Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Wednesday, November 27, 2019

Of mice and men

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I usually start from the premise that insulin makes you fat. The most simplistic prediction from this is that eating carbohydrate raises ins...
44 comments:
Monday, November 11, 2019

Protons (51) From peripheral cells to the brain

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Hunger and satiety. Can these be modelled from a very simple energy availability concept? This post is a minimally referenced ramble throu...
9 comments:
Friday, November 08, 2019

Insulin makes you hungry (11) But not in Denmark?

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Preamble. The best papers are those which challenge your ideas. When they conflict with what appears to be very hard evidence which support ...
8 comments:
Sunday, November 03, 2019

Insulin makes you hungry (10) Processing

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I picked up a link to this paper from an image of a table, somewhere on Tinternet. I didn't realise which paper it was. It was really i...
20 comments:
Sunday, October 20, 2019

Ketogenic diets are unhelpful and dangerous for managing mitochondrial diseases. Maybe (2)

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I'm hoping we all remember Sauer. If not there's a post here: Sauer vs Lisanti And a brief summary at the start of this one: S...
71 comments:
Friday, October 18, 2019

Total Cholesterol and major cardiovascular events

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This is a pure observational study: Low total cholesterol is associated with increased major adverse cardiovascular events in men aged ≥70...
4 comments:
Saturday, October 12, 2019

Metformin (11) a SHORT paradox

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I'll just throw this one out there as I found it while looking for something else: Metformin paradoxically worsens insulin resistance ...
17 comments:
Friday, October 11, 2019

Ketogenic diets are unhelpful and dangerous for managing mitochondrial diseases. Maybe.

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I think this is probably an abstract from a short communication at a conference. I picked it up from Miki Ben-Dor on twitter I think we ...
28 comments:
Saturday, October 05, 2019

Confirmation bias is so nice

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Excellent work: Scientific discourse in the era of open science: a response to Hall et al. regarding the Carbohydrate-Insulin Model Via ...
3 comments:
Tuesday, October 01, 2019

Personal update 2019

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Okay, personal update time. Back in the middle of May this year Paul emailed me to let me know that Dr Kwasniewski had died at the age of ...
114 comments:
Monday, September 23, 2019

The paradoxical fat mice (2)

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This is the intra-peritoneal insulin tolerance test (ITT) result from the mice in Caloric Restriction Paradoxically Increases Adiposity in...
Saturday, September 21, 2019

Ketones in Tehran

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Just a one-liner This is a quite fascinating paper from Iran. Bear in mind that none of the authors appears to be a native english speaker...
11 comments:
Sunday, September 15, 2019

The paradoxical fat mice (1)

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This paper is very interesting. I think I picked it up via Raphi on twitter. It comes from Jim Johnson's lab. Caloric Restriction Para...
10 comments:
Thursday, September 05, 2019

Hyperlipid Protons ambassadors

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Many people may have noticed that the blog Hyperlipid is not exactly the most user friendly of blogs. The prose clearly appears to make sens...
34 comments:
Sunday, September 01, 2019

The sweet taste of DMEM

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I mentioned in the last post that few papers ever specify the glucose concentration used for cell culture. This came up in comments from Ale...
2 comments:
Wednesday, August 28, 2019

Who gave you pancreatitis?

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Background: Propofol is a mainstay anaesthetic induction agent. Its use is associated with occasional pancreatitis episodes. I won't wan...
24 comments:

Protons (50) The video

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Dave Speijer has a great video up on YouTube based largely around his recent paper in BioEssays. Can All Major ROS Forming Sites of the Re...
9 comments:
Monday, August 19, 2019

Protons (49) Complex III

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Dave Speijer, an extremely insightful person if ever there was one, has a new paper out: Can All Major ROS Forming Sites of the Respirator...
10 comments:
Tuesday, July 23, 2019

On belief structures in lipidology (2) KODA-CP

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Altavista put up an excellent link to an article describing an AI algorithm capable of mining pubmed abstracts and coming up with gold. The...
26 comments:
Monday, June 24, 2019

On belief structures in lipidology

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Dr Thomas "Just-take-the-statin" Dayspring writes on twitter: "Any apoB-lipoprotein less than 70 nm in diameter can pass be...
63 comments:
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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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