tag:blogger.com,1999:blog-36840063.post9027413816074041236..comments2024-03-29T06:45:45.894+00:00Comments on Hyperlipid: ARDS and linoleic acidPeterhttp://www.blogger.com/profile/14527788116058656094noreply@blogger.comBlogger36125tag:blogger.com,1999:blog-36840063.post-10178080469818913652020-03-29T13:19:44.699+00:002020-03-29T13:19:44.699+00:0018 months. 18 months. DrCatehttps://www.blogger.com/profile/00938046745458730615noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-73822783744114045912020-03-28T18:08:15.813+00:002020-03-28T18:08:15.813+00:00Thanks a lot for the respond Peter! Having fed la...Thanks a lot for the respond Peter! Having fed lambs with a feed tube hundreds of times, I can only imagine what it would be like to snake a tube past both the esophageal and pyloric sphincters in a human! Thanks for the links and look forward to spending some time reading them.<br /><br />JustinJustinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-71169927462727339182020-03-28T16:49:59.286+00:002020-03-28T16:49:59.286+00:00Hi Justin,
I'd never made the connection betw...Hi Justin,<br /><br />I'd never made the connection between propofol and ARDS until about a week ago and currently it's only the observational studies tying plasma FFA PUFAs to ARDS (a friend sent me the full text of the abstract I linked to, ask if you'd like it). However propofol induction is well recognised as a trigger for pancreatitis https://high-fat-nutrition.blogspot.com/2019/08/who-gave-you-pancreatitis.html and there is some concern over enteral vs parenteral feeding in severe pancreatitis with poorer outcome from parenteral (containing Intralipid) https://www.ncbi.nlm.nih.gov/pubmed/24687866. Parenteral feeding is much simpler to set up than enteral, placing an enteral tube in the small intestine is a lot more complex than placing a central venous line. I'm not up to speed about the current alternatives to propofol for ITU sedation, it was pretty popular when I was still active in anaesthesia. Midazolam has its own problems. There is some interest in medetomidine. Perhaps it could be done... Have to say I've not hunted particularly hard as yet.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-41324890143972735532020-03-28T12:15:30.233+00:002020-03-28T12:15:30.233+00:00Peter, sorry if I missed any relevant posts on thi...Peter, sorry if I missed any relevant posts on this. I just started following you after a multiple year hiatus. Do you have links to papers specifically looking at ARDS and propofol administration? I understand how linoleic acid can be converted to arachidonic acid which can potentially lead to increased levels of arachidonate-derived proinflammatory metabolites through the ecosonoid pathway. If you have posted anything recently and I have missed it, I apologise. Thanks again for such an awesome blog!Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-10256246838105493612020-03-26T21:52:48.918+00:002020-03-26T21:52:48.918+00:00cave, propofol is a near miraculous anaesthetic in...cave, propofol is a near miraculous anaesthetic induction agent. Those of us brought up on thiopentone and methohexitone would never want to go back. But it really is intravenous soybean oil and I would not want this for myself in the ITU. But then I absolutely would not want to be awake/conscious during IPPV at the time that my lungs finally failed. The reports from Italy suggest that this is not a pleasant process.<br /><br />As Stuart commented there are IV lipids based on fish oil or MCT oils. The later might be a better option. Solubilised beef dripping would obviously be the best option but I'm not holding my breath 'til that one arrives!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-71258921248989133922020-03-26T14:38:17.004+00:002020-03-26T14:38:17.004+00:00Stuart—I read the entire Wolverine site years ago ...Stuart—I read the entire Wolverine site years ago and it made an indelible impression. Not only in terms of the effect of sugar and soy oil, but also the story of how he landed in the hospital in the first place (a botched "routine" colonoscopy). A friend of mine is the editor of a prestigious pathophysiology textbook. She advised to never get health care in Florida.<br /><br />Peter—out of curiosity I looked up propofol. "... Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation." If Intralipid is the vehicle used for it, and the soy oil may be a recipe for poor outcomes in terms of ARDS, maybe the physical restraint is preferable.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-25792647642121290432020-03-26T14:18:26.678+00:002020-03-26T14:18:26.678+00:00My other bugbear about intralipid is that it is th...My other bugbear about intralipid is that it is the vehicle for propofol used as a sedative in the ITU. I get the impression that this is not being used/not available in the current situation because there are reports of patients needing physical restraint, so I'm assuming no sedation. Doesn't sound pleasant.