tag:blogger.com,1999:blog-36840063.post7666031649907038863..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: Cardiac ischaemia and low carbohydrate dietsPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger28125tag:blogger.com,1999:blog-36840063.post-4209438430992987782014-08-10T18:50:18.484+00:002014-08-10T18:50:18.484+00:00This just figures though, the diet scene tells us ...This just figures though, the diet scene tells us to avoid carbs completely but that's not true, we need them just as much as we need certain fats and oils, it's just like anything else, too much of a good thing is bad. The science is helpful to see what's behind the reasoning but it just seems like common sense should prevail.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-36840063.post-69349804256634766662014-07-11T15:22:19.139+00:002014-07-11T15:22:19.139+00:00Zorica, I've not really given that a huge amou...Zorica, I've not really given that a huge amount of thought. Resisting insulin in the periphery and in the liver might both be a normal aspect of ketogenic diets. Even the brain might be involved in fine tuning blood glucose, as it undoubtedly always is...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-89252584689438023892014-07-01T03:41:27.990+00:002014-07-01T03:41:27.990+00:00Peter, when someone has a higher fasting glucose o...Peter, when someone has a higher fasting glucose on LC or keto, is that higher sugar from GNG? I know there's beneficial physiological insulin resistance, so if it is GNG, then that is a good thing? <br /><br />I'm interested to know, and would like to know if it's another mechanism (ketone bodies interacting here?) <br /><br />Thanks. Zorica Vuletichttps://www.blogger.com/profile/05793548904884383364noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-91227991091427327572014-06-30T22:14:46.683+00:002014-06-30T22:14:46.683+00:00Phillpa Wiggins work on water density and action t...Phillpa Wiggins work on water density and action takes Pollack's ideas even further.......Anonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-58588348653169305482014-06-30T22:13:49.625+00:002014-06-30T22:13:49.625+00:00I think when you read all of his ideas and see all...I think when you read all of his ideas and see all the experiments he has done in one place you will get it. The high pH and large exclusion zone are congruent.......the high the pH the lower the proton amounts. The more electrons present the more negative the charge and the more dense water is around those smokers to provide the energy to drive a zero entropy self assembly. The earliest pathways.....like the reducing pathways could all be run adiabatically when you consider the massive charges in water that is constantly restored. It can be done by the sun or by IR heat. Anonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-30964190408257689462014-06-29T21:31:47.358+00:002014-06-29T21:31:47.358+00:00Jack, Lane/Martin look at acetogens and methanogen...Jack, Lane/Martin look at acetogens and methanogens, nowadays using reduced ferredoxin to reduce CO2. This reduced ferredoxin is hard to come by and today the trick is turned by using electron bifurcation, i.e. BOTH electrons from H2 are used, at the same time, to generate the necessary reduced ferrodoxin. Without reduced ferredoxin CO2 is not going to be reduced to CO as the needed redox potential is -520mV.<br /><br />I don’t see how you can have this happening pre-genes and pre-proteins, using an IR induced aqueous exclusion zone potential of -200mV.<br /><br />Lane/Martin posit disordered mackinawite with a Eh of ~300mV at pH 7.5, becoming more negative by with rising pH, i.e. under alkaline vent conditions it may well be able to supply a redox potential of nearly -600mV needed to reduce CO2 to CO. This is at an iron/sulphur boundary between acidic CO2 rich ocean and an alkaline H2 rich serpentinisation effluent.<br /><br />I struggle to get these sorts of processes from some infra red photons acting on water to expand/contract a structured water exclusion zone. If infra red could allow hydrogen to reduce CO2 under biological conditions the world would be teeming with IR photosynthetic organisms, which it’s not… I may have missed some of Pollacks better points as I’m working from his 2009 paper http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680624/<br /><br />I have no problem with structured water on FeS surfaces, I have no doubt it is of consequence, but I still don’t see how it might replace Lane/Martins arithmetic.