For an absolute, all singing, all dancing excellent review of the JUPITER trial go read Sandy Szwarc over at Junkfood Science.
Don't expect to be done in 2 minutes!
Peter
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You need to get calories from somewhere, should it be from carbohydrate or fat?
About Me
- Peter
- I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them.
Organisation (or lack of it)!
The "labels" function on this blog has been used to function as an index and I've tended to group similar subjects together by using labels starting with identical text. If they're numbered within a similar label, start with (1). The archive is predominantly to show the posts I've put up in the last month, if people want to keep track of recent goings on. I might change it to the previous week if I ever get to time to put up enough posts in a week to justify it. That seems to be the best I can do within the limits of this blogging software!
Blog Archive
Labels
- !Kung Bushmen and mongongo nuts again (1)
- !Kung Bushmen and mongongo nuts yet again (1)
- A aargh BROKEN LINKS (1)
- A bit more on ketones and diabetic nephropathy (1)
- A brief aside in to statins and FH and all cause mortality (1)
- A brief discussion of ketosis (1)
- A defect of fat metabolism and a few thanks (1)
- A glimmer of light (1)
- A heads up (1)
- A little more on PCSK9 inhibitors (1)
- A load of crap in Gartnavel (1)
- A Peek at Paleo (1)
- A post not about Walter Kempner (1)
- A tale of two abstracts (1)
- A wander off in to dietary protein calories (1)
- ACCORD and musings on insulin (1)
- Acetoacetate and arterial oxygen tension (1)
- Acetone to oxaloacetate (1)
- Acipimox (2) and weight gain (1)
- Acipimox and insulin (1)
- Acipimox and insulin action (1)
- Adipose triglyceride lipase knockout mice (1)
- Adipotide and the Bad Fat (1)
- Adrian Ballinger on Everest (1)
- AGE RAGE and ALE (1): The AGE of LDL (1)
- AGE RAGE and ALE (2): The ALE of LDL (1)
- AGE RAGE and ALE (3): oxLDL (1)
- AGE RAGE and ALE (4): segregation (1)
- AGE RAGE and ALE (5): fasting (1)
- AGE RAGE and ALE (6): low fat (1)
- AGE RAGE and ALE (7): VLDL degradation (1)
- AGE RAGE and ALE (8): VLDL degradation and Krauss (1)
- AGE RAGE and ALE (9): VLDL degradation and Fish Oil (1)
- AGE RAGE and ALE posts (10): small dense Krauss (1)
- AGE RAGE and ALE posts (11): linoleic acid (1)
- AHA approved egg! (1)
- Alcohol and fructose are the same to your liver (1)
- Alcohol and weight loss (1)
- Alzheimer's (1)
- Alzheimers and ketones (1)
- Alzheimers and omega 6s (1)
- Alzheimers and Tau proteins (1) (1)
- Alzheimers and Tau proteins (2) (1)
- Amgen share price and PCSK9 inhibition with Repatha (1)
- Amgen share price and PCSK9 inhibition with Repatha (2) (1)
- an aside (1)
- An aside on psychiatric links from Sid Dishes (1)
- An embarrassment of cress (1)
- An Error (1)
- An exchange of half bricks (1)
- Anacetrapib and phytotoxins (1)
- Anger vs diet in Japan (1)
- Animal fat and cholesterol (1)
- ARDS and linoleic acid (1)
- ARDS and Tucker Goodrich (1)
- ARDS isoprostanes and isofurans (1)
- Are COVID-19 vaccines useful? (1)
- Are COVID-19 vaccines useful? (2) (1)
- Are COVID-19 vaccines useful? (3) (1)
- Are humans just multicellular yeasts? (1)
- Are ketone esters dangerous? (1)
- Are you lino-philic? (2) (1)
- Are you on clenbuterol? (3) (1)
- Are you trans-phobic? (1) (1)
- Arteriosclerosis (1) in 1957 (1)
- Arteriosclerosis (2) and sulphation factor (1)
- Arteriosclerosis (3) and von Willebrand Disease (1)
- Arteriosclerosis (4) GAG and sudden death (1)
- Arteriosclerosis (5) GAG and sudden death part two; the pictures (1)
- Arteriosclerosis (6) and Subbotin (1)
