Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Saturday, March 21, 2026

Insulin resistance (12) Lipopolysaccharide

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I've mentioned this paper by Nowotni from Shulman's lab on several occasions Mechanisms Underlying the Onset of Oral Lipid–Induced S...
Saturday, March 14, 2026

Insulin resistance (11) NAC might cure your diabetes

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The next scenario is to look at the effect of NAC on metabolic syndrome with or without marked hyperinsulinaemia. We're looking at this ...
Tuesday, March 03, 2026

Insulin resistance (10) NAC might make you diabetic

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Here is the next paper Complexity of NAC Action as an Antidiabetic Agent: Opposing Effects of Oxidative and Reductive Stress on Insulin Secr...
13 comments:
Monday, February 23, 2026

Insulin resistance (09) NAC and body weight

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 Let's start here with: N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders in particular with Fig 1: That...
12 comments:
Friday, February 20, 2026

Insulin resistance (08) UCP2

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Another accidental find from my hard drive, probably saved somewhere around 2020. Differential effects of saturated versus unsaturated dieta...
12 comments:
Friday, February 13, 2026

Insulin resistance (07) Astrup's FFAs in the post-obese

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Preamble/caveat. You have to be careful with Astrup's work over the years. When you get in to the fine print some of his control groups ...
17 comments:
Thursday, February 12, 2026

Insulin resistance (06) VMH

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I've got these three, apparently independent, origins for the concept that insulin resistance is an evolutionary conserved mechanism, es...
6 comments:
Tuesday, February 10, 2026

Insulin resistance (05) Spanish butter in Noddy numbers.

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Let's go back to butter vs PUFA as in the last post . I'm going to use reductio ad absurdum to try make it absolutely clear why a fa...
8 comments:
Saturday, February 07, 2026

Insulin resistance (04) Spanish butter

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I am firmly convinced that linoleic acid induces the rapid onset of insulin resistance in humans. This is beautifully illustrated by this pa...
3 comments:
Friday, February 06, 2026

Insulin restance (03) The failure to resist hat trick

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I was searching my hard drive for another paper when I came across this one: Substituting dietary saturated fat with polyunsaturated fat cha...
2 comments:
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About Me

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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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