tag:blogger.com,1999:blog-36840063.post5834895421672799007..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Ketones for ALS?Peterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger14125tag:blogger.com,1999:blog-36840063.post-65390774486384503102018-07-10T18:22:45.010+00:002018-07-10T18:22:45.010+00:00Hello Petro
Just curious if you had a comment abou...Hello Petro<br />Just curious if you had a comment about Wahls Protocol. Dr Wahls is of the opinion that ketones are better for mitochondria, for ATP production as it is the way humanoids and humans used energy before the ever increasing dependency on carbs. She has dealt with MS but the ketogenic diet is proposed as essential for all NMDs.<br />You mention that you dont think ketones are helpful in ALS, but i am thinking, based on Wahls, that one cannot look in isolation of the ketone themselves rather the diet which leads to ketogenic nutrition. In fact, i think the problem is that we cannot understand the complex of interactions of such diet and thus ketones.<br />Thank you<br />Regards<br />MarianUnknownhttps://www.blogger.com/profile/17854952984597385060noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-16047005741671417992018-07-10T18:22:27.589+00:002018-07-10T18:22:27.589+00:00Hello Petro
Just curious if you had a comment abou...Hello Petro<br />Just curious if you had a comment about Wahls Protocol. Dr Wahls is of the opinion that ketones are better for mitochondria, for ATP production as it is the way humanoids and humans used energy before the ever increasing dependency on carbs. She has dealt with MS but the ketogenic diet is proposed as essential for all NMDs.<br />You mention that you dont think ketones are helpful in ALS, but i am thinking, based on Wahls, that one cannot look in isolation of the ketone themselves rather the diet which leads to ketogenic nutrition. In fact, i think the problem is that we cannot understand the complex of interactions of such diet and thus ketones.<br />Thank you<br />Regards<br />MarianUnknownhttps://www.blogger.com/profile/17854952984597385060noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-60872178316299634152018-07-10T18:20:50.371+00:002018-07-10T18:20:50.371+00:00Hello Petro
Just curious if you had a comment abou...Hello Petro<br />Just curious if you had a comment about Wahls Protocol. Dr Wahls is of the opinion that ketones are better for mitochondria, for ATP production as it is the way humanoids and humans used energy before the ever increasing dependency on carbs. She has dealt with MS but the ketogenic diet is proposed as essential for all NMDs.<br />You mention that you dont think ketones are helpful in ALS, but i am thinking, based on Wahls, that one cannot look in isolation of the ketone themselves rather the diet which leads to ketogenic nutrition. In fact, i think the problem is that we cannot understand the complex of interactions of such diet and thus ketones.<br />Thank you<br />Regards<br />MarianUnknownhttps://www.blogger.com/profile/17854952984597385060noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-32063792328362089182018-07-10T18:20:01.457+00:002018-07-10T18:20:01.457+00:00Hello Petro
Just curious if you had a comment abou...Hello Petro<br />Just curious if you had a comment about Wahls Protocol. Dr Wahls is of the opinion that ketones are better for mitochondria, for ATP production as it is the way humanoids and humans used energy before the ever increasing dependency on carbs. She has dealt with MS but the ketogenic diet is proposed as essential for all NMDs.<br />You mention that you dont think ketones are helpful in ALS, but i am thinking, based on Wahls, that one cannot look in isolation of the ketone themselves rather the diet which leads to ketogenic nutrition. In fact, i think the problem is that we cannot understand the complex of interactions of such diet and thus ketones.<br />Thank you<br />Regards<br />MarianUnknownhttps://www.blogger.com/profile/17854952984597385060noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-66075056045863914282015-12-17T21:40:22.325+00:002015-12-17T21:40:22.325+00:00Can someone please elaborate on Lacie's commen...Can someone please elaborate on Lacie's comment that intermittent fasting isn't a good idea for patients with neurodegenerationRussellhttps://www.blogger.com/profile/09242803514937913148noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-80809416870631517852014-10-15T14:30:31.858+00:002014-10-15T14:30:31.858+00:00Spot-on, Peter: "Using MCTs on a moderate to ...Spot-on, Peter: "Using MCTs on a moderate to high carbohydrate diet is unlikely to lead to the metabolic changes of a true ketogenic diet. Normoglycaemia is probably not on the menu."<br /><br />I wrote a paper about the therapeutic use of low-carb/ketogenic diets for Alzheimer's, and the way I phrased it was: "MCTs could certainly be a powerful *adjunct* to a reduced carbohydrate diet. The latter *would* reset the metabolic machinery, ease oxidative stress, and reduce glycation. In the absence of dramatic dietary overhaul, however, the administration of KBs is akin to bailing water out of a leaky boat without stopping to patch the hole: you merely manage the effects while the root cause continues wreaking havoc."Tuit Nutritionhttps://www.blogger.com/profile/15708859914305178756noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-86875993386674435112014-10-09T18:19:31.420+00:002014-10-09T18:19:31.420+00:00Peter, I'm so glad you're writing about ke...Peter, I'm so glad you're writing about ketones and ALS. I have a particular interest, as I have something called multifocal motor neuropathy (MMN) which is often misdiagnosed as ALS. Most of the stuff I read online treats neurodegenerative disease as primarily in the brain, which makes it hard for someone like me to extrapolate, as my problem is strictly peripheral. Any little crumbs you can drop about whether effects are similar in the brain and in peripheral nerves would be greatly appreciated.