Hyperlipid

You need to get calories from somewhere, should it be from carbohydrate or fat?

Saturday, July 02, 2022

Brand on 4-HNE facilitated uncoupling

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This is one of those papers with strong confirmation bias reinforcing properties, so care is needed. I do indeed have some difficulties with...
14 comments:
Thursday, June 23, 2022

FFA vs 4-HNE for activating uncoupling

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Another basic mitochondrial concept. This is Brand again. The paper features mitochondria extracted from yeast cells which have been transfe...
3 comments:
Saturday, June 18, 2022

Insulin increases coupling in mitochondria

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Back in the 1990s Veech's lab noted that supra maximal insulin, combined with glucose at 11mmol/l, markedly improved the ability of an i...
18 comments:
Monday, June 06, 2022

Beta oxidation intermediates control ETC function

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Back to the paper provided by met4health, briefly mentioned previously: Electron Transport Chain-dependent and -independent Mechanisms of Mi...
7 comments:

Brand insights

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In the comments to a previous post met4health provided a link to this paper: Electron Transport Chain-dependent and -independent Mechanisms...
1 comment:
Monday, May 16, 2022

Deuterium protected linoleic acid

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This is a fascinating paper which has distracted me from my thought train on uncoupling, mitochondrial membrane potential and ROS generation...
22 comments:
Sunday, May 08, 2022

Protons (70) Uncoupling does suppress insulin signalling

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The premise of the last post is that mild mitochondrial uncoupling is protective against fatty liver because it disables insulin signalling...
18 comments:
Saturday, May 07, 2022

Protons (69) BAM15

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Completely at random Tucker emailed me this paper using the classical model of Bl/6 mice fed an unspecified 60% fat diet to become obese. He...
4 comments:
Wednesday, May 04, 2022

Protons (68) Pathological ROS (1)

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This is another non-referenced, thinking out loud post which is the precursor to more normal technical posts. Here we go. The whole underpin...
25 comments:
Sunday, April 03, 2022

Random COVID discussions

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 Gotcha Eric.
85 comments:
Monday, March 28, 2022

Linoleic acid panel discussion

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Here's the link to the panel discussion about PUFA and obesity, hosted by David Gornoski. My Big Fat Panel: How Seed Oils Cause Obesity ...
24 comments:
Wednesday, March 16, 2022

Chatting post

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 Here we go Peter
85 comments:
Friday, February 18, 2022

Ioannidis

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I have great respect John Ioannidis   Saving Democracy From the Pandemic I'm also coming to accept that prison or sectioning for the pri...
69 comments:
Monday, January 31, 2022

How's it going, Pfi$rael?

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There may be some readers who genuinely believe the pfvacine really does protect agains severe illness and even death from covid. That's...
80 comments:
Friday, January 28, 2022

More covid chit chat

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Here you go, time flies! Peter
10 comments:
Saturday, January 22, 2022

So you want some DHA? Chickens in Norway

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Again via twitter, Tucker retweeted a thread which included the link to this paper Increased EPA levels in serum phospholipids of humans aft...
28 comments:
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About Me

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Peter
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
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