Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Sunday, November 25, 2018

More on insulin and the glycerophosphate shuttle

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Raphi tweeted this paper recently Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS whic...
36 comments:
Saturday, November 24, 2018

Metallic iron and the origin of metabolism

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Over the years I've been convinced that carbon monoxide derived formaldehyde/formate are probably the initial molecular precursors of ac...
Wednesday, November 14, 2018

A brief aside in to statins and FH and all cause mortality

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I must admit that I have not read this paper, just the abstract. My excuse is, once again, that I have no access to any ondansetron. Stati...
28 comments:

Listeriosis is no fun

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Just doing my bit Vegetables, nine dead of listeriosis Quick edit for when the link dies: "9 people dead following Listeria outbr...
8 comments:
Wednesday, November 07, 2018

Green Tea Extract; superb antioxidant?

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Here is a little more from this paper: High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS This is insu...
13 comments:
Friday, November 02, 2018

Stone Agers in the Fast Lane?

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A destruction of Paleo Diet ™  as a management tool for metabolic syndrome in modern humans surfaced recently in a tweet from Miki Ben-Dor, ...
30 comments:
Tuesday, October 30, 2018

Selenium induced glutathione peroxidase generation

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TLDR: excess selenium induces excess glutathione peroxidase which blunts physiological superoxide/H2O2 signalling within a cell. This, as yo...
11 comments:
Sunday, October 21, 2018

Metformin (09) Islets

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This is another very abstracted study using isolated mouse islets in cell culture to assess the effect of metformin on insulin secretion. ...
14 comments:
Monday, October 15, 2018

Metformin (08) Insulin and AMPK

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This is a simplified diagram of most of the pathways around AMP-kinase (AMKP) which I found at the website of a commercial company on tinte...
3 comments:
Saturday, September 15, 2018

Insulin makes you hungry (9) Women

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Intranasal insulin does not, under any circumstances, reduce food intake or bodyweight in women. That's half the population. Hallsch...
6 comments:
Wednesday, September 12, 2018

Insulin makes you hungry (8) Blokes

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Now it's time to look at the simple situation of men given intranasal insulin. We have a chronic study using 40iu and an acute study usi...
Sunday, September 09, 2018

Insulin makes you hungry (7) superoxide is satiety

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What causes satiety, if it's not insulin? This has to be understood if there is to be any chance of understanding the effects of intrana...
3 comments:
Thursday, August 23, 2018

Insulin makes you hungry (6) except when you snort it

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TLDR: The action of insulin is the inhibition of lipolysis. This is our next paper: Sniffing neuropeptides: a transnasal approach to the...
7 comments:
Tuesday, August 21, 2018

Another brief housekeeping post

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OK. I published the "awaiting moderation" comments. Lots of them are insightful and need a response. Time for this is not looking ...
2 comments:

Insulin makes you hungry (5) except when you resist

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TLDR: The function of insulin is the inhibition of lipolysis. Does resisting insulin facilitate lipolysis? This the next paper: Improvin...
2 comments:
Friday, August 03, 2018

Holiday reading

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I'm off on vacation for a while so the next posts are likely to be delayed. If anyone would like a light summary of the ideas I'm th...
2 comments:
Wednesday, August 01, 2018

Insulin makes you hungry (4) unless you keep it out of your brain

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TLDR: The function of insulin is the inhibition of lipolysis. Especially via the brain. Where insulin detemir doesn't go. People will ...
10 comments:
Monday, July 30, 2018

Insulin makes you hungry (3) a matter of semantics and free fatty acids

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OK. There is absolutely nothing technically incorrect with the description of the results contained within the title of this paper: Effect...
5 comments:
Tuesday, July 24, 2018

Insulin makes you hungry (2) even in the presence of hyperglycaemia

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TLDR: The function of insulin is the inhibition of lipolysis. Really. This is the paper cited by Woo: Effect of Insulin and Glucose on F...

Insulin makes you hungry (1)

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TLDR: The function of insulin is the inhibition of lipolysis. In the brain. In the periphery. If you want to think about the central effec...
3 comments:
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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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