Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Sunday, January 20, 2019

Metformin (10) Macavity

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TLDR: Macavity, Macavity, there's no one like Macavity, He's broken every human law, he breaks the law of gravity. His power...
7 comments:
Saturday, January 19, 2019

Cell surface oxygen consumption (2)

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How does cell surface oxygen consumption happen? Here is the main reaction overall (it's probably not that simple!): 4e - + 4 H + + ...
2 comments:
Friday, January 18, 2019

Cell surface oxygen consumption (1)

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Back in the comments thread to the More on insulin and the glycerophosphate shuttle post there has been some discussion as to whether Warbu...
12 comments:
Friday, January 11, 2019

How primordial is oxidative phosphorylation?

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It is perfectly possible to run a sophisticated metabolism using the energy available from an hydrogen rich geochemical proton gradient of t...
7 comments:
Monday, December 31, 2018

How much linoleic acid to get fat and insulin resistant?

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Tucker and Mike both gave me the heads-up on this paper recently. Linoleic acid causes greater weight gain than saturated fat without hypo...
21 comments:
Thursday, December 20, 2018

Urinary c-peptide

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It's the Winter Solstice tomorrow, greetings to all! My favourite astronomical event of the year, even though we do the major feasting o...
9 comments:
Wednesday, December 12, 2018

A post not about Walter Kempner

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I've had this paper on my hard drive for a while. It's been sitting somewhere near the front of the back of my mind but was doing no...
15 comments:
Tuesday, December 04, 2018

An exchange of half bricks

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I would guess that everyone is aware of the study by Ebbeling et al, Ludwig's group, looking at the metabolic effect of low carbohydrate...
22 comments:
Sunday, November 25, 2018

More on insulin and the glycerophosphate shuttle

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Raphi tweeted this paper recently Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS whic...
36 comments:
Saturday, November 24, 2018

Metallic iron and the origin of metabolism

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Over the years I've been convinced that carbon monoxide derived formaldehyde/formate are probably the initial molecular precursors of ac...
Wednesday, November 14, 2018

A brief aside in to statins and FH and all cause mortality

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I must admit that I have not read this paper, just the abstract. My excuse is, once again, that I have no access to any ondansetron. Stati...
28 comments:

Listeriosis is no fun

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Just doing my bit Vegetables, nine dead of listeriosis Quick edit for when the link dies: "9 people dead following Listeria outbr...
8 comments:
Wednesday, November 07, 2018

Green Tea Extract; superb antioxidant?

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Here is a little more from this paper: High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS This is insu...
13 comments:
Friday, November 02, 2018

Stone Agers in the Fast Lane?

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A destruction of Paleo Diet ™  as a management tool for metabolic syndrome in modern humans surfaced recently in a tweet from Miki Ben-Dor, ...
30 comments:
Tuesday, October 30, 2018

Selenium induced glutathione peroxidase generation

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TLDR: excess selenium induces excess glutathione peroxidase which blunts physiological superoxide/H2O2 signalling within a cell. This, as yo...
11 comments:
Sunday, October 21, 2018

Metformin (09) Islets

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This is another very abstracted study using isolated mouse islets in cell culture to assess the effect of metformin on insulin secretion. ...
14 comments:
Monday, October 15, 2018

Metformin (08) Insulin and AMPK

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This is a simplified diagram of most of the pathways around AMP-kinase (AMKP) which I found at the website of a commercial company on tinte...
3 comments:
Saturday, September 15, 2018

Insulin makes you hungry (9) Women

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Intranasal insulin does not, under any circumstances, reduce food intake or bodyweight in women. That's half the population. Hallsch...
6 comments:
Wednesday, September 12, 2018

Insulin makes you hungry (8) Blokes

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Now it's time to look at the simple situation of men given intranasal insulin. We have a chronic study using 40iu and an acute study usi...
Sunday, September 09, 2018

Insulin makes you hungry (7) superoxide is satiety

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What causes satiety, if it's not insulin? This has to be understood if there is to be any chance of understanding the effects of intrana...
3 comments:
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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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