- Arteriosclerosis and saturated fat (1)
- Arteriosclerosis and the breeder rat (1)
- Arteriosclerosis images (2): Models (1)
- Athletic acid reflux (1)
- Atrial tachycardia and fibrillation (1)
- Axen and Axen (1) (1)
- Axen and Axen (2) (1)
- Axen and Axen (3) Hawks (1)
- Axen and Axen (4) Ketogenic insulin resistance. It's all over now... (1)
- Axen and Axen (5) The tradition continues (1)
- Back on line (2)
- Back to a semblance of normality: A couple of conversations (1)
- BAM15 and semaglutide are not insulin sensitising (1)
- Barja (1)
- Best ever statin study comment? (1)
- Best ever statin study? (1)
- Beta oxidation intermediates control ETC function (1)
- Blood "energy" content (1)
- Bob Michell on meta-analysis (1)
- Boiled mashed potatoes for miracle weight loss? (1)
- Boxes (1)
- Brain on a statin (1)
- Brain on chocolate (1)
- Brand insights (1)
- Brand on 4-HNE facilitated uncoupling (1)
- Breast cancer and starch (1)
- Breast cancer BRCA1 and metabolic syndrome (1)
- butter and leptin receptors: Speculation! (1)
- Butter gives you fatty liver! Again. (1)
- Butter insulin and Dr Davis (1)
- Butter vs peanut butter (1)
- Can linoleic acid keep you slim? (1)
- Cancer and ketones (1)
- Cardiac ischaemia and low carbohydrate diets (1)
- Casein and gluten and gastric pH (1)
- Casein vs gluten (1)
- Cat rawfeeding; scroll down the comments (1)
- Cell surface oxygen consumption (1) (1)
- Cell surface oxygen consumption (2) (1)
- Cell surface oxygen consumption (3) (1)
- Cell surface oxygen consumption (4) Influenza (1)
- Chicken fillets are not meat. If you're a cat. (1)
- Cholesterol (the HDL sort) kills? (1)
- Cholesterol and Carruthers (1)
- Cholesterol and cholestyramine (1)
- Cholesterol and heart attack survival (1)
- Cholesterol and innate immunity (1)
- Cholesterol and memory (1)
- Cholesterol and Son of J-LIT (1)
- Cholesterol and the J-LIT study (1)
- Cholesterol and the J-LIT update (1)
- Cholesterol fed rabbit (1)
- Cholesterol heart attacks and JUPITER (1)
- Cholesterol hypothesis in 2010 (1)
- Cholesterol hypothesis in 2010 part 2 (1)
- Cholesterol JUPITER link (1)
- Cholesterol Milano style (1)
- Cholesterol pacitimbe and ACAT (1)
- Cholesterol presentation: Between countries (1)
- Cholesterol ratios through the looking glass (1)
- Cholesterol ratios: Torcetrapib again (1)
- Cholesterol reflectivity at 400nm (1)
- Cholesterol within nations studies (1)
- Cholesterol; it's not a competition (1)
- Cholesterol; MESA and EBCT (1)
- Cholesterol; statins kill? (1)
- Cholesterol: ASTEROID destroys lipid hypothesis (1)
- Cholesterol: Do chylomicrons clog your arteries? (1)
- Cholesterol: Do chylomicrons clog your arteries? (2) (1)
- Cholesterol: LCAT and rabbits (1)
- Cholesterol: LDL in Oslo (1)
- Cholesterol: More epidemiology (1)
- Cholesterol: Near miss in Edinburgh (1)
- Cholesterol: Peto seeing some light? (1)
- Cholesterol: statins and oxLDL (1)
- Choose your insulin sensitivity well (1)
- Cirrhosis and corn oil (1)
- Cirrhosis and fish oil (1)
- Cirrhosis and fructose (1)
- Clofibrate and PUFA (1)
- Coconut oil and obesity (1)
- Coconuts and Cornstarch in the Arctic? (1)
- Coffee (1)
- Colorectal cancer and cholesterol (1)
- Colorectal cancer; fiber and the PPT (1)
- Complex I: Hoffer and B3 (1)
- Complex IV and control of delta psi (1)
- Conditioning Research on bad carbs (1)
- Confirmation Bias in my head (1)
- Confirmation bias is not just in my head (1)
- Confirmation bias is so nice (1)
- Coronary Artery Calcium Score and Scleroderma (1)
- Coronavirus is possibly everywhere (1)
- Costa del Glasgow (1)
- Covid playground (1)
- COVID-19 (1)
- CPT1aL479 resurfaces nicely (1)
- Crabtree and cardiovascular surgery (1)