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-86184688554573557872020-03-26T09:59:06.790+00:002020-03-26T09:59:06.790+00:00I'm astonished that they're still using so...I'm astonished that they're still using soy oil in parenteral nutrition despite the knowledge that it causes liver failure in long-term patients, when there's a safe alternative in fish oil. See what this guy has to say about it<br />THE TRUTH ABOUT SOY<br />http://roarofwolverine.com/archives/1557<br />The high percentage of glucose in the solution does a number on your arteries too<br />THE EFFECT OF SUGAR ON ARTERIES<br />http://roarofwolverine.com/archives/1377<br /><br />With regard to the high number of deaths in Italy (and increasingly in Spain) although 28% of all men might be smokers today I'd bet that the % of smokers and former smokers in the senior male cohort was a lot higher. Add in a diet high in olive oil and you have a perfect storm.Stuarthttps://www.blogger.com/profile/06408876411408437836noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-44459575335126835062020-03-25T15:19:20.989+00:002020-03-25T15:19:20.989+00:00Bob, that's not how I'd view it. Being loa...Bob, that's not how I'd view it. Being loaded with hearthealthyPUFA will transfer you from supplementary oxygen to IPPV in the ITU to try and manage ARDS. You probably ended up on supplementary oxygen due to the consequences of hyperglycaemia/hyperinsulinaemia/PUFA aka metabolic syndrome, as in hearthealthyeating via Public Health England.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-4794211678533467072020-03-24T15:55:19.464+00:002020-03-24T15:55:19.464+00:00So going to the ICU may actually be making your ch...So going to the ICU may actually be making your chances of recovery worse. Holy hell.Bob Johnstonhttps://www.blogger.com/profile/14546741492390207599noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-24433532769567768582020-03-23T01:09:57.471+00:002020-03-23T01:09:57.471+00:00https://www.evolutamente.it/covid-19-pneumonia-inf...https://www.evolutamente.it/covid-19-pneumonia-inflammasomes-the-melatonin-connection/Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-6968139698941944542020-03-22T15:08:41.282+00:002020-03-22T15:08:41.282+00:00It has a strong antibacterial effect, and can kill...It has a strong antibacterial effect, and can kill both bacteria and viruses.<br /><br />https://www.breatheology.com/nitrogen-oxide-pleasant-poison/?fbclid=IwAR0FOtvhySrppRrrtvFWxhDqlOFeywAFT9R7PXj7OXvpdqR_wcIvjCIzH5kKajushttps://www.blogger.com/profile/06750298925760439779noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-5880611218184850142020-03-21T22:30:22.314+00:002020-03-21T22:30:22.314+00:00Sober reality.Sober reality.Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-64575196805318681702020-03-21T21:22:28.257+00:002020-03-21T21:22:28.257+00:00This guy has been reporting on the virus for some ...This guy has been reporting on the virus for some time. He predicted panic buying way back in Jan and his many followers continue thanking him as they had started stocking supplies then.He is very much doom/gloom and believes lockdowns are the only way to flatten the curve.He believes it will get a lot worse, very depressing https://youtu.be/yOIvGIukZhkJasmineJohendhttps://www.blogger.com/profile/11807503482277639920noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-83658592684527622882020-03-20T13:01:53.744+00:002020-03-20T13:01:53.744+00:00I raise you a 100 tins of Brazilian corned beef!I raise you a 100 tins of Brazilian corned beef!Ivohttps://www.blogger.com/profile/16328140864539105779noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-90829836387394038222020-03-20T10:10:44.660+00:002020-03-20T10:10:44.660+00:00My pretend apocalypse shopping wasn't too diff...My pretend apocalypse shopping wasn't too difficult this week. There was no TP of course, no bread or flour and not much chicken (yawn to all of those!). But I came away with a big lump of fatty beef roast and a dozen blocks of grass fed dripping which are the cheapest bulk calories on offer, and almost as many blocks of butter. No-one seemed to be paying much attention to the saturated fats, lipophobia works in your favour sometimes. This isn't very different to my usual fortnightly lipid shopping anyway. There's rice and masa harina in the cupboard if I get a carby substrate yearning. <br /><br />Lamb flaps (ribs plus belly cuts) will continue to be cheap and available here since they are regarded as only fit for pet food. Woof! Passthecreamhttps://www.blogger.com/profile/01214860448492630477noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-12374924204673959932020-03-20T00:48:55.552+00:002020-03-20T00:48:55.552+00:00Hi