Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Wednesday, November 30, 2022

Sugar on your coconut oil?

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I mentioned this paper in the last post: Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential R...
9 comments:
Monday, November 28, 2022

Coconut oil and obesity

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Over the past six months or so I've spent a lot of time thinking about all sorts of things. Two of my main irritating problems are the o...
12 comments:
Tuesday, August 02, 2022

Choose your insulin sensitivity well

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People may or may not realise that I dislike meta-analysis. In the words of the great Malcolm Kendrick "One, two, skip a few, 99, one h...
31 comments:
Saturday, July 02, 2022

Brand on 4-HNE facilitated uncoupling

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This is one of those papers with strong confirmation bias reinforcing properties, so care is needed. I do indeed have some difficulties with...
14 comments:
Thursday, June 23, 2022

FFA vs 4-HNE for activating uncoupling

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Another basic mitochondrial concept. This is Brand again. The paper features mitochondria extracted from yeast cells which have been transfe...
3 comments:
Saturday, June 18, 2022

Insulin increases coupling in mitochondria

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Back in the 1990s Veech's lab noted that supra maximal insulin, combined with glucose at 11mmol/l, markedly improved the ability of an i...
18 comments:
Monday, June 06, 2022

Beta oxidation intermediates control ETC function

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Back to the paper provided by met4health, briefly mentioned previously: Electron Transport Chain-dependent and -independent Mechanisms of Mi...
7 comments:

Brand insights

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In the comments to a previous post met4health provided a link to this paper: Electron Transport Chain-dependent and -independent Mechanisms...
1 comment:
Monday, May 16, 2022

Deuterium protected linoleic acid

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This is a fascinating paper which has distracted me from my thought train on uncoupling, mitochondrial membrane potential and ROS generation...
22 comments:
Sunday, May 08, 2022

Protons (70) Uncoupling does suppress insulin signalling

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The premise of the last post is that mild mitochondrial uncoupling is protective against fatty liver because it disables insulin signalling...
18 comments:
Saturday, May 07, 2022

Protons (69) BAM15

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Completely at random Tucker emailed me this paper using the classical model of Bl/6 mice fed an unspecified 60% fat diet to become obese. He...
4 comments:
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About Me

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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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