- Credo (1)
- Cynthia Kenyon link (1)
- Dave Asprey and Dr Veech (1)
- David Blaine and refeeding syndrome (1)
- Dead people DO bleed... (1)
- Death by dogma (1)
- Delta psi and insulin and ROS (1)
- Delta psi and ROS (1)
- Denmark purchased using Flora profits? (1)
- Deuterium protected linoleic acid (1)
- DHA in rats (1)
- Diabetes and cardiac apotosis (1)
- Diabetes and hunger (1)
- Diabetes in Sweden (1)
- Diabetes in Sweden update (1)
- Diabetes; endothelial damage (1)
- Diabetic and hungry? (1)
- Diabetic nephropathy and the lost Swede (1)
- Diagnosing and Treating Vitamin B12 Deficiency Video (1)
- Do you believe in MRI scanners? (1)
- Dodgy D'Anci (1)
- Double Bond Index and longevity in humans (1)
- Dr Davis links (1)
- Dr Doug Wallace on mitochondria (1)
- Dr Ravnskov on statins for primary prevention of CVD (1)
- Dr Uffe Ravnskov MD PhD interview (1)
- Dr Wolfgang Lutz Obituary (1)
- Dunnigan Familial Partial Lipodystrophy (1)
- Earning a crust (1)
- Easiyo (1)
- Eat as much starch as you wish (1)
- Eating lots of meat and nothing much else (1)
- EBCT scan (1)
- EFA deficiencies? (1)
- Eggs are here (1)
- Eggs in Ontario (1)
- Electrochemistry (1)
- Electrochemistry (2) Superoxide (1)
- Electron Transport Chain image (1)
- Endocannabinoids in brain and adipocytes (1)
- Endotoxin Absorption on a High Fat Diet (1)
- Endurance and oxygen flux during fatty acid oxidation (1)
- Energy expenditure in obese vs slim non dieters (1)
- EPIC HbA1c and heart attacks (1)
- Essential fatty acids are essential (1)
- Excession (1)
- Faking it with selenium (1)
- Familial Hypercholesterolaemia (1)
- Familial Hypercholesterolaemia and glucose (1)
- Familial Hypercholesterolaemia and porcelain (1)
- Familial Hypercholesterolaemia Brown and Goldstein (1)
- Familial Hypercholesterolaemia heterozygous survival (1)
- Fancy some serology? (1)
- Fancy some serology? (2) (1)
- Fancy some serology? (3) In Japan (1)
- Fasting insulin and weight loss (1)
- Fasting insulin and weight loss and calories-in vs calories-out (1)
- Fasting insulin and weight loss on a water fast (1)
- Fat storage and retrieval (1)
- Fathead Supersize Me and Sweden (1)
- Fathead Supersize Me and Sweden (2) (1)
- Fats and absorbing endotoxin (1)
- Feeling experimental? (1)
- FFA vs 4-HNE for activating uncoupling (1)
- Fiaf (1) Who's fat is it anyway? (1)
- Fiaf (2) starving amidst plenty (1)
- Fiaf (3) where next? (1)
- Fiaf (4) memes and fat (1)
- Fiaf (5) Meme Watching (1)
- Fiber inulin and cancer (1)
- Fiber sucrose and ulcers (1)
- FIP vaccines etc (1)
- FIRKO mice (1)
- FIRKO-isation without all the hassle? (1)
- FIRKO-ise (1)
- First meat (1)
- Flow Mediated Dilation: What does it mean? (1)
- Foie Gras (1) Peroxisomes (1)
- Foie Gras (10) Liver (1)
- Foie Gras (11) Hepatocyte mitochondria (1)
- Foie Gras (2) Lard fed rats (1)
- Foie Gras (3) carbohydrate (1)
- Foie Gras (4) RER (1)
- Foie Gras (5) An aside on how to stay slim (1)
- Foie Gras (6) inflammatory mRNAs (1)
- Foie Gras (7) What do you mean by inflammation? (1)
- Foie Gras (8) Vaughan's macrophages (1)
- Foie gras (9) Adipocyte ROS (1)
- Foie gras from safflower oil hiatus (1)
- Folate and homocysteine (1)
- Follow on to Tucker's post on PUFA in rats (1)
- Food fermented cream (1)
- Food; carnitas (1)
- Food; chicken salsa (1)
- Food; Mutton followed by cheesecake (1)
- Food; sausages (1)
- Food; steak and kidney casserole (1)
- Food: African Beef Stew (1)
- Food: Burgers (1)
- Food: Lardo; the real thing (1)
- Food: Liver and bacon (1)
- Food: Liver; can you over do it? (1)
- Food: Mutton or lamb in orange sauce (1)
- Food: Offal (1)
- Food: Optimal ice cream (1)
- Food: Pork in green salsa and random dessert (1)