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-30124663687140724352014-06-29T16:44:22.231+00:002014-06-29T16:44:22.231+00:00I've watched Pollack's lectures, I still d...I've watched Pollack's lectures, I still don't know how to go about racking up a better exclusion zone and cranking up my negative charges. <br /><br />Dunno, maybe just vigorously stir my water and leave it in the sun for a while, maybe it'll spontaneously develop higher ratios of H3O2.Ash Simmondshttps://www.blogger.com/profile/02912627973649715025noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-43123337323057737482014-06-29T15:16:47.361+00:002014-06-29T15:16:47.361+00:00Peter I agree........your missing piece is Gerald ...Peter I agree........your missing piece is Gerald Pollack. Read his book the fourth phase of water and you will see how his experiments built upon Ling's ideas and extended them and totally explains why Mitchell's ideas are wrong. Ling gave us the thermodynamic reason Mitchell was wrong but Ling could not explain precisely the mechanism of how water structures. Pollack does. IT solves Lane's problems at the smokers in the ocean too. Infrared radiation requires no sunlight for charge separation in water. Anonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-51315584978056911772014-06-29T05:30:40.057+00:002014-06-29T05:30:40.057+00:00Ilaine, I have seen too many drugs come and go ove...Ilaine, I have seen too many drugs come and go over the last 30 years to get too excited about anything new. The latest NSAID has me rushing to observe the effects on my co-worker’s patients before I prescribe. About a year for most drugs, five years for an NSAID!<br /><br />Jack, we both realise that lactate is the preferred fuel for neurons. I have a set of links from Edward and an email query to tie together on this.<br /><br />And to Jack and Rémi,<br /><br />I came up through the 1980s without in-house K+ measurements, in a small rural practice. I can remember poring over the ECG of critically ill patients looking for spiked T waves and flat P waves. The Vetlyte 8008 in-house analyser was a godsend. I also remember a sepsis patient (post pyometra resection) which went from ambulant through hind limb ataxia to quadriparesis in just over an hour. Some KCl fixed it equally rapidly. The potassium analyser paid for itself that day.<br /><br />It’s only as I came to metabolism, insulin and Ling that I started to ask deeper questions. The structured nature of water in modern cells is a given. I have a paper suggesting ATP is moved through structured water using chains of adenylate kinase and an ATP/AMP:2ADP shuttle system. Diffusion does not seem to be where it’s at.<br /><br />But, at the most basic level, I cannot see ATP as primal. Jack, I know you see Ling and Lane/Martin’s ideas as incompatible. I cannot see anything other than they must be reconciled as two views of the same system. If, as I do currently, you go with Lane/Martin, you are looking at the core starting points to metabolism as being reduced ferredoxin based. Probably as FeS, obviously without the protein carrier structure (http://www.nick-lane.net/Lane-Martin%20Cell%20origin%20membrane%20bioenergetics.pdf). The use of reduced ferredoxin is still core to the most evolved organisms on earth, the methanogens and acetogens. While they have clearly accepted ATP, they still have reduced ferredoxin at the core of their energy metabolism. While they are highly sophisticated, extremely “evolved” organisms, they still give us the best insights as to where metabolism probably started. I would agree ATP is a very early development (the ATP synthase complex clearly predates the differentiation of methanogens and acetogens from each other. ATP synthase developed before the formation of lipid membranes). So, to me, metabolism and synthesis had to be on-going well before ATP evolved. Some other molecule would need to be put forward as the as the structuring agent to cell water before the highly developed molecule of ATP came along. Lane/Martin’s ideas put in place a limited metabolism within a physically limited structure, with continuous energy throughput.<br /><br />While a great deal has changed since the origin of life I see the complex protein/water/potassium/ATP interaction as being subsequent to its development. For Ling to be primal I would want an explanation of how structured water gives us proto-methanogens to become eukaryotes with proto-acetogens to become the mitochondria. These ideas seem to drop easily out of Lane/Martin but I struggle to see how Ling’s ideas would explain them, not that Ling’s ideas do not have explanatory power in their own right.<br /><br />As I say, I feel they are views of the same phenomenon…<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-40736415258372524502014-06-29T03:46:04.178+00:002014-06-29T03:46:04.178+00:00This comment has been removed by the author.JasmineJohendhttps://www.blogger.com/profile/11807503482277639920noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-16480769593333550352014-06-28T23:39:06.035+00:002014-06-28T23:39:06.035+00:00I went into the detail of how Ling dovetails with ...I went into the detail of how Ling dovetails with Sinclair and Pollack here @ Bill's blog: http://caloriesproper.com/?p=4903#disqus_threadAnonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-67375202111848613532014-06-28T23:35:27.338+00:002014-06-28T23:35:27.338+00:00He extended Ling's work. But the K+ is the k...He extended Ling's work. But the K+ is the key for the heart. K+ links water molecules to ATP molecules stochastically. This is what