Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Wednesday, February 28, 2018

More on drinking varnish

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This paper is a gem. Reducing the Dietary Omega-6:Omega-3 Utilizing α-Linolenic Acid; Not a Sufficient Therapy for Attenuating High-Fat-Di...
18 comments:

Alcohol steatosis and NASH

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This came to me via George in the comments to an earlier post: Supplementation of Saturated Long-Chain Fatty Acids Maintains Intestinal Eu...
7 comments:

Fructose and lipolysis

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You have to be very, very careful with fructose feeding papers. It is very easy to slant your methods to give strange and conflicting result...
Sunday, February 25, 2018

Registered Dietitian Health Educators: how fat do you want to get?

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I guess everyone has seen this: Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Associatio...
22 comments:
Tuesday, February 20, 2018

Alcohol and weight loss

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This is a paper I really like. It's about the slimming effect of alcohol: Chronic alcohol exposure stimulates adipose tissue lipolysis...
16 comments:
Thursday, February 15, 2018

Systemic fructose is important

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****************************************************************** TLDR: Be cautious of anyone who tells you fructose metabolism is limited...
35 comments:
Wednesday, February 14, 2018

TRAK2 and HDL. Do we care?

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George posted the link to this editorial in the comments of a post some considerable time ago (so it seems now). So this is another old post...
14 comments:

Collateral damage from saturophobia. People really do get hurt.

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I've spent the last few posts talking about the parlous state of research in to NAFLD and the techniques for justifying saturophobia. Th...
12 comments:

Saturated fat and fatty liver. Payday in Colorado.

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Dophamn supplied the link to another interesting study: The role of visceral and subcutaneous adipose tissue fatty acid composition in liv...
11 comments:
Monday, February 12, 2018

Saturated fat and fatty liver. Payday in Sweden.

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DLS posted a link to this paper in the comments on the last post . Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects o...
20 comments:
Monday, February 05, 2018

Follow on to Tucker's post on PUFA in rats

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Tucker posted an excellent discussion  of this paper on his blog. Go read it: Fat Quality Influences the Obesogenic Effect of High Fat Die...
31 comments:
Saturday, January 20, 2018

Metformin (07) glargine 50iu/kg causes diabetes

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The group which demonstrated that exogenous insulin induces insulin resistance in T1DM NOD mice went on to demonstrate that exogenous insuli...
27 comments:
Friday, January 19, 2018

Metformin (06) Insulin-induced insulin resistance is real

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When I started reading about insulin-induced insulin resistance I began with this paper: Insulin Is a Stronger Inducer of Insulin Resistan...
10 comments:
Sunday, January 14, 2018

A wander off in to dietary protein calories

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There is prize for developing the longest-lived mouse in the world. It was set up in 2003 and the first award went to Dr Bartke. "On ...
18 comments:
Sunday, December 24, 2017

Metformin (05) Insulin Resistance

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Happy Christmas all. Would have been Happy Solstice but one of our cats died that day. Anyhoo. Back to this image from the Japanese paper ...
18 comments:
Saturday, November 04, 2017

Metformin (04) Pre and Post Prandial

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The next metformin paper to look at is this one: Beneficial effects of metformin on energy metabolism and visceral fat volume through a po...
7 comments:

Succinate doesn't drive reverse electron transport. Maybe.

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Mike Eades sent me this paper: Reactive oxygen species are generated by the respiratory complex II – evidence  for lack of contribution of...

Metformin (03) In-vivo experiments require non-lethal dose rates!

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Just before I move on to metformin-induced substrate oxidation changes in healthy volunteers, I think it's worth looking at this neoplas...
Wednesday, August 02, 2017

Metformin (02) The dose makes the poison

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Before the days of interest in metformin as an anti-neoplastic agent, a performance enhancing drug or a longevity promoter, it was just give...
10 comments:
Tuesday, July 25, 2017

Metformin (01) Insulin

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This image is taken from the paper  Insulin requirement for the antihyperglycaemic effect of metformin  and it deserves a little considerati...
7 comments:
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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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