- Food: Recipe group (1)
- Food: steak and kidney casserole (1)
- French paradox in Sweden (1)
- From Yeasts to Chloroquine (1)
- Fructose (01) There's a signal (1)
- Fructose (02) Obesogen (1)
- Fructose (03) NOX vs RET (1)
- Fructose (04) Normal Adults (1)
- Fructose (05) Four out of five diabetics (1)
- Fructose (06) Acipimox tangent (1)
- Fructose (07) Acipimox tangent II (1)
- Fructose (08) Acipimox and FFAs (1)
- Fructose (09) The Surwit hepatocyte (1)
- Fructose (10) A can of cola (1)
- Fructose and gout (1) (1)
- Fructose and gout (2) (1)
- Fructose and heart attacks (1)
- Fructose and lactic acid in Naked Mole Rats (1)
- Fructose and leptin (1)
- Fructose and lipolysis (1)
- Fructose and metabolic syndrome: Uric acid (1)
- Fructose and triglycerides (1)
- Fructose Glucose and Cholesterol (1)
- Fruit and vegetables (1) cause DNA damage (1)
- Fruit and vegetables (1) re post (1)
- Fruit and vegetables (10) WHI and cancer (1)
- Fruit and vegetables (11) link (1)
- Fruit and vegetables (12) WHEL and CVD (1)
- Fruit and vegetables (13) become eggs (1)
- Fruit and vegetables (14) Listeriosis is no fun (1)
- Fruit and vegetables (2) damage your DNA... latest study headline (1)
- Fruit and vegetables (3) last post (almost) (1)
- Fruit and vegetables (4) The asterisk (1)
- Fruit and vegetables (5) in Holland (1)
- Fruit and vegetables (6) WHEL study (1)
- Fruit and Vegetables (7) Mediterranean France (1)
- Fruit and vegetables (8) WHEL study and McDougall (1)
- Fruit and vegetables (9) potato fruits (1)
- Fruit Flies and NDI1 (1)
- FSA apple (1)
- FSA in Glasgow (1)
- Full blown linoleic acid deficiency: speculation (1)
- Getting fat (1) staying fat (1)
- Getting fat (2) staying fat; follow on (1)
- Getting fat (3) is good (1)
- Getting fat (4) is bad when you stop (1)
- Getting fat (5) Hunger (1)
- Getting fat is good (6) Official (1)
- GLP-1 agonists (1)
- Glucosamine and aged mice (1)
- Glucose as a cure for hypertriglyceridaemia? (1)
- Glucose from fatty acids: RQ of 0.454 (1)
- Glucose lactate and cancer (1)
- Gluten and cardiomyopathy (1)
- Gluten and gall bladders (1)
- Gluten and NK cells (forget the antibodies) (1)
- Gluten and rheumatoid arthritis (1)
- Gluten and schizophrenia SPECT scan (1)
- Gluten ataxia (1)
- Gluten coeliac and multiple sclerosis (1)
- Gluten Dr Briffa link (1)
- Gluten links from Bloggeier (1)
- Gluten poppy pictures (1)
- Gluten-Congratulations: You have coeliac disease (1)
- Gluten; thyroid and auto immunity (1)
- Gluten: Does coeliac disease require an infection? (1)
- Gluten: Not your average plant toxin? (1)
- Gluten: The NICE guidelines for UK diagnosis (1)
- Glycaemic load and breast cancer (1)
- Gourmand Rats? (1)
- Great Barrington Declaration (1)
- Great Barrington Declaration (2) (1)
- Green Tea Extract; superb antioxidant? (1)
- GSD IIIa ketones MAD and Veech again (1)
- GSD type I vs GSD type III: Cornstarch vs ketones (1)
- Guddling in the dark (1)
- Guddling in the dark for a respiratory quotient (2) (1)
- Guess the weight of the mouse competition (1)
- Gwyneth Paltrow has osteopaenia (1)
- Hall and CICO again (1)
- Hall and CICO part 2 (1)
- Hall and CICO part 3 (1)
- Have you thought about electron transporting flavoprotein dehydrogenase and its substrate electron transporting flavoprotein? (1)
- Hazel eats butter (1)
- HbA1c and Familial Hypercholesterolaemia (1)
- HbA1c: Crack vs smack for a lower reading? (1)
- HbA1c: Low glucose and acid (palmitic) (1)
- Heart failure and insulin resistance (1)
- Helicobacter and glucose (1)
- Helicobacter and hydrogen (1)
- Hepatic extraction of fructose (1)
- Hepatic insulin resistance (1)
- Hepatic insulin resistance in KD fed mice (1)
