tag:blogger.com,1999:blog-36840063.post8009612286788698255..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: Systemic fructose is importantPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger35125tag:blogger.com,1999:blog-36840063.post-53407277025852367042018-07-16T21:05:41.098+00:002018-07-16T21:05:41.098+00:00Moderate doses of fructose and small intestine?
h...Moderate doses of fructose and small intestine?<br /><br />https://www.sciencenews.org/article/small-intestine-not-liver-first-stop-processing-fructosecfmoraishttps://www.blogger.com/profile/17581904946398682003noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-66142885561675341452018-03-25T07:41:39.469+00:002018-03-25T07:41:39.469+00:00Karl, I do wonder how much of this blindness goes ...Karl, I do wonder how much of this blindness goes back to Keys and his biases, bullying and general unconcern with the truth. You just have to PubMed his publications through the 60s and 70s to see what a driving force he was. Right over the metabolic cliff from the 70s onwards. It's hard to be understanding with Keys. Or the more you understand, the less you like his legacy...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-25236504610965911152018-03-23T17:43:09.370+00:002018-03-23T17:43:09.370+00:00What has always amazed me it that it was well esta...What has always amazed me it that it was well established a long time ago that fructose spiked Trygly - yet the cholesterol=bad folks didn't pick up on it ( Trygly is associated with CAD ) instead focusing on LDL.<br /><br />see https://xtronics.com/wiki/History_of_Fructose_Carbs_and_weight-loss.html - there are a set of links to work on chemically defined diets.. such work seems missing in action today. <br /><br />karlhttps://www.blogger.com/profile/13490274388549702613noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-85360199585201722212018-03-04T06:20:25.594+00:002018-03-04T06:20:25.594+00:00Yes, I think that when at a public health message,...Yes, I think that when at a public health message, which may be correct, becomes unconcerned about the truth it then becomes a political slogan rather than a scientific statement. As always, be careful when you see a politician's lips move....<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-32425205413953050542018-03-03T19:26:46.327+00:002018-03-03T19:26:46.327+00:00Another reason to be cautious of anyone who tells ...Another reason to be cautious of anyone who tells you fructose metabolism is limited to the liver: fructose is first cleared by the small intestine, so fructose only really reaches the liver after the small intestine has been saturated. <br />http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30729-5<br /><br />Also fructose malabsorption appears pretty common:<br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994910/<br />https://www.ncbi.nlm.nih.gov/pubmed/24918018Anonymoushttps://www.blogger.com/profile/15999737028336152056noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-50533252843316767682018-02-25T21:13:35.465+00:002018-02-25T21:13:35.465+00:00@Gyan said
"You get sick but with what sickn...@Gyan said<br /><br />"You get sick but with what sickness? <br />What does essential fatty acid deficiency look like?<br />I know DHA is essential to infants for eyes and brain but why are omega-6 fats essential in adults?"<br /><br />I can't answer that. I only know that some fatty acids are considered essential because we can't make them ourselves, like there are some essential amino acids. Perhaps google will help.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-36033980219220740772018-02-25T17:44:04.433+00:002018-02-25T17:44:04.433+00:00Interesting stuff raphi.Interesting stuff raphi.Peterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-57241279581677217972018-02-25T10:45:47.949+00:002018-02-25T10:45:47.949+00:00oooppss forgot to link to a podcast i did with Gab...oooppss forgot to link to a podcast i did with Gabor on study where monkeys were fed lots of fructose http://breaknutrition.com/episode-13-happens-fructose-fed-monkeys/ (show notes available for those who don't have the time to listen)<br /><br />study https://www.ncbi.nlm.nih.gov/pubmed/21884510 <> Bremer et al. 2011<br /><br />“the animals showed a progressive decrease in fat oxidation throughout the study period" and didn't do so by increasing their calories (gasp! shock! awe!)<br /><br />PS: don't mind the comments regarding fructose being seen as hepatocentricraphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-68329634961124930812018-02-25T10:38:35.266+00:002018-02-25T10:38:35.266+00:00regarding the fructose-cytoskeleton-GLUT4 thingy, ...regarding the fructose-cytoskeleton-GLUT4 thingy, here's part of the rationale<br /><br />http://www.jbc.org/content/274/25/17742.long "aldolase functions as a scaffolding protein for GLUT4 and that glucose metabolism may provide a negative feedback signal for the regulation of glucose transport by insulin"raphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-61882089841575323492018-02-25T10:36:24.986+00:002018-02-25T10:36:24.986+00:00i just saw this post of your now, glad I didn'...i just saw this post of your now, glad I didn't miss it entirely.<br /><br />My podcast co-host Gabor Erdosi and I have been talking about how fructose can wreck metabolic.<br /><br />1) Fructose can mess with adipocyte differentiation. From there it's easy to speculate about how this can then result in hyperplasia and hypertrophy, with more insulin sensitive fat cells sending a 'call' for more food to fill 'em up.<br />2) Fructose seems to mess with the adipocyte's cytoskeletal network. GLUT4 requires proper F-actin guidance which, maybe, fructose interferes with. If this is the case, maybe this is what stops proper glucose uptake but excessive lipolytic release of FFAs towards ectopic invasion<br /><br />just some thoughtsraphihttps://www.blogger.com/profile/08992252569979714724noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3187953415005980092018-02-23T06:10:33.399+00:002018-02-23T06:10:33.399+00:00cavenewt,
You get sick but with what sickness?
