Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Thursday, November 03, 2016

An Error

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Back in January of this year I made a significant artimetical error which, combined with the massive confirmation bias from which I suffer,...
13 comments:
Thursday, September 29, 2016

Flow Mediated Dilation: What does it mean?

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Flow mediated dilation (FMD) is one of the last bastions of low fat dogma. FMD is particularly interesting as you appear to be able to prov...
21 comments:
Monday, September 19, 2016

On the bike

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Just back from a pushbike/teaching tour from (my bit, Mike went much further) Orkney to Inverness. I'll try to get up to speed on emails...
Thursday, August 11, 2016

Protein catabolism should generate an RQ of around 0.8

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Anyone who has read Martha's story and put her narrative together with the folks in Phinney's 1980 study will have immediately won...
22 comments:
Tuesday, August 09, 2016

Glucose from fatty acids: RQ of 0.454

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This is a section from Table V of Heinbecker's 1928 paper: Studies on the Metabolism of Eskimos This tells us certain very...
25 comments:
Sunday, August 07, 2016

Just a heads-up

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Protons (44) has been markedly updated . Just a heads up in case the update doesn't come through as a "New Post" to anyone who...
Thursday, August 04, 2016

Protons (44) Does fatty acid oxidation really drive reverse electron transport and superoxide generation at complex I?

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This post has been extended and adjusted quite considerably in the light of further information. The first five comments in the comments sec...
28 comments:
Tuesday, August 02, 2016

Acetone to oxaloacetate

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Some time back in May this year I posted on what I considered to be gluconeogenesis from acetoacetate via acetone (You don't have to re...
26 comments:
Sunday, July 31, 2016

A load of crap in Gartnavel

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This came to me via Facebook from Wally Courie: Poop Pill’s Surprise Failure Shows That the Microbiome is Still a Mystery The original f...
3 comments:
Wednesday, July 06, 2016

Arteriosclerosis (6) and Subbotin

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It seems a very long time ago that I wrote a series of posts on the mechanism of the development of the arterial tunica intima from a single...
45 comments:
Monday, May 23, 2016

The degradation of mitochondrial research

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Does everyone remember this? Most especially this bit: Control is using pyruvate at 5 mmol/...
8 comments:

Will fasting destroy your mitochondria? (No).

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I started with this paper: Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Huma...
7 comments:
Sunday, May 15, 2016

Fruit Flies and NDI1

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The Protons thread originated when I asked myself: What is the difference between fat oxidation and glucose oxidation? This rapidly led to t...
5 comments:
Friday, May 13, 2016

Uncoupling in a can?

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In response the suggestion from E-S, at top of comments to the last post, that caloric output should be measured using a calorimeter: Dire...
8 comments:
Wednesday, May 11, 2016

Uncoupling and weight loss

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I've spent the last three posts making the point that fatty acid oxidation (supplemented by ketosis) increases the amount of ATP (and en...
35 comments:
Monday, May 02, 2016

On Stephen Phinney and an RQ of 0.62

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****Edit**** There is an update on this post here ****End edit**** Now, oxidising long chain saturated fat gives you an RQ of 0.69. Lowe...
23 comments:
Friday, April 29, 2016

Endurance and oxygen flux during fatty acid oxidation

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I was browsing Pubmed looking for other things when I came across this ancient publication by Stephen Phinney, from back in 1980. Those were...
8 comments:
Tuesday, April 26, 2016

Dave Asprey and Dr Veech

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Dave Asprey has a very interesting extended discussion with Dr Veech on his Bulletproof website, mostly about ketones but also about the his...
24 comments:
Sunday, April 24, 2016

When is a ketogenic diet not a ketogenic diet?

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I've listened to a few youtube/podcasts videos recently. Seyfried, Veech and D'Agostino appear to besettled in to what looks like a ...
10 comments:
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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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