- Hepatic insulin resistance through caloric overload (1)
- Here we go in to Lockdown 2 (1)
- Heroin and IBS (1)
- High fat diet and fertility (1)
- High fat diets make you fat and stupid (1) (1)
- High fat diets make you fat and stupid (2) (1)
- High fat Dutch style (1)
- High fat fed mice on stearic acid (1)
- High fat meal is analgesic (1)
- HLA-B27 and Ebringer (1)
- HLA-B27 and Ebringer BSE text (1)
- HLA-B27 and Ebringer speech text (1)
- HLA-B27 some more (1)
- Holiday reading (1)
- How can insulin resistance cause weight gain? (1) ALDH2 (1)
- How can insulin resistance cause weight gain? (2) 0.1 μM (1)
- How can insulin resistance cause weight gain? (3) AD-9308 (1)
- How can insulin resistance cause weight gain? (4) amplification (1)
- How can insulin resistance cause weight gain? (5) MCTs (1)
- How incomplete was LUCA? (1)
- HOW MANY bananas a day? (1)
- How many eggs per day? (1)
- How much linoleic acid to get fat and insulin resistant? (1)
- How toxic is wheat? (1)
- How's it going (1)
- Hunting gathering and starving (1)
- Hyperglycaemia and free radicals (1)
- Hyperglycaemia is bad (1)
- Hyperlipid Protons ambassadors (1)
- I'm back (1)
- If there were time... (1)
- IgG IgA and sniffing a virus (1)
- IgG IgA and sniffing a virus which stinks (1)
- IHD and ghee (1)
- IHD single vessel disease (1)
- IHD Tracking plaque 1950s style (1)
- Impaired glucose tolerance in low-carbohydrate diet: maybe only a physiological state (1)
- In the gym (1)
- Inhibiting lipolysis using acipimox (1)
- Insulin and confusion (1)
- Insulin and the Rewards of overfeeding (1)
- Insulin detemir (1) (1)
- Insulin detemir (2) (1)
- Insulin detemir (3) (1)
- Insulin glucagon and protein (1)
- Insulin in the brain: Hyperphagia? (1)
- Insulin in the brain: off topic giggle (1)
- Insulin increases coupling in mitochondria (1)
- Insulin makes you hungry (1) (1)
- Insulin makes you hungry (10) Processing (1)
- Insulin makes you hungry (2) even in the presence of hyperglycaemia (1)
- Insulin makes you hungry (3) a matter of semantics and free fatty acids (1)
- Insulin makes you hungry (4) unless you keep it out of your brain (1)
- Insulin makes you hungry (5) except when you resist (1)
- Insulin makes you hungry (6) except when you snort it (1)
- Insulin makes you hungry (7) superoxide is satiety (1)
- Insulin makes you hungry (8) Blokes (1)
- Insulin makes you hungry (9) Women (1)
- Insulin mimesis and NOX enzymes (1) A principle (1)
- Insulin mimesis and NOX enzymes (2) Lactate (1)
- Insulin mimesis and NOX enzymes (3) MCT (1)
- Insulin mimesis without NOX enzymes (4) MCT (1)
- Insulin mimesis without NOX enzymes (5) MCT plus linoleic acid (1)
- Insulin mimesis without NOX enzymes (6) MCT versus linoleic acid (1)
- Insulin sensitivity makes you fat (1)
- Insulin sensitivity makes you fat: growth hormone receptor deletion (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (02) (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (03) Visceral vs subcutaneous (1)
- Insulin sensitivity makes you fat. Insulin resistance makes you fat. Discuss. (04) M scores (1)
- Insulin; the Un-dead and coffin nails (1)
- Insulin: Are you hungry? (1)
- Insulin: Are you hungry? Part 2 (1)
- Insulin: The Flatline Days (1)
- Intellectual honesty vs obfuscation (1)
- Interesting times on Mars (1)
- Intimal wall volume reductions with weight loss (1)
- Is the astrocyte-neuron lactate shuttle finished? (1)
- Is vaccine efficacy a statistical illusion? (1)
- It's never too late to normalise your glucose (so long as you are still alive) (1)
- Jan Kwasniewski comment (1)
- Japan and a Seven Countries Study follow on (1)
- Jay Bhattacharya in conversation with Lord Sumption (1)