Peter! Silent reader, never left! Dat friday 13...Hi Peter! Silent reader, never left! Dat friday 13 shit sounds nasty... heres hoping my past/present super hi sfa intake spares from some of that lovely pufa damage @ while gasting... also pufa in the form of peanuts ( vit e?) No deep refried transShit made with corn oil<br />... time will tell, so far im great! XoD1Shttps://www.blogger.com/profile/08750123947536499341noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3558356838913376932020-03-19T21:53:47.608+00:002020-03-19T21:53:47.608+00:00I'm just glad I have plenty of quail, chickens...I'm just glad I have plenty of quail, chickens, sheep and an incubator! Not to mention 10 new lambs on the ground! BTW, it's blogs like yours that inspired me to start my own farm.Justinhttps://www.blogger.com/profile/05688462291078238507noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-81705337499060271512020-03-19T20:36:08.404+00:002020-03-19T20:36:08.404+00:00cave,
Yes, but we mustn't forget Sauer's...cave, <br /><br />Yes, but we mustn't forget Sauer's work and 13-HODE released by fasting in rats fed a typical omega-6 rich diet pre fasting...<br /><br />Hi DLS!<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-79194984633626621112020-03-19T14:37:44.309+00:002020-03-19T14:37:44.309+00:00DLS, I'm sure there could be a large range of ...DLS, I'm sure there could be a large range of turnovers based on eating habits and other factors. If one has a large depot content of PUFA there could be Herxheimer reactions as it is released (there was an entire episode of House MD based on this concept, one of my favorites actually). Peter pointed out that there may be preferential releases of saturated fat…This would be a fascinating subject to explore.cavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-3290803334671986762020-03-18T23:21:47.323+00:002020-03-18T23:21:47.323+00:00fast and clean adipose turnover please!!! 3 mont...fast and clean adipose turnover please!!! 3 months ago i choose to eliminate all pufa, increased my long-chain SFA intake... and rapidly lost body fat, then gained a bit back, all my pains are gone, so adeus crunchy peanuts... its time to say goodbye! so 5 years? that's seems ridiculous Peter, i bet ( hope) it takes my a fraction of the time... still doing IF intermittent fasting 4 times a week or more + good ol regular keto + 0 carbs most days + the "sane" pkd parts ( more organ meat, liver, cow fat) not ready 2 dive in a pool of chicharrones and raw shit or give up butter, cream, cheese. my only true crime now is coke no sugar/ caffeine / artificial sweeteners... also not ready to give up the sweetness! i do expect to hear they are the root off all evil soon...D1Shttps://www.blogger.com/profile/08750123947536499341noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-61915626620525745662020-03-18T21:34:44.345+00:002020-03-18T21:34:44.345+00:00Yes cave, I read that one too. Ultimately we will ...Yes cave, I read that one too. Ultimately we will need a body count when all is settled and it can be compared to an average or a bad flu year. It's quite normal to run out of mortuary space at my local hospital in a bad flu year so refrigerated storage gets brought in. There has also been a long term policy of not putting critically ill patients on to ventilators unless there is a realistic chance of weaning them off after successful treatment. Traumatising n=1 experience of unwean-able patients tends to sharpen your anaesthetist's decision making about instituting ventilation in the ITU. Always has done, it's not new to this pandemic.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-69798685376314769082020-03-18T21:00:32.259+00:002020-03-18T21:00:32.259+00:00Along those lines, ran across this today. I've...Along those lines, ran across this today. I've long respected John Ioannidis, so this is making me really scratch my head and wonder what to believe.<br /><br />"A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data"<br /><br />https://www.statnews.com/2020/03/17/a-fiasco-in-the-making-as-the-coronavirus-pandemic-takes-hold-we-are-making-decisions-without-reliable-datacavenewthttps://www.blogger.com/profile/08461541719892430585noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-50052028141317871162020-03-18T20:14:15.480+00:002020-03-18T20:14:15.480+00:00Ivo, nice video.
Time will tell, hopefully he is...Ivo, nice video. <br /><br />Time will tell, hopefully he is correct.<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-36840063.post-32175659933512582472020-03-18T18:31:25.055+00:002020-03-18T18:31:25.055+00:00After they watch the Dr. Wodarg video they will wa...After they watch the Dr. Wodarg video they will want their money back. https://youtu.be/p_AyuhbnPOIIvohttps://www.blogger.com/profile/16328140864539105779noreply@blogger.com