Wh...cavenewt,<br />You get sick but with what sickness? <br />What does essential fatty acid deficiency look like?<br />I know DHA is essential to infants for eyes and brain but why are omega-6 fats essential in adults?Gyanhttps://www.blogger.com/profile/09941686166886986037noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-70467315609905525772018-02-22T22:58:58.194+00:002018-02-22T22:58:58.194+00:00There are several brands available on Amazon and i...There are several brands available on Amazon and in stores in the US. Probably not flying off shelves, patented and $$, but there it is.Anonymoushttps://www.blogger.com/profile/00942809754735691624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-537536819752904502018-02-21T19:24:17.655+00:002018-02-21T19:24:17.655+00:00@Eric re http://roarofwolverine.com/archives/1557
...@Eric re http://roarofwolverine.com/archives/1557<br /><br />I read, with total fascination, this entire website years ago. It made a lasting impression on me. If I ever need TPN, gawd forbid, I'm going to Europe. Another tip: avoid any medical treatment in Florida. A friend of mine who edits medical textbooks (Pathophysiology) confirmed this bit of advice.<br /><br />I especially remember the comment that the high level of sugar will destroy your veins within six months. This could be important for other people, such as those who get regular infusions of immunoglobulin; some brands are stabilized in glucose. Yikes.<br />------------------------------------------<br />@Gyan "I don't quite understand why it should be necessary to supply a great deal of essential fatty acids to adults."<br /><br />Because...they're essential? Essential means we can't make them ourselves.<br /><br />"What happens if this "essential nutrient" is not supplied?" You get sick!<br /><br />Perhaps your question was ironic, in which case, my bad.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-57904003751910936682018-02-19T21:23:22.319+00:002018-02-19T21:23:22.319+00:00meant to type no fructosemeant to type no fructoseErichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-60103238637528492572018-02-19T21:22:48.877+00:002018-02-19T21:22:48.877+00:00https://nyti.ms/2BBkLN0
Have non-alcoholic beer t...https://nyti.ms/2BBkLN0<br /><br />Have non-alcoholic beer three weeks prior to and two weeks after a marathon? Aren't we past carb loading? Beer does one thing right, it has to fructose but still too much starch for my taste.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-76765636625760891032018-02-19T13:47:29.276+00:002018-02-19T13:47:29.276+00:00At least takes out the nasty soy oil to harm peopl...At least takes out the nasty soy oil to harm people elsewhere. <br /><br />My wife picked up some pretty good tasting und not too sweet burger sauce in France, but after reading the label, I don't want to touch it: main ingredient is soy oil. Also, some pretty decent mayonaise. Main fatty ingredient is not egg, but canola oil :(Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-24090498646516323182018-02-19T11:57:18.169+00:002018-02-19T11:57:18.169+00:00Defatted soy chunks. Mmmmmmmm, yumee!
