I'm off on vacation for a while so the next posts are likely to be delayed. If anyone would like a light summary of the ideas I'm thinking about, this is a nice review:
Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism
For a level deeper of understanding you just need to add in that saturated fats have an FADH2:NADH ratio around 0.49 which is the physiological signal for insulin resistance and MUFA generate one of around 0.47, giving the signal for insulin sensitivity. This is physiology.
Adding in PUFA as a bulk calorie source, with an insulin hyper-sensitivity generating FADH2:NADH ratio of well below 0.47, leads to expanded adipocytes. This is pathology.
Because a core function of insulin is the inhibition of lipolysis.
Peter
Enjoy your vacation/holiday!
ReplyDeleteSo, would you characterize MUFA as being slightly insulin sensitizing and PUFA as being dramatically insulin sensitizing?
It's amazing to me that such a small difference (.02) causes either insulin resistance or insulin sensitivity (or less insulin resistance? I assume it's a "scale" with high IR/low insulin sensitivity on one side and low IR/high insulin sensitivity on the other).
This is one of the reasons -- oddly enough -- why I consider you to be trustworthy. You let the numbers lie where they fall. This is unlike everything else in nutrition/health: BMI of 29.9 is OK, but 30.0 is "overweight"; total cholesterol of 200.0 or greater is "bad"; blood pressure of 140/80 is "bad". The numbers are too round. If a scientist made them, they'd at least have a decimal point (eg, 210.7 is "high" cholesterol). ;-)
Just to deposit the links, two recent articles.
ReplyDeleteOne adheres mostly to conventional stupidity, i.e. less than 40% of carbs bad, if you must eat high fat, eat vegetable oils:
https://www.theguardian.com/lifeandstyle/2018/aug/16/both-low-and-high-carb-diets-can-raise-risk-of-early-death-study-finds
And one with quite good data. Apparently, folks in the 70s didn't exercise more but actually ate more calories than today:
https://www.theguardian.com/commentisfree/2018/aug/15/age-of-obesity-shaming-overweight-people