Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Tuesday, September 03, 2024

Protons (77) Shulman PUFA and insulin sensitisation. Or not. Or so.

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Over in the comments to the last post on metformin and Shulman's lab,  Tucker pointed out that Shulman was an author (penultimate, so ...
7 comments:
Sunday, September 01, 2024

Metformin (16) The LaMoia Shulman review

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I first came across Gerard Shulman and his research group at Yale here: Metformin suppresses gluconeogenesis by inhibiting mitochondrial gly...
3 comments:
Sunday, August 25, 2024

Protons (76) Those D12492 fed mice (Speakman and Tucker again)

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For people who are thinking about re-listening to Tucker's discussion with Prof Speakman, at Ep. 22: John Speakman—What Causes Obesity? ...
19 comments:
Wednesday, August 21, 2024

Protons (75) Tucker; Speakman; Astrup and linoleic acid. And insulin sensitivity

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Tucker has a podcast episode in which he chats to John Speakman about obesity. It's one of the more interesting podcasts I've listen...
17 comments:
Thursday, July 11, 2024

Protons (74) Arne Astrup and the formerly obese

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I have a soft spot for Arne Astrup. Back in the days of the depths of the Danish fat taxation stupidity, he was one of the voices of reason ...
37 comments:
Saturday, June 01, 2024

Protons (73) Spanish vs Canadian studies or 3% LA vs 10.3% LA

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I hope no one has forgotten the "Spanish Study" Distinctive postprandial modulation of beta cell function and insulin sensitivity ...
44 comments:
Thursday, May 30, 2024

Protons (72) Humans: 8% LA vs 74% LA by sustained oral ingestion

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This study in humans is very different to the previous rat study. People were fed repeated oral fat loads (you could call this Bulletproof C...
5 comments:

Protons (71) Rats: 13% LA vs 61% (mostly) LA by infusion

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I have a certain, very specific, idea of how linoleic acid produces obesity. It seems as though relatively few people share this point of vi...
6 comments:
Wednesday, May 29, 2024

Foie Gras (11) Hepatocyte mitochondria

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Another tidy up, this time related to  Fat Quality Influences the Obesogenic Effect of High Fat Diets and the paradox of mitochondrial uncou...
11 comments:

Foie Gras (10) Liver

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Just to tidy up my thoughts on A High Linoleic Acid Diet does not Induce Inflammation in Mouse Liver or Adipose Tissue TLDR: I suppose all I...
Saturday, March 30, 2024

Foie gras (9) Adipocyte ROS

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Time to look at the Vaughan mouse weight gains and actual diet compositions. Here is a recap of the weight gains: and here is Table 1 with ...
17 comments:
Sunday, March 24, 2024

Foie Gras (8) Vaughan's macrophages

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Okay, back to the Vaughan paper A High Linoleic Acid Diet does not Induce Inflammation in Mouse Liver or Adipose Tissue and a look at their ...
1 comment:

Foie Gras (7) What do you mean by inflammation?

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This paper contains a very superficial and bullet point overview of the inflammatory cascade. It omits swathes of anti inflammatory pathways...
12 comments:
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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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