<br /><br />I looked at that Deanna Protocol a couple of years ago. I actually wrote to them asking why they did not recommend reducing carbs in conjunction with the AAKG. Didn't get a useful answer back that I recall. Perhaps they figure that it would just be too difficult for people to change their diet, despite being under what is essentially a death sentence.<br /><br />That said, a lot of the supplements in the Deanna Protocol align with what I have been able to discover independently.<br /><br />You might also find this of interest: Reversal of cognitive decline: A novel therapeutic program <br />http://impactaging.com/papers/v6/n9/full/100690.htmltwitchyfireflyhttps://www.blogger.com/profile/16211453353458346786noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-69630289903731996802014-09-26T09:40:29.496+00:002014-09-26T09:40:29.496+00:00@NY
If it's the study I'm thinking of fro...@NY<br /><br />If it's the study I'm thinking of from like decades ago, you should actually read it.<br /><br />It compares the insulinogenic AND glucogenic profiles of protein, fat, and carbs.<br /><br />Long story short - fat does fk all, protein causes a *mild* increase of BOTH insulin and glucagon, and carbs spike insulin and suppress glucagon.<br /><br />It's really dumb how it's painted in sound bites like "beef spikes insulin just like pasta".Ash Simmondshttps://www.blogger.com/profile/02912627973649715025noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-73699416853705592242014-09-24T21:58:30.102+00:002014-09-24T21:58:30.102+00:00Great post Peter, as usual!Great post Peter, as usual!Guillermo Fernandezhttps://www.blogger.com/profile/04734920550168633233noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-53732969936973075862014-09-24T16:40:45.261+00:002014-09-24T16:40:45.261+00:00Lacie,
Back in my days of anaesthesia examination...Lacie,<br /><br />Back in my days of anaesthesia examination endurance the rumour was that if you were stumped for an answer you just said nitric oxide. If wrong it might still get a laugh in the viva. It does everything. It reminds me of superoxide!<br /><br />Physiologist's T shirts had "Just Say NO" written on them. Nothing to do with recreational drugs.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-22216893372764660832014-09-24T16:35:46.340+00:002014-09-24T16:35:46.340+00:00NY, lean protein is for paleotards. I eat fat! Ade...NY, lean protein is for paleotards. I eat fat! Adequate protein hidden in fat and some carbs as flavourings.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-18792809370330223172014-09-24T14:32:32.928+00:002014-09-24T14:32:32.928+00:00Hi Peter,
Would love to know your take on the stu...Hi Peter,<br /><br />Would love to know your take on the study which came out apparently showing that some protein sources are more insulinogenic than even carbs eg., lean beef and fish raised quite a bit of insulin as compared to pasta. If keeping insulin low is the whole point of cutting carbs then do you think we should also be careful about lean sources of protein? Also, what do you think optimal fasting insulin levels are? Mine came at 3.5 iu/ml. <br />ThanksNYhttps://www.blogger.com/profile/07643338459560611241noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-84564630477474150402014-09-24T02:45:11.273+00:002014-09-24T02:45:11.273+00:00Thank you so much, Peter - I've been waiting f...Thank you so much, Peter - I've been waiting for you to explain AAKG as no one else inclined to do so.<br /><br />As I've posted previously in various neighborhoods we hang around in, my partner with Parkinson's decided to refuse L-dopa and instead take AAKG, 1:1 ratio Primaforce, 18g per day. We heard about it on Deanna Tedone's website, winningthefight.net in a document by Dominic D'Agostino, Ph.D., University of South Florida, who helped Deanna's father develop the protocol.<br /><br />My partner is six years past onset of PD and has a slight tremor in his right thumb that's worse in the morning (dawn glucose/cortisol dump, probably), when he's hungry (IF isn't a good idea for patients with neurodegeneration), or in times of stress. Insulinogenic foods also wreak havoc with his movement, but when he stays low carb <40g per day and pumps the AAKG, the tremor is barely noticeable. No problems with walking or balance. He should be in far worse shape.<br /><br />The AKG is the active ingredient but the arginine is needed as a buffer for the stomach. The nitric oxide produced by arginine is a concern as NO seems to trigger apoptosis but is also neuroprotective. See http://www.ncbi.nlm.nih.gov/pubmed/16005074 http://www.ncbi.nlm.nih.gov/pubmed/15691583 and http://www.ncbi.nlm.nih.gov/pubmed/17408564 (PM if you want full text.)Laciehttps://www.blogger.com/profile/01121430731539402156noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-25702525211897376732014-09-23T20:48:43.003+00:002014-09-23T20:48:43.003+00:00This Deanna protocol is very interesting. I have ...This Deanna protocol is very interesting. I have some AAKG just sitting around because I forget to take it, and I've ordered some picamilon, which is a compound of niacin and GABA.<br /><br />I didn't intend to attempt to use either as a therapy for the unexplained pain on the left side of my face, but now I shall. Been in pain since 2010 and doctors are of no help.Augusthttps://www.blogger.com/profile/08758314961163692341noreply@blogger.com