- Jebb VS Nutt (1)
- Jimmy Moore on Dr Weil (1)
- John Hawks on Paleo in NY (1)
- Junk Food binge (1)
- Just a heads-up (1)
- Just a little on complex I and models (1)
- Just an announcement (1)
- Just an update (1)
- Kebabs (1)
- Ketoacidotic death in lactation! (1)
- Ketogenic Diet: Eat Food (1)
- Ketogenic diets are unhelpful and dangerous for managing mitochondrial diseases. Maybe (2) (1)
- Ketogenic diets are unhelpful and dangerous for managing mitochondrial diseases. Maybe. (1)
- Ketogenic vs moderate carbohydrate diets (1)
- Ketones for ALS? (1)
- Ketones in Tehran (1)
- Ketones without the side order of Danish Pastry please (1)
- Ketones: Should idiots be allowed to write the methods section of any "scientific" paper? (1)
- Ketosis and Protein (1)
- Ketosis links (1)
- Kitava: uric acid (1)
- Kwasniewski and cancer (1)
- Kwasniewski paper (1)
- Kwasniewski; praise the lard (1)
- Lactate as bulk energy transport (1)
- Lard makes hungry mice live longest (1)
- Latest obesity paradox (1)
- Let them eat fat: Ron Rosenbaum (1)
- Life (01) Random musings on carbon monoxide (1)
- Life (02) Polyprenyl derivatives at the origin of life (1)
- Life (03) ATP synthase (1)
- Life (04) On the bench top (1)
- Life (05) Why sodium ions? (1)
- Life (06) What's wrong with sodium ions? (1)
- Life (07) Two timelines (1)
- Life (08) Proto-Ech (1)
- Life (09) Ech (1)
- Life (10) Methyltransferase in methanogens (1)
- Life (11) Ferredoxin (1)
- Life (12) Loki and its membrane potential (1)
- Life (13) Skulachev in 1978 (1)
- Life (14) From Skulachev to LUCA (1)
- Life (15) Skulachev addendum (1)
- Life (16) Mulkidjanian: Na+ pump or Na+/H+ antiporter? (1)
- Life (17) Nick Lane on Proto-Ech (1)
- Life (18) Why stop at formaldehyde? (1)
- Life (19) Metallic iron and the origin of metabolism (1)
- Life (20) How primordial is oxidative phosphorylation? (1)
- Life (21) Pyrococcus furiosus (1)
- Life (22) FeNi hydrogenase (1)
- Life (23) Antiporting: Choose your ion well (1)
- Life (24) Porting over CCCP (1)
- Life (25) Left or right hand? (1)
- Life (26) MrpA MrpD NuoL NuoM and NuoN. Plus nt-Nha. (1)
- Life (27) Alphabet soup (1)
- Life (28) Proton Billiards (1)
- Life (29) Applied billiards to MRP and MBH (1)
- Life (30) Guesses about Na+ channels (1)
- Life (31) Chinese whispers (1)
- Life (32) On the correct side of the fence (1)
- Life (33) Transient hunger (1)
- Life (34) Complex I pumping (1)
- Life (35) NiFe pumping (1)
- Life (36) Complex I. Protons are large (1)
- Life (37) Just a gif of complex I (1)
- Life (38) Water Wires (1)
- Life (39) NuoH (1)
- Life (40) Proton pumping (1)
- Linoleic acid and Tuberous Sclerosis (1)
- Linoleic acid makes you hungry (1)
- Linoleic acid panel discussion (1)
- Lipid blockage (1)
- Lipoprotein(a) a prickly subject (1)
- Lipoprotein(a) and ascorbate (1)
- Lipoprotein(a) and DELTA (1)
- Lipoprotein(a) and genetics (1)
- Lipoprotein(a) and oxidised cholesterol (1)
- Lipoprotein(a) and oxidised lipids: What's your mimium requirement? (1)
- Lipoprotein(a) and the Fairies at the bottom of my garden (1)
- Lipoprotein(a) and tissue transglutaminase (1)
- Lipoprotein(a) Bantu recap (1)
- Lipoprotein(a) Bantu recap 2 (1)
- Lipoprotein(a) genetics press release (1)
- Lipoprotein(a) is oxidised (1)
- Lipoprotein(a) Oxford abstract (1)
- Lipoprotein(a); Bantu Lp(a) and Swedish Lp(a) (1)
- Lipoprotein(a): 7-ketocholesterol and cancer (1)
- LIRKO mice (1) (1)
- LIRKO mice (2) (1)
- LIRKO mice (3) The MCQ (1)
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19 comments:
Actually just knowing that the trial was sponsored by AstraZeneca saves us the trouble of even having to read the Jupiter study.
