Hyperlipid

Before the days of interest in metformin as an anti-neoplastic agent, a performance enhancing drug or a longevity promoter, it was just give...

This image is taken from the paper  Insulin requirement for the antihyperglycaemic effect of metformin  and it deserves a little considerati...

Hi All. We've moved house. It has not been the simplest of moves. OK, it was awful. However it was also worth it as we live here now. ...

If we consider the dissociation of hydrogen: the right hand side of the equation can supply electrons to another reaction. The tende...

Nick Lane has a few more downloadable papers available on his website, two of which focus on ideas I've thought a lot about. Here are a ...

Back at the end of 2015 Mike Brampton and I had a conversation about climbing Everest. Based on Graph A from Fig 3 in D'Agostino's...

Naked Mole Rats appear to use fructose as their preferred metabolic substrate when exposed to both physiological hypoxia (which is common in...

Some weeks ago a friend sent me a full text copy of the Naked Mole Rats (NMR) paper Fructose-driven glycolysis supports anoxia resistance ...

Mulkidjanian is a co-worker with Skulachev and extremely wedded to the primacy of Na+ bioenergetics, which is good. He has been looking at N...

This is the final paragraph in the discussion section of the paper by Skulachev , regarding the use of a Na+/K+ concentration gradient acros...

TLDR: Cells become islands of raised K+ ion concentration when energy is supplied. Okay, here come the doodles based on Skulachev's p...

We know from papers like Effect of Very Small Concentrations of Insulin on Forearm Metabolism. Persistence of Its Action on Potassium and ...

Well, this post is about rho zero  (ρ °)  cells. TLDR: It's even more obscure than usual. This is the basic ETC plus the ATP:ADP antip...

Nick Lane makes some interesting comments about Loki, currently accepted as being the closest living descendent of the archaeon which merged...

I had an email from a PR company representing Amgen, re Repatha and all cause mortality. Here's the bit of interest: *****************...

Aaron posted the link to this paper via Facebook: Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes As t...

Just a one-liner to bookmark the death of Repatha. PCSK9 inhibitors have bombed and the cardiology community is in complete denial. Now th...

Again thanks to Mike Eades for the full text of this paper and to Marco for poking me about it. Targeting metastasis-initiating cells thro...

OK, just a brief summary of the parts I like most from the excellent The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficienc...

Mike Eades forwarded this paper to me, by Dr Speijer: Being right on Q: shaping eukaryotic evolution How good is it? He covers a vast ...