tag:blogger.com,1999:blog-36840063.post5942694495388304983..comments2024-03-27T22:57:00.742+00:00Comments on Hyperlipid: Hepatic insulin resistance through caloric overloadPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-36840063.post-71434033661756651772010-10-16T03:43:05.867+00:002010-10-16T03:43:05.867+00:00I wonder if subcutaneous, visceral/ectopic, and he...I wonder if subcutaneous, visceral/ectopic, and hepatic fat cells can each "fill up" at different rates, and dump FFAs differentially, and then I wonder if you would have different metabolic impacts depending on which fat cells are dumping FFAs. <br /><br />Like, I bet if hepatic fat cells fill up and dump FFAs, well they are right there in the liver, and can directly cause hepatic insulin resistance, leading to high blood sugar and high insulin. <br /><br />Whereas subcutaneous fat dumping FFAs may not have as powerful of an effect on hepatic IR. <br /><br />If so, fatty liver isn't really a problem, until the liver can't get any fatter, then it's a REAL problem. <br /><br />I'm trying to understand the mechanics behind fatty liver leading to hepatic IR, and I wonder if this is it.Edhttps://www.blogger.com/profile/02404726297092447442noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-59204966684884188372010-05-23T05:25:53.931+00:002010-05-23T05:25:53.931+00:00Hi Robert,
I get email alerts, let's me keep ...Hi Robert,<br /><br />I get email alerts, let's me keep the viagra spam down!<br /><br />I found this fascinating. I would have thought type 2 diabetes was a small price to pay to have that strength, if you are driven that way!<br /><br />We humans are such strange creatures. We have to own the fastest racehorse, the most respiratory crippled bulldog, the strongest biceps. It's a real human trait, certainly for agricultural humans..... The cost in suffering seems irrelevant.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-16423102938937038492010-05-19T16:17:51.740+00:002010-05-19T16:17:51.740+00:00Hey I am not sure if you still read comments from ...Hey I am not sure if you still read comments from this long ago but I wanted to share this gem from a bodybuilding site:<br /><br />http://www.tmuscle.com/free_online_article/sports_body_training_performance/the_dave_tate_project_i<br /><br />Dave Tate is quoted in the article in eating 10,500 kcal/d. Pop-tarts, McDonalds and mini-muffins iirc. <br /><br />Love the blog.Robbie-Ohttps://www.blogger.com/profile/16643378202435702202noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-44216020237552846162009-09-21T12:07:35.034+00:002009-09-21T12:07:35.034+00:00Hi Rob,
Yes, I'd forgotten de novo lipogenesi...Hi Rob,<br /><br />Yes, I'd forgotten de novo lipogenesis as it's such a small feature of reasonable calorie mixed diets, but on this carb load it's going to be providing palmitic acid perfectly well.<br /><br />Malpaz, no, not at all. Occasional alcohol is no worse than occasional fructose, we should be well able to deal with it but a perfectionist might prefer not too. A high fat, combined with a high carb, meal equal to your daily caloric requirements, repeated three times in a day for 12 weeks is VERY bad news. High fat LC with probably the safest for your liver in the face of either alcohol or fructose, provided the fat is saturated so doesn't precipitate the inflammatory form of fatty liver disease. That is no corn oil and certainly keep the fish oil under 1000kcal/d.<br /><br />J, You don't need science if you have as much money as these people have!<br /><br />Leelo, Stephansson actually discusses sled dogs and changes in diet and they don't like them. Once pushed they will adapt but feeding dogs to dogs in an emergency instead of cariboo meat didn't work. Personally I'd sneak in some beef mince and work up slowly. Make sure they're hungry at the time too! It's actually far worse switching cats in general and I'm really relieved that my old girl switched quite happily at about 14 years of age. Over 18 now. The RMB people don't seem to worry about fat too much but I agree, a bit extra would be worth while.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-47674987540474834502009-09-20T08:20:45.290+00:002009-09-20T08:20:45.290+00:00Hi Peter,
been reading your blog silently for near...Hi Peter,<br />been reading your blog silently for nearly a year - superb content.This is on topic with regards dogs and fat I suppose!! My 3 are on raw beef tripe, minced organs, chicken wings. They have been all their lives (6 years plus) Should I be adding butter or lard? How else can I get fat into them - they wont eat mutton for some strange reason!Leehttps://www.blogger.com/profile/10381929991597416864noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3671172968614023212009-09-19T21:11:13.701+00:002009-09-19T21:11:13.701+00:00No control group = no scientific value whatsoever....No control group = no scientific value whatsoever. I wish they'd teach that in journalism schools.Unknownhttps://www.blogger.com/profile/18197517376357000470noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-9630423164771609202009-09-19T03:50:26.336+00:002009-09-19T03:50:26.336+00:00so are you saying a high fat all meat diet with oc...so are you saying a high fat all meat diet with occassional alcohol is one of the worst choices out there??Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-36840063.post-58469858316258359332009-09-18T23:04:52.795+00:002009-09-18T23:04:52.795+00:00Once the liver and muscle tissues are all saturate...Once the liver and muscle tissues are all saturated with glycogen, the liver will turn on de nova lipogenesis to transform an excess glucose into saturated fat. It's not the first disposal pathway for glucose, since it's a very useful, high intensity, emergency fuel supply, but when you overfeed on glucose it will happen and you'll get free fatty acids coming out over the liver.Robert McLeodhttps://www.blogger.com/profile/05270962906437456350noreply@blogger.com