Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Sunday, October 24, 2021

Are COVID-19 vaccines useful? (2)

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I really, really don't like this: Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination I picked it u...
42 comments:
Friday, October 22, 2021

Are COVID-19 vaccines useful?

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Mike Eades updated the current copy of the Arrow to include Alex Berenson's observation that the  COVID-19 vaccine surveillance report W...
25 comments:
Saturday, October 16, 2021

Modelling energy intake (3): empagliflozin

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In the aftermath of the of canfliglozin post I picked up this paper via Tucker: Energy Balance After Sodium–Glucose Cotransporter 2 Inhibiti...
11 comments:
Tuesday, September 14, 2021

Modelling energy intake (2): Corn oil

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This post has been waiting around for some time so I thought I'd just put it up before settling down to read The carbohydrate-insulin mo...
32 comments:
Monday, September 06, 2021

Modelling energy intake: Canagliflozin

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It is quite possible to make a very reasonable estimate of how many calories a given person has consumed over the previous few weeks by esti...
26 comments:
Wednesday, September 01, 2021

Back to a semblance of normality: A couple of conversations

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Hi all. Life is back to a semblance of normality now. I've de-spammed/approved the comments on older posts and will try to read all of t...
2 comments:
Thursday, August 12, 2021

COVID-19

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Brief one-liner: There was a question in comments about what tweaks people might apply to themselves to minimise the risk of severe COVID-19...
73 comments:
Wednesday, August 11, 2021

Update

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Lots of posts part written but currently I'm getting camping gear ready for our family holiday with kayaks, hills and tents. At the same...
5 comments:
Sunday, July 25, 2021

Nourish Balance Thrive Podcast

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I had a chat with Megan Hall of Nourish Balance Thrive. I feel it went quite well and I got most of the core ideas of the Protons/ROS hypot...
35 comments:
Tuesday, July 20, 2021

Jay Bhattacharya in conversation with Lord Sumption

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This came to me via Ivor and Facebook. I keep struggling with the worry that the current pandemic might be the beginning of the end of weste...
11 comments:
Wednesday, July 14, 2021

More time wasted on vaccines

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My thanks to Jonathan Engler for the tweet. This is HMS Queen Elizabeth. She has a complement of 1,600 when fully staffed (dirtied my hands ...
87 comments:
Monday, July 05, 2021

Lockdowns Summit

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You can register for free on-line access. Donations are optional. Lockdowns Summit Someone has to map out a route out of the current politic...
39 comments:

Mongongo nuts

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Just recently Raphi had a very interesting and very thought provoking chat with Herman Pontzer . They touched upon honey and the Hadza but d...
35 comments:
Sunday, July 04, 2021

Obesity and diabetes (3) Acipimox

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I first went looking for papers on Acipimox in 2014. I had read that it was an inhibitor of lipolysis and I was interested in how much weigh...
15 comments:
Wednesday, June 30, 2021

Obesity and diabetes (2) Basal lipolysis and weight gain

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This is a paper at the "dislike" end of my bias spectrum: In Vitro Lipolysis is Associated with Whole Body Lipid Oxidation and Wei...
10 comments:
Monday, June 28, 2021

Obesity and diabetes (1)

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There is absolutely no doubt in my mind that adipocytes can become insulin resistant. The most convincing paper I've come across is this...
9 comments:
Saturday, June 26, 2021

Metformin (12) You don't need to be SHORT

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Metformin is a drug which blunts the action of insulin. Metformin is the most widely prescribed insulin sensitising agent in the world. Disc...
2 comments:
Thursday, June 24, 2021

Ossabaw pigs

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I notice that Brad Marshall has a great post out on PUFA/insulin sensitivity and especially ALA. Brad is seriously thinking along ROS/Proton...
6 comments:
Monday, June 21, 2021

Random musings on uncoupling (7) DNP and metformin

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NAFLD, NASH, ALD and alcoholic steatohepatitis (ASH?) are all associated with the accumulation of lipid within liver cells. The two primary ...
15 comments:
Saturday, June 19, 2021

Random musings on uncoupling (6) Nouveaux DNP

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 I started here with with DNP 2,4 Dinitrophenol as Medicine Several links came out of the paper. First was this one from Shulman's group...
11 comments:
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About Me

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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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