Gilbert Ling proved 60 years ago and no one seems to know about it. Potassium levels tell you about the relationships to ATP. For every 0.3 mEq below 3.8 mEq that potassium is on a standard blood lab draw, means there is 100 mEq deficit inside a cell. The atomic size and its redox potential is huge for potassium “gluing of water” for it to function as the optimal electrical adapter to transfer energy throughout the cell coherently. ATP is designed to unfold proteins fully to open their carbonyl and imino side chain groups on all amino acids to intracellular water. This action allows binding and polarization to separate water into subatomic particles that are positively and negatively charged. This action is called building or expanding the exclusion zone (EZ) of water. Pollack's experiments showed these effects. Ling proved by experiment that each molecule of ATP in a cell controls 8,800 water molecule binding sites and 20 potassium ions to allow water to become structured inside every cell of your body. The first step in photosynthesis and ox/phos is the charge separation of water. Ling was the first to realize K+ linked water to the ATPase. So when you have altered poor K+ your dehydrated and the interior or your cell is pseudo-hypoxic and this causes the redox shift of the mitochondria.Anonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-39642754841746391312014-06-28T23:34:57.519+00:002014-06-28T23:34:57.519+00:00Regarding GIK for CVD, PAD, or CVA: I sent Peter ...Regarding GIK for CVD, PAD, or CVA: I sent Peter Sinclair's 2013 paper on pseudo-hypoxia a few blogs back. It perfectly describes what Ling said about GIK long ago. Quick summary for those interested:The Sinclair paper linked here before shows that mitochondrial dysfunction is cause by a metabolic shift due to altered epigenetic redox changes in cell water or plasma. This results Warburg-type metabolism under pseudo-hypoxic states in cell water. This is where protons are more plentiful than electrons from ETC. Peter has beautifully laid this out here over 30 blogs. Warburg metabolism are fully reversible with the supplementation of NAD+ precursors (niacin) or a DHA laden ketogenic diet and metformin. Ketosis also happens to replenish NAD+ for the nucleus! Ketosis is protective because it allows passage of electrons and protons from fats (FFA) to make some ATP and salvage the mitochondria damaged by the metabolic redox shift these cells or tissues possess to keep them from oncogenesis. It promotes senescence instead. If the mitochondria is not trashed it can recycle itself using autophagy. Ketogenic diets have also been shown to aid deep sea divers and special force soldiers overcome situation where they face chronic hypoxia. Ketogenic diets help prevent brain cancer and improve cardiac function in heart disease because it improves NAD+ ratio's fast at cytochrome one. (http://www.nature.com/nature/journal/v487/n7408/full/487435a.html) There are many reports that a sick brain does not really use glucose (you'd never know that reading the blogosphere Guyenet, Kresser or Jaminet) but changes it to lactate which neurons love to use as a fuel with fats. Here is where saturated fats have a protective role. The humans brain loves fats and lactate fuels together. The heart also loves this combo because both tissues are loaded with mitochondria that have been shifted. Moreover, but guess what also likes this combo of lactate and fats? All other tissues in your body do. So when you eat fat you will not get CVD, cancer, or get fat. Peter knows the data on lactate because he has blogged on it. Lactate usage by the brain and heart appears to be the best way of postponing apoptosis (cell suicide), short of abandoning your brain/heart mitochondria altogether. This is why CVD walks hand and hand with neurodegenerative disorders because both tissues have high mitochondrial dependency. Glucose use comes in as a second choice in the heart and brain when they have redox issues. GIK is hogwash for CVD, PAD and CVA because of the "GI portions" of this equation. Ling showed K+ was the key to water structure inside a cell. Gerald Pollack extended Ling's work, by showing in hydrophilic nafion tubes naturally create adiabatic protons flows by charge separting water. Anonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-5872313589254550602014-06-28T17:26:31.889+00:002014-06-28T17:26:31.889+00:00Peter said "Ask me when 100,000 people have t...Peter said "Ask me when 100,000 people have taken it for 30 years at some standardised dosage protocol."<br /><br />This is wisdom. Exactly why I don't take anything but metformin and low carb for my Type 2 diabetes. Tweak one metabolic process with a drug (and yes, refined berberine is a drug) and where does it end? I don't want to be the test case. Fools rush in where angels fear to tread.Ilaine Uptonhttps://www.blogger.com/profile/03184690720703307375noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-6296556227418466522014-06-27T19:48:28.346+00:002014-06-27T19:48:28.346+00:00HI Peter, thank you for you answer.