Though I did anyway, just for the laugh.
Ok, not so funny for those who are going to have this poison pushed on them, and who will have to pay for it to...
Peter, what do you think about the (JunkfoodscienceBlog-) "Obesity Paradox"-articles?
Sven, just flicked through a few (not read all of them by any means) and I think she is basically correct. To my mind the poo poo hits the fan when you STOP getting fatter. Once the fat cells say no to calories those calories then slosh around in your blood stream as elevated glucose and trigs. My only problem with obesity is that you are eating a diet that will eventually, at some point, lead your fat cells to say no to calories. Then you are in trouble. For some people this may be at BMI 25, for others at BMI 40. It's not the obesity that is the problem, more the eating style which promotes it.... And of course throw in plasticisers and anything else which might put a spanner in your metabolic works (stains, beta blockers and thiazide diuretics all spring to mind as glucose elevators, see JUPITER and diabetes incidence). I'd even accept genetics as a factor!
Being overweight with normal glucose and insulin is fine by me, though I think it gets harder to maintain this as you get heavier and your adipocytes overfill.
You get stuck in the rut of vanity though and I like weighting 64ish kgs.... This is not obligatory for health. Hee hee, you reading Windmill?
Peter
I haven't gone to that link yet, but Dr. Eades got to it too:
http://www.proteinpower.com/drmike/cardiovascular-disease/1853/
MTflight, thanks for that link. I didn't know JUPITER is actually an anagram for "Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin".
How dare they call it a study at all...
Peter,
"My only problem with obesity is that you are eating a diet that will eventually, at some point, lead your fat cells to say no to calories."
According to the studies Sandy cites this doesn´t seem to be a big problem overall. Beeing overweight is associated with longevity in elderly. Do the researcher miss something or is there a causal relationship between overweight and longevity? What could that be? Or is it just an association?
Probably more telling than BMI would be hip/waist-ratio. Maybe quite a lot in the "normal BMI group" are thin with huge "beer bellies".
I think I would phrase it as "people who are able become overweight and carry it in to old age without becoming diabetic (ie without exceding their enregy storage ability) do well". Whether they do better than people of "normal" weight who HAVE exceeded their abilty to store energy is very probable. But then what about people of normal weight and normal glucose/insulin metabolism. Do they do worse that a metabolically similar heavy person? Not aware that anyone has checked this but, if the study is out there, it would make very interesting reading.
Peter
Heh, someone brought in the marketing guy to make a catchy acronym
for the public - Justification for the Use of Statins in Primary Prevention: an
Intervention Trial Evaluating Rosuvastatin -instead of doing real work. Come to think of it, that may sum up all you need to know about statins,
Paul.
News on the eastern front: TK announced he had been asked by JK to write and publish a book on cholesterol. He mentioned something about writing in English - I doubt it, though. Anyway, can't wait...! Statins are scarily in vogue in PL too.
Peter,
Since April, we have stopped consuming vegetable oils except for some rapeseed oil and using the bulk of cooking in ghee.
We eat mostly wheat with lentils.
I have lost about 4 kgs from 76 to 72.
However, I have having problems with weakness and had a fainting spell about a couple of weeks ago.
Yesterday I got some tests done (for insurance purposes).
The total cholesterol was 125 compared with 215 in August this year.
