Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Saturday, March 25, 2017

Amgen share price and PCSK9 inhibition with Repatha

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Just a one-liner to bookmark the death of Repatha. PCSK9 inhibitors have bombed and the cardiology community is in complete denial. Now th...
19 comments:
Friday, March 24, 2017

Will palmitic acid give you cancer or fuel metastasis?

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Again thanks to Mike Eades for the full text of this paper and to Marco for poking me about it. Targeting metastasis-initiating cells thro...
8 comments:
Thursday, March 23, 2017

Just a little on complex I and models

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OK, just a brief summary of the parts I like most from the excellent The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficienc...
4 comments:
Thursday, March 16, 2017

Protons: More from Dr Speijer

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Mike Eades forwarded this paper to me, by Dr Speijer: Being right on Q: shaping eukaryotic evolution How good is it? He covers a vast ...

Stearic acid, FADH2, complex I and cancer

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Just a quick aside: George cited this study in the comments of the last but one post : Metformin inhibits mitochondrial complex I of can...
6 comments:

That poor old C57Bl/6 mouse

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There is a is a link within the GuarĂ¡s et al CoQ paper I put up in the last post (which I'll probably go back to in some detail in futu...
Thursday, March 09, 2017

Protons: The destruction of complex I

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It is quite difficult to express how exciting this paper is to a Protons thread True Believer: The CoQH2/CoQ Ratio Serves as a Sensor of ...
61 comments:
Saturday, March 04, 2017

Trans fats vs linoleic acid

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****************************************************************** TLDR: Trans fats may not be as bad as they are made out to be. ********...
36 comments:
Friday, March 03, 2017

Mitochondria in cancer cells

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****************************************************************** TLDR: This is just a speculative post about a paper which is interesting...
7 comments:
Wednesday, February 15, 2017

Linoleic acid and Tuberous Sclerosis

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********************************************************** TLDR: I don't like linoleic acid much. ************************************...
35 comments:
Thursday, February 09, 2017

Musing about linoleic acid

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***************************************************************** TLDR: I have long wanted to know how you could have differential insulin ...
38 comments:

Can linoleic acid keep you slim?

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***************************************************************** T LDR This is a weird study which might show the insulin sensitising eff...
5 comments:
Wednesday, February 08, 2017

Acromegaly produces a lean and well muscled diabetic

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***************************************************************** TLDR: Growth hormone causes lipolysis, makes you slim, preserves muscle m...
11 comments:

Protons: Obesity and diabetes

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***************************************************************** TLDR: Linoleic acid makes your adipocytes insulin sensitive. As the adipo...
7 comments:

Acipimox (2) and weight gain

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***************************************************************** TLDR: Forced lipolysis gives weight loss and elevates FFAs which cause in...

Long time no post

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Hello blog. Months of neglect means that I've just found "n" unread comments awaiting moderation. They are all so old that all...
Tuesday, December 06, 2016

Dunnigan-type Familial Partial Lipodystrophy

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Ivor posted a link to this paper on FB: Premature atherosclerosis associated with monogenic insulin resistance Obviously the role of hyp...
19 comments:
Thursday, December 01, 2016

Inhibiting lipolysis using acipimox

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Okay, time to start doing a little blogging again. I've been thinking about various aspects of free fatty acids largely derived from stu...
5 comments:
Thursday, November 03, 2016

An Error

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Back in January of this year I made a significant artimetical error which, combined with the massive confirmation bias from which I suffer,...
13 comments:
Thursday, September 29, 2016

Flow Mediated Dilation: What does it mean?

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Flow mediated dilation (FMD) is one of the last bastions of low fat dogma. FMD is particularly interesting as you appear to be able to prov...
21 comments:
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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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