Actually i&#...HI Peter, thank you for you answer. <br /><br />Actually i'm not a super strong believer of the GIK cocktail to improve cardiac ischemia. The Immediate trial is the latest stuff and its primary endpoint is negative. <br /><br />But as an anesthesiologist in human medicine, i often face myocardium ischemia and after a surgery i'm more prone to give gik than a super-dangerous cocktail of antiplatelets agents and anticoagulants that cardiologists (and big pharma) love.<br /><br />I would also say that GIK costs nothing, what about the new *grel stuff and the even newer antiinflammatory *mab stuff which are in the pipeline...<br /><br />I also think that the K in GIK is very important, i give some hints about K in this french post : http://www.nfkb0.com/2014/06/09/mon-ami-le-potassium/ (hope web translators help)<br /><br />Finally i love your blog, i've discovered it a few weeks ago and i try to understand it patiently :) I'm not turning into a LCHF eater because i'm a slim but big breadholic french ;) However i love your explanations and i'm reading more and more basic physiology (and Lane books) to understand your blog and i like it :)<br /><br />PS i'm Rémi F on FB.<br />PPS when will you open a twitter account ? Twitter is a super toolnfkb0https://www.blogger.com/profile/18313043690714725141noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-58357693543773368732014-06-27T15:18:02.879+00:002014-06-27T15:18:02.879+00:00Berberine mimics the effects on the SNS of cold th...Berberine mimics the effects on the SNS of cold thermogenesis. It is the same of how niacin mimics a ketogenic diet by its effects on NAD+Anonymoushttps://www.blogger.com/profile/06619419812590914435noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-49372032463106494802014-06-27T11:39:57.392+00:002014-06-27T11:39:57.392+00:00Thank you, LomaxZ, for ansvering my question.
I go...Thank you, LomaxZ, for ansvering my question.<br />I got curious about the change started to notice in stores on labels of re-formulated products which previously contained trans-fats, like peanut butter, but nowadays the list of ingredients often contains hydrogenated or even fully hydrogenated vegetable oils. Armour lard in my local groceries store contains Lard and Hydrogenated lard. I don't buy that staff anyway.Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-78386536007394211282014-06-26T19:20:55.185+00:002014-06-26T19:20:55.185+00:00@Galina - It's not totally true to say that hy...@Galina - It's not totally true to say that hydrogenation is a synonym of saturation; however, if you fully hydrogenate, then it is true. I'm not aware of any commercially available lard that is fully hydrogenated, but if it were it would end up with little to no trans-fat and a lot of stearic acid since lard contains a lot of oleic acid.LomaxZhttps://www.blogger.com/profile/06003718448666699247noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-71854101713821689272014-06-26T06:05:11.687+00:002014-06-26T06:05:11.687+00:00Caffeine is pretty good for breaking DNA, but coff...Caffeine is pretty good for breaking DNA, but coffee prevents liver cancer. Berberine naturally occurs in a few herbs; it is related to opiate precursors that occur in many more, none of these are highly toxic, many are useful. But if you use a berberine supplement the dose is higher than a human used historically, and the effect is not being modified by other components of the herb. (similar to digitalis; toxicity when using the herbal extract was supposedly easier to identify and avoid than when using digoxin).<br />I suggest olive leaf extract as a more food-like substitute for berberine if the goal is lowering GNG.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-25442945515766356702014-06-26T03:43:26.292+00:002014-06-26T03:43:26.292+00:00Hi nfkb0,