HDL 40 (57 in August)
LDL 77 (130 ")
Fasting sugar 72 (83.5)
Post-dinner I frequently feel a sharp urge to sleep (passes in a few minutes) and is accompanied by some mental confusion (during telling a bedtime story to my 3 yr old daughter).
I am somewhat apprehensive that something is wrong somewhere but not able to fix and wondering if the doctors can help.
Could you give some advice?
Another dodgy paper alert:
http://cancerres.aacrjournals.org/cgi/content/abstract/68/22/9274
This is weird because previous population study of that kind (Willett's) found a correlation with processed meat but not with fat. This one found the opposite: saturated fat but not meat itself. It would be nice to dissect the full text like the previous one. 8-:)
Regards,
Stan
gyan (We eat mostly wheat with lentils.
I have lost about 4 kgs from 76 to 72.)
Are you getting enough protein? How about high quality protein ( non-plant) that doesn't rely on amino combinations, like eggs? How about eliminating wheat in case it is damaging your gut lining?
Have you calculated your lean body mass? Perhaps the weight you have lost isn't fat but muscle, bone, and tissue, perhaps due to protein insufficiency.
Hi Gyan,
Just back on line after 5 days working. Your lipid parameters look to be quite typical of someone on a starch based diet, something like Ornish. Classically saturated fats raise HDL, you either don't follow this pattern of biochemistry or you have accidentally reduced your fat intake when you switched to ghee... The drop in weight would fit with decreased calories, in fact that seems like the only way you could loose weight on a wheat/lentil based diet.
The low LDL would be appropriate for someone on a high fibre, carbohydrate based diet. This seems quite plausible on a whole food diet based on wheat and lentils. The lower fasting blood glucose would fit with this too, as on Kitava.
The question then is whether you can live on a Kitava style diet and stay healthy. As you know, I doubt it is possible to stay healthy on a wheat based diet....
If your insulin sensitivity is good your post prandial glucose figures may be reasonable and if you can stay that way you might be okay. An HbA1c or a few glucometer readings over a couple of hours following a wheat/lentil meal would be interesting.
Bare in mind that I haven't eaten wheat or lentils in a very long time, so really you are way out of my personal experience. But that's how the lipid/glucose numbers look to me.
Best wishes and good luck
Peter
BTW this could be of interest too, just depends really on you ghee intake vs wheat/lentils and I guess on how wrong my suggestions might be!
Peter,
Should I eat less wheat and more potatoes?
Are sweet potatoes a betetr option than potatoes?
(as they contain pre-vitamin A).
I forgot to mention I stopped eating eggs in August as the egg quality in my town has gone to pits. And the eggs seemed to give me stomach achs.
Hi Gyan,
Well the not eating eggs fits in with the posts on G's blog about the benefits they provide vs your lipid numbers... As for potatoes vs grains vs sweet potatoes, you are well beyond what I have any idea about, bearing in mind I live on butter, dripping, egg yolks, cream and some meat with enough root vegetables to just keep out of ketosis... At a guess I'd go for the most paleo, which is sweet potatoes. I don't know what constrains you are under for food choices, personally I'm still living as cheaply as practically on UK supermarket food... Seem to be doing OK on 50g of carbs per day.
Good luck
Peter
Hi Peter, hi everybody,
In case if you have some spare time and an inclination, please have a look at the following list of papers posted by Jeff N. proving (?) that eating more whole grains is protective against cancer etc. Regards,
h:) [hysterical laughter]
http://drmcdougall.com/forums/viewtopic.php?t=9386&postdays=0&postorder=asc&start=18
Hi Stan,
The message I get from epidemiology is that well educated health conscious people get less cancer despite whole grain consumption. Until you do an intervention study that's all epidemiology can tell you. Intervention gives you WHEL and PPT. The only intervention to show benefit was the Lyon Heart study and that was a multivariable intervention. Did do some good though.
BTW back in the real world some time next week...
Peter
I agree. Almost every time I look at an epidemiological study I find something wrong. For example this one "proving" that fruit and veg are good for BP had 3 times as many smokers in the low veg group and 3 times as many men than women:
http://www.ncbi.nlm.nih.gov/pubmed/18957815?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
I suspect that one can find similar blatant biases in all of them, since if they were true I and you would be dead 8-:)
In this case I didn't have a time to go through all Jeff's list, but it could be an educational experience.
Stan
http://michel.delorgeril.info/dwnl/JUPITER/2010_Answers-to-Ridker-by-de-Lorgeril.pdf
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