:<br /><br />http://www.amazon.com/What-Your-Doctor-About-Hypothyroidism/dp/0446690619/ref=sr_1_1?ie=UTF8&qid=1342225763&sr=8-1&keywords=kenneth+blanchard+hypothyroidism<br /><br />His comments on a couple of the T3 studies often trotted out to defend T4-only therapy:<br /><br />http://jcem.endojournals.org/content/89/3/1486.1.fullWilliamShttps://www.blogger.com/profile/09021312909928686165noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-28812009614494546562012-07-13T22:23:36.023+00:002012-07-13T22:23:36.023+00:00@tess thyroid status is not black and white; it...@tess thyroid status is not black and white; it's not like you either are or are not hypothyroid; thyroid activity is a gradient where one crosses over to under or over active thyroid. Some people naturally have slightly higher or lower thyroid activity. <br /><br />For example, I have "adequate" energy, I do not feel cold that often, and all of this remains true as long as I keep insulin and leptin high enough to maintain my weight, or slowly gain body fat. <br /><br />The moment I start restricting calories and losing any body fat worth mentioning, eventually I will feel cold and lethargic. Low carb will make it worse because low carb causes more fat tissue atrophy at the same calorie intake; there is less insulin stimulation of fat tissue to make leptin and bolster thyroid (and also keep me fatter).<br /><br />OTOH If I was taking leptin, I would feel warmer and much more energetic, with symptomatic higher T3 (and my body fat would thin as well).<br /><br />In all of these cases I am "euthyroid" as I do not have thyroid illness. However, my thyroid can shift from high normal to low normal to based on endocrine status mediated by my fat tissue.<br /><br />Regarding your case, tess, you have pathological hypothyroidism, primary thyroid disease. You are not at all like dieters who are 30 years old and healthy and euthyroid. Our thyroid fluctuates functionally in response to energy changes.<br /><br />In your case, the reason VLC improves your thyroid could be any number of issues.<br /><br />- A VLC has less fiber to inhibit absorption of levothyroxine, your medication is therefore more effective.<br />- The digestive environment of a vLC results in superior absorption of levothyroxine. It is known levothyroxine is absorbed best on an empty stomach; the VLC diet is more similar to fasting than a LC diet.<br />-You may have an autoimmunity to some dietary element like wheat which inhibits your thyroid (common in pathologial hypothyroidism) which you are opting out of when you go VLC<br /><br /><br /><br />However, as a person without hypothyroidism, with a normal thyroid that is functionally inhibited or not by my fat tissue status, I can say that VLC produces more lower thyroid symptoms than LC does, and high carb produces the least. Of course this mirrors perfectly my level of fatness and fat tissue energy balance and predicted SNS/leptin/insulin levels.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-48548775704011143922012-07-13T21:52:58.588+00:002012-07-13T21:52:58.588+00:00but Wooo, Peter's info explains why i feel ade...but Wooo, Peter's info explains why i feel adequately energetic on VLC, not full of hypo symptoms like i SHOULD feel according to CW. i DO get those symptoms even at LC levels.tesshttps://www.blogger.com/profile/04254045589639201707noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-90114794078052431212012-07-13T19:37:08.332+00:002012-07-13T19:37:08.332+00:00Example of leptin/insulin control of thyroid:
Whe...Example of leptin/insulin control of thyroid:<br /><br />When I was fat my TSH was WNL but slightly elevated ~2.<br /><br />As I lost weight my TSH continued to drop. It was below 1 at my thinnest. In pathological thyroid function a TSH that is low suggests hyperthyroidism, but I actually had every sign of hypothyroidism. This suggests my brain was purposely NOT making TSH.<br /><br />When I took leptin, my TSH continued to increase, and my T3 increased. Subjectively my energy was much higher and in spite of the fact I continued to emaciate body fat I felt warmer.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.com