Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Sunday, March 12, 2023

Adipose triglyceride lipase knockout mice

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People may have noticed that I'm quite interested in basal lipolysis, adipocyte size and metabolic syndrome. That is correct. What happe...
17 comments:
Sunday, March 05, 2023

How can insulin resistance cause weight gain? (5) MCTs

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The problems posed to the Protons hypothesis by the failure of fully hydrogenated coconut oil to suppress obesity in rodent models continues...
21 comments:
Tuesday, February 21, 2023

How can insulin resistance cause weight gain? (4) amplification

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Okay. Here are the basics of insulin facilitated glucose oxidation: Insulin -> Insulin Receptor (IR) -> G coupled protein -> NADPH ...
11 comments:
Monday, February 20, 2023

How can insulin resistance cause weight gain? (3) AD-9308

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This is a random, throw away post. A one-liner, don't laugh. I happened on this paper following a link in a link to a link during my 4-H...
3 comments:

How can insulin resistance cause weight gain? (2) 0.1 μM

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When you type adipocyte + 4-HNE to Pubmed, this is your first hit 4-hydroxynonenal causes impairment of human subcutaneous adipogenesis and ...
5 comments:
Sunday, February 19, 2023

How can insulin resistance cause weight gain? (1) ALDH2

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Mea culpa. Sorry all for neglected comments else where on the blog and IRL. Blame Tucker for this link in here ... Here's the next post...
31 comments:
Saturday, February 18, 2023

Delta psi and ROS

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I'll post this now as I've gone off down a related but more concise rabbit hole for the next posts. Okay. Here are a couple more bui...
3 comments:
Sunday, February 05, 2023

Warning: Politics

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Over the years I have only very rarely touched upon politics, outside of the corruption intrinsic to certain types of scientific publication...
33 comments:
Monday, January 23, 2023

Delta psi and insulin and ROS

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The hypothesis paper New Control of Mitochondrial Membrane Potential and ROS Formation – A Hypothesis mentions some factors which might floo...
11 comments:
Saturday, January 21, 2023

Complex IV and control of delta psi

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There was a time, quite early in my anaesthesia training, when we used to use a calcium infusion to support blood pressure in anaesthetised ...
8 comments:
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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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