Here is a link to an interview with Cynthia Kenyon, published in New Scientitst back in 2003. It's subscription only now and though I've got a copy on my hard drive it might be better if I just direct you to a site where someone called James Hughes will provide the text!
She is heavily committed to finding a life extending drug. To me, personally, this will run smack bang in to the Law of Unintended Consequences head on. Lowering insulin by diet choices, as she currently practices, seems to be the best plan for a reduction in the diseases old age. (Peter crosses fingers).
Peter
Thank you Peter for the interesting post and link!! See... there are people in the US (even UCSF) as progressive as yourself. *chuckle* What do you think of that TG/HDL ratio?! I love it! I'm glad she mentioned that as well -- it's an excellent surrogate marker for small LDL -- I'd predict she has no plaque -- just as your specialized carotid doppler would indicate as well :)
ReplyDeleteHi chainey,
ReplyDeleteA lot to listen to!
Thanks
Peter
I read this a while ago from Art De Vany's Evolutionary Fitness blog, I think. I debate Kenyon's claim that carbs make you sleepy. I never feel sleepy, even after holiday meals in the family home. Most of the carbs I eat are natural and paleo - fruit and unheated honey. Maybe a potato, sourdough bread, or sprouted breads sometimes. Also, I eat in a certain order. Not haphazardly. Generally I eat the lightest food first and the heaviest food last, by feel.
ReplyDeleteGood point, Chainey, about how most longevity pursuers fail. Look at Dr Roy Walford. He thought he'd thrive beyond 120. He died from ALS at 79. (No thanks due to his low-fat plant based diet, of course.)
I understand that Roy Walford's daughter weighs 80 lbs and subsists on 4 almonds and 6 walnuts a day ...
ReplyDeleteSo she'll live to be a thousand???? Mixing up C elegans and humans is probably a mistake.
ReplyDeletePeter
The Law of Unintended Consequences rules supreme.
ReplyDeleteI like this quote from Michael Rose:
NYTimes: Do you believe there is such a thing as a limited life span for humans?
Michael Rose: No. Life span is totally tunable. In my lab, we tune it up and down all the time.
Not by developing technology to postpone human aging a la Aubrey Grey, in his famous, long-running fruit flies experiment he simply retards fertility and gets longevity.
JohnN