I've been interested in GIK for yea...Hi nfkb0,<br /><br />I've been interested in GIK for years, mostly as it might make the management of DKA significantly easier. Practically I never deal with ischaemic heart disease so it has no appeal there. It's use is very much based around Ling's structured water ideas which I feel are correct but very difficult to integrate with the more superficial level of physiology which my brain is locked in to. <br /><br />The people who use it are working at my type of superficial level too, cells need ATP, drive glucose in with insulin and try not to kill your patient with hypokalaemia. The studies seem to show that it works well if you are a believer and that it is very easy to arrange a non-believer study design to have it fail. So the benefits are probably not huge.<br /><br />I would guess it might well be helpful in a transfat based experiment (i.e. much of the world, especially the USA) where the loss of downstream insulin effects on the ETC are lost through failure of insulin to act appropriately...<br /><br />ZomaxZ, wow, USA food!<br /><br />Zorica and Jasmin, that would need a ton of reading. Metformin is lethal in overdose or if you use more potent analogues. The lifespan enhancing effect of metformin can be equally well generated with rotenone, yet high dose rotenone is the standard method for generating a Parkinsons-like model for drug testing. Where does berberine fit in to this spectrum? Ask me when 100,000 people have taken it for 30 years at some standardised dosage protocol. Any drug with major metabolic effects will have major toxicity when you get it wrong. My garden is full of foxgloves but the few patients I ever digitalise get very, very controlled dose rates with routine blood digoxin measurements during stabilisation. Not that I can remember the last time I digitalised a patient!<br /><br />Galina, if only what they say was done is what was actually done……..<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-40851955201653683462014-06-26T01:14:25.696+00:002014-06-26T01:14:25.696+00:00@LomaxZ,
but if fats are fully hydrogenated, not ...@LomaxZ, <br />but if fats are fully hydrogenated, not partially hydrogenated (trans-fats), would it be accurate to say than that a complete hydrogenation is the synonym of a saturation?Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-5111871975274631342014-06-25T23:32:57.269+00:002014-06-25T23:32:57.269+00:00Zorica, I was also interested in Berberine for the...Zorica, I was also interested in Berberine for the same reason but Jenny from Blood Sugar 101 is scathing of it and believes it may be harmful. A commenter also provides links to studies relating to DNA damage but I would certainly be interested in Peter's view...http://www.fda.gov/aboutfda/centersoffices/oc/officeofscientificandmedicalprograms/nctr/whatwedo/nctrpublications/ucm363503.htm<br />1. Berberine, are potent inducers of DNA damage<br />2. Berberine-treated cells, DNA damage was shown to be directly associated with the inhibitory effect of topoisomerase II (an essential enzyme for DNA replication) and a key element for cell division and gene duplication fidelity.<br />Theoretically, this means any proliferating or newly dividing cells could subject to the cell division damaging inhibited by Berberine. Targeted delivery system for this compound may be preferred not to elucidate the long term damages of gene duplication.Jasmin Johendhttps://www.blogger.com/profile/10174428786206885943noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-37885228131192442172014-06-25T22:59:03.368+00:002014-06-25T22:59:03.368+00:00Peter, what are your thoughts on berberine:
For e...Peter, what are your thoughts on berberine:<br /><br />For example I know that you are a fan of physiological insulin resistance, and this substance is claimed to improve insulin sensitivity from receptor cells. Would taking berberine make one 'too insulin sensitive' ? Or is it a case where it is beneficial ?<br /><br />Thanks. :)Zorica Vuletichttps://www.blogger.com/profile/05793548904884383364noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-24642337457989123042014-06-25T22:50:37.690+00:002014-06-25T22:50:37.690+00:00Peter, another thing you might want to add to the ...Peter, another thing you might want to add to the article is that they also used lard and I highly doubt they rendered their own. In which case it's almost universally hydrogenated, thus adding even more trans-fats. So even the ~20% of calories you state from 'Vegetable Shortening' understates the amount of trans-fat in the mouse chow.<br /><br />http://soursaltybittersweet.com/sites/soursaltybittersweet.com/files/ThingsThatMightKillYouVolume1Transfats_23E1/lard.jpgLomaxZhttps://www.blogger.com/profile/06003718448666699247noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-62220851452182211762014-06-25T20:42:50.297+00:002014-06-25T20:42:50.297+00:00Hi !
what do you think about all the GIK littera...Hi ! <br /><br />what do you think about all the GIK litterature ? bullshit ?nfkb0https://www.blogger.com/profile/18313043690714725141noreply@blogger.com