PeterDefatted soy chunks. Mmmmmmmm, yumee!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-55074955651512887182018-02-19T08:22:56.532+00:002018-02-19T08:22:56.532+00:00Defatted soy chunks are popular among vegetarians ...Defatted soy chunks are popular among vegetarians in India. They actually have a very favorable protein to carb ratio.<br /><br />I don't quite understand why it should be necessary to supply a great deal of essential fatty acids to adults. What happens if this "essential nutrient" is not supplied?Gyanhttps://www.blogger.com/profile/09941686166886986037noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-48596828434788422862018-02-18T13:03:21.594+00:002018-02-18T13:03:21.594+00:00Peter:
This is off-topic with regards to PUFA, bu...Peter:<br /><br />This is off-topic with regards to PUFA, but might interest you for its Protons implications.<br /><br />So we already know cancer is very much a disease of cellular respiration:<br />https://www.youtube.com/watch?v=OjpmPtz777s<br /><br />And Laurent Schwartz recently hinted that osmotic pressure from glucose onto the mitochondrial membrane can be shown (or made ?) to cause the full Warburg effect and turn a healthy cell into a cancerous one. He says inflamation and chloride dioxyde play a major role in this, but he's keeping the details and publications under wrap until their 11th of March presentation in France:<br />https://www.youtube.com/watch?v=bUKZxFRpR7o<br /><br />Sorry if you already know about all this, feel free to delete...E-Shttps://www.blogger.com/profile/11618396250935467279noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-79719680931774138012018-02-18T07:14:47.552+00:002018-02-18T07:14:47.552+00:00MitoqQ sounds a bit like ---> there's an Ik...MitoqQ sounds a bit like ---> there's an Ikea table kit in a flatpack, just squirt some superglue in there and it'll all come together properly. <br /><br />Could varnish it with linoleic acid afterwards I suppose. There actually is a wood polishing method that uses linseed oil and superglue!Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-8032356987245673672018-02-18T06:48:33.049+00:002018-02-18T06:48:33.049+00:00HI Robert,
Dr Speijer is a researcher who thinks...HI Robert, <br /><br />Dr Speijer is a researcher who thinks about LECA, Last Eukaryote Common Ancestor. I integrated his ideas about FADH2:NADH ratio and peroxisomes vs mitochondria in to the Protons thread at http://high-fat-nutrition.blogspot.co.uk/2012/08/protons-fadh2nadh-ratios-and-mufa.html This essay by Dr S was my introduction http://www.ncbi.nlm.nih.gov/pubmed/21137096 and I see from Pubmed that he is still actively promoting follow on ideas which I really need to read!<br /><br />Peter<br /><br />Yes, MitoQ will be amazing if it is as good as it sounds..... Needless to say there are a lot of questions about what it would do OUTSIDE of a lab rat cage!Peterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-10613538888493411992018-02-17T17:39:46.537+00:002018-02-17T17:39:46.537+00:00Mitochondrially targeted PUFA... Peter, would you ...Mitochondrially targeted PUFA... Peter, would you be so kind as to expand that a bit?<br /><br />Tangentially, I've been thinking about MitoQ, having seen it in some clinical trials. Does anyone else find the idea of replacing a key component of the ETC with a new,improved alternative sort of weird?Anonymoushttps://www.blogger.com/profile/00942809754735691624noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-61675121983994996992018-02-17T06:00:25.541+00:002018-02-17T06:00:25.541+00:00Monica, there are replies from April of 2017 in th...Monica, there are replies from April of 2017 in the second link. I believe he was also posting in summer.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-35687992735414400382018-02-17T04:02:57.222+00:002018-02-17T04:02:57.222+00:00Is Wolverine still alive though? His last article ...Is Wolverine still alive though? His last article was written in spring 2014, and his last reply to a comment in the fall 2016. Another comment written in 2017 is left unanswered. Monicahttps://www.blogger.com/profile/01328203937421867217noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-73415961083524133722018-02-16T12:12:34.350+00:002018-02-16T12:12:34.350+00:00Yes, not pretty. Wolverine's web page is a rab...Yes, not pretty. Wolverine's web page is a rabbithole to get lost in for a day easily. It contains plenty of rants but also incredible insights about medical thruths vs. medical reality.<br /><br />Poor guy is battling multiple myeloma now which he credits to two tours of Campath that his doctors prescribed "preemtively" because one could not wait for 48 h for the pathology results to come back to confirm rejection. Unbelievably, he later learned it was possible to get results in 3-4 h in the same hospital if the doctor deigned to put an urgent sticker on the job.Erichttps://www.blogger.com/profile/15626165768870